Vitamin C in Health and Disease: Its Role in the Metabolism of Cells and Redox State in the Brain

Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930

Physiological functions of thioredoxin and thioredoxin reductase

Arnér, E. S. J., & Holmgren, A. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01701.x · Cited by 2,525

The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate

Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417 · cited 1×

The blood–brain barrier: an overview

Ballabh, P., Braun, A., & Nedergaard, M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.016 · Cited by 2,261

Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention

Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949

Ascorbate is an outstanding antioxidant in human blood plasma

Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870

The SLC2 (GLUT) family of membrane transporters

Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328

Astrocyte-endothelial Interactions and Blood-Brain Barrier Permeability*

Abbott, N. J. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00064.x · Cited by 1,168

Facilitative glucose transporters

MUECKLER, M. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18550.x · Cited by 1,093

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506390102 · Cited by 1,075

Ascorbic acid: Chemistry, biology and the treatment of cancer

Du, J., Cullen, J. J., & Buettner, G. R. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.06.003 · Cited by 1,070

A family of mammalian Na+-dependent L-ascorbic acid transporters

Tsukaguchi, H., Tokui, T., Mackenzie, B., Berger, U. V., Chen, X.-Z., Wang, Y., Brubaker, R. F., & Hediger, M. A. (1999) · Nature · doi:10.1038/19986 · Cited by 882

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., Khosh, D. B., Drisko, J., & Levine, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804226105 · Cited by 854

Vitamin C exhibits pro-oxidant properties

Podmore, I. D., Griffiths, H. R., Herbert, K. E., Mistry, N., Mistry, P., & Lunec, J. (1998) · Nature · doi:10.1038/33308 · Cited by 800

Vitamin C. Biosynthesis, recycling and degradation in mammals

Linster, C. L., & Van Schaftingen, E. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05607.x · Cited by 757

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

Chen, Q., Espey, M. G., Sun, A. Y., Lee, J.-H., Krishna, M. C., Shacter, E., Choyke, P. L., Pooput, C., Kirk, K. L., Buettner, G. R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702854104 · Cited by 676

Vitamin C function in the brain: Vital role of the ascorbate transporter SVCT2

Harrison, F. E., & May, J. M. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.018 · Cited by 661

Tissue oxygen tension and brain sensitivity to hypoxia

Erecińska, M., & Silver, I. A. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(01)00306-1 · Cited by 615

Thioredoxin reductase

MUSTACICH, D., & POWIS, G. (2000) · Biochemical Journal · doi:10.1042/bj3460001 · Cited by 592

In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals

Buettner, G. R. (1988) · Journal of Biochemical and Biophysical Methods · doi:10.1016/0165-022x(88)90100-5 · Cited by 509

New developments and novel therapeutic perspectives for vitamin C

Li, Y., & Schellhorn, H. E. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.10.2171 · Cited by 508

Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man.

Nishikimi, M., Fukuyama, R., Minoshima, S., Shimizu, N., & Yagi, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36884-9 · Cited by 503

The facilitative glucose transporter GLUT3: 20 years of distinction

Simpson, I. A., Dwyer, D., Malide, D., Moley, K. H., Travis, A., & Vannucci, S. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90388.2008 · Cited by 473

Interaction among vitamin C, vitamin E, and beta-carotene

Niki, E., Noguchi, N., Tsuchihashi, H., & Gotoh, N. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1322s · Cited by 464

REGULATION OF VITAMIN C TRANSPORT

Wilson, J. X. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092647 · Cited by 377

Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase

Kagan, V. E., Shvedova, A., Serbinova, E., Khan, S., Swanson, C., Powell, R., & Packer, L. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90482-x · Cited by 365

SVCT1 and SVCT2: Key proteins for vitamin C uptake

Savini, I., Rossi, A., Pierro, C., Avigliano, L., & Catani, M. V. (2008) · Amino Acids · doi:10.1007/s00726-007-0555-7 · Cited by 358

Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux

Jackson, P. S., & Strange, K. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.6.c1489 · Cited by 338

Vitamin E and Vitamin C Supplement Use and Risk of Incident Alzheimer Disease

Morris, M. C., Beckett, L. A., Scherr, P. A., Hebert, L. E., Bennett, D. A., Field, T. S., & Evans, D. A. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00001 · Cited by 332

Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters.

Agus, D. B., Gambhir, S. S., Pardridge, W. M., Spielholz, C., Baselga, J., Vera, J. C., & Golde, D. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119832 · Cited by 329

Differential compartmentalization of brain ascorbate and glutathione between neurons and glia

Rice, M. E., & Russo-Menna, I. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00347-3 · Cited by 313

Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant

Valpuesta, V., & Botella, M. A. (2004) · Trends in Plant Science · doi:10.1016/j.tplants.2004.10.002 · Cited by 308

Ascorbic acid in the brain

Grünewald, R. A. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90010-w · Cited by 293

Thioredoxin reductase.

Mustacich, D. J., & Powis, G. (2000) · PubMed Central · Cited by 290

Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2

Daruwala, R., Song, J., Koh, W. S., Rumsey, S. C., & Levine, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01393-9 · Cited by 272

SOME PROPERTIES OF THE ASCORBATE FREE RADICAL*

Bielski, B. H. J., Richter, H. W., & Chan, P. C. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb29283.x · Cited by 259

GLUT8, a Novel Member of the Sugar Transport Facilitator Family with Glucose Transport Activity

Doege, H., Schürmann, A., Bahrenberg, G., Brauers, A., & Joost, H.-G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16275 · Cited by 258

Dehydroascorbic acid, a blood–brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

Huang, J., Agus, D. B., Winfree, C. J., Kiss, S., Mack, W. J., McTaggart, R. A., Choudhri, T. F., Kim, L. J., Mocco, J., Pinsky, D. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171325998 · Cited by 225

The physiological role of dehydroascorbic acid

Wilson, J. X. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03167-8 · Cited by 218

Absorption, transport, and disposition of ascorbic acid in humans

Rumsey, S. C., & Levine, M. (1998) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(98)00002-3 · Cited by 209

Is ascorbic acid an antioxidant for the plasma membrane?

May, J. M. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9.995 · Cited by 198

Outer-sphere electron-transfer reactions of ascorbate anions

Williams, N., & Yandell, J. (1982) · Australian Journal of Chemistry · doi:10.1071/ch9821133 · Cited by 197

Cellular pathways for transport and efflux of ascorbate and dehydroascorbate

Corti, A., Casini, A. F., & Pompella, A. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.014 · Cited by 193 · cited 5×

Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis

Nishikimi, M., & Yagi, K. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1203s · Cited by 191

Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate

Majewska, M. D., Bell, J. A., & London, E. D. (1990) · Brain Research · doi:10.1016/0006-8993(90)90379-p · Cited by 177

Vitamin C and Vitamin E for Alzheimer's Disease

Boothby, L. A., & Doering, P. L. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1e495 · Cited by 174

Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors

Yan, J., Studer, L., & McKay, R. D. G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00073.x · Cited by 172

Role of Monosaccharide Transport Proteins in Carbohydrate Assimilation, Distribution, Metabolism, and Homeostasis

Cura, A. J., & Carruthers, A. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110024 · Cited by 171

Ascorbic Acid: a Promising Memory-Enhancer in Mice

Parle, M., & Dhingra, D. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.129 · Cited by 156

Enzymic synthesis of l-ascorbic acid in different animal species

Grollman, A. P., & Lehninger, A. L. (1957) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(57)90510-6 · Cited by 151

Swelling-activated organic osmolyte efflux: A new role for anion channels

Strange, K. B., & Jackson, P. S. B. (1995) · Kidney International · doi:10.1038/ki.1995.381 · Cited by 150

CHEMISTRY AND METABOLISM OF ASCORBIC ACID AND ASCORBATE SULFATE*

Tolbert, B. M., Downing, M., Carlson, R. W., Knight, M., & Baker, E. M. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb29267.x · Cited by 142

Intestinal Dehydroascorbic Acid (DHA) Transport Mediated by the Facilitative Sugar Transporters, GLUT2 and GLUT8

Corpe, C. P., Eck, P., Wang, J., Al‐Hasani, H., & Levine, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436790 · Cited by 142

Glucose Modulates Vitamin C Transport in Adult Human Small Intestinal Brush Border Membrane Vesicles

Malo, C., & Wilson, J. X. (2000) · Journal of Nutrition · doi:10.1093/jn/130.1.63 · Cited by 140

Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity

Qiu, S., Li, L., Weeber, E. J., & May, J. M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21204 · Cited by 131

Dehydroascorbate reduction

Wells, W. W., & Xu, D. P. (1994) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762777 · Cited by 128

Astrocyte–endothelial interactions and blood–brain barrier permeability

Abbott, N. J. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00047_13.x · Cited by 126

Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C

Puskás, F., Gergely, P., Bánki, K., & Perl, A. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.10.1352 · Cited by 121

Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium

Myriam, M., Sabatier, M., Steiling, H., & Williamson, G. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061817 · Cited by 119

Effects of combined treatment with vitamins C and E on passive avoidance learning and memory in diabetic rats

Hasanein, P., & Shahidi, ‬. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.01.004 · Cited by 116

D ‐Erythroascorbic acid is an important antioxidant molecule inSaccharomyces cerevisiae

Huh, W., Lee, B., Kim, S., Kim, Y.-R., Rhie, G., Baek, Y., Hwang, C., Lee, J., & Kang, S. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01133.x · Cited by 116

Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells

Boyer, J. C., Campbell, C. E., Sigurdson, W. J., & Kuo, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.069 · Cited by 115

Dementia and Alzheimer's Disease in Community-Dwelling Elders Taking Vitamin C and/or Vitamin E

Fillenbaum, G. G., Kuchibhatla, M. N., Hanlon, J. T., Artz, M. B., Pieper, C. F., Schmader, K. E., Dysken, M. W., & Gray, S. L. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1g280 · Cited by 113 · cited 1×

Regional distribution of ascorbate in human brain

Mefford, I. N., Oke, A. F., & Adams, R. N. (1981) · Brain Research · doi:10.1016/0006-8993(81)90056-1 · Cited by 107

Sodium vitamin C cotransporter SVCT2 is expressed in hypothalamic glial cells

García, M. D. L. Á., Salazar, K., Millán, C., Rodríguez, F., Montecinos, H., Caprile, T., Silva, C., Cortés‐Campos, C., Reinicke, K., Vera, J. C., et al. (2004) · Glia · doi:10.1002/glia.20133 · Cited by 102

Role of the extracellular matrix in myelination of peripheral nerve

Podratz, J. L., Rodriguez, E. H., & Windebank, A. J. (2001) · Glia · doi:10.1002/glia.1068 · Cited by 88

Release of ascorbate from a synaptosomal fraction of rat brain

Grünewald, R. A., & Fillenz, M. (1984) · Neurochemistry International · doi:10.1016/0197-0186(84)90120-7 · Cited by 86

Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes

Michels, A. J., Joisher, N., & Hagen, T. M. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00678-1 · Cited by 78

Ascorbate‐induced differentiation of embryonic cortical precursors into neurons and astrocytes

Lee, J., Chang, M., Park, C., Kim, H., Kim, J., Son, H., Lee, Y., & Lee, S. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10647 · Cited by 77

Synthesis and Characterization of a Series of Novel Monoacylated Ascorbic Acid Derivatives, 6-O-Acyl-2-O-α- d -glucopyranosyl- l -ascorbic Acids, as Skin Antioxidants

Yamamoto, I., Tai, A., Fujinami, Y., Sasaki, K., & Okazaki, S. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm010379f · Cited by 74

Effect of middle cerebral artery occlusion on mRNA expression for the sodium‐coupled vitamin C transporter SVCT2 in rat brain

Berger, U. V., Lu, X. M., Liu, W., Tang, Z., Slusher, B. S., & Hediger, M. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01891.x · Cited by 71

Vitamin C or Vitamin B6 supplementation prevent the oxidative stress and decrease of prostacyclin generation in homocysteinemic rats

Mahfouz, M., & Kummerow, F. A. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.01.028 · Cited by 68

Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH

Seitz, G., Gebhardt, S., Beck, J. F., Böhm, W., Lode, H. N., NIETHAMMER, D., & Bruchelt, G. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00129-3 · Cited by 66

Expression of the protein zero myelin gene in axon-related Schwann cells is linked to basal lamina formation

Fernández‐Valle, C., Fregien, N. L., Wood, P. M., & Bunge, M. B. (1993) · Development · doi:10.1242/dev.119.3.867 · Cited by 65

In VivoDual Effects of Vitamin C on Paraquat-Induced Lung Damage: Dependence on Released Metals from the Damaged Tissue

Ahkang, S., Jang, Y. J., & Park, H. S. (1998) · Free Radical Research · doi:10.3109/10715769809097880 · Cited by 61

Osmotic Swelling Stimulates Ascorbate Efflux from Cerebral Astrocytes

Siushansian, R., Dixon, S., & Wilson, J. X. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66031227.x · Cited by 56

The presence of ascorbate induces expression of brain derived neurotrophic factor in SH‐SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival

Grant, M. M., Barber, V. S., & Griffiths, H. R. (2005) · PROTEOMICS · doi:10.1002/pmic.200300924 · Cited by 55

Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress

Steiling, H., Longet, K., Moodycliffe, A., Mansourian, R., Bertschy, E., Smola, H., Mauch, C., & Williamson, G. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.001 · Cited by 50

Sodium‐dependent vitamin C transporter 2 (SVCT2) is necessary for the uptake of L ‐ascorbic acid into Schwann cells

Gess, B., Lohmann, C., Halfter, H., & Young, P. (2009) · Glia · doi:10.1002/glia.20923 · Cited by 50

High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers

Mühlhöfer, A., Mrosek, S., Schlegel, B., Trommer, W. E., Rozario, F., Böhles, H. J., Schremmer, D., Zoller, W. G., & Biesalski, H. K. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601943 · Cited by 48

The glucose transporter-2 (GLUT2) is a low affinity dehydroascorbic acid transporter

Mardones, L., Ormazábal, V., Romo, X., Jaña, C., Binder, P., Peña, E., Vergara, M., & Zuñiga, F. A. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.070 · Cited by 42

Does vitamin C have a pro-oxidant effect?

Levine, M. N., Daruwala, R., Park, J. B., Rumsey, S. C., & Wang, Y. (1998) · Nature · doi:10.1038/26137 · Cited by 39

Changes of gene expression profiles during neuronal differentiation of central nervous system precursors treated with ascorbic acid

Yu, D., Lee, K., Lee, J., Kim, S., Shin, D., Kim, J., Lee, Y.-S., Lee, Y., Oh, S. K., Moon, S. Y., et al. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20220 · Cited by 39

Identification of L-ascorbic acid in secretion granules of the rat parotid gland.

von Zastrow, M. E., Tritton, T. R., & Castle, J. D. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)71274-3 · Cited by 38

Development of ascorbate transporters in brain cortical capillary endothelial cells in culture

Qiao, H., & May, J. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.102 · Cited by 38

Transfer of ascorbic acid across the vascular endothelium: mechanism and self-regulation

May, J. M., Qu, Z., & Qiao, H. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00674.2008 · Cited by 36

Recycling of the ascorbate free radical by human erythrocyte membranes

May, J. M. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00566-4 · Cited by 34

α-Tocopherol and ascorbic acid prevent memory deficits provoked by chronic hyperprolinemia in rats

Delwing, D., Bavaresco, C. S., Monteiro, S. C., Matté, C., Netto, C. A., & Wyse, Â. T. D. S. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.08.014 · Cited by 32

Ascorbic acid stimulates gonadotropin release by autocrine action by means of NO

Karanth, S., Yu, W. H., Walczewska, A., Mastronardi, C. A., & McCann, S. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191369398 · Cited by 31

Hypoosmotic and glutamate‐induced swelling of bipolar cells in the rat retina: comparison with swelling of M üller glial cells

Vogler, S., Grosche, A., Pannicke, T., Ulbricht, E., Wiedemann, P., Reichenbach, A., & Bringmann, A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12307 · Cited by 27

Functional FceRIa expression on human bone marrow-derived mast cells cultured with SCF+IL-6 - Essential role of IL-3 for function and granule contents

Sakai, K., Morishita, Y., Ishikawa, S., Miura, T., Nemoto, T., Mori, M., & Shimizu, Y. (1999) · The FASEB Journal · Cited by 24

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases

Conti, V., Izzo, V., Corbi, G., Russomanno, G., Manzo, V., De Lise, F., Di Donato, A., & Filippelli, A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00024 · Cited by 304

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Hemilä, H., & Chalker, E. (2019) · Nutrients · doi:10.3390/nu11040708 · Cited by 257

Vitamin C supplementation for prevention and treatment of pneumonia

Padhani, Z. A., Moazzam, Z., Ashraf, A., Bilal, H., Salam, R. A., Das, J. K., & Bhutta, Z. A. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013134.pub2 · Cited by 50

Impact of N‐Truncated Aβ Peptides on Cu‐ and Cu(Aβ)‐Generated ROS: CuI Matters!

Esmieu, C., Ferrand, G., Borghesani, V., & Hureau, C. (2021) · Chemistry – A European Journal · doi:10.1002/chem.202003949 · Cited by 43

Trends in Vitamin C consumption in the United States: 1999-2018

Brauchla, M., Dekker, M. J., & Rehm, C. D. (2021) · Nutrients · doi:10.3390/nu13020420 · Cited by 35