Prevalence of mental disorders and impact on quality of life in patients with pulmonary arterial hypertension.
Open accessAbstract
Objective: Mental health may affect the quality of life (QoL) in patients with pulmonary arterial hypertension (PAH). However, mental disorders have not been systematically assessed in these patients. We examined the prevalence of mental disorders using structured interviews and determined their impact on QoL in patients with PAH. Methods: This study included 217 patients with PAH from two German referral centers. Psychiatric disorders were assessed using the structured clinical interview for DSM-V. QoL was assessed using the WHO Quality of Life questionnaire (short form). The diagnostic value of the Hospital Anxiety and Depression Scale was evaluated by receiver operating characteristic curve analysis. Results: More than one third of the patients had psychological disorders with current or past adjustment disorder (38.2%), current major depressive disorder (23.0%), and panic disorder (15.2%) being the most prevalent mental illnesses. About half of the patients with a history of adjustment disorder developed at least one other mental illness. The presence of mental disorders had a profound impact on QoL. The Hospital Anxiety and Depression Scale ruled out panic disorder and depression disorder with negative predictive values of almost 90%. Conclusion: Mental disorders, in particular adjustment disorder, major depression, and panic disorder, are common in patients with PAH and contribute to impaired QoL in these patients. The Hospital Anxiety and Depression Scale may be used as a screening tool for the most common mental health disorders. Future studies need to address interventional strategies targeting mental disorders in patients with PAH.
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Psychiatric symptoms and illnesses are associated with worse outcomes regarding the CVD, including poorer prognosis, lower quality of life, increased risk of mortality, and interference with CVD treatment.
“Psychiatric symptoms and illnesses are in turn associated with several worse outcomes regarding the CVD: poorer prognosis of the course of the CVD, lower quality of life (QoL), increased risk of mortality, and interference with the CVD treatment, for example, due to worse adherence (3, 7–11).”
From Metacognitive Short-Term Intervention in Patients With Mental Disorders Following Cardiovascular Events (2022) · cites this paper as [3]
The Results (Determinants of QoL) associate depression and panic disorder with lower quality of life in patients with pulmonary arterial hypertension. The Discussion says the study was cross-sectional and lacked longitudinal data; the copy does not establish poorer cardiovascular prognosis, increased mortality, or interference with treatment through worse adherence. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe most common disorders among CVD patients are pathological stress reactions after a cardiovascular event, depressive and anxiety disorders.
“The most common disorders among CVD patients are pathological stress reactions after a cardiovascular event, depressive and anxiety disorders (3–6).”
From Metacognitive Short-Term Intervention in Patients With Mental Disorders Following Cardiovascular Events (2022) · cites this paper as [3]
The Abstract and Discussion identify adjustment disorder after a PAH diagnosis, major depression, and panic disorder as common in patients with pulmonary arterial hypertension. The claim extends these findings to CVD patients generally and describes the trigger as a cardiovascular event rather than a PAH diagnosis; this study does not establish that broader statement. (LLM, conf=0.87)
Experimental — accuracy not yet measuredMental disorders are common among patients with severe cardiovascular diseases (CVD).
“Mental disorders are common among patients with severe cardiovascular diseases (CVD).”
From Metacognitive Short-Term Intervention in Patients With Mental Disorders Following Cardiovascular Events (2022) · cites this paper as [3]
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- Authors
- Olsson, K. M., Meltendorf, T., Fuge, J., Kamp, J. C., Park, D.-H., Richter, M. J., Gall, H., Ghofrani, H. A., Ferrari, P., Schmiedel, R., Kulla, H.-D., Heitland, I., Lepsy, N., Dering, M.-R., Hoeper, M. M., & Kahl, K. G.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Justus-Liebig-Universität Gießen (DE)
- Corresponding author
- Olsson, Karen M.
- ORCID
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2021-05-31
- Volume
- 12
- Pages
- 667602-667602
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC8200462
- OpenAlex
- W3170373849
- Cited by
- 55
- References
- 25
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 6 · 2023: 14 · 2022: 16 · 2021: 1
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- pulmonary arterial hypertension, mental illness, quality of life, adjustment disorder, major depressive disorder, panic disorder, anxiety, depression screening, Hospital Anxiety and Depression Scale, prevalence
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