Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
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Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phylogeny and amplified fragment length polymorphism typing methods report the C. auris population as clonal. Here, using whole genome sequencing analysis, we decipher for the first time that C. auris strains from four Indian hospitals were highly related, suggesting clonal transmission. Further, all C. auris isolates originated from cases of fungaemia and were resistant to fluconazole (MIC >64 mg/L).
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C. auris and C. albicans are related closely enough to share the same noncanonical genetic code.
“particularly for species related closely enough to share the same noncanonical genetic code40,41.”
From The emerging fungal pathogen <i>Candida auris</i> induces IFNγ to colonize mammalian hair follicles (2025) · cites this paper as [41]
The Results (Functional annotation of C. auris; page not provided) place C. auris in the CUG clade based on codon-usage analysis. But the paper does not state that C. auris and C. albicans share the same noncanonical genetic code; its Discussion instead describes C. auris as highly divergent from C. albicans. (LLM, conf=0.81)
Experimental — accuracy not yet measuredMany putative transporter genes in the C. auris genome suggest that drug efflux may be an important determinant of azole resistance.
“Further, the identification of many putative transporter genes in the C. auris genome suggests that drug efflux may also be an important determinant of azole resistance (16–18).”
From Genetic Analysis of <i>Candida auris</i> Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance (2019) · cites this paper as [17]
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- Authors
- Sharma, C., Kumar, N., Pandey, R., Meis, J. F., & Chowdhary, A.
- Affiliations
- University of Delhi (IN)
- Wellcome Sanger Institute (GB)
- Institute of Genomics and Integrative Biology (IN)
- Radboud University Nijmegen (NL)
- Corresponding author
- Chowdhary, A.
- Venue
- New Microbes and New Infections
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 13
- Pages
- 77-82
- ISSN
- 2052-2975 (ISSN-L)
- PMC
- PMC5006800
- OpenAlex
- W2473558636
- Cited by
- 202
- References
- 24
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 18 · 2023: 18 · 2022: 15 · 2021: 22 · 2020: 23 · 2019: 31 · 2018: 21 · 2017: 21 · 2016: 6
- FWCI
- 24.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- New Microbes and New Infections (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Astellas
- Basilea
- Merck
- United Medical
- Gilead
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida auris, multidrug resistance, clonal transmission, genetic relatedness, fluconazole resistance, azole resistance, amphotericin B resistance, caspofungin resistance, emerging fungal pathogens, Indian hospitals
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