TNF- downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
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Obesity is associated with chronic low-grade inflammation. Thus, at metabolically relevant sites, including adipose tissue and muscle, there is abnormal production of proinflammatory cytokines such as TNF-alpha. Here we demonstrate that eNOS expression was reduced, with a concomitant reduction of mitochondrial biogenesis and function, in white and brown adipose tissue and in the soleus muscle of 3 different animal models of obesity. The genetic deletion of TNF receptor 1 in obese mice restored eNOS expression and mitochondrial biogenesis in fat and muscle; this was associated with less body weight gain than in obese wild-type controls. Furthermore, TNF-alpha downregulated eNOS expression and mitochondrial biogenesis in cultured white and brown adipocytes and muscle satellite cells of mice. The NO donors DETA-NO and SNAP prevented the reduction of mitochondrial biogenesis observed with TNF-alpha. Our findings demonstrate that TNF-alpha impairs mitochondrial biogenesis and function in different tissues of obese rodents by downregulating eNOS expression and suggest a novel pathophysiological process that sustains obesity.
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Lower NOS3 abundance is found in both adipose tissue and skeletal muscle of obese humans and rodents.
“lower NOS3 abundance is found in both adipose tissue and skeletal muscle of obese humans and rodents [120-124].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [123]
TNFα downregulates NOS3 expression and abundance by decreasing the stability of NOS3 mRNA, effectively shortening its half-life.
“was shown to downregulate NOS3 expression and abundance [123, 131-134] by decreasing the stability of NOS3 mRNA [135, 136], effectively shortening its half-life [137].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [123]
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- Authors
- Valerio, A.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Valerio, A.
- ORCID
- Valerio, A.
- Venue
- Journal of Clinical Investigation
- Published
- 2006-10-02
- Volume
- 116
- Issue
- 10
- Pages
- 2791-2798
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2147649093
- Cited by
- 327
- References
- 56
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 5 · 2023: 14 · 2022: 10 · 2021: 7 · 2020: 12 · 2019: 14 · 2018: 15 · 2017: 19 · 2016: 14 · 2015: 19 · 2014: 24 · 2013: 16 · 2012: 27
- FWCI
- 14.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- TNF-α, endothelial nitric oxide synthase, mitochondrial biogenesis, obesity, adipose tissue, brown adipose tissue, white adipose tissue, skeletal muscle, TNF receptor 1, low-grade inflammation, nitric oxide, satellite cells, adipocytes, weight gain
- MeSH terms
- Adenosine Triphosphate, Adipose Tissue, Animals, Cells, Cultured, Electron Transport Complex IV, DNA-Binding Proteins, Female, High Mobility Group Proteins, Male, Mice, Inbred C57BL, Mice, Obese, Mitochondria, Obesity, Oxygen Consumption, Rats, Zucker, Tumor Necrosis Factor-alpha, Down-Regulation, Receptors, Tumor Necrosis Factor, Mice, Knockout, Muscle, Skeletal, Nitric Oxide Donors, Cytochromes c, Nuclear Respiratory Factor 1, Mice, Rats, Nitric Oxide Synthase Type III
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