Cited by 143Ruminant Nutrition and Digestive PhysiologyAnimal Nutrition and PhysiologyMilk Quality and Mastitis in Dairy Cows

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

A Meta-analysis Describing the Effects of the Essential oils Blend Agolin Ruminant on Performance, Rumen Fermentation and Methane Emissions in Dairy Cows

Open access

Belanche, Alejandro, Newbold, Charles, Morgavi, Diego, Bach, Alex, Zweifel, Beatrice, Yáñez-Ruiz, David·2020·Animals

DOI 10.3390/ani10040620PMC PMC7222807

Open this paper in CoChat — free account Open PDF

Abstract

Ruminant on the productivity of dairy cows in comparison to non-treated animals. A total of 23 in vivo studies were identified in which Agolin was supplemented at 1 g/d per cow; then a meta-analysis was performed to determine the response ratio on milk yield, rumen fermentation, methane emissions and health. Results indicated that an adaptation period of at least 4 weeks of treatment is required. Whereas short-term studies showed minor and inconsistent effects of Agolin, long-term studies (>4 weeks of treatment) revealed that Agolin supplementation increases milk yield (+3.6%), fat and protein corrected milk (+4.1%) and feed efficiency (+4.4%) without further changes in milk composition and feed intake. Long-term treatment also decreased methane production per day (-8.8%), per dry matter intake (-12.9%) and per fat and protein corrected milk yield (-9.9%) without changes in rumen fermentation pattern. In conclusion, despite the mode of action is still unclear and the small number of studies considered, these findings show that Agolin represents an encouraging alternative to improve productivity in dairy cows.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ani10040620

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554
Conducting Meta-Analyses in R with the metafor Package
Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464
Imputing missing standard deviations in meta-analyses can provide accurate results
Furukawa, T. A., Barbui, C., Cipriani, A., Brambilla, P., & Watanabe, N. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.06.006 · Cited by 1,568
Invited review: essential oils as modifiers of rumen microbial fermentation
Calsamiglia, S., Busquet, M., Cardozo, P. W., Castillejos, L., & Ferret, A. (2007) · Journal of Dairy Science · doi:10.3168/jds.2006-644 · Cited by 1,014
Invited Review: Integrating Quantitative Findings from Multiple Studies Using Mixed Model Methodology
St-Pierre, N. R. (2001) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(01)74530-4 · Cited by 846 · cited 1×
“This approach implied the existence of between-studies variance based on the assumption that studies included in the analysis correspond to a random sample of all possible studies [24].”
Background
A review of plant-derived essential oils in ruminant nutrition and production
Benchaar, C., Calsamiglia, S., Chaves, A. V., Fraser, G. R., Colombatto, D., McAllister, T. A., & Beauchemin, K. A. (2007) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2007.04.014 · Cited by 664

Flagged first, then by citations

Show all 42 references

Research works printed but not linked: 3

Dunkel, 2016, Die Wirkung der Zulage einer Mischung aus ätherischen Ölen auf die Leistung von Milchkühen. VDLUFA-Schriftenreihe, Tierische Produktion, 69, 592
Jones, H., Newbold, C.J., and Zweifel, B. (2017, January 26–27). The effect of essential oils on rumen bacteria and protozoa in dairy cattle. Proceedings of the British Society of Animal Science, Chester, UK.
Borenstein, M., Hedges, L.V., Higgins, J.P., and Rothstein, H.R. (2011). Introduction to meta-analysis, John Wiley & Sons.

Sorted by citations

The rumen microbiome: balancing food security and environmental impacts
Mizrahi, I., Wallace, R. J., & Moraïs, S. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00543-6 · Cited by 490
Invited review: current enteric methane mitigation options
Beauchemin, K. A., Ungerfeld, E. M., Abdalla, A. L., Alvarez, C., Arndt, C., Becquet, P., Benchaar, C., Berndt, A., Mauricio, R. M., McAllister, T. A., et al. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-22091 · Cited by 324
Role of Secondary Plant Metabolites on Enteric Methane Mitigation in Ruminants
Kú-Vera, J. C., Jiménez‐Ocampo, R., Valencia-Salazar, S. S., Montoya-Flores, M. D., Molina-Botero, I. C., Arango, J., Gómez, C., Aguilar-Pérez, C. F., & Solorio‐Sánchez, F. J. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00584 · Cited by 300
Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction
Hassan, F.-U., Arshad, M. A., Ebeid, H. M., Rehman, M. S.-U., Khan, M. S., Shahid, S., & Yang, C. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.575801 · Cited by 186
Symposium review: Effective nutritional strategies to mitigate enteric methane in dairy cattle
Hristov, A. N., Audino Melgar, M., Wasson, D. E., & Arndt, C. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-21398 · Cited by 159
Strategies Used to Reduce Methane Emissions from Ruminants: Controversies and Issues
Króliczewska, B., Pecka‐Kiełb, E., & Bujok, J. (2023) · Agriculture · doi:10.3390/agriculture13030602 · Cited by 170
Global Warming and Dairy Cattle: How to Control and Reduce Methane Emission
Bačėninaitė, D., Džermeikaitė, K., & Antanaitis, R. (2022) · Animals · doi:10.3390/ani12192687 · Cited by 137
Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production
Tedeschi, L. O., MUIR, J. P., Naumann, H. D., Norris, A. B., Ramírez-Restrepo, C. A., & Mertens‐Talcott, S. U. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.628445 · Cited by 132
Effects of Dietary Tannins’ Supplementation on Growth Performance, Rumen Fermentation, and Enteric Methane Emissions in Beef Cattle: A Meta-Analysis
Orzuna‐Orzuna, J. F., Dorantes-Iturbide, G., Lara-Bueno, A., Martínez, G. D. M., Miranda‐Romero, L. A., & Hernández-García, P. A. (2021) · Sustainability · doi:10.3390/su13137410 · Cited by 102
Essential Oils as a Dietary Additive for Small Ruminants: A Meta-Analysis on Performance, Rumen Parameters, Serum Metabolites, and Product Quality
Dorantes-Iturbide, G., Orzuna‐Orzuna, J. F., Lara-Bueno, A., Martínez, G. D. M., Miranda‐Romero, L. A., & Lee-Rangel, H. A. (2022) · Veterinary Sciences · doi:10.3390/vetsci9090475 · Cited by 81
Animal board invited review – Beef for future: technologies for a sustainable and profitable beef industry
Pulina, G., Acciaro, M., Atzori, A. S., Battacone, G., Crovetto, G. M., Mele, M. L., Pirlo, G., & Rassu, S. P. G. (2021) · animal · doi:10.1016/j.animal.2021.100358 · Cited by 69
Enteric methane mitigation interventions
Fouts, J. Q., Honan, M. C., Roque, B. M., Tricárico, J. M., & Kebreab, E. (2022) · Translational Animal Science · doi:10.1093/tas/txac041 · Cited by 85
The Applicability of Essential Oils in Different Stages of Production of Animal-Based Foods
Mucha, W., & Witkowska, D. (2021) · Molecules · doi:10.3390/molecules26133798 · Cited by 70
A Meta-Analysis of Essential Oils Use for Beef Cattle Feed: Rumen Fermentation, Blood Metabolites, Meat Quality, Performance and, Environmental and Economic Impact
Orzuna‐Orzuna, J. F., Dorantes-Iturbide, G., Lara-Bueno, A., Miranda‐Romero, L. A., Martínez, G. D. M., & Santiago-Figueroa, I. (2022) · Fermentation · doi:10.3390/fermentation8060254 · Cited by 61
Selected Alternative Feed Additives Used to Manipulate the Rumen Microbiome
Michalak, M., Wojnarowski, K., Cholewińska, P., Szeligowska, N., Bawej, M., & Pacoń, J. (2021) · Animals · doi:10.3390/ani11061542 · Cited by 65
Feed additives for methane mitigation: Recommendations for testing enteric methane-mitigating feed additives in ruminant studies
Hristov, A. N., Bannink, A., Battelli, M., Belanche, A., Sanz, M. C. C., Fernández-Turren, G., García, F. J. G., Jonker, A., Kenny, D. A., Lind, V., et al. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25050 · Cited by 67
Invited review: Rumen modifiers in today's dairy rations
Firkins, J. L., & Mitchell, K. E. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-22644 · Cited by 54
Dietary Ruminant Enteric Methane Mitigation Strategies: Current Findings, Potential Risks and Applicability
Lileikis, T., Nainienė, R., Bliznikas, S., & Uchockis, V. (2023) · Animals · doi:10.3390/ani13162586 · Cited by 67
Essential Oils as In Vitro Ruminal Fermentation Manipulators to Mitigate Methane Emission by Beef Cattle Grazing Tropical Grasses
Benetel, G., Silva, T. D. S., Fagundes, G. M., Welter, K. C., Melo, F. A., Lobo, A. A. G., MUIR, J. P., & Bueno, I. C. D. S. (2022) · Molecules · doi:10.3390/molecules27072227 · Cited by 48
Modulation of milking performance, methane emissions, and rumen microbiome on dairy cows by dietary supplementation of a blend of essential oils
Bach, À., Elcoso, G., Escartín, M., Spengler, K., & Jouve, A. (2023) · animal · doi:10.1016/j.animal.2023.100825 · Cited by 54
Recent Advances in Enteric Methane Mitigation and the Long Road to Sustainable Ruminant Production
Roques, S., Martínez, G., Ramayo‐Caldas, Y., Popova, M., Denman, S. E., Meale, S. J., & Morgavi, D. (2023) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-021022-024931 · Cited by 64
The Impact of Essential Oil Feed Supplementation on Enteric Gas Emissions and Production Parameters from Dairy Cattle
Carrazco, A. V., Peterson, C. B., Zhao, Y., Pan, Y., McGlone, J. J., DePeters, E. J., & Mitloehner, F. M. (2020) · Sustainability · doi:10.3390/su122410347 · Cited by 54
Growth Performance, Meat Quality and Antioxidant Status of Sheep Supplemented with Tannins: A Meta-Analysis
Orzuna‐Orzuna, J. F., Dorantes-Iturbide, G., Lara-Bueno, A., Martínez, G. D. M., Miranda‐Romero, L. A., & Lee-Rangel, H. A. (2021) · Animals · doi:10.3390/ani11113184 · Cited by 48
Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
Belanche, A., Bannink, A., Dijkstra, J., Durmic, Z., García, F. J. G., dos Santos, F. G., Huws, S., Jeyanathan, J., Lund, P., Mackie, R. I., et al. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25046 · Cited by 43
Research progress on the application of feed additives in ruminal methane emission reduction: a review
Sun, K., Liu, H., Fan, H., Liu, T., & Zheng, C. (2021) · PeerJ · doi:10.7717/peerj.11151 · Cited by 49
Effect of a Blend of Essential Oils, Bioflavonoids and Tannins on In Vitro Methane Production and In Vivo Production Efficiency in Dairy Cows
Rossi, C. A. S., Grossi, S., Dell’Anno, M., Compiani, R., & Rossi, L. (2022) · Animals · doi:10.3390/ani12060728 · Cited by 39
Effect of a garlic and citrus extract supplement on performance, rumen fermentation, methane production, and rumen microbiome of dairy cows
Khurana, R., Brand, T., Tapio, I., & Bayat, A. R. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-22838 · Cited by 38
Mitigating enteric methane emissions: An overview of methanogenesis, inhibitors and future prospects
Xie, X., Cao, Y., Li, Q., Li, Q., Yang, X., Wang, R., Zhang, X., Tan, Z., Lin, B., & Wang, M. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.02.001 · Cited by 44
Implementing an appropriate metric for the assessment of greenhouse gas emissions from livestock production: A national case study
Hörtenhuber, S. J., Seiringer, M., Theurl, M. C., Größbacher, V., Piringer, G., Kral, I., & Zollitsch, W. J. (2022) · animal · doi:10.1016/j.animal.2022.100638 · Cited by 36
A Review of Potential Feed Additives Intended for Carbon Footprint Reduction through Methane Abatement in Dairy Cattle
Hodge, I., Quille, P., & O’Connell, S. (2024) · Animals · doi:10.3390/ani14040568 · Cited by 40
Recent advances in feed additives with the potential to mitigate enteric methane emissions from ruminant livestock
Kelly, L., & Kebreab, E. (2023) · Journal of Soil and Water Conservation · doi:10.2489/jswc.2023.00070 · Cited by 42
Feed additives for methane mitigation: Modeling the impact of feed additives on enteric methane emission of ruminants—Approaches and recommendations
Dijkstra, J., Bannink, A., Congio, G. F. D. S., Ellis, J. L., Eugène, M., Garcia, F., Niu, M., Vibart, R. E., Yáñez-Ruíz, D. R., & Kebreab, E. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25049 · Cited by 37
A review of in vitro approaches as tools for studying rumen fermentation and ecology: effectiveness compared to in vivo outcomes
Scicutella, F., Foggi, G., Daghio, M., Mannelli, F., Viti, C., Mele, M. L., & Buccioni, A. (2025) · Italian Journal of Animal Science · doi:10.1080/1828051x.2025.2463507 · Cited by 34
Lactational performance, rumen fermentation, nutrient use efficiency, enteric methane emissions, and manure greenhouse gas-emitting potential in dairy cows fed a blend of essential oils
Silvestre, T., Martins, L. F., Cueva, S. F., Wasson, D. E., Stepanchenko, N., Räisänen, S. E., Sommai, S., Hile, M. L., & Hristov, A. N. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-23181 · Cited by 29
Effects of essential oils on economically important characteristics of ruminant species: A comprehensive review
Wells, C. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.05.017 · Cited by 40
Quantifying the Impact of Different Dietary Rumen Modulating Strategies on Enteric Methane Emission and Productivity in Ruminant Livestock: A Meta-Analysis
Pepeta, B. N., Hassen, A., & Tesfamariam, E. H. (2024) · Animals · doi:10.3390/ani14050763 · Cited by 35
Evaluation of ruminal methane and ammonia formation and microbiota composition as affected by supplements based on mixtures of tannins and essential oils using Rusitec
Foggi, G., Terranova, M., Daghio, M., Amelchanka, S. L., Conte, G., Ineichen, S., Agnolucci, M., Viti, C., Mantino, A., Buccioni, A., et al. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01005-8 · Cited by 32
Effects of dose, dietary nutrient composition, and supplementation period on the efficacy of methane mitigation strategies in dairy cows: A meta-analysis
Martins, L. F., Cueva, S. F., Wasson, D. E., Almeida, C. V., Eifert, C., de Ondarza, M. B., Tricárico, J. M., & Hristov, A. N. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-24783 · Cited by 30
Mitigation strategies for methane emissions in ruminant livestock: a comprehensive review of current approaches and future perspectives
Malyugina, S., Holik, S., & Horký, P. (2025) · Frontiers in Animal Science · doi:10.3389/fanim.2025.1610376 · Cited by 37
In vitro screening of the ruminal methane and ammonia mitigating potential of mixtures of either chestnut or quebracho tannins with blends of essential oils as feed additives
Foggi, G., Terranova, M., Conte, G., Mantino, A., Amelchanka, S. L., Kreuzer, M., & Mele, M. L. (2022) · Italian Journal of Animal Science · doi:10.1080/1828051x.2022.2130832 · Cited by 24
Effects of a Polyherbal Dietary Additive on Performance, Dietary Energetics, Carcass Traits, and Blood Metabolites of Finishing Lambs
Dorantes-Iturbide, G., Orzuna‐Orzuna, J. F., Lara-Bueno, A., Miranda‐Romero, L. A., Martínez, G. D. M., & Hernández-García, P. A. (2022) · Metabolites · doi:10.3390/metabo12050413 · Cited by 21
Essential Oils as a Dietary Additive for Laying Hens: Performance, Egg Quality, Antioxidant Status, and Intestinal Morphology: A Meta-Analysis
Orzuna‐Orzuna, J. F., & Lara-Bueno, A. (2023) · Agriculture · doi:10.3390/agriculture13071294 · Cited by 21
Diet supplementation with a mixture of essential oils: Effects on enteric methane emissions, apparent total-tract nutrient digestibility, nitrogen utilization, and lactational performance
Benchaar, C., & Hassanat, F. (2025) · Journal of Dairy Science · doi:10.3168/jds.2024-25447 · Cited by 20
Comparison of Quantification Methods to Estimate Farm-Level Usage of Antimicrobials Other than in Medicated Feed in Dairy Farms from Québec, Canada
Lardé, H., Francoz, D., Roy, J., Massé, J., Archambault, M., Paradis, M.-È., & Dufour, S. (2021) · Microorganisms · doi:10.3390/microorganisms9051106 · Cited by 20
The roles of phytogenic feed additives, trees, shrubs, and forages on mitigating ruminant methane emission
Bature, I., Wu, X., Yang, F., Liang, Z., Yang, C., Jing, L., Xu, S., & Ding, X. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1475322 · Cited by 26
Enteric Methane Emissions from Dairy–Beef Steers Supplemented with the Essential Oil Blend Agolin Ruminant
Miller, G. A., Bowen, J. M., Dewhurst, R. J., Zweifel, B., Spengler, K., & Duthie, C.-A. (2023) · Animals · doi:10.3390/ani13111826 · Cited by 19
Impact of specific essential oils blend on milk production, serum biochemical parameters and kid performance of goats
El-Azrak, K. E.-D. M., Morsy, A. S., Soltan, Y. A., Hashem, N. M., & Sallam, S. M. A. (2021) · Animal Biotechnology · doi:10.1080/10495398.2021.1898978 · Cited by 19
Enteric methane emission reduction potential of natural feed supplements in ewe diets
Roskam, E., O’Donnell, C., Hayes, M., Kirwan, S. F., Kenny, D. A., O’Flaherty, V., McGovern, F., Claffey, N. A., & Waters, S. M. (2024) · Journal of Animal Science · doi:10.1093/jas/skad421 · Cited by 21
Impact of orange essential oil on enteric methane emissions of heifers fed bermudagrass hay
Jiménez‐Ocampo, R., Montoya-Flores, M. D., Pámanes-Carrasco, G. A., Herrera-Torres, E., Arango, J., Estarrón‐Espinosa, M., Aguilar-Pérez, C. F., Araiza-Rosales, E. E., Guerrero-Cervantes, M., & Kú-Vera, J. C. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.863910 · Cited by 19
Impact of essential oils on methane emissions, milk yield, and feed efficiency and resulting influence on the carbon footprint of dairy production systems
Becker, F., Spengler, K., Reinicke, F., & Diepen, C. H.-V. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26129-8 · Cited by 20
Effect of a blend of cinnamaldehyde, eugenol, and Capsicum oleoresin on methane emission and lactation performance of Holstein-Friesian dairy cows
van Gastelen, S., Yáñez-Ruíz, D. R., Khelil-Arfa, H., Blanchard, A., & Bannink, A. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23406 · Cited by 18
Effects of quercetin on in vitro rumen fermentation parameters, gas production and microflora of beef cattle
Xiao, M., Du, L., Wei, M., Wang, Y., Dong, C., Ju, J., Zhang, R., Peng, W., Wang, Y., Zheng, Y., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1527405 · Cited by 15
Tailored Nanoparticles With the Potential to Reduce Ruminant Methane Emissions
Altermann, E., Reilly, K., Young, W., Ronimus, R. S., & Muetzel, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.816695 · Cited by 16
Immunity, rumen metagenomics, ruminal variables, and growth performance of calves fed milk with sage (Salvia officinalis) essential oil
Kara, K., & Pi̇rci̇, G. (2023) · Tropical Animal Health and Production · doi:10.1007/s11250-023-03831-w · Cited by 16
Optimizing Essential Oil Mixtures: Synergistic Effects on Cattle Rumen Fermentation and Methane Emission
Nasir, M., Rodríguez-Prado, M., Simoni, M., Martín-Orúe, S. M., Pérez, J. F., & Calsamiglia, S. (2025) · Animals · doi:10.3390/ani15142105 · Cited by 15
Harnessing plant bioactivity for enteric methane mitigation in Australia
Durmic, Z., Black, J. L., Martin, G. B., & Vercoe, P. E. (2021) · Animal Production Science · doi:10.1071/an21004 · Cited by 18
Effect of Dietary Supplementation with a Mixture of Natural Antioxidants on Milk Yield, Composition, Oxidation Stability and Udder Health in Dairy Ewes
Karageorgou, A., Tsafou, M., Goliomytis, M., Hager-Theodorides, A. L., Politi, K. A., & Simitzis, P. (2023) · Antioxidants · doi:10.3390/antiox12081571 · Cited by 15
Synergistic Effects of Essential Oil Blends and Fumaric Acid on Ruminal Fermentation, Volatile Fatty Acid Production and Greenhouse Gas Emissions Using the Rumen Simulation Technique (RUSITEC)
Alabi, J. O., Dele, P. A., Okedoyin, D. O., Wuaku, M., Anotaenwere, C. C., Adelusi, O. O., Gray, D., Ike, K. A., Oderinwale, O. A., Subedi, K., et al. (2024) · Fermentation · doi:10.3390/fermentation10020114 · Cited by 14
Long-Term Mootral Application Impacts Methane Production and the Microbial Community in the Rumen Simulation Technique System
Brede, J., Peukert, M., Egert, B., Breves, G., & Brede, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.691502 · Cited by 13
Effect of supplementing an α-amylase enzyme or a blend of essential oil components on the performance, nutrient digestibility, and nitrogen balance of dairy cows
den Bossche, T. V., Goossens, K., Ampe, B., Tamassia, L. F. M., Boever, J. L. D., & Vandaele, L. (2024) · Journal of Dairy Science · doi:10.3168/jds.2023-24073 · Cited by 11
Dietary fat and carbohydrate-balancing the lactation performance and methane emissions in the dairy cow industry: A meta-analysis
Zhang, C., Jiang, X., Wu, S., Zhang, J., Wang, Y., Li, Z., & Yao, J. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.02.004 · Cited by 10
Meta-analysis of the effects of essential oils on consumption, performance, and ruminal fermentation of beef cattle
Ferreira, F. D. J., FERNANDES, L. D., Júnior, A. R. L., Rosado, G. L., & Bento, C. B. P. (2024) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2024.115956 · Cited by 14
Greenhouse-gas abatement on Australian dairy farms: what are the options?
Garnett, L., & Eckard, R. (2024) · Animal Production Science · doi:10.1071/an24139 · Cited by 12
Comparison of Quantification Methods to Estimate Farm-Level Usage of Antimicrobials in Medicated Feed in Dairy Farms from Québec, Canada
Lardé, H., Francoz, D., Roy, J., Archambault, M., Massé, J., Paradis, M.-È., & Dufour, S. (2021) · Microorganisms · doi:10.3390/microorganisms9091834 · Cited by 9
The essential oil blend Agolin Ruminant L reduces methane production in vitro and in vivo when included in the drinking water of cattle
Batley, R. J., Romanzini, E. P., da Silva, K. D., de Souza, W. L., Quigley, S. P., Harper, K. J., Trotter, M. G., Bernardes, P. A., Naiker, M., & Costa, D. F. A. (2024) · Journal of Animal Science · doi:10.1093/jas/skae315 · Cited by 9
Effects of monensin and essential oil blend supplementation on lactation performance and feeding behavior in dairy cows
Diepersloot, E. C., Pupo, M. R., Heinzen, C., de Souza, M. S., & Ferraretto, L. F. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25834 · Cited by 9
Is early life programming a promising strategy for methane mitigation and sustainable intensification in ruminants?
Kolathingal-Thodika, N., Elayadeth‐Meethal, M., Dunshea, F. R., Eckard, R., Flavel, M., & Chauhan, S. S. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.179654 · Cited by 10
Developments in nutrition for pasture-based cattle and sheep systems in Ireland
Patton, J., Dineen, M., Keady, T. W. J., McGee, M., & Waters, S. M. (2022) · Irish Journal of Agricultural and Food Research · doi:10.15212/ijafr-2020-0148 · Cited by 9
Solutions to enteric methane abatement in Ireland
Cummins, S., Lanigan, G. J., Richards, K. G., Boland, T. M., Kirwan, S. F., Smith, P. E., & Waters, S. M. (2022) · Irish Journal of Agricultural and Food Research · doi:10.15212/ijafr-2022-0014 · Cited by 7
Implementing IPCC 2019 Guidelines into a National Inventory: Impacts of Key Changes in Austrian Cattle and Pig Farming
Hörtenhuber, S. J., Größbacher, V., Schanz, L., & Zollitsch, W. J. (2023) · Sustainability · doi:10.3390/su15064814 · Cited by 9
The Effect of Saponite Clay on Ruminal Fermentation Parameters during In Vitro Studies
Pikhtirova, A., Pecka‐Kiełb, E., Króliczewska, B., ZACHWIEJA, A., Króliczewski, J., & Kupczyński, R. (2024) · Animals · doi:10.3390/ani14050738 · Cited by 10
Mitigating methane emissions and promoting acetogenesis in ruminant livestock
Mrutu, R. I., Abdussamad, A. M., Umar, K., Abdulhamid, A., & Farny, N. G. (2025) · Frontiers in Animal Science · doi:10.3389/fanim.2025.1489212 · Cited by 11
Evaluation of Agolin®, an Essential Oil Blend, as a Feed Additive for High Producing Cows
Williams, P., Clark, J. H., & Bean, K. (2021) · Open Journal of Animal Sciences · doi:10.4236/ojas.2021.112018 · Cited by 8
Environmental performance of commercial beef production systems utilizing conventional productivity-enhancing technologies
Aboagye, I. A., Cordeiro, M. R. C., McAllister, T. A., May, M. L., Hannon, S. J., Booker, C. W., Parr, S. L., Schunicht, O. C., Burciaga-Robles, L. O., Grimson, T. M., et al. (2022) · Translational Animal Science · doi:10.1093/tas/txac074 · Cited by 8
Evaluation of a dietary blend of essential oils and polyphenols on methane emission by ewes
Atzori, A. S., Porcu, M. A., Fulghesu, F., Ledda, A., & Correddu, F. (2023) · Animal Production Science · doi:10.1071/an23070 · Cited by 7
— Invited Review — Ruminal ciliates as modulators of the rumen microbiome
Park, T. (2023) · Animal Bioscience · doi:10.5713/ab.23.0309 · Cited by 9
Towards climate neutrality: Comparison of mitigation strategies for agricultural emissions using GWP100 and GWP* metrics
Zerbe, M., Mörlein, D., & Hörtenhuber, S. J. (2024) · Environmental Challenges · doi:10.1016/j.envc.2024.101060 · Cited by 9
Effect of Phytochemical Feed Additives on Health Status, Milk Yield, and Quality Characteristics in Ruminants
Tsiplakou, E., Mavrommatis, A., Gelasakis, A. Ι., Kalogianni, A. I., & Simitzis, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-42855-5_21 · Cited by 6
Phytogenic additives increase the performance and improve the tenderness of lamb meat: a meta-analytical and systematic review approach
da Silva, N. I. S., Lima, P. D. O., Souza, F. J. C., Pereira, M. W. F., Moreira, R. H. R., Firmino, S. S., de Araújo, T. L. A. C., & Júnior, D. M. D. L. (2025) · Semina Ciências Agrárias · doi:10.5433/1679-0359.2025v46n1p231 · Cited by 5
Impact of Monensin Sodium and Essential Limonene Oil on the Fermentation and Chemical Composition of Total Mixed Ration Silages with Moisture Variations
de Andrade, R. C., Orrico, M. A. P., da Silva, Y. A., Retore, M., Fernandes, T., Orrico, A. C. A., de Vargas, F. M., & Amaral, I. P. D. O. (2024) · Agriculture · doi:10.3390/agriculture14081319 · Cited by 5
Effect of Plant‐Derived Feed Additives on Enteric Methane Emission, Nutrient Digestibility and Immune Status of Adult Male Goats
Kumari, N., Kala, A., Agarwal, N., Chaturvedi, V. B., Vijayalakshmy, K., & Chaudhary, L. C. (2025) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.14105 · Cited by 5
Evaluation of Agolin® Ruminant, an Essential Oil Blend, as a Feed Additive for Cows at Two Levels of Production
Brambila, R., & Noricumbo-Saenz, J. (2022) · Open Journal of Animal Sciences · doi:10.4236/ojas.2022.123029 · Cited by 5
Impacts of thyme and/or garlic oils on growth, immunity, antioxidant and net farm income in Damascus goats
Imbabi, T. A., Hassan, T. M. M., Osman, A., El-Aziz, A. H. A., Tantawi, A. A., & Nasr, M. A. F. (2024) · Scientific Reports · doi:10.1038/s41598-024-62417-0 · Cited by 5
Rapid Screening of Methane-Reducing Compounds for Deployment in Livestock Drinking Water Using In Vitro and FTIR-ATR Analyses
Batley, R. J., Chaves, A. V., Johnson, J. B., Naiker, M., Quigley, S. P., Trotter, M. G., & Costa, D. F. A. (2024) · Methane · doi:10.3390/methane3040030 · Cited by 6
The carbon footprint of beef cattle systems in the Southeast United States
Dubeux, J. C. B., Garcia, L., Queiroz, L. M. D., Santos, E. R. S., Oduor, K. T., & Bretas, I. L. (2022) · Carbon Footprints · doi:10.20517/cf.2022.16 · Cited by 5
Nutritional Approaches to Reduce Enteric Methane Emission from Ruminants
Lind, V., Schwarm, A., Mele, M. L., Cappucci, A., Foggi, G., Sızmaz, Ö., Tsiplakou, E., Atzori, A. S., Mullem, J. V., & Peiren, N. (2023) · Smart animal production · doi:10.1007/978-3-031-19730-7_4 · Cited by 7
Control of Methanogenesis in Dairy Animals
Beauchemin, K. A., Ungerfeld, E. M., & Gruninger, R. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818766-1.00072-6 · Cited by 6
Essential oil blend and monensin for feedlot steers consuming backgrounding and finishing diets: growth performance, methane emissions using the GreenFeed system, and feeding behavior
Terry, S. A., & Beauchemin, K. A. (2025) · Translational Animal Science · doi:10.1093/tas/txae182 · Cited by 4
Novel Antioxidants for Animal Nutrition
Rossi, L., & Dell’Anno, M. (2024) · MDPI eBooks · doi:10.3390/books978-3-7258-1157-1 · Cited by 5
Use of essential oils as feed additive for modulation of rumen fermentation and methanogenesis in buffalo
Pawar, M. M., Kamra, D. N., Agarwal, N., Chaudhary, L. C., & Chaturvedi, V. B. (2021) · Animal Nutrition and Feed Technology · doi:10.5958/0974-181x.2021.00004.4 · Cited by 4
Leverage of Essential Oils on Faeces-Based Methane and Biogas Production in Dairy Cows
Mazurkiewicz, J., Sidoruk, P., Dach, J., Szumacher‐Strabel, M., Lechniak, D., Galama, P. J., Kuipers, A., Antkowiak, I. R., & Cieślak, A. (2023) · Agriculture · doi:10.3390/agriculture13101944 · Cited by 4
Mitigating methane in dairy cattle: Integrated strategies and the evolving role of precision livestock farming
Mixtajová, E., Nery, J., Kasarda, R., Denli, M., Schiavone, A., Çağl&#, A., Pérez, J. F., İpçak, H. H., Repetto, J. L., Drotárová, S., et al. (2026) · Czech Journal of Animal Science · doi:10.17221/116/2025-cjas · Cited by 4
Effect of Padina gymnospora biowaste inclusion on in vitro methane production, feed fermentation, and microbial diversity
Mohapatra, A., Trivedi, S., Kolte, A. P., Tejpal, C. S., Elavarasan, K., Vaswani, S., Malik, P. K., RAVISHANKAR, C. N., & Bhatta, R. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1431131 · Cited by 4
Rapid Screening of Methane-Reducing Compounds for Deployment via Water with a Commercial Livestock Supplement Using In Vitro and FTIR-ATR Analyses
Batley, R. J., Romanzini, E. P., Johnson, J. B., de Souza, W. L., Naiker, M., Trotter, M. G., Quigley, S. P., Congio, G. F. D. S., & Costa, D. F. A. (2024) · Methane · doi:10.3390/methane3030025 · Cited by 3
Effects of pulse-dosing an essential oil blend to dairy cows on enteric methane emissions and productivity
Fouts, J. Q., Grossi, S., Tricárico, J. M., & Kebreab, E. (2025) · Translational Animal Science · doi:10.1093/tas/txaf056 · Cited by 3
The use of plant bioactive compounds to reduce greenhouse gas emissions from farmed ruminants
INRAE, F., Martin, C., Niderkorn, V., INRAE, F., Maxin, G., INRAE, F., Guyader, J., INRAE-ADM NEOVIA, F., Eugène, M., INRAE, F., et al. (2021) · Burleigh Dodds series in agricultural science · doi:10.19103/as.2020.0077.13 · Cited by 4
Laser methane smart detector for measuring the reduction of emissions in dairy cows: a pilot study
Senatore, E., Foggi, G., Silvi, A., Mantino, A., Conte, G., & Mele, M. L. (2023) · IEEE International Workshop on Metrology for Agriculture and Forestry (MetroAgriFor) · doi:10.1109/metroagrifor58484.2023.10424231 · Cited by 2
Response of the Ruminal Microbial Environment to a High‐Dose Supplementation of Blended Essential Oils
Zhaoyu, P., Fujimura, K., Endo, A., & Uyeno, Y. (2025) · Animal Science Journal · doi:10.1111/asj.70087 · Cited by 2
In Vitro Evaluation of Spearmint Essential Oil (Mentha spicata L.) Supplementation on Gas Production, Rumen Fermentation, and Microbial Community Structure
Huang, C., Chen, J., Wang, L., Wang, L., Li, J., & Dong, L. (2026) · Animals · doi:10.3390/ani16071007 · Cited by 2
Characterization of Nigella sativa Meal (NSM) and the Effects on In Vitro Rumen Fermentation and Degradability
Juandita, K. N., Ramdani, D., Hernaman, I., Chaudhry, A. S., Sukarman, & Sarwono, K. A. (2026) · Animals · doi:10.3390/ani16071091 · Cited by 2

Authors: Belanche, A., Newbold, C., Morgavi, D., Bach, A., Zweifel, B., & Yáñez-Ruiz, D.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
Scotland's Rural College (GB)
Université Clermont Auvergne (FR)
Institució Catalana de Recerca i Estudis Avançats (ICREA), 08005 Barcelona, Spain
Agolin SA, 1145 Bière, Switzerland
Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas (CSIC), Profesor Albareda 1, 18008 Granada, Spain
Corresponding author: Belanche, Alejandro
ORCID: Belanche, Alejandro
Newbold, Charles
Morgavi, Diego
Yáñez-Ruiz, David
Venue: Animals
Publisher: MDPI AG
Published: 2020-04-03
Volume: 10
Issue: 4
Pages: 620
ISSN: 2076-2615 (ISSN-L)
DOI: 10.3390/ani10040620
PMC: PMC7222807
OpenAlex: W3014733351
Cited by: 143
References: 42
Citations by year: 2026: 19 · 2025: 23 · 2024: 32 · 2023: 27 · 2022: 20 · 2021: 19 · 2020: 3
FWCI: 2.33
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Animals (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by)
HAL (submittedVersion, cc-by)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
IRTA (Institut de Recerca i Tecnologia Agroalimentaries) (submittedVersion, cc-by)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Milk Quality and Mastitis in Dairy Cows
Keywords: essential oil blends, dairy cattle, milk yield, rumen fermentation, methane emissions, feed efficiency, feed additives, adaptation period, ruminant nutrition

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Meta-analysis Describing the Effects of the Essential oils Blend Agolin Ruminant on Performance, Rumen Fermentation and Methane Emissions in Dairy Cows

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks