Emerging Therapeutic Role of PPAR–α in Cognition and Emotions

The mechanisms of action of PPARs

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Endocannabinoid system and stress and anxiety responses

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Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial.

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The endocannabinoid system: a general view and latest additions

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Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

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Estrogens, Neuroinflammation, and Neurodegeneration

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Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis

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The amygdala modulates prefrontal cortex activity relative to conditioned fear

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A critical review of chronic stress effects on spatial learning and memory

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In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

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The role of allopregnanolone in depression and anxiety

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Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder

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The role of the innate immune system in psychiatric disorders

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PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases

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Brain 5α-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation

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Immobilization stress induces interleukin-1β mRNA in the rat hypothalamus

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Functional role of local GABAergic influences on the HPA axis

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Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder

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Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans

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Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness?

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Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

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Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat

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Localization of PPAR isotypes in the adult mouse and human brain

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In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine

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Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development

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The impact of stress on neutral and emotional aspects of episodic memory

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Effects of endocannabinoid system modulation on cognitive and emotional behavior

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Endocannabinoid system in neurodegenerative disorders

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Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress

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A meta-analysis of cognitive functioning in older adults with PTSD

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Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice

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Does PTSD Impair Cognition Beyond the Effect of Trauma?

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Depression in Alzheimer's Disease: Epidemiology, Mechanisms, and Management

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Social isolation stress-induced aggression in mice: A model to study the pharmacology of neurosteroidogenesis

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Lack of Efficacy for Fluoxetine in PTSD: A Placebo Controlled Trial in Combat Veterans

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SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake

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Open-label, proof-of-concept study of brexanolone in the treatment of severe postpartum depression

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Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies

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Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

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Brain allopregnanolone regulates the potency of the GABAA receptor agonist muscimol

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Chronic Stress is Prospectively Associated with Sleep in Midlife Women: The SWAN Sleep Study

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Neurosteroid biosynthesis down‐regulation and changes in GABA_Areceptor subunit composition: a<i>biomarker axis</i>in stress‐induced cognitive and emotional impairment

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PPAR Regulation of Inflammatory Signaling in CNS Diseases

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Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice

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The PPARα Agonist Fenofibrate Preserves Hippocampal Neurogenesis and Inhibits Microglial Activation After Whole-Brain Irradiation

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Lack of Efficacy for Fluoxetine in PTSD: A Placebo Controlled Trial in Combat Veterans

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PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation

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GABAAreceptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: Possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders

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Endocannabinoid concentrations in hair are associated with PTSD symptom severity

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Neurosteroid Biosynthesis Regulates Sexually Dimorphic Fear and Aggressive Behavior in Mice

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Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands

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Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegenerationin vivo

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Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

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PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma.

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Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects

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Peroxisome Proliferator‐Activated Receptorsαandγare Linked with Alcohol Consumption in Mice and Withdrawal and Dependence in Humans

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Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder

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CB1 receptor signaling regulates social anxiety and memory

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The Role of Brain Interleukin-1 in Stress-Enhanced Fear Learning

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PPAR Agonists as Therapeutics for CNS Trauma and Neurological Diseases

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Neuroactive steroids and PTSD treatment

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Sexual neurosteroids and synaptic plasticity in the hippocampus.

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Effects of alpha-MSH on sleep, behavior, and brain temperature: interactions with IL 1

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Short communication - N-palmitoylethanolamide, an endocannabinoid, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice

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The endocannabinoid system and Post Traumatic Stress Disorder (PTSD): From preclinical findings to innovative therapeutic approaches in clinical settings

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Novel Use of a Lipid-Lowering Fibrate Medication to Prevent Nicotine Reward and Relapse: Preclinical Findings

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Peroxisome Proliferator-Activated Receptor (PPAR) Agonists as Promising New Medications for Drug Addiction: Preclinical Evidence

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Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain

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Neurotransmitter, Peptide, and Steroid Hormone Abnormalities in PTSD: Biological Endophenotypes Relevant to Treatment

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Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function

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The Peroxisomal Proliferator-Activated Receptor (PPAR) α Agonist, Fenofibrate, Prevents Fractionated Whole-Brain Irradiation-Induced Cognitive Impairment

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Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α

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Social Isolation in Early versus Late Adolescent Mice Is Associated with Persistent Behavioral Deficits That Can Be Improved by Neurosteroid-Based Treatment

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Is There a Future for PPARs in the Treatment of Neuropsychiatric Disorders?

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Central Adiponectin Signaling – A Metabolic Regulator in Support of Brain Plasticity

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PPARα Signaling: A Candidate Target in Psychiatric Disorder Management

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PPARα Modulation-Based Therapy in Central Nervous System Diseases

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Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner

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The Alpha-7 Nicotinic Receptor Positive Allosteric Modulator PNU120596 Attenuates Lipopolysaccharide-Induced Depressive-Like Behaviors and Cognitive Impairment by Regulating the PPAR-α Signaling Pathway in Mice

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Decrypting the Possible Mechanistic Role of Fenofibrate in Alzheimer's Disease and Type 2 Diabetes: The Truth and Mystery

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Peroxisome proliferator-activated receptor-α activation facilitates contextual fear extinction and modulates intrinsic excitability of dentate gyrus neurons

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PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice

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Gypenoside XLIX alleviates sepsis-associated encephalopathy by targeting PPAR-α

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Targeting TNIP1 as a new therapeutic avenue for major depressive disorder

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Division of Labor among Worker Bees Is Associated with the Lipidomic Plasticity in Their Brains

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Phytohormone abscisic acid boosts pentobarbital-induced sleep through activation of GABA-A, PPARβ and PPARγ receptor signaling

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Tetracosahexaenoylethanolamide, a novel N-acylethanolamide, is elevated in ischemia and increases neuronal output

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Class switching of carbonic anhydrase isoforms mediates remyelination in CA3 hippocampal neurons during chronic hypoxia

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The Strategy of Targeting Peroxisome Proliferator-Activated Receptor (PPAR) in the Treatment of Neuropsychiatric Disorders

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In vivo brain levels of acetylcholine and 5‐hydroxytryptamine after oleoylethanolamide or palmitoylethanolamide administrations are mediated by PPARα engagement

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Endocannabinoid levels in female-sexed individuals with diagnosed depression: a systematic review

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Modeling Suicidal Behavior

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Changes in transcription of genes encoding NAD-dependent enzymes and mitochondrial proteins in Alzheimer’s disease animal model. Indication of early targets in neuroprotectionPreprint

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Modeling Suicidal Behavior

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Possible Targets Related to Connexins and Ceramides in the Treatment of Depression Using a Combination Approach

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Targeting PPARs in the Brain: From Old Knowledge to Emerging Therapeutic Roles

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Disruption of the retinoid X receptor–PPAR-γ axis is associated with appetite hormone dysregulation and cognitive dysfunction: A cross-sectional study of adolescents with first-episode bipolar disorder

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Targeting PTSD with ultramicronized palmitoylethanolamide: Results from a randomized trial integrating pharmacotherapy and cognitive behavioral therapy

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Additional file 1 of Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner

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The Function of PPARα in Cancer Drug Development: A Promising Target for Cancer Treatment

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P.4.07 Peroxisome proliferator-activated receptors (PPARs): new target for attention and memory function

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PPARα Signaling: A Candidate Target in Psychiatric Disorder Management

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Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice

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Is There a Future for PPARs in the Treatment of Neuropsychiatric Disorders?

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