Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives

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Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review

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Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases

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Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

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Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models

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Involvement of CXCR4 in Normal and Abnormal Development

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Herbal Medications in Cardiovascular Medicine

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A review on the mechanisms of the effect of silymarin in milk thistle ( Silybum marianum ) on some laboratory animals

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Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive review

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Effect of Silybum marianum seeds as a feed additive on growth performance, serum biochemical indices, antioxidant status, and gene expression of Nile tilapia, Oreochromis niloticus (L.) fingerlings

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Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury

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Dietary silymarin supplementation promotes growth performance and improves lipid metabolism and health status in grass carp (Ctenopharyngodon idellus) fed diets with elevated lipid levels

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The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review

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How to Increase Cellular Glutathione

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Antioxidants in Poultry Nutrition and Reproduction: An Update

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Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review

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Recent advances in the analysis of flavonolignans of Silybum marianum

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Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance

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RAGE-dependent mitochondria pathway: a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products

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Metabolism, Transport and Drug–Drug Interactions of Silymarin

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Vitagenes in poultry production: Part 1. Technological and environmental stresses

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Dietary Supplementation of Postbiotics Mitigates Adverse Impacts of Heat Stress on Antioxidant Enzyme Activity, Total Antioxidant, Lipid Peroxidation, Physiological Stress Indicators, Lipid Profile and Meat Quality in Broilers

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Effects of Silymarin on Diabetes Mellitus Complications: A Review

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Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?

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Skin Protective Activity of Silymarin and its Flavonolignans

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Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia

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Improving silymarin oral bioavailability using silica-installed redox nanoparticle to suppress inflammatory bowel disease

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Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells

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Antioxidant Action of Carnitine: Molecular Mechanisms and Practical Applications

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Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformation

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Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity

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Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model

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A Descriptive Review of the Antioxidant Effects and Mechanisms of Action of Berberine and Silymarin

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Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2

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Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathways

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Selenium in sow nutrition

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Silymarin: not just another antioxidant

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The Possible Neuroprotective Effect of Silymarin against Aluminum Chloride-Prompted Alzheimer’s-Like Disease in Rats

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Silymarin and Inflammation: Food for Thoughts

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Nutraceutical approaches to non-alcoholic fatty liver disease (NAFLD): A position paper from the International Lipid Expert Panel (ILEP)

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Silymarin is an ally against insulin resistance: A review

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A systematic review of the protective effects of silymarin/silibinin against doxorubicin-induced cardiotoxicity

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Silymarin: a potent hepatoprotective agent in poultry industry

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Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells

Kim, S., Choo, G., Yoo, E., Woo, J., Han, S., Lee, J., & Jung, J. (2019) · Oncology Reports · doi:10.3892/or.2019.7295 · Cited by 67

Toxicopathological effects of feeding aflatoxins B1 in broilers and its ameliosration with indigenous mycotoxin binder

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Vitagenes in poultry production: Part 2. Nutritional and internal stresses

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Collagen Nanoparticle-Mediated Brain Silymarin Delivery: An Approach for Treating Cerebral Ischemia and Reperfusion-Induced Brain Injury

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Chronic Liver Disease and Silymarin: A Biochemical and Clinical Review

Tighe, S. P., Akhtar, D. H., Iqbal, U., & Ahmed, A. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00012 · Cited by 64

Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications

Vargas-Mendoza, N., Morales‐González, Á., Morales-Martínez, M., Soriano-Ursua, M. A., Delgado‐Olivares, L., Sandoval-Gallegos, E. M., Madrigal‐Bujaidar, E., Álvarez‐González, I., Madrigal‐Santillán, E., & Morales‐González, J. A. (2020) · Biomedicines · doi:10.3390/biomedicines8050122 · Cited by 66

Plant‐Derived Agents for Counteracting Cisplatin‐Induced Nephrotoxicity

Ojha, S. K., Venkataraman, B., Kurdi, A., Mahgoub, E., Sadek, B. S., & Rajesh, M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4320374 · Cited by 63

Metabolic effect of berberine–silymarin association: A meta‐analysis of randomized, double‐blind, placebo‐controlled clinical trials

Fogacci, F., Grassi, D., Rizzo, M., & Cicero, A. F. G. (2019) · Phytotherapy Research · doi:10.1002/ptr.6282 · Cited by 61

In Silico and In Vitro Studies of Mycotoxins and Their Cocktails; Their Toxicity and Its Mitigation by Silibinin Pre-Treatment

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Berberine Inhibits Telomerase Activity and Induces Cell Cycle Arrest and Telomere Erosion in Colorectal Cancer Cell Line, HCT 116

Samad, M. A., Saiman, M. Z., Majid, N. B. A., Karsani, S. A., & Yaacob, J. S. (2021) · Molecules · doi:10.3390/molecules26020376 · Cited by 61

Differential accumulation of silymarin induced by exposure of Silybum marianum L. callus cultures to several spectres of monochromatic lights

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The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview

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Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin

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Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

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Selenium and L-Carnitine Ameliorate Reproductive Toxicity Induced by Cadmium in Male Mice

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Cancer Chemoprevention by Flavonoids, Dietary Polyphenols and Terpenoids

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Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-Inflammatory Potential

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Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies

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Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats

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Mitochondrial Targeting Therapeutics: Promising Role of Natural Products in Non-alcoholic Fatty Liver Disease

Xu, J., Shen, J., Yuan, R., Jia, B., Zhang, Y., Wang, S., Zhang, Y., Liu, M., & Wang, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.796207 · Cited by 53

Vitagenes in poultry production: Part 3. Vitagene concept development

Surai, P. F., & Fisinin, V. I. (2016) · World s Poultry Science Journal · doi:10.1017/s0043933916000751 · Cited by 54

Performance and serum biochemical profile of Japanese quail supplemented with silymarin and contaminated with aflatoxin B1

Sakamoto, M., Murakami, A. E., Fernandes, A. M., Ospina-Rojas, I. C., Nunes, K. C., & Hirata, A. K. (2017) · Poultry Science · doi:10.3382/ps/pex277 · Cited by 53

Sylimarin as hepatic protector and immunomodulator in Nile tilapia during Streptococcus agalactiae infection

Owatari, M. S., Jesus, G. F. A., Brum, A., Pereira, S. A., Lehmann, N. B., Pereira, U. D. P., Martins, M. L., & Mouriño, J. L. P. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.08.061 · Cited by 53

Taurine in poultry nutrition

Surai, P. F., Kochish, I. I., & Kidd, M. T. (2019) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2019.114339 · Cited by 52

Histological effects on the kidney, spleen, and liver of Nile tilapia Oreochromis niloticus fed different concentrations of probiotic Lactobacillus plantarum

Ruiz, M. L., Owatari, M. S., Yamashita, M. M., Ferrarezi, J. V. S., Garcia, P., Cardoso, L. G., Martins, M. L., & Mouriño, J. L. P. (2019) · Tropical Animal Health and Production · doi:10.1007/s11250-019-02001-1 · Cited by 51

Antioxidant systems in poultry biology: Nutritional modulation of vitagenes

Surai, P. F., Kochish, I. I., & Fisinin, V. I. (2017) · Archiv für Geflügelkunde · doi:10.1399/eps.2017.214 · Cited by 51

Trichotillomania (hair pulling disorder): Clinical characteristics, psychosocial aspects, treatment approaches, and ethical considerations

França, K., Kumar, A., Castillo, D., Jafferany, M., Hyczy da Costa Neto, M., Damevska, K., Wollina, U., & Lotti, T. (2019) · Dermatologic Therapy · doi:10.1111/dth.12622 · Cited by 51

The Milk Thistle Seed Cakes and Hempseed Cakes are Potential Feed for Poultry

Šťastní­k, O., Pavlata, L., & Mrkvicová, E. (2020) · Animals · doi:10.3390/ani10081384 · Cited by 53

The lipids

Turchini, G. M., Francis, D. S., Du, Z., Olsen, R. E., Ringø, E., & Tocher, D. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819587-1.00003-3 · Cited by 60

A Newly Developed Silymarin Nanoformulation As a Potential Antidiabetic Agent in Experimental Diabetes

El‐Far, Y. M., Zakaria, M. M., Gabr, M. M., Gayar, A. M. E., El-sherbiny, I. M., & Eissa, L. A. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0204 · Cited by 50

Hydrogel containing silibinin nanocapsules presents effective anti-inflammatory action in a model of irritant contact dermatitis in mice

Rigon, C., Marchiori, M. C. L., Jardim, F. D. S., Pegoraro, N. S., Chaves, P. D. S., Velho, M. C., Beck, R. C. R., Ourique, A. F., Sari, M. H. M., Oliveira, S. M., et al. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.104969 · Cited by 50

Pharmacological, Biochemical and Therapeutic Potential of Milk Thistle (Silymarin): A Review

Adetuyi, B. O., Omolabi, F. K., Olajide, P. A., & Oloke, J. K. (2021) · doi:10.5281/zenodo.18486423 · Cited by 49

Dietary Vitamin A Improved the Flesh Quality of Grass Carp (Ctenopharyngodon idella) in Relation to the Enhanced Antioxidant Capacity through Nrf2/Keap 1a Signaling Pathway

Wu, P., Zhang, L., Jiang, W., Liu, Y., Jiang, J., Kuang, S., Li, S., Tang, L., Tang, W., Zhou, X., et al. (2022) · Antioxidants · doi:10.3390/antiox11010148 · Cited by 49

Antioxidant Defences and Redox Homeostasis in Animals

Surai, P. F., & Earle-Payne, K. (2022) · Antioxidants · doi:10.3390/antiox11051012 · Cited by 49

Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer

Keshk, W. A., Zahran, S. M., Katary, M. A., & Ali, D. A.-E. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.06.022 · Cited by 49

Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice

Wang, M., Zhang, X., Feng, R., Jiang, Y., Zhang, D., He, C., Li, P., & Wan, J. (2017) · Chinese Medicine · doi:10.1186/s13020-017-0153-x · Cited by 49

Silymarin: not just another antioxidant

Camini, F. C., & Costa, D. C. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0206 · Cited by 71

Flavonoids of Silybum marianum (Milk thistle): Their multifaceted hepatoprotective effects against oxidative stress: A comprehensive review of preclinical and clinical evidence

Saadallah, H. A., AL-krdoshi, M. A., Aljarjary, N. H. S., Gaddawi, F. Y., & Fathi, S. M. (2026) · American Journal of Biopharmacy and Pharmaceutical Sciences · doi:10.25259/ajbps_5_2026

Milk Thistle ( Silybum marianum ) for the Therapy of Liver Disease

Flora, K. D., Hahn, M., Rosen, H. R., & Benner, K. G. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00139.x · Cited by 747

Silymarin

National Cancer Institute (2020) · Definitions · doi:10.32388/zode09

silymarin 的 Hepatoprotective 效果

Nancy, Vargas-Mendoza, Eduardo, E., Madrigal-Santillán, ngel, Morales-González, Jaime, Esquivel-Soto, César, Esquivel-Chirino, et al. (2014)