The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Endothelial dysfunction and preeclampsia: role of oxidative stress
Open accessAbstract
Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5-10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk factors for the development of PE include obesity, insulin resistance and hyperlipidemia that stimulate inflammatory cytokine release and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations concur to develop PE is still not very well understood. The related poor trophoblast invasion and uteroplacental artery remodeling described in PE, increases reactive oxygen species (ROS), hypoxia and ED. Here we aim to review current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation.
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Cited by
Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies
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Leone Roberti Maggiore, U., Ferrero, S., Mangili, G., Bergamini, A., Inversetti, A., Giorgione, V., Viganò, P., & Candiani, M. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv045 · Cited by 321
Aldosterone in gynecology and its involvement on the risk of hypertension in pregnancy
Sabbadin, C., Andrisani, A., Ambrosini, G., Bordin, L., Donà, G., Manso, J., Ceccato, F., Scaroni, C., & Armanini, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00575 · Cited by 22
Metadata
- Authors
- Sánchez-Aranguren, L. C., Prada, C. E., Riaño-Medina, C. E., & Lopez, M.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2014-10-10
- Volume
- 5
- Pages
- 372-372
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W1987358907
- Cited by
- 438
- References
- 14
- FWCI
- 25.73
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sánchez-Aranguren, L. C., Prada, C. E., Riaño-Medina, C. E., & Lopez, M. (2014). Endothelial dysfunction and preeclampsia: role of oxidative stress. Frontiers in Physiology. https://doi.org/10.3389/fphys.2014.00372
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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