An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters

Straub, Jürg

doi:10.3390/antibiotics2010115

Cited by 61Pharmaceutical and Antibiotic Environmental ImpactsEnvironmental Toxicology and EcotoxicologyEnvironmental Chemistry and Analysis

An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters

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Straub, Jürg·2013·Antibiotics

DOI 10.3390/antibiotics2010115PMC PMC4790302

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Abstract

An environmental risk assessment (ERA) for the aquatic compartment in Europe from human use was developed for the old antibiotic Trimethoprim (TMP), comparing exposure and effects. The exposure assessment is based on European risk assessment default values on one hand and is refined with documented human use figures in Western Europe from IMS Health and measured removal in wastewater treatment on the other. The resulting predicted environmental concentrations (PECs) are compared with measured environmental concentrations (MECs) from Europe, based on a large dataset incorporating more than 1800 single MECs. On the effects side, available chronic ecotoxicity data from the literature were complemented by additional, new chronic results for fish and other organisms. Based on these data, chronic-based deterministic predicted no effect concentrations (PNECs) were derived as well as two different probabilistic PNEC ranges. The ERA compares surface water PECs and MECs with aquatic PNECs for TMP. Based on all the risk characterization ratios (PEC÷PNEC as well as MEC÷PNEC) and risk graphs, there is no significant risk to surface waters.

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Trimethoprim is considered chemically stable in various environmental samples.
“trimethoprim is considered to be chemically stable in various environmental samples [37,38]”
From Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion (2025) · cites this paper as [37]

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Authors: Straub, J.
Affiliations: F. Hoffmann-La Roche AG (CH)
Corresponding author: Straub, Jürg
ORCID: Straub, Jürg
Venue: Antibiotics
Publisher: MDPI AG
Published: 2013-03-18
Volume: 2
Issue: 1
Pages: 115-162
ISSN: 2079-6382 (ISSN-L)
DOI: 10.3390/antibiotics2010115
PMC: PMC4790302
OpenAlex: W2085266534
Cited by: 61
References: 136
Citations by year: 2026: 3 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 2
FWCI: 3.92
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Antibiotics (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: F. Hoffmann-La Roche
École Polytechnique Fédérale de Lausanne
Ministerio de Economía y Competitividad
Danmarks Tekniske Universitet
Bundesamt für Umwelt
Topics: Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Physical Sciences › Environmental Science › Environmental Chemistry › Environmental Chemistry and Analysis
Keywords: trimethoprim, environmental risk assessment, surface water, predicted environmental concentration, predicted no-effect concentration, chronic ecotoxicity, pharmaceutical pollutants

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An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters

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