Influence of Vitamin C on Lymphocytes: An Overview
Open accessAbstract
Vitamin C or ascorbic acid (AA) is implicated in many biological processes and has been proposed as a supplement for various conditions, including cancer. In this review, we discuss the effects of AA on the development and function of lymphocytes. This is important in the light of cancer treatment, as the immune system needs to regenerate following chemotherapy or stem cell transplantation, while cancer patients are often AA-deficient. We focus on lymphocytes, as these white blood cells are the slowest to restore, rendering patients susceptible to often lethal infections. T lymphocytes mediate cellular immunity and have been most extensively studied in the context of AA biology. In vitro studies demonstrate that T cell development requires AA, while AA also enhances T cell proliferation and may influence T cell function. There are limited and opposing data on the effects of AA on B lymphocytes that mediate humoral immunity. However, AA enhances the proliferation of NK cells, a group of cytotoxic innate lymphocytes. The influence of AA on natural killer (NK) cell function is less clear. In summary, an increasing body of evidence indicates that AA positively influences lymphocyte development and function. Since AA is a safe and cheap nutritional supplement, it is worthwhile to further explore its potential benefits for immune reconstitution of cancer patients treated with immunotoxic drugs.
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Vitamin C is crucial for immune system function.
“Vitamin C is crucial for immune system function [1,2,3,4] and protects against damage from reactive oxygen species [5,6].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [4]
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- Authors
- Van Gorkom, G., Klein Wolterink, R., Van Elssen, C., Wieten, L., Germeraad, W., & Bos, G.
- Affiliations
- Division of Hematology, Department of Internal Medicine, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, 6202AZ Maastricht, The Netherlands
- Maastricht University Medical Centre (NL)
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2018-03-10
- Volume
- 7
- Issue
- 3
- Pages
- 41
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC5874527
- OpenAlex
- W2792690644
- Cited by
- 139
- References
- 65
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 17 · 2023: 16 · 2022: 23 · 2021: 27 · 2020: 21 · 2019: 13 · 2018: 3
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- vitamin C, lymphocytes, T cells, B cells, natural killer cells, T cell development, T cell proliferation, NK cell function, immune reconstitution, cancer patients, chemotherapy, stem cell transplantation, scurvy, immunotoxicity
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