Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases
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Three patients, each of whom had required intensive open-ended antimicrobial therapy for control of the symptoms of chronic relapsing neurological Lyme disease and relapsing babesiosis, were able to discontinue treatment and remain clinically well for periods of observation of 6-23 months following the completion of a finite course of treatment solely with disulfiram. One patient relapsed at six months and is being re-treated with disulfiram.
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In 2019, three clinical instances introduced disulfiram as a potential treatment for chronic, relapsing tick-borne illnesses, initiating off-label use of disulfiram in Lyme disease.
“In 2019, three clinical instances were published, introducing DIS as a potential treatment for chronic, relapsing tick-borne illnesses,28 unintended initiating the off-label use of DIS in Lyme disease.”
From Off-label and repurposed use of disulfiram beyond alcohol dependence: A systematic review of clinical and preclinical evidence (2026) · cites this paper as [28]
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- Authors
- Liegner, K. B.
- Affiliations
- Northern Westchester Hospital (US)
- Corresponding author
- Liegner, Kenneth B.
- Venue
- Antibiotics
- Publisher
- MDPI AG
- Published
- 2019-05-30
- Volume
- 8
- Issue
- 2
- Pages
- 72
- ISSN
- 2079-6382 (ISSN-L)
- PMC
- PMC6627205
- OpenAlex
- W2947236316
- Cited by
- 35
- References
- 118
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 4
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antibiotics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
- Health Sciences › Veterinary › Small Animals › Brucella: diagnosis, epidemiology, treatment
- Keywords
- disulfiram, Lyme disease, babesiosis, antimicrobial therapy, treatment discontinuation, relapse
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