Cited by 5Memory and Neural MechanismsRedox biology and oxidative stressNeuroscience and Neuropharmacology Research

Behavioral and synaptic phenotypes of female Prdx6(-/-) Mice

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Pairojana, Tanita, Phasuk, Sarayut, Suresh, Pavithra, Liu, Ingrid Y.·2022·Antioxidants

Abstract

Peroxiredoxin 6 (PRDX6) is expressed throughout the brain, including the hippocampus, where it plays a potential role in synaptic regulation and forming emotional and spatial memories. PRDX6 is predominantly detected in the female mouse’s hippocampus; thus, we investigate the effect of the Prdx6 gene on behavioral phenotypes and synaptic functions using female Prdx6 knockout (Prdx6−/−) mice. Our results demonstrate that female Prdx6−/− mice exhibited anxiety-like behavior, enhanced contextual fear memory, and impaired spatial memory. We also found increased, paired–pulse facilitation ratios, and decreased long-term potentiation (LTP) in the hippocampal region of these female Prdx6−/− mice. The present study helps to understand better the PRDX6’s role in emotional response and spatial memory formation in female mice.

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Crossref · 10.3390/antiox11061201

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  • PRDX6 has been linked to depressive and anxiety-like behavior in mice as well as to paroxetine, escitalopram, and sertraline administration in rats.

    “PRDX6 has been linked to depressive (Gu et al., 2022) and anxiety-like (Pairojana et al., 2022) behavior in mice as well as to paroxetine (McHugh et al., 2010), escitalopram, and sertraline (Bisgaard et al., 2012) administration in rats.”

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Authors
Pairojana, T., Phasuk, S., Suresh, P., & Liu, I. Y.
Affiliations
Tzu Chi University (TW)
Corresponding author
Liu, Ingrid Y.
Venue
Antioxidants
Publisher
MDPI AG
Published
2022-06-19
Volume
11
Issue
6
Pages
1201
ISSN
2076-3921 (ISSN-L)
OpenAlex
W4283121899
Cited by
5
References
48
Citations by year
2025: 1 · 2024: 3 · 2022: 1
FWCI
0.64
Type
journal article
Language
en
Open access
Locations
  • Antioxidants (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Ministry of Science and Technology (MOST), Taiwan (MOST_107-2410-H-320-001-MY3, TCMF-SP-108-04)
  • Buddhist Tzu Chi Medical Foundation (MOST_107-2410-H-320-001-MY3, TCMF-SP-108-04)
  • Tzu Chi University (MOST_107-2410-H-320-001-MY3, TCMF-SP-108-04)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
peroxiredoxin 6, female mice, hippocampus, anxiety-like behavior, contextual fear memory, spatial memory, paired-pulse facilitation, long-term potentiation, synaptic plasticity, emotional memory

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