Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for Psychosis
Open accessAbstract
BACKGROUND: High rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-clinical adolescent population. This study aimed to investigate the comorbid mental disorder in non-clinical CHR adolescents and the impact on attenuated psychosis symptoms (APS) as well as clinical outcome. METHODS: The sample consisted of 32 CHR students, who were screened from 2,800 university students. CHR status was evaluated with the Structured Interview of Prodromal Syndromes, comorbid mental disorder diagnoses with the International Neuropsychiatric Interview. RESULTS: In the CHR sample, 46.9% was found at least one non-psychotic comorbid mental disorder. The CHR participants presenting comorbid mental disorder had significantly more severity of APS than those without comorbid mental disorders, and the remission rate at 6-month follow-up is significantly higher in the individuals without comorbid mental disorders at baseline. CONCLUSION: In the non-clinical sample of individuals at CHR, non-psychotic comorbid mental disorders are common and anxiety disorder is most frequent. Copresence of anxiety and/or depression is related to higher level of attenuated psychotic symptoms and unfavorable clinical outcome at 6-month follow-up. Assessment and intervention in anxiety and depression for non-clinical CHR adolescents are suggested.
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The comorbidity pattern confirms previous findings outside of COVID-19 context.
“Also, two concomitant symptomatic dimensions among anxiety, depressive, and posttraumatic symptoms affected 4.1% of participants and two of them in 7.0%, confirming previous findings outside of COVID-19 context (41).”
From Prevalence and Psychosocial Correlates of Mental Health Outcomes Among Chinese College Students During the Coronavirus Disease (COVID-19) Pandemic (2020) · cites this paper as [41]
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Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
Mental health of young people: A global public-health challenge
Patel, V., Flisher, A. J., Hetrick, S., & McGorry, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60368-7 · Cited by 3,126 · see citing works
The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review
Fusar-Poli, P., Borgwardt, S., Bechdolf, A., Addington, J., Riecher-Rössler, A., Schultze-Lutter, F., Keshavan, M., Wood, S., Ruhrmann, S., Seidman, L. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.269 · Cited by 1,483 · see citing works
Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group
Yung, A. R., Phillips, L. J., Yuen, H. P., Francey, S. M., McFarlane, C. A., Hallgren, M., & McGorry, P. D. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00167-6 · Cited by 1,136 · see citing works
Global Assessment of Functioning
Hall, R. C. W. (1995) · Psychosomatics · doi:10.1016/s0033-3182(95)71666-8 · Cited by 1,099 · see citing works
Fusar-Poli, P., Nelson, B., Valmaggia, L., Yung, A. R., & McGuire, P. K. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs136 · Cited by 589 · see citing works
People living with psychotic illness in 2010: the second Australian national survey of psychosis
Morgan, V. A., Waterreus, A., Jablensky, A., Mackinnon, A., McGrath, J. J., Carr, V., Bush, R., Castle, D., Cohen, M., Harvey, C., et al. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412449877 · Cited by 504 · see citing works
Ising, H. K., Veling, W., Loewy, R. L., Rietveld, M. W., Rietdijk, J., Dragt, S., Klaassen, R. M. C., Nieman, D. H., Wunderink, L., Linszen, D. H., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs068 · Cited by 460 · cited 1× · see citing works
“It includes nine items concerning hallucinations and perceptual abnormalities, five items on symptoms as delusional thoughts, paranoia and unusual thinking content, and the other two items about negative symptoms (15).”
BackgroundWoods, S. W., Addington, J., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., HEINSSEN, R. K., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., et al. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp027 · Cited by 404 · see citing works
Wigman, J. T. W., van Nierop, M., Vollebergh, W. A. M., Lieb, R., Beesdo-Baum, K., Wittchen, H.-U., & van Os, J. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr196 · Cited by 392 · see citing works
Progress for children: a report card on adolescents
Cappa, C., Wardlaw, T., Langevin-Falcon, C., & Diers, J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60531-5 · Cited by 319 · see citing works
Prospective investigations of the prodromal state of schizophrenia: review of studies
Olsen, K. A., & Rosenbaum, B. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00697.x · Cited by 142 · see citing works
Kelleher, I., Murtagh, A., Molloy, C., Roddy, S., Clarke, M. C., Harley, M., & Cannon, M. D. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr164 · Cited by 141 · see citing works
Why are help-seeking subjects at ultra-high risk for psychosis help-seeking?
Falkenberg, I., Valmaggia, L., Byrnes, M., Frascarelli, M., Jones, C., Rocchetti, M., Straube, B., Badger, S., McGuire, P. K., & Fusar‐Poli, P. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.018 · Cited by 131 · see citing works
The Psychosis Prodrome in Adolescent Patients Viewed Through the Lens of DSM-IV
MEYER, S. E., Bearden, C. E., Lux, S. R., Gordon, J. L., Johnson, J. K., O’Brien, M. P., Niendam, T. A., Loewy, R. L., Ventura, J., & Cannon, T. D. (2005) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2005.15.434 · Cited by 121 · see citing works
The early course of schizophrenia and depression*
Häfner, H., Maurer, K., Trendler, G., der Heiden, W. A., & Schmidt, M. H. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0584-8 · Cited by 118 · see citing works
Salokangas, R., Ruhrmann, S., von Reventlow, H. V., Heinimaa, M., Svirskis, T., From, T., Luutonen, S., Juckel, G., Linszen, D., Dingemans, P., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.03.008 · Cited by 114 · see citing works
Prospective investigations of the prodromal state of schizophrenia: assessment instruments
Olsen, K. A., & Rosenbaum, B. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00698.x · Cited by 104 · see citing works
Hui, C., Morcillo, C., Russo, D. A., Stochl, J., Shelley, G. F., Painter, M., Jones, P. B., & Perez, J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.05.026 · Cited by 96 · see citing works
Sources of clinical distress in young people at ultra high risk of psychosis
Rapado‐Castro, M., McGorry, P. D., Yung, A. R., Calvo, A., & Nelson, B. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.03.022 · Cited by 60 · see citing works
Identification and characterization of college students with attenuated psychosis syndrome in China.
Chen, F.-Z., Wang, L., Heeramun-Aubeeluck, A., Wang, J.-K., Shi, J.-Y., Yuan, J., & Zhao, X.-D. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.01.051 · Cited by 43 · see citing works
Self-citationPathways to care for those at clinical high risk of developing psychosis
Stowkowy, J., Colijn, M. A., & Addington, J. (2012) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2012.00368.x · Cited by 31 · see citing works
Tan, E. J., & Rossell, S. L. (2016) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2015.12.007 · Cited by 27 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [1]Murray CJ Summary: The Golbal Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 and Projected to 2020. Cambridge: Harvard University Press (1996).
- [14]McGlashan T Walsh B Woods SW The Psychosis-Risk Syndrome. New York: Oxford University Press (2010).
- [17]Zheng L Wang J Zhang T Li H Li C Jiang K Reliability and validity of the Chinese version of scale of psychosis – risk symptoms. Chin Mental Health J (2012) 26: 571– 6. 10.3969/j.issn.1000-6729.2012.08.003 · DOI
Cited by
Sorted by citations
Chi, X., Becker, B., Yu, Q., Willeit, P., Jiao, C., Huang, L., Hossain, M. M., Grabovac, I., Yeung, A., Lin, J., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00803 · Cited by 309 · see citing works
- Authors
- Shi, J., Wang, L., Yao, Y., Su, N., Zhan, C., Mao, Z., & Zhao, X.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Shi, Jingyu
- Zhao, Xudong
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2017-10-23
- Volume
- 8
- Pages
- 209-209
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC5660058
- OpenAlex
- W2761573618
- Cited by
- 13
- References
- 26
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- clinical high risk for psychosis, comorbid mental disorders, attenuated psychotic symptoms, anxiety disorders, depression, university students, adolescents, functional outcome, remission, Chinese population
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