The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Vascular stiffness in insulin resistance and obesity
Open accessAbstract
Obesity, insulin resistance, and type 2 diabetes are associated with a substantially increased prevalence of vascular fibrosis and stiffness, with attendant increased risk of cardiovascular and chronic kidney disease. Although the underlying mechanisms and mediators of vascular stiffness are not well understood, accumulating evidence supports the role of metabolic and immune dysregulation related to increased adiposity, activation of the renin angiotensin aldosterone system, reduced bioavailable nitric oxide, increased vascular extracellular matrix (ECM) and ECM remodeling in the pathogenesis of vascular stiffness. This review will give a brief overview of the relationship between obesity, insulin resistance and increased vascular stiffness to provide a contemporary understanding of the proposed underlying mechanisms and potential therapeutic strategies.
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Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682
Policy: NIH to balance sex in cell and animal studies
Clayton, J. A., & Collins, F. S. (2014) · Nature · doi:10.1038/509282a · Cited by 1,816
The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals
Blüher, M. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283346ccc · Cited by 632
Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity
Weisbrod, R. M., Shiang, T., Al Sayah, L., Fry, J. L., Bajpai, S., Reinhart-King, C. A., Lob, H. E., Santhanam, L., Mitchell, G., Cohen, R. A., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01744 · Cited by 317
Vascular stiffening and arterial complianceImplications for systolic blood pressure
SCHIFFRIN, E. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.08.019 · Cited by 183
Overnutrition, mTOR signaling, and cardiovascular diseases
Jia, G., Aroor, A. R., Martinez-Lemus, L. A., & Sowers, J. R. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00262.2014 · Cited by 122
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Cited by
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
Endothelial cell senescence in aging-related vascular dysfunction
Jia, G., Aroor, A. R., Jia, C., & Sowers, J. R. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.008 · Cited by 454
Self-citation‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue
Pérez, L. M., Pareja‐Galeano, H., Sanchis‐Gomar, F., Emanuele, E., Lucia, A., & Gálvez, B. G. (2016) · The Journal of Physiology · doi:10.1113/jp271691 · Cited by 215
Han, Y., & Kim, S. Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00906-w · Cited by 201
Teulings, N. E. W. D., Wood, A. M., Sovio, U., Ozanne, S. E., Smith, G. C. S., & Aiken, C. E. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0627-2 · Cited by 30
Metadata
- Authors
- Jia, G., Aroor, A. R., DeMarco, V. G., Martinez-Lemus, L. A., Meininger, G. A., & Sowers, J. R.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2015-08-14
- Volume
- 6
- Pages
- 231-231
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W1571027240
- Cited by
- 166
- References
- 7
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jia, G., Aroor, A. R., DeMarco, V. G., Martinez-Lemus, L. A., Meininger, G. A., & Sowers, J. R. (2015). Vascular stiffness in insulin resistance and obesity. Frontiers in Physiology. https://doi.org/10.3389/fphys.2015.00231
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
