Behavioral and synaptic phenotypes of female Prdx6(-/-) Mice
Open accessAbstract
Peroxiredoxin 6 (PRDX6) is expressed throughout the brain, including the hippocampus, where it plays a potential role in synaptic regulation and forming emotional and spatial memories. PRDX6 is predominantly detected in the female mouse’s hippocampus; thus, we investigate the effect of the Prdx6 gene on behavioral phenotypes and synaptic functions using female Prdx6 knockout (Prdx6−/−) mice. Our results demonstrate that female Prdx6−/− mice exhibited anxiety-like behavior, enhanced contextual fear memory, and impaired spatial memory. We also found increased, paired–pulse facilitation ratios, and decreased long-term potentiation (LTP) in the hippocampal region of these female Prdx6−/− mice. The present study helps to understand better the PRDX6’s role in emotional response and spatial memory formation in female mice.
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PRDX6 has been linked to depressive and anxiety-like behavior in mice as well as to paroxetine, escitalopram, and sertraline administration in rats.
“PRDX6 has been linked to depressive (Gu et al., 2022) and anxiety-like (Pairojana et al., 2022) behavior in mice as well as to paroxetine (McHugh et al., 2010), escitalopram, and sertraline (Bisgaard et al., 2012) administration in rats.”
From Epigenome-wide DNA methylation in unipolar depression: predictive biomarker of antidepressant treatment response? (2024) · cites this paper as Pairojana et al., 2022
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- Authors
- Pairojana, T., Phasuk, S., Suresh, P., & Liu, I. Y.
- Affiliations
- Tzu Chi University (TW)
- Corresponding author
- Liu, Ingrid Y.
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2022-06-19
- Volume
- 11
- Issue
- 6
- Pages
- 1201
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC9219992
- OpenAlex
- W4283121899
- Cited by
- 5
- References
- 48
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of Science and Technology (MOST), Taiwan (MOST_107-2410-H-320-001-MY3, TCMF-SP-108-04)
- Buddhist Tzu Chi Medical Foundation (MOST_107-2410-H-320-001-MY3, TCMF-SP-108-04)
- Tzu Chi University (MOST_107-2410-H-320-001-MY3, TCMF-SP-108-04)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- peroxiredoxin 6, female mice, hippocampus, anxiety-like behavior, contextual fear memory, spatial memory, paired-pulse facilitation, long-term potentiation, synaptic plasticity, emotional memory
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