The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Output of neurogliaform cells to various neuron types in the human and rat cerebral cortex
Open accessAbstract
Neurogliaform cells in the rat elicit combined GABAA and GABAB receptor-mediated postsynaptic responses on cortical pyramidal cells and establish electrical synapses with various interneuron types. However, the involvement of GABAB receptors in postsynaptic effects of neurogliaform cells on other GABAergic interneurons is not clear. We measured the postsynaptic effects of neurogliaform cells in vitro applying simultaneous whole-cell recordings in human and rat cortex. Single action potentials of human neurogliaform cells evoked unitary IPSPs composed of GABAA and GABAB receptor-mediated components in various types of inteneuron and in pyramidal cells. Slow IPSPs were combined with homologous and heterologous electrical coupling between neurogliaform cells and several human interneuron types. In the rat, single action potentials in neurogliaform cells elicited GABAB receptor-mediated component in responses of neurogliaform, regular spiking, and fast spiking interneurons following the GABAA receptor-mediated component in postsynaptic responses. In conclusion, human and rat neurogliaform cells elicit slow IPSPs and reach GABAA and GABAB receptors on several interneuron types with a connection-specific involvement of GABAB receptors. The electrical synapses recorded between human neurogliaform cells and various interneuron types represent the first electrical synapses recorded in the human cortex.
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“NGFCs, called spiderweb cells by Cajal, have a characteristic multipolar morphology consisting of a small, round soma from which multiple, very short dendrites spread radially in all directions and have a wider, spherical, very dense axonal plexus composed of fine branches (Kawaguchi and Kubota, 1997; Kubota, 2014; Olah et al., 2007).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Olah et al., 2007
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“The properties of the output synapses of NGFCs are very distinct from those of other INs. NGFCs elicit slow, long-lasting IPSPs on PCs and other INs through a combined activation of both GABAA and GABAB receptors (Olah et al., 2007; Tamas et al., 2003).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Olah et al., 2007
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“coupling coefficients for gap junctions (0.05±0.05) were similar to those found earlier between human and rodent interneurons23.”
From Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type (2018) · cites this paper as [23]
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“In addition, the cloud of GABA generated from NGFC release can also activate presynaptic GABABR to mediate homosynaptic and heterosynaptic depression of GABAergic and glutamatergic release (48, 858, 859, 926, 927) sometimes with remarkable target cell specificity (204).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [859]
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Cites
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416
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Electrical Coupling and Neuronal Synchronization in the Mammalian Brain
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ELECTRICAL SYNAPSES IN THE MAMMALIAN BRAIN
Connors, B. W., & Long, M. A. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131128 · Cited by 784
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Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons
Tamás, G., Buhl, E. H., Lörincz, A., & Somogyi, P. (2000) · Nature Neuroscience · doi:10.1038/73936 · Cited by 648
Expression and functions of neuronal gap junctions
Söhl, G., Maxeiner, S., & Willecke, K. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1627 · Cited by 586
Electrical synapses between Gaba-Releasing interneurons
Galarreta, M., & Hestrin, S. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077566 · Cited by 434
Extensive dye coupling between rat neocortical neurons during the period of circuit formation
Peinado, A., Yuste, R., & Katz, L. C. (1993) · Neuron · doi:10.1016/0896-6273(93)90246-n · Cited by 391
Identified sources and targets of slow inhibition in the neocortex
Tamás, G., Simon, A. L., & Szabadics, J. (2003) · Science · doi:10.1126/science.1082053 · Cited by 359
Research works printed but not linked: 1
- Cajal S. R. y. (1904). Textura del Systema Nervioso del Hombre y los Vertebrados (Madrid, Spain, Moya), Vol. 2
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GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033
Reconstruction and Simulation of Neocortical Microcircuitry
Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., Ailamaki, A., Alonso-Nanclares, L., Antille, N., Arsever, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.029 · Cited by 1,557
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Rudy, B., Fishell, G., Lee, S., & Hjerling‐Leffler, J. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20853 · Cited by 1,420
Pfeffer, C. K., Xue, M., He, M., Huang, Z. J., & Scanziani, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3446 · Cited by 1,353
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
Metadata
- Authors
- Oláh, S.
- Affiliations
- University of Szeged (HU)
- Corresponding author
- Oláh, Szabolcs
- Venue
- Frontiers in Neural Circuits
- Publisher
- Frontiers Media SA
- Published
- 2007
- Volume
- 1
- Pages
- 4-4
- ISSN
- 1662-5110 (ISSN-L)
- PMC
- PMC2526278
- OpenAlex
- W2030434469
- Cited by
- 118
- References
- 44
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neural Circuits (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Wellcome Trust
- Boehringer Ingelheim Fonds
- Hungarian Scientific Research Fund
- Magyar Tudományos Akadémia
- Nemzeti Kutatási és Technológiai Hivatal
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R29NS035915, R01NS035915, R37NS035915)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- neurogliaform cells, GABAA receptor, GABAB receptors, inhibitory postsynaptic potentials, electrical synapses, cortical interneurons, pyramidal neurons, human cerebral cortex, rat cortex, fast-spiking interneurons, GABAergic inhibition
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