Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder
Open accessAbstract
Autism Spectrum Disorder (ASD) is a severe neurodevelopmental disorder. To enhance the understanding of the gut microbiota structure in ASD children at different ages as well as the relationship between gut microbiota and fecal metabolites, we first used the 16S rRNA sequencing to evaluate the gut microbial population in a cohort of 143 children aged 2–13 years old. We found that the α-diversity of ASD group showed no significant change with age, while the TD group showed increased α-diversity with age, which indicates that the compositional development of the gut microbiota in ASD varies at different ages in ways that are not consistent with TD group. Recent studies have shown that chronic constipation is one of the most commonly obvious gastrointestinal (GI) symptoms along with ASD core symptoms. To further investigate the potential interaction effects between ASD and GI symptoms, the 30 C-ASD and their aged-matched TD were picked out to perform metagenomics analysis. We observed that C-ASD group displayed decreased diversity, depletion of species of Sutterella, Prevotella, and Bacteroides as well as dysregulation of associated metabolism activities, which may involve in the pathogenesis of C-ASD. Consistent with metagenomic analysis, liquid chromatography-mass spectrometry (LC/MS) revealed some of the differential metabolites between C-ASD and TD group were involved in the metabolic network of neurotransmitters including serotonin, dopamine, histidine, and GABA. Furthermore, we found these differences in metabolites were associated with altered abundance of specific bacteria. The study suggested possible future modalities for ASD intervention through targeting the specific bacteria associated with neurotransmitter metabolism.
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Prevotella has been reported to be correlated negatively with PD and autism spectrum disorder (ASD).
“Prevotella has been reported to be correlated negatively with PD [37] and autism spectrum disorder (ASD) [38].”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [38]
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Zhou, X., Lu, J., Wei, K., Wei, J., Tian, P., Yue, M., Wang, Y., Hong, D., Li, F., Wang, B., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9424582 · Cited by 85 · see citing works
Hung, L. Y., & Margolis, K. G. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00857-1 · Cited by 96 · see citing works
Systematic Review: Autism Spectrum Disorder and the Gut Microbiota
Korteniemi, J., Karlsson, L., & Aatsinki, A. (2023) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13587 · Cited by 77 · see citing works
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Self-citationRelationships between Brain Activity, Tryptophan-Related Gut Metabolites, and Autism Symptomatology
Aziz-Zadeh, L., Ringold, S. M., Jayashankar, A., Kilroy, E., Butera, C., Jacobs, J. P., Tanartkit, S., Mahurkar-Joshi, S., Bhatt, R. R., Dapretto, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58459-1 · Cited by 51 · see citing works
Gut Microbiota in Systemic Lupus Erythematosus and Correlation With Diet and Clinical Manifestations
Wang, X., Shu, Q., Song, L., Liu, Q., Qu, X., & Li, M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.915179 · Cited by 33 · see citing works
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“Specifically, the relative abundance of Bacteroides genus was significantly enriched in many patients with ASD and several scientific works reported that exercise can reduce its relative abundance (109– 111).”
BackgroundTherapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy
Li, S., Guo, H., Xu, X., Hua, R., Zhao, Q., Li, J., Lv, J., & Li, J. (2021) · Shock · doi:10.1097/shk.0000000000001758 · Cited by 18 · see citing works
- Authors
- Dan, Z., Mao, X., Liu, Q., Guo, M., Zhuang, Y., Liu, Z., Chen, K., Chen, J., Xu, R., Tang, J., Qin, L., Gu, B., Liu, K., Su, C., Zhang, F., Xia, Y., Hu, Z., & Liu, X.
- Affiliations
- Department of Pathogen-Microbiology Division, State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, China
- Jiangsu University (CN)
- State Key Laboratory of Reproductive Medicine (CN)
- Department of Clinical Laboratory, Affiliated Yixing People’s Hospital, Jiangsu University, Wuxi, China
- Children Growth Center of Bo’ai Homestead in Yixing, Yixing, China
- Xuzhou Medical College (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Corresponding author
- Liu, Xingyin
- ORCID
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2020-04-21
- Volume
- 11
- Issue
- 5
- Pages
- 1246-1267
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC7524265
- OpenAlex
- W3016963629
- Cited by
- 350
- References
- 85
- Citations by year
- 2026: 53 · 2025: 64 · 2024: 74 · 2023: 47 · 2022: 66 · 2021: 37 · 2020: 9
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81671983)
- ational Natural Science Foundation of China (81871628)
- Starting package from NJMU (Xingyin Liu)
- Natural Science Foundation of Jiangsu Province (BK20161025, BK20161572)
- Starting funding for the Team of Gut microbiota Research in NJMU (Xingyin LIu)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- autism spectrum disorder, gut microbiota, chronic constipation, gastrointestinal symptoms, fecal metabolites, microbial diversity, Sutterella, Prevotella, Bacteroides, neurotransmitter metabolism, serotonin, dopamine, histidine, GABA, metagenomics
- MeSH terms
- Autism Spectrum Disorder, Gastrointestinal Microbiome, Adolescent, Bacteria, Child, Child, Preschool, Constipation, Feces, Female, Humans, Male, RNA, Ribosomal, 16S, Cohort Studies, Gastrointestinal Tract, Metabolome, Metagenomics
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