The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Vitamin C in Health and Disease: Its Role in the Metabolism of Cells and Redox State in the Brain
Open accessAbstract
Ever since Linus Pauling published his studies, the effects of vitamin C have been surrounded by contradictory results. This may be because its effects depend on a number of factors such as the redox state of the body, the dose used, and also on the tissue metabolism. This review deals with vitamin C pharmacokinetics and its participation in neurophysiological processes, as well as its role in the maintenance of redox balance. The distribution and the concentration of vitamin C in the organs depend on the ascorbate requirements of each and on the tissue distribution of sodium-dependent vitamin C transporter 1 and 2 (SVCT1 and SVCT2). This determines the specific distribution pattern of vitamin C in the body. Vitamin C is involved in the physiology of the nervous system, including the support and the structure of the neurons, the processes of differentiation, maturation, and neuronal survival; the synthesis of catecholamine, and the modulation of neurotransmission. This antioxidant interacts with self-recycling mechanisms, including its participation in the endogenous antioxidant system. We conclude that the pharmacokinetic properties of ascorbate are related to the redox state and its functions and effects in tissues.
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Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis
Hemilä, H., & Chalker, E. (2019) · Nutrients · doi:10.3390/nu11040708 · Cited by 257
Vitamin C supplementation for prevention and treatment of pneumonia
Padhani, Z. A., Moazzam, Z., Ashraf, A., Bilal, H., Salam, R. A., Das, J. K., & Bhutta, Z. A. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013134.pub2 · Cited by 50
Impact of N‐Truncated Aβ Peptides on Cu‐ and Cu(Aβ)‐Generated ROS: CuI Matters!
Esmieu, C., Ferrand, G., Borghesani, V., & Hureau, C. (2021) · Chemistry – A European Journal · doi:10.1002/chem.202003949 · Cited by 43
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Metadata
- Authors
- Figueroa-Méndez, R., & Rivas-Arancibia, S.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2015-12-23
- Volume
- 6
- Pages
- 397-397
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W2228668600
- Cited by
- 257
- References
- 94
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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