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Cited by 6Antifungal resistance and susceptibilityBacterial biofilms and quorum sensingFungal and yeast genetics research

Undesired effect of vancomycin prolonged treatment: enhanced biofilm production of the nosocomial pathogen Candida auris

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Maione, Angela, Pietra, Alessandra La, Salvatore, Maria Michela, Guida, Marco, Galdiero, Emilia, de Alteriis, Elisabetta·2022·Antibiotics
DOI 10.3390/antibiotics11121771PMC PMC9774269
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Abstract

Fungal infections are often consequent to prolonged antibiotic treatments. Vancomycin (Van) is the first-choice antibiotic in the treatment of Staphylococcus aureus infections associated with colonization of catheter surfaces. We demonstrate the direct effect of Van in promoting the formation of the biofilm of the emergent yeast pathogen Candida auris, developed in the conventional polystyrene microwell plate model, as well as on silicone surfaces (22 and 28% increase in total biomass, respectively) and on an S. aures biofilm, residual after vancomycin treatment, where C. auris achieved 99% of the mixed biofilm population. The effect of Van was assessed also in vivo, in the Galleria mellonella infection model, which showed higher mortality when infected with the yeast pathogen in the presence of the antibiotic. This evidence enhances awareness of the potential risk associated with prolonged antibiotic use in promoting fungal infections.

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  • Vancomycin promotes C. auris growth in vitro and in a Galleria mellonella infection model.

    “vancomycin has been shown to promote C. auris growth in vitro and in a Galleria mellonella infection model [48]”

    From Host–Candida auris interactions in the skin (2026) · cites this paper as [48]

    The Discussion (page not provided) reports that vancomycin promoted C. auris biofilm formation in vitro. Results §2.2 reports higher mortality in infected Galleria mellonella larvae given vancomycin, but the Discussion says this only suggests increased fungal growth and/or virulence in vivo; it does not establish increased growth in the larvae. (LLM, conf=0.88)

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Research works printed but not linked: 31

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Cited by

Sorted by citations

Authors
Maione, A., Pietra, A. L., Salvatore, M. M., Guida, M., Galdiero, E., & de Alteriis, E.
Affiliations
  • University of Naples Federico II (IT)
  • Institute for Sustainable Plant Protection (IT)
  • Department of Biology, University of Naples Federico II, 80126 Naples, Italy
Corresponding author
Galdiero, Emilia
ORCID
Venue
Antibiotics
Publisher
MDPI AG
Published
2022-12-08
Volume
11
Issue
12
Pages
1771
ISSN
2079-6382 (ISSN-L)
DOI
10.3390/antibiotics11121771
PMC
PMC9774269
OpenAlex
W4311852724
Cited by
6
References
4
Citations by year
2026: 1 · 2024: 1 · 2023: 4
FWCI
0.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Antibiotics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
vancomycin, Candida auris, biofilm formation, antibiotic adverse effects, long-term antibiotic therapy, Staphylococcus aureus, catheter colonization, silicone surfaces, polymicrobial biofilms, Galleria mellonella infection model, fungal infection risk, nosocomial infections

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