Psychiatric morbidity, functioning and quality of life in young people at clinical high risk for psychosis

Hui, Christy; Morcillo, Carmen; Russo, Debra A.; Stochl, Jan; Shelley, Gillian F.; Painter, Michelle; Jones, Peter B.; Perez, Jesus

doi:10.1016/j.schres.2013.05.026

Cited by 96Schizophrenia research and treatmentBipolar Disorder and TreatmentMental Health and Psychiatry

Psychiatric morbidity, functioning and quality of life in young people at clinical high risk for psychosis

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Hui, Christy, Morcillo, Carmen, Russo, Debra A., Stochl, Jan, Shelley, Gillian F., Painter, Michelle, Jones, Peter B., Perez, Jesus·2013·Schizophrenia Research

DOI 10.1016/j.schres.2013.05.026PMC PMC3744805

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Abstract

OBJECTIVE: Recent studies suggest that psychotic-like experiences may also act as markers for non-psychotic psychiatric disorders, which may indicate that the focus of research in individuals at high risk (HR) for psychosis needs updating. In this study we thoroughly examined the clinical and functional characteristics of a consecutive cohort of young people at HR for psychosis and compared them to a matched sample of healthy volunteers. METHOD: Between February 2010 and September 2012 60 help-seeking HR individuals, aged 16-35, were recruited from CAMEO Early Intervention in Psychosis Service, Cambridgeshire, UK. Forty-five age- and gender-matched healthy volunteers were randomly recruited from the same geographical area. Sociodemographic, psychiatric morbidity, functioning and quality of life measures were compared between both groups. RESULTS: HR individuals suffered a wide range of DSM-IV psychiatric disorders, mainly within the affective and anxiety diagnostic spectra. In comparison to healthy volunteers, young people at HR reported more suicidal ideation/intention, depressive and anxiety symptoms and presented with remarkably poor functioning and quality of life. CONCLUSION: The presence of co-morbid moderate or severe depressive and anxiety symptoms was common in our sample of young people at enhanced risk for psychosis. A HR mental state may be associated not only with an increased risk for psychosis, but also other psychiatric disorders. Our findings may have implications for the future implementation of therapeutic interventions that this population could benefit from.

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No formal, categorical diagnosis was applicable in the early psychosis group.
“Indeed, even in the early psychosis group, no formal, categorical diagnosis was applicable (although it is known that such groups have a high risk of transition to full psychiatric illness) (15).”
From Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals (2015) · cites this paper as [15]
Individuals with early psychosis who fall below the threshold for a categorical diagnosis already show symptoms and have an increased risk for transitioning to a severe mental illness such as schizophrenia or an affective disorder.
“Although, at the time of testing, these individuals fell below the threshold for a categorical diagnosis, they already showed symptoms and have an increased risk for transitioning to a severe mental illness such as schizophrenia or an affective disorder (15).”
From Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals (2015) · cites this paper as [15]
Psychosis is associated with a range of different psychiatric disorders.
“As well as offering a purer assessment of the emergence of psychotic experiences, this approach is inspired by growing evidence suggesting that psychosis lies on a continuum with normality (19,20) and is associated with a range of different psychiatric disorders (15,21).”
From Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals (2015) · cites this paper as [15]

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Authors: Hui, C., Morcillo, C., Russo, D. A., Stochl, J., Shelley, G. F., Painter, M., Jones, P. B., & Perez, J.
Affiliations: University of Cambridge (GB)
Cambridgeshire and Peterborough NHS Foundation Trust (GB)
ORCID: Hui, Christy
Painter, Michelle
Jones, Peter B.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2013-08
Volume: 148
Issue: 1-3
Pages: 175-180
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2013.05.026
PMC: PMC3744805
OpenAlex: W2046355430
Cited by: 96
References: 50
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 12 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 10 · 2015: 12 · 2014: 9
FWCI: 7.35
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/3.0/ (vor)
Locations: Schizophrenia Research (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders: National Institute for Health and Care Research (RP-PG-0606-1335, NF-SI-0509-10215)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: clinical high risk for psychosis, youth
MeSH terms: Adolescent, Adult, Anxiety, Depression, Female, Humans, Male, Morbidity, Psychiatric Status Rating Scales, Psychotic Disorders, Quality of Life, Retrospective Studies, Risk, Case-Control Studies, Young Adult

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Psychiatric morbidity, functioning and quality of life in young people at clinical high risk for psychosis

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