Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455

Role of nrf2 in oxidative stress and toxicity

Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,210

The thioredoxin antioxidant system

Lu, J., & Holmgren, A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.036 · Cited by 2,055

Regulation of NF-κB by TNF family cytokines

Hayden, M. S., & Ghosh, S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.05.004 · Cited by 1,167

Efficiently Capturing Mitochondria-Targeted Constituents with Hepatoprotective Activity from Medicinal Herbs

Yang, X., Li, L., Liu, X., Li, F.-J., Dong, J.-C., Mu, J.-K., Zeng, L., Bi, Q., Gu, W., & Yu, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4353791 · Cited by 3

Focus on Estimation and Antioxidant Studies of Salacia Species

Priya, G., Gopalakrishnan, M., Rajesh, E., & Sekar, T. (2019) · International Journal of Scientific Research in Biological Sciences · doi:10.26438/ijsrbs/v6i1.6574 · Cited by 3

SUSTAINED RELEASE TABLETS OF SORAFENIB-SILIBININ COMBINATIONS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA

Mishra, S., Hora, S., Shukla, V., Das, M., Kharkwal, H., & Katare, D. P. (2018) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2018v10i5.27597 · Cited by 3

The efficacy and safety of silymarin in the treatment of chemotherapy-induced peripheral neuropathy, a randomized double-blinded clinical trialPreprint

Shekarriz, R., Ghorbani, H., Mousazadeh, M., Vahedi, K., & Salehifar, E. (2021) · doi:10.22541/au.162837649.93180154/v1 · Cited by 3

Anthony Cemaluk C Egbuonu and Gift E Ejike (2017). Effect of pulverized Mangifera indica (mango) seed kernel on monosodium glutamate-intoxicated rats’ serum antioxidant capacity, brain function and histologyPreprint

Egbuonu, A. C. C. (2017) · SSRN Electronic Journal · doi:10.2139/ssrn.3965559 · Cited by 3

In-vitro Antioxidant and In-vitro Anti-inflammatory activities of Ethanolic leaves extract of Ormocarpum Cochinchinense

Somashekar, G., Sudhakar, U., Prakash, S. G., Suresh, S., Srividya, S., & Rao, S. H. (2022) · Journal of Orofacial Sciences · doi:10.4103/jofs.jofs_253_22 · Cited by 2

The Effects of Supplementation of the Freezing Extender with Silymarin on the Quality Parameters of Frozen-Thawed Arabian Stallion Sperm: A Preliminary Evaluation

Khorsand, F., Hamali, H., Qasemi-Panahi, B., & Tohidkia, M. (2024) · Biopreservation and Biobanking · doi:10.1089/bio.2023.0131 · Cited by 2

Investigation of the effects of silymarin and vitamin C on kidney damage and aquaporin-2 downregulation in lithium-induced nephrogenic diabetes insipidus in rats

Yakut, S., Tarakçı, B. G., Yalçın, M. H., Aydın, S., & Yüksel, H. (2025) · Drug and Chemical Toxicology · doi:10.1080/01480545.2025.2450475 · Cited by 2

The Role of the Extracellular Matrix in Cancer Prevention

Baker, S. G., & Sauter, E. R. (2025) · Cancers · doi:10.3390/cancers17091491 · Cited by 2

Silymarin and zinc oxide loaded semi-solid lipid nanoparticle formulations against UV-induced skin damage

Rençber, S., Aydın, H. H., Gülteki̇n, H. E., Köse, F. A., & Şenyiğit, Z. A. (2025) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2025.2514806 · Cited by 2

Herbal management of TAA-induced liver toxicity: Fibrosis, cirrhosis, and hepatocellular carcinoma

Mohamed, A. A., Shoun, A. A., El‐Kadi, R. A., El-Maseh, S. O. A., & Abass, S. A. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156141 · Cited by 2

Intrathecal silymarin administration improves recovery after compression spinal cord injury: evidence for neuroprotection, antioxidant, and anti-inflammatory action

Bahmani, O., Kiani, A., Fakhri, S., Abbaszadeh, F., Rashidi, K., & Echeverría, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1592682 · Cited by 2

Hepatoprotective effects of silibinin and chlorogenic acid standardised extract to alleviate the fatty liver syndrome and improve blood indices in caged-laying hens after the peak of production

Guerrini, A., Muscatello, L. V., del Zozzo, F., Harper, V., Fiorini, L., Archetti, I., Serra, V., Carlu, C., Chabrillat, T., & Tedesco, D. E. A. (2025) · Veterinary and Animal Science · doi:10.1016/j.vas.2025.100522 · Cited by 2

Silymarin enhances the performance of Nile tilapia fed an aflatoxin B1-contaminated diet

Haggag, N. A., Elbadawy, M., Elkomy, A., & Sherif, A. H. (2025) · Aquaculture International · doi:10.1007/s10499-025-02297-x · Cited by 2

Transcriptional insights into aflatoxin B1 induced hepatotoxicity and comparative effects of medicinal herbs in pigs

Nalpadan, A. A., Reyer, H., Oster, M., Trakooljul, N., Ponsuksili, S., Kozera, W., Karpiesiuk, K., Kępka-Borkowska, K., Chałaśkiewicz, K., Pierzchała, M., et al. (2026) · BMC Veterinary Research · doi:10.1186/s12917-025-05270-1 · Cited by 2

Formulation and Characterization of Hydrogel Chitosan–Pectin Active Films Containing Silymarin

Dyankova, S. M., Bozakova, N., Boneva, V., Solak, A., & Иванов, В. (2026) · Molecules · doi:10.3390/molecules31020322 · Cited by 2

Silymarin ameliorates post-weaning bisphenol A exposure-induced cardiotoxicity via suppression of TLR4/VCAM signaling in male Wistar rats

Saka, W. A., Ashonibare, V. J., Aderoju, R. A., Lawal, A. T., Kajola, P. O., Adegbola, C. A., Akhigbe, T. M., Ogunkola, B. D., Akintola, A. O., & Akhigbe, R. E. (2026) · Drug and Chemical Toxicology · doi:10.1080/01480545.2025.2592930 · Cited by 2

Silibinin alleviates lung fibrosis by targeting Annexin A6 to suppress endoplasmic reticulum stress and oxidative stress

Guan, R., Zhang, Y., Wang, Z., Huang, D., Bai, Y., Deng, M., Li, K., Hu, X., Huang, F., Dai, Y., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158041 · Cited by 2

Neuropeptide Y Receptor Modulators in Gut Physiology and Therapy

Thombre, K. R., Rahangdale, N. D., Gupta, K. R., & Umekar, M. J. (2026) · Current Protein and Peptide Science · doi:10.2174/0113892037432130260204153437 · Cited by 2

Immunomodulatory and anticancer effects of phytochemicals: A comprehensive analysis

Eltokhy, M. A., Curcic, M., Modaresahmadi, S., Gaikwad, S. R., La-Beck, N. M., & Srivastava, S. K. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100134 · Cited by 3

Natural Products Targeting Oxidative Stress–Inflammation Crosstalk in Endometriosis

Mhatre, D., Jadhav, T., Shirodkar, S., & Doshi, G. (2026) · American Journal of Reproductive Immunology · doi:10.1111/aji.70293 · Cited by 2

The course of oxidative processes in the hepatopancreas of age-2 carp after supplementing the feeds with thistle (Siliybum marianum) seeds

Koryliak, M. Z., Hrytsyniak, I. I., Deren, O. V., & Dobryanska, О. (2017) · Ribogospodarsʹka nauka Ukraïni · doi:10.15407/fsu2017.01.073 · Cited by 2

Hepatoprotective Effect Of Silymarin Against Diethylnitrosamine Induced Oxidative-Nitrosative Stress in Rats

KARAKURT, E., & DAĞ, S. (2020) · Van veterinary journal · doi:10.36483/vanvetj.680365 · Cited by 2

Nutraceuticals for Non-alcoholic Fatty Liver Disease

Sonmez, A., Ercin, C., Cesur, M., & Doğru, T. (2021) · Contemporary cardiology · doi:10.1007/978-3-030-62632-7_9 · Cited by 2

Biochemical Effect of Silymarin Treatment on Blood and Tissue Parameters in Experimental non Alcoholic Steatohepatitis in Rats

Marzouk, M. A., El-Senosy, Y. A. Y., Mahfouz, M. K., El-Mageid, A. D. A., & Hussein, S. A. (2017) · Benha Journal of Applied Sciences · doi:10.21608/bjas.2017.164550 · Cited by 2

Uso da homeopatia no gado de leite como modulador da função hepática: uma revisão

Pinheiro, J. K., Henriques, L. T., Neto, S. G., Signoretti, R. D., de Oliveira, J. S., Pinheiro, J. K., & Júnior, R. T. A. (2021) · CES Medicina Veterinaria y Zootecnia · doi:10.21615/cesmvz.16.1.2 · Cited by 2

The Cytoprotective Activity of Nrf2 Is Regulated by Phytochemicals (Sulforaphane, Curcumin, and Silymarin)

Vargas-Mendoza, N., Sandoval-Gallegos, E. M., Madrigal‐Santillán, E., Morales-Martínez, M., Soriano-Ursua, M. A., Ángeles-Valencia, M., Morales‐González, Á., Portillo-Reyes, J., & Morales‐González, J. A. (2021) · Reference series in phytochemistry · doi:10.1007/978-3-030-45299-5_34-1 · Cited by 2

CONCENTRATIONS OF SILYMARIN ON THE RUMEN ACTIVITIES IN LAMBS

Dawood, T. N. (2023) · Nativa · doi:10.31413/nat.v11i2.15895 · Cited by 2

In Vivo and in Vitro Regulatory Effect of Silibinin on Some Metabolic Enzyme Activities against Cobalt Induced Toxicity in Rats: A Biochemical Approach

Temel, Y., Akkoyun, H. T., Akkoyun, M. B., Karagözoğlu, F., Melek, Ş., Bengü, A. Ş., Erdem, S. A., & Çiftçi, M. (2023) · ACS Omega · doi:10.1021/acsomega.3c06953 · Cited by 2

Protective effects of leaf aqueous extracts from Gardenia ternifolia Schumach. on alcoholic liver disease in Wistar rats

Sakou, D. N., & Tietcheu, B. R. G. (2024) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2023.100851 · Cited by 1

Possible Uses for Silymarin in Human Health: Systematic Review

Gonçalves, G. M. S., & Eisinger, A. B. D. C. (2024) · American Journal of Plant Sciences · doi:10.4236/ajps.2024.152007 · Cited by 2

"Insights From a Rat Model of Paracetamol-Induced Hepatotoxicity into the Molecular Mechanisms of Silymarin and Resveratrol Combination Therapy for Protecting Liver Function"

Balaha, M. F. H. (2023) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2023.54.008497 · Cited by 2

A Silymarin Antioxidant Serum Improves Facial Acne Alone and as Part of a Treatment Regimen

Draelos, Z. D., Kerscher, M. J., Lynch, S., White, S., & Choudhary, H. (2024) · Journal of Drugs in Dermatology · doi:10.36849/jdd.8120 · Cited by 2

Comparative assessment of climate resilient potential in four poultry genotypes reared in hot-humid tropical environment: a preliminary evaluation

Hemanth, M. S. K., Venugopal, S. A., Devaraj, C., Shashank, C. G., Ponnuvel, P., Mandal, P. K., & Sejian, V. (2024) · International Journal of Biometeorology · doi:10.1007/s00484-024-02744-z · Cited by 2

Hepatoprotective effect of silymarin-chitosan nanocomposite against aluminum-induced oxidative stress, inflammation, and apoptosis

El-Demerdash, F. M., Ahmed, M. M., Kang, W., Mohamed, T. M., & Radwan, A. M. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102591 · Cited by 2

Beneficial Effect of Fenofibrate in Combination with Silymarin on Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an Animal Model of Metabolic Syndrome

Soukop, J., Kazdová, L., Hüttl, M., Malínská, H., Marková, I., Oliyarnyk, O., Miklánková, D., Gurská, S., Rácová, Z., Poruba, M., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13010212 · Cited by 2

Potential Effect of Silymarin Supplementation on Metabolic Complications and Graft Function in Kidney Transplant Recipients—A Pilot, Monocentric Study

Vnučák, M., Graňák, K., Kleinová, P., Blichová, T., Kollár, A., & Dedinská, I. (2025) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-025-00096-7 · Cited by 2

Silymarin attenuates cobalt chloride-induced redox imbalance and cardio-renal dysfunctions in rats

Ajibade, T. O., Ohore, O. M., Esan, O. O., Adeoye, B. O., Ake, A. S., Adetona, M. O., Awoyomi, O. V., Igado, O. O., Oyagbemi, T. O., Adeogun, A. V., et al. (2025) · Drug and Chemical Toxicology · doi:10.1080/01480545.2025.2499540 · Cited by 2

Protective potential of Irosustat, STX140 and the sulfonate derivative 1G in counteracting cisplatin-induced renal and hepatic toxicities: An in vivo comparative study

Anbar, H. S., Radi, A. W., Shaker, H. A., Janoudi, L. F., Zain, H. N. A., Hassan, H. M., Hersi, F., El–Gamal, M. I., Döhle, W., Potter, B. V. L., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123793 · Cited by 2

Nutritional Modulation of Epigenetic Changes Induced by Mycotoxins: A Biochemical Perspective for At-Risk Populations in Africa

Anih, D. C., Arowora, K. A., Ugwuoke, K. C., Abah, M. A., & Habibu, B. (2025) · Science International · doi:10.17311/sciintl.2025.90.109 · Cited by 2

The Effect of Dietary Micelle Silymarin Supplementation on Growth Performance, Nutrient Digestibility, Gas Emission, Fecal Score, and Blood Profile in Growing‐Finishing Pigs

Ahammad, G. S., & Kim, I. H. (2025) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.70008 · Cited by 2

Effects Alliume Satium and Silybum Marianum Supplements with four Weeks Incremental Training on Some Serum Indicators of Serum Muscle and Liver Damage in Wrestlers

Sharifian, M., Behpoor, N., Mohajerani, H. R., & Darabi, F. (2020) · Alborz University Medical Journal · doi:10.29252/aums.9.2.154 · Cited by 2

“Molecular aspects of dietary polyphenols in pregnancy”

Santangelo, C., & Masella, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813862-5.00010-4 · Cited by 2

The Milk Thistle (Silybum marianum) Compound Silibinin Inhibits Cardiomyogenesis of Embryonic Stem Cells by Interfering with Angiotensin II Signaling

Ali, E. H., Sharifpanah, F., Taha, A., Tsang, S. Y., Wartenberg, M., & Sauer, H. (2018) · Stem Cells International · doi:10.1155/2018/9215792 · Cited by 2

The effects of different levels of protein and silymarin on the population growth and hypopharyngeal gland surface of honey bee workers (Apis mellifera meda)

Hossaini, S. J., Sari, M., Tahmasbi, G., & Chaji, M. (2020) · Biotechnology in Animal Husbandry · doi:10.2298/bah2003341h · Cited by 2

Effects of methanolic leaf extract of Pterocarpus santalinoides on the recovery from gentamicin-induced nephrotoxicity in albino rats

Ihedioha, T. E., Nnadozie, A. E., Asuzu, I. U., Anaga, A. O., & Ihedioha, J. I. (2020) · Comparative Clinical Pathology · doi:10.1007/s00580-020-03173-1 · Cited by 2

Mycotoxin deoxynivalenol and oxidative stress: Role of silymarin and inulin protection

Abdel-Wahhab, M. A., & El‐Nekeety, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819092-0.00045-5 · Cited by 2

In Silico Insight into the Inhibitory Effects of Active Antidiabetic Compounds from Medicinal Plants Against SARS-CoV-2 Replication and Posttranslational Modification

Tijjani, H., Matinja, A. I., Olatunde, A., Zangoma, M. H., Mohammed, A., Akram, M., Adeoye, A. O., & Lawal, H. (2021) · Coronaviruses · doi:10.2174/2666796702666210118154948 · Cited by 2

The influence of mountain papaya and bitter melon extract supplementation on aspartate transaminase enzyme in diabetic rats models

Sasongko, H., Shofa, A. N., & Advaita, N. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1912/1/012043 · Cited by 2

The in vivo ameliorative effect of silymarin on cisplatin-associated ovarian and testicular histopathological and biochemical alterations

El-Hameed, S. A., Mahgoub, H. A., Awadin, W. F., & El-Shaieb, A. (2021) · Mansoura Veterinary Medical Journal · doi:10.21608/mvmj.2021.56846.1025 · Cited by 2

Restoration of plasma kidney and liver biomarkers in doxorubicin-treated Wistar rats by aqueous extracts of Pleurotus tuberregium sclerotia and Cnidoscolus aconitifolius leaves

Ikewuchi, C. C., Ikewuchi, J. C., & Ifeanacho, M. O. (2021) · Biotechnologia · doi:10.5114/bta.2021.108726 · Cited by 2

Silybum marianum (L.) Gaertn.: Traditional Uses, Phytochemistry, and Pharmacological Activities

Khatri, D., Chhetri, S. B. B., & Devkota, H. P. (2022) · Springer eBooks · doi:10.1007/978-981-19-6080-2_13 · Cited by 2

Ethyl acetate crude fraction of Macaranga subpeltata and silymarin increase Vero cell survival and HepG2 cell death due to oxidative stress

Widodo, H., & Rohman, A. (2023) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2023.84845 · Cited by 2

Herbs used in cardiovascular diseases

Saiyed, F., Maheshwari, R. A., Gohil, D., & Joshi, K. (2023) · International Journal of Ayurvedic Medicine · doi:10.47552/ijam.v14i1.3382 · Cited by 2

Polycaprolactan/ tragacanth nanoscaffold enriched with sililymarin as a protector of neural progenitor cells under oxidative stress conditions

Najafi, R., Asadi, A., Zahri, S., & Abdolmaleki, A. (2023) · Cell and Tissue Journal · doi:10.61186/jct.14.1.66 · Cited by 2

Exploring the hepatoprotective effects of silymarin in experimentally induced- diclofenac sodium toxicity in rabbits

Haq, S. U., Khalid, A., Meghwar, K. H., Khan, A., Siddiqui, S. A., Ullah, R., Sadeeq, M., Usmani, M. W., & Ashfaq, K. (2023) · World Journal of Biology and Biotechnology · doi:10.33865/wjb.009.01.1207 · Cited by 2

Silymarin and Oral Cancer: A Review on Clinical and Analytical Reports

Jonnalagadda, R., & Vinodhini, C. (2022) · The Thai Journal of Pharmaceutical Sciences · doi:10.56808/3027-7922.2617 · Cited by 2

Effects of Silybum marianum Aqueous Extract and L-carnitine on Stereological Changes in Diazinon-Treated Rat Liver

Masoumi, F., Shariati, M., & Mokhtari, M. (2020) · Jurnal Ilmu Ternak dan Veteriner · doi:10.14334/jitv.v25i2.2467 · Cited by 2

Optimizing Cultivation Technique of Silybum marianum (L.) Gaertn. under Tropical Climate

Sudrajad, H., Widodo, H., ⁠Fauzi, ⁠., & Widiyastuti, Y. (2021) · Indian Journal of Agricultural Research · doi:10.18805/ijare.a-665 · Cited by 2

EFFECT OF GUARDIZEN-M AS A PROBIOTIC ON SOME BLOOD PARAMETERS AND HISTOLOGICAL STRUCTURE OF SOME INTERNAL ORGANS OF NILE TILAPIA OREOCHROMIS NILOTICUS

youssif, S., AFIF, O. S., Abdel‐Fattah, M., Tolba, A., & Abd‐Elhafeez, H. H. (2020) · Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ · doi:10.21608/avmj.2020.167322 · Cited by 1

Characterization and Synthesis of Milk Thistle Nanoparticles to overcome Oxidative Stress Induce Testicular damage in male rats

Jalloob, E. D., Heider, R., Zahid, A. A. A., Jaber, I. J., Jasim, A. M., Mohsin, M., Rawaa, R., Kareem, K., Dirwal, A. R., & Ali.Neamah, D. (2022) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2022.00278 · Cited by 4

ANTIOXIDANTLY-MODULATIVE, CHEMOPREVENTIVE AND ANTI-SARS-COVID 19 ACTION OF MEDICINAL PLANTS

Karamalakova, Y. D., Georgieva, E. D., Ivanov, V., Parlapanska, K., & Nikolova, G. D. (2022) · Trakia Journal of Sciences · doi:10.15547/tjs.2022.04.001 · Cited by 1

Silybin, the Main Active Component of Silybum marianum, Affects Blood Coagulation: An In Vitro Pilot Study

Mlicka, A., Siemiątkowska, K., Plaku, I., Żekanowska, E., & Słomka, A. (2023) · International Electronic Conference on Biomedicines (IECBM) · doi:10.3390/ecb2023-14081 · Cited by 1

Exploring the drug repurposing potential of silymarin beyond hepatotoxicity treatment through WNT/β-catenin signaling pathway

Gültekin, S. (2023) · Çukurova medical journal (Online)/Çukurova medical journal · doi:10.17826/cumj.1366590 · Cited by 1

The Gap and Food Security of Poultry Meat in the Kingdom of Saudi Arabia

Harajin, N. M. F. A., Shehata, M. S., & Abdelmonem, S. M. A. (2024) · Alexandria Science Exchange Journal · doi:10.21608/asejaiqjsae.2024.347405 · Cited by 1

Evaluation of efficacy of cholecalciferol and silymarin in improving lower urinary tract symptoms of benign prostatic hyperplasia: A double-blind, randomized, controlled trial

Valipour, R., Narouie, B., Momeni, H., Radpour, N., Torabinavid, P., Momeni, A., & Jowzi, A. (2024) · Urologia Journal · doi:10.1177/03915603241274467 · Cited by 1

Pharmacological Therapy for Drug-Induced Liver Injury

Wu, Q., Wang, T., Li, Q., Gao, F., Liu, C., & Qi, X. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1009951 · Cited by 1

Silibinin enhanced the efficacy of albendazole in treating the muscular phase of experimental trichinellosis

Fahmy, M.-E. A., Esmat, M., Badawi, M., & Abdel-Shafi, I. R. (2025) · Tropical Animal Health and Production · doi:10.1007/s11250-025-04429-0 · Cited by 1

Comparative efficacy of liver tonics (LIV100-Amorvet) on production performance of commercial broilers

Bhaisare, D. B., Kadam, M. M., Bisht, R., Srikanth, K., Dabral, D., Pajai, D., Bhaisare, D. B., Patil, A. R., & Nagre, G. K. (2025) · International Journal of Advanced Biochemistry Research · doi:10.33545/26174693.2025.v9.i6sd.4529 · Cited by 1

Investigation of Antioxidant/Oxidant Potential of Some Natural Biomaterials

Güven, A., Deveci, H. A., Allahverdi, T. D., Allahverdi, E., & Çolak, M. Y. (2025) · Sinop Üniversitesi Fen Bilimleri Dergisi · doi:10.33484/sinopfbd.1554557 · Cited by 1

Promising efficacy of oral nano-silymarin formulation on prevention of vancomycin-induced nephrotoxicity: a randomized, triple-blinded, placebo-controlled clinical trial

Soleimani, V., Khodashahi, R., Arian, M., Tavanaee, A., Omidkhoda, N., Karimi, G., & Elyasi, S. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04469-1 · Cited by 1

Feeding a clay mineral-based feed additive improves performance, eating behavior and liver health by feedlot beef cattle fed a high-concentrate diet

Gouvêa, D. I. C. G., Niehues, M. B., de Carvalho, V. V., Perdigão, A., Faas, J., Artavia, I., Pereira, M. C. S., Arrigoni, M. D. B., & Martins, C. L. (2025) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2025.116489 · Cited by 1

Silymarin-functionalized nanohydroxyapatite-chitosan nanocomposite: a promising biomaterial for oral health applications

Subramanian, A. K., Sivamurthy, G., Karapetyan, K. S., AL-Farga, A. M., Saleh, R. A., & Shariati, M. A. (2025) · BMC Oral Health · doi:10.1186/s12903-025-06784-8 · Cited by 1

Processed silkworm powder (Hongjam) ameliorates metabolic dysfunction-associated steatotic liver disease via GPR35/PKA and SIRT1/AMPK pathways

Lee, D.-Y., Ahn, H.-R., Han, Y.-M., Song, M.-Y., Lee, S., Jang, Y.-K., Kim, S., Go, E.-J., & Kim, E. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1727043 · Cited by 1

Boosting muscle health in aging rats: The synergistic effect of vitamin C, silymarin, and endurance swimming on a high-fat diet

Aghaei, F., Arabzadeh, E., Feizolahi, F., Bezdi, A. N., Abasi, M., & Zargani, M. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103290 · Cited by 1

Hepatoprotective Effects and Antioxidant Properties of a Herbal Detoxifying Formula Against Chlorpyrifos-Induced Toxicity in Sprague-Dawley Rats

Kunnaja, P., Chansakaow, S., Taychaworaditsakul, W., Intatham, S., Jaijoy, K., Wittayapraparat, A., Yusuk, P., Suksathan, R., & Sireeratawong, S. (2025) · Biology · doi:10.3390/biology15010017 · Cited by 2

Metabolism, Mechanisms of Antioxidants in Plants, Microbes and Animals

Mouhli, M., Subhashini, S., Thirupathy, C., & Ramesh, R. (2026) · Springer eBooks · doi:10.1007/978-981-95-3758-7_3 · Cited by 1

Safeguarding Spermatogenesis: Garcinia kola Extract and Kolaviron Effectively Ameliorate Testicular Toxicity in Rats Treated With Bleomycin, Etoposide, and Cisplatin Combination Therapy

Ayedogba, O. A., Olorundare, O. E., Adeneye, A., Ajayi, A. M., Teles, Y. C. F., & Fatokun, A. A. (2026) · Andrologia · doi:10.1155/and/6620108 · Cited by 1

Chemistry and Structural Diversification of Flavonoids

Prajapati, A., Kachhadiya, R. N., Zinzuvadiya, B., & Patel, H. D. (2026) · Springer eBooks · doi:10.1007/978-981-95-8165-8_7 · Cited by 1

Subchronic Cadmium-Induced Xenobiotic Toxicity in Male Wistar Rats: Antioxidant and Reproductive Protection by Standardized Silymarin with Molecular Docking Insights

Hammami, I., Arrari, F., Mahjoub, R., Ali, R. B., El-Hentati, H., Nahdi, A., López‐Maldonado, E. A., & Talbi, E. (2026) · Journal of Xenobiotics · doi:10.3390/jox16030103 · Cited by 1

Milk thistle ( Silybum marianum ) application in aquaculture: a phytogenic powerhouse for health and sustainability – a comprehensive review

Shehata, A. I., Li, S., Habib, Y. J., Bakky, M. A. H., Rahman, A. N. A., & Basuini, M. F. E. (2026) · Annals of Animal Science · doi:10.2478/aoas-2025-0121 · Cited by 1

A quantum-chemical study on the antioxidant properties of natural phenolic compounds

Kazakova, O. A. (2016) · Himia Fizika ta Tehnologia Poverhni · doi:10.15407/hftp07.04.463 · Cited by 1

Silymarin for Treatment of Nonalcoholic Steatohepatitis–A New Kid on the Block?

Hupa‐Breier, K. L., Jaeckel, E., & Manns, M. P. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.08.005 · Cited by 1

Plant Polyphenols in Obesity and Obesity-Associated Metabolic Disorders: A Narrative Review of Resveratrol and Flavonoids Upon the Molecular Basis of Inflammation

Bueno, A. A. (2018) · Journal of Obesity and Nutritional Disorders · doi:10.29011/2577-2244.100029 · Cited by 1

Protective Effects of Silymarin on Indomethacin-Induced Gastric Ulcer in Rats

Boyacıoğlu, M. (2019) · Erciyes Üniversitesi Veteriner Fakültesi Dergisi · doi:10.32707/ercivet.595636 · Cited by 1

The effects of silibinin on oxidative stress and microRNA-10b expression in animal models of breast cancer

Soleimani, F., Sharifi, R., Mahmoodi, M., & Kassaee, S. M. (2020) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2019-0333 · Cited by 1

Efficacy of l-carnitine and silymarin administration on the health-related quality of life in 120 patients with cancer undergoing anthracycline-based chemotherapy

Zalat, Z., Abdel-Latif, M., Alotaibi, B. S., El‐Din, M. A. A., Kohaf, N. A., & Elewa, H. (2020) · Journal of Medical and Life Science · doi:10.21608/jmals.2020.111233 · Cited by 1

The Cytoprotective Activity of Nrf2 Is Regulated by Phytochemicals (Sulforaphane, Curcumin, and Silymarin)

Vargas-Mendoza, N., Sandoval-Gallegos, E. M., Madrigal‐Santillán, E., Morales-Martínez, M., Soriano-Ursua, M. A., Ángeles-Valencia, M., Morales‐González, Á., Portillo-Reyes, J., & Morales‐González, J. A. (2022) · Reference series in phytochemistry · doi:10.1007/978-3-030-78160-6_34 · Cited by 1

Analyze the Efficacy of Silymarin in Treating Newly Diagnosed Cases of Type 2 Diabetes Mellitus by Contrasting its Effects on Glycemic Control and Insulin Resistance

Khan, S., Salman, M., Ali, I., Fatima, N., Mastoor, M., & Sayed, T. M. (2022) · doi:10.53350/pjmhs221610365 · Cited by 1

The effects of silymarin plus glutathione on the prevention of liver ischemia-reperfusion injury

Aliyeva, D. M., Amanvermez, R., Karabulut, K., & Gün, S. (2022) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902022e20561 · Cited by 1

Evaluation of Total Phenolic, Flavonoid Content and Antioxidant Capacity of Different Parts of Averrhoa carambola L.

Rhaman, M. M., Shoeb, M., & Islam, M. N. (2022) · Dhaka University Journal of Pharmaceutical Sciences · doi:10.3329/dujps.v21i2.63115 · Cited by 1

QUANTITATIVE RESEARCH ON THE ACTIVE COMPONENT OF SILYMARIN IN SILYBUM MARIANUM SEED POWDER FROM VARIOUS GEOGRAPHICAL AREAS

Poroch-Seriţan, M., Jarcău, M., & CORNEA, N. M. (2022) · Food and Environment Safety Journal · doi:10.4316/fens.2022.008 · Cited by 1

An overview of the antioxidant effects of silymarin and its role in reducing the harmful effects of some heavy metals, radiation and nicotine on sperm quality.

Khodaei‐Motlagh, M. (2023) · Cell and Tissue Journal · doi:10.61186/jct.14.1.1 · Cited by 1

Pengaruh Ekstrak Metanol Buah Lakum (Cayratia trifolia L. Domin) terhadap Nilai SGOT dan SGPT Tikus Putih Diinduksi Parasetamol

Rousdy, D. W., Wardoyo, E. R. P., & Wulandari, C. A. (2023) · Bioscientist Jurnal Ilmiah Biologi · doi:10.33394/bioscientist.v11i2.8530 · Cited by 1

Obtaining and Studying the Antioxidant Activity and Hepatoprotective Effect of a Polymer Composition Containing Silybin

Кузнецов, С. Л., Гукасова, Н. В., Тубашева, И. А., Zavarzina, V. V., Aleshin, S. V., Муравьева, А. И., Lapin, A. A., Николаевич, З. В., & Poltavets, Y. I. (2023) · Nanobiotechnology Reports · doi:10.1134/s263516762360061x · Cited by 1

Potential Protective Effects of Milk Thistle (Silybum Marianum L.) Seeds Against Benzo[a]Pyrene-Induced Hepatic and Nephritic Injuries in Rats: Biochemical and Histopathological Studies.

Elhassaneen, Y. A., & Mahran, M. (2024) · Alexandria Science Exchange Journal · doi:10.21608/asejaiqjsae.2024.347415 · Cited by 1

Evaluation of the hepatoprotective and nephroprotective properties of bael fruit extract against carbon tetrachloride-induced toxicity in rats

Garg, D., Sharma, A. K., Pragi, & Kumar, V. (2024) · Journal of Applied Pharmaceutical Research · doi:10.69857/joapr.v12i3.524 · Cited by 1

Himalayan phytochemicals and their role as epigenetic modulating agents in cancer, diabetes and neurodegenerative disorders

Kumar, S., Singh, J., Dwibedi, V., Swati, Singhal, D., & Sharma, S. (2024) · Vegetos · doi:10.1007/s42535-024-01015-x · Cited by 1

Polyethylene Glycol/Pullulan-Based Carrier for Silymarin Delivery and Its Potential in Biomedical Applications

Iwaniec, J., Niziołek, K., Polanowski, P., Słota, D., Kosińska, E., Sadlik, J., Miernik, K., Jampílek, J., & Sobczak‐Kupiec, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189972 · Cited by 1

Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice

Şimşek, S., Solmaz, M., Nur, İ. H., Körez, M. K., Ünlükal, N., & Erdoğan, E. (2024) · Revista Científica de la Facultad de Ciencias Veterinarias · doi:10.52973/rcfcv-e34481 · Cited by 1

Silymarin: not just another antioxidant

Camini, F. C., & Costa, D. C. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0206 · Cited by 71

Flavonoids of Silybum marianum (Milk thistle): Their multifaceted hepatoprotective effects against oxidative stress: A comprehensive review of preclinical and clinical evidence

Saadallah, H. A., AL-krdoshi, M. A., Aljarjary, N. H. S., Gaddawi, F. Y., & Fathi, S. M. (2026) · American Journal of Biopharmacy and Pharmaceutical Sciences · doi:10.25259/ajbps_5_2026

Milk Thistle ( Silybum marianum ) for the Therapy of Liver Disease

Flora, K. D., Hahn, M., Rosen, H. R., & Benner, K. G. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00139.x · Cited by 747

Silymarin

National Cancer Institute (2020) · Definitions · doi:10.32388/zode09

silymarin 的 Hepatoprotective 效果

Nancy, Vargas-Mendoza, Eduardo, E., Madrigal-Santillán, ngel, Morales-González, Jaime, Esquivel-Soto, César, Esquivel-Chirino, et al. (2014)