Ascorbic acid serum levels are reduced in patients with hematological malignancies
Open accessAbstract
In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
30% of solid cancer patients had vitamin C levels below 11 μM, while 19% of patients with similar values were observed in a group of hematological malignancies.
“Additionally, 30% of solid cancer patients had vitamin C levels below 11 µM, while 19% of patients with similar values were observed in a group of hematological malignancies [59,175].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [59]
There is no difference between serum and plasma vitamin C levels.
“There is no difference between serum and plasma [59,60,61,62,63].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [59]
The Results report serum vitamin C levels in patients and healthy volunteers, and the Discussion describes serum measurements as the current gold standard. Neither section compares serum with plasma; a search for “plasma” found no comparison in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Vitamin C pharmacokinetics: Implications for oral and intravenous use
Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992 · see citing works
The biochemical functions of ascorbic acid
Englard, S., & Seifter, S. (1986) · Annual Review of Nutrition · doi:10.1146/annurev.nu.06.070186.002053 · Cited by 564 · see citing works
Schleicher, R. L., Carroll, M. D., Ford, E. S., & Lacher, D. A. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27016 · Cited by 504 · see citing works
Nutritional support of the cancer patient: issues and dilemmas
Nitenberg, G., & Raynard, B. (2000) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(00)00048-2 · Cited by 421 · see citing works
Immune reconstitution after anti-thymocyte globulin-conditioned hematopoietic cell transplantation
Bosch, M., Dhadda, M., Hoegh-Petersen, M., Liu, Y., Hagel, L. M., Podgorny, P. J., Ugarte-Torres, A., Khan, F. M., Luider, J. M., Auer-Grzesiak, I. A., et al. (2012) · Cytotherapy · doi:10.3109/14653249.2012.715243 · Cited by 163 · see citing works
Breathing-in epigenetic change with vitamin C
Monfort, A., & Wutz, A. (2013) · The EMBO Reports · doi:10.1038/embor.2013.29 · Cited by 140 · see citing works
Huijskens, M. J. A. J., Walczak, M., Koller, N., Briedé, J. J., Senden-Gijsbers, B. L. M. G., Schnijderberg, M. C. A., Bos, G. M. J., & Germeraad, W. T. V. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1ta0214-121rr · Cited by 109 · see citing works
Huijskens, M. J. A. J., Walczak, M., Sarkar, S., Atrafi, F., Senden-Gijsbers, B. L. M. G., Tilanus, M. G. J., Bos, G. M. J., Wieten, L., & Germeraad, W. T. V. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.01.004 · Cited by 91 · see citing works
Ströhle, A., Wolters, M., & Hahn, A. (2011) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152811794352105 · Cited by 56 · see citing works
Nannya, Y., Shinohara, A., Ichikawa, M., & Kurokawa, M. (2013) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2013.12.554 · Cited by 40 · see citing works
Kletzel, M., Powers, K., & Hayes, M. (2014) · Pediatric Transplantation · doi:10.1111/petr.12285 · Cited by 19 · see citing works
Ströhle, A., Wolters, M., & Hahn, A. (2011) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152811794352097 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
Agathocleous, M., Meacham, C. E., Burgess, R. J., Piskounova, E., Zhao, Z., Crane, G. M., Cowin, B. L., Bruner, E., Murphy, M. M., Chen, W., et al. (2017) · Nature · doi:10.1038/nature23876 · Cited by 545 · see citing works
Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553 · see citing works
Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine
Liu, M., Ohtani, H., Zhou, W., Ørskov, A. D., Charlet, J., Zhang, Y. W., Shen, H., Baylin, S. B., Liang, G., Grønbæk, K., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612262113 · Cited by 225 · see citing works
Vitamin C in stem cell reprogramming and cancer
Cimmino, L., Neel, B. G., & Aifantis, I. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.04.001 · Cited by 197 · see citing works
Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly
Shenoy, N. K., Creagan, E. T., Witzig, T. E., & Levine, M. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.07.014 · Cited by 207 · see citing works
Vitamin C and immune cell function in inflammation and cancer
Ang, A., Pullar, J. M., Currie, M. J., & Vissers, M. C. M. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180169 · Cited by 191 · see citing works
van Gorkom, G. N. Y., Lookermans, E. L., Van Elssen, C. H. M. J., & Bos, G. M. J. (2019) · Nutrients · doi:10.3390/nu11050977 · Cited by 159 · see citing works
Self-citationDysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies
Lio, C. J., Yuita, H., & Rao, A. (2019) · Blood · doi:10.1182/blood.2019791475 · Cited by 146 · see citing works
Influence of Vitamin C on Lymphocytes: An Overview
Van Gorkom, G., Klein Wolterink, R., Van Elssen, C., Wieten, L., Germeraad, W., & Bos, G. (2018) · Antioxidants · doi:10.3390/antiox7030041 · Cited by 139 · see citing works
Self-citationIntravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge
Carr, A. C., & Cook, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01182 · Cited by 133 · see citing works
Reprogramming the epigenome with vitamin C
Lee Chong, T., Ahearn, E. L., & Cimmino, L. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00128 · Cited by 120 · see citing works
Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells
Shenoy, N., Bhagat, T., Nieves, E., Stenson, M., Lawson, J., Choudhary, G. S., Habermann, T., Nowakowski, G., Singh, R., Wu, X., et al. (2017) · Blood Cancer Journal · doi:10.1038/bcj.2017.65 · Cited by 111 · see citing works
Vitamin C as a Modulator of the Response to Cancer Therapy
Błaszczak, W., Barczak, W., Masternak, J., Kopczyński, P., Zhitkovich, A., & Rubiś, B. (2019) · Molecules · doi:10.3390/molecules24030453 · Cited by 104 · see citing works
TET family dioxygenases and the TET activator vitamin C in immune responses and cancer
Yue, X., & Rao, A. (2020) · Blood · doi:10.1182/blood.2019004158 · Cited by 105 · see citing works
Epigenetic Regulation of Genomic Stability by Vitamin C
Brabson, J. P., Leesang, T. E., Mohammad, S., & Cimmino, L. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.675780 · Cited by 105 · see citing works
Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation
Mastrangelo, D., Pelosi, E., Castelli, G., Lo‐Coco, F., & Testa, U. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.09.005 · Cited by 89 · see citing works
Gillberg, L., Ørskov, A. D., Nasif, A., Ohtani, H., Madaj, Z., Hansen, J. W., Rapin, N., Mogensen, J. B., Liu, M., Dufva, I. H., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0739-5 · Cited by 89 · see citing works
Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Fu, Y., Xu, F., Jiang, L., Miao, Z., Liang, X., Yang, J., Larsson, S. C., & Zheng, J. (2021) · BMC Medicine · doi:10.1186/s12916-021-02041-1 · Cited by 70 · see citing works
High-Dose Vitamin C in Advanced-Stage Cancer Patients
Zasowska‐Nowak, A., Nowak, P. J., & Ciałkowska-Rysz, A. D. (2021) · Nutrients · doi:10.3390/nu13030735 · Cited by 69 · see citing works
The role of vitamin C in epigenetic cancer therapy
Mikkelsen, S. U., Gillberg, L., Lykkesfeldt, J., & Grønbæk, K. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.017 · Cited by 61 · see citing works
Baaten, C. C. F. M. J., Heubel-Moenen, F. C. J. I., Henskens, Y., Swieringa, F., Wetzels, R. J. H., van Oerle, R., Heijnen, H. F. G., Cate, H. T., Holloway, G. P., Beckers, E. A. M., et al. (2018) · Haematologica · doi:10.3324/haematol.2017.185165 · Cited by 56 · see citing works
Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia
Guan, Y., Greenberg, E. F., Hasipek, M., Shi, C., Liu, X., Kerr, C. M., Gackowski, D., Zarakowska, E., Radivoyevitch, T., Gu, X., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01220-9 · Cited by 57 · see citing works
High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
Giansanti, M., Karimi, T., Faraoni, I., & Graziani, G. (2021) · Cancers · doi:10.3390/cancers13061428 · Cited by 50 · see citing works
Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer
Saggese, P., Sellitto, A., Martinez, C. A., Giurato, G., Nassa, G., Rizzo, F. M., Tarallo, R., & Scafoglio, C. (2020) · Cancers · doi:10.3390/cancers12123788 · Cited by 46 · see citing works
Lykkesfeldt, J., Carr, A. C., & Tveden‐Nyborg, P. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100043 · Cited by 44 · see citing works
Whole-genome analysis of TET dioxygenase function in regulatory T cells
Yue, X., Samaniego‐Castruita, D., González‐Avalos, E., Li, X., Barwick, B. G., & Rao, A. (2021) · EMBO Reports · doi:10.15252/embr.202152716 · Cited by 40 · see citing works
Liu, J., Hong, J., Han, H., Park, J., Kim, D., Park, H., Ko, M., Koh, Y., Shin, D., & Yoon, S. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0788-8 · Cited by 38 · see citing works
N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins
Ulfig, A., Schulz, A. V., Müller, A., Lupilov, N., & Leichert, L. I. O. (2019) · eLife · doi:10.7554/elife.47395 · Cited by 30 · see citing works
Fischer, A. P., & Miles, S. L. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.056 · Cited by 31 · see citing works
Wang, D., Meng, Y., Zhang, Y., Wang, Q., Lu, W., Shuang, S., & Dong, C. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.132135 · Cited by 31 · see citing works
Choi, Y. K., Kang, J.-I., Han, S. H., Kim, Y. R., Jo, J., Kang, Y. W., Choo, D. R., Hyun, J. W., Koh, Y. S., Yoo, E.-S., et al. (2020) · Nutrients · doi:10.3390/nu12051351 · Cited by 30 · see citing works
Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics
White, R., Nonis, M., Pearson, J. F., Burgess, E. R., Morrin, H. R., Pullar, J. M., Spencer, E. S., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2020) · Nutrients · doi:10.3390/nu12082338 · Cited by 30 · see citing works
Isola, S., Gammeri, L., Furci, F., Gangemi, S., Pioggia, G., & Allegra, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137284 · Cited by 27 · see citing works
Role of Vitamin C in Selected Malignant Neoplasms in Women
Markowska, A., Antoszczak, M., Markowska, J., & Huczyński, A. (2022) · Nutrients · doi:10.3390/nu14040882 · Cited by 27 · see citing works
Epidemiology and Pathogenesis of Myelodysplastic Syndrome
Rotter, L. K., Shimony, S. O., Ling, K., Chen, E., Shallis, R. M., Zeidan, A. M., & Stahl, M. F. (2023) · The Cancer Journal · doi:10.1097/ppo.0000000000000665 · Cited by 27 · see citing works
Das, A. B., Smith-Díaz, C. C., & Vissers, M. C. M. (2020) · Haematologica · doi:10.3324/haematol.2020.259283 · Cited by 25 · see citing works
Carr, A. C., Spencer, E. S., Das, A. B., Meijer, N., Lauren, C., MacPherson, S. A., & Chambers, S. T. (2020) · Nutrients · doi:10.3390/nu12061879 · Cited by 24 · see citing works
Transport of Vitamin C in Cancer
Muñoz-Montesino, C., Peña, E., Roa, F. J., Sotomayor, K., Escobar, E., & Rivas, C. I. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8166 · Cited by 24 · see citing works
Sb-doped FeOCl nanozyme-based biosensor for highly sensitive colorimetric detection of glutathione
Chen, J., Wu, H., Liu, J., Su, Y., Li, H., Lin, P., Chen, Y., Xiao, W., & Cao, D. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04503-8 · Cited by 23 · see citing works
Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy
Jung, I., An, J., & Ko, M. (2023) · Biomedicines · doi:10.3390/biomedicines11030654 · Cited by 22 · see citing works
Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review)
Renner, O., Burkard, M., Michels, H., Vollbracht, C., Sinnberg, T. W., & Venturelli, S. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5215 · Cited by 22 · see citing works
Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin
Rubiś, B., Łuczak, M. W., Krawic, C., & Zhitkovich, A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.03.026 · Cited by 19 · see citing works
Vitamin C Deficiency in Patients With Acute Myeloid Leukemia
Ottone, T., Faraoni, I., Fucci, G., Divona, M., Travaglini, S., Bellis, E. D., Marchesi, F., Angelini, D. F., Palmieri, R., Gurnari, C., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.890344 · Cited by 20 · see citing works
Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia
Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.709543 · Cited by 19 · see citing works
van Gorkom, G. N. Y., Senden-Gijsbers, B. L. M. G., Ververs, E.-J., Molla, A. E., Sarodnik, C., Riess, C., Wodzig, W. K. W. H., Bos, G. M. J., & van Elssen, C. H. M. J. (2022) · Antioxidants · doi:10.3390/antiox11010134 · Cited by 18 · see citing works
Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia
Brabson, J. P., Leesang, T. E., Yap, Y. S., Wang, J., Lam, M. Q., Fang, B., Dolgalev, I., Barbieri, D. A., Strippoli, V., Bañuelos, C. P., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112027 · Cited by 18 · see citing works
Foster, M. N., Carr, A. C., Antony, A., Peng, S., & Fitzpatrick, M. (2018) · Antioxidants · doi:10.3390/antiox7070092 · Cited by 18 · see citing works
Vitamin C and D supplementation in acute myeloid leukemia
Mouchel, P., Bérard, E., Tavitian, S., Gadaud, N., Vergez, F., Rieu, J., Luquet, I., Sarry, A., Huguet, F., Largeaud, L., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010559 · Cited by 17 · see citing works
Antioxidant Roles/Functions of Ascorbic Acid (Vitamin C)
Agwu, E., Ezihe, C. O., & Kaigama, G. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110589 · Cited by 23 · see citing works
Travaglini, S., Gurnari, C., Antonelli, S., Silvestrini, G., Noguera, N. I., Ottone, T., & Voso, M. T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.930205 · Cited by 17 · see citing works
Liang, J., Na, X., Meng, L., He, L., Shu, T., Fang, Y., Zhang, B., Zhao, Z., Guo, C., Li, J., et al. (2025) · MedComm · doi:10.1002/mco2.70245 · Cited by 15 · see citing works
Comazzetto, S., Cassidy, D. L., DeVilbiss, A., Jeffery, E. C., Ottesen, B. R., Reyes, A. R., Paul, A., Bansal, S., Xie, S. Z.-J., Muh, S., et al. (2024) · Blood · doi:10.1182/blood.2024024769 · Cited by 14 · see citing works
Zhou, L., Zhu, R., Miranda, G. F., Neis, M., Offenhäusser, A., & Mayer, D. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342823 · Cited by 13 · see citing works
van Gorkom, G. N. Y., Boerenkamp, L. S., Senden-Gijsbers, B. L. M. G., van Ojik, H. H., Wodzig, W. K. W. H., Wieten, L., van Elssen, C. H. M. J., & Bos, G. M. J. (2022) · Nutrients · doi:10.3390/nu14224784 · Cited by 13 · see citing works
Rasheed, M., Simmons, G. L., Fisher, B., Leslie, K. A., Reed, J. C., Roberts, C. H., Natarajan, R., Fowler, A. A., & Toor, A. A. (2019) · European Journal Of Haematology · doi:10.1111/ejh.13287 · Cited by 13 · see citing works
Maity, J., Majumder, S., Pal, R., Saha, B., & Mukhopadhyay, P. K. (2023) · BioEssays · doi:10.1002/bies.202300035 · Cited by 14 · see citing works
Cioboată, R., Nicolosu, D., Bălășoiu, A.-T., Bălteanu, M. A., Zlatian, O. M., Osman, A., Biciuşcă, V., Țieranu, E. N., Mogoș, G. F. R., & Ghenea, A. E. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13226715 · Cited by 10 · see citing works
Vitamin C: C-ing a New Way to Fight Leukemia
Schönberger, K., & Cabezas‐Wallscheid, N. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.09.015 · Cited by 10 · see citing works
The metabolic baton: conducting the dance of N6-methyladenosine writing and erasing
Rabelo-Fernández, R. J., Yuen, M., & Batista, P. J. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102206 · Cited by 9 · see citing works
Geissler, K. H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.751668 · Cited by 9 · see citing works
Premnath, N., Chung, S. S., Weinberg, O. K., Ikpefan, R., Pandey, M., Kaur, G., Geethakumari, P. R., Afrough, A., Awan, F. T., Anderson, L. D., et al. (2022) · Leukemia Research · doi:10.1016/j.leukres.2022.107001 · Cited by 9 · see citing works
Ezim, O. E., & Abarikwu, S. O. (2023) · Andrologia · doi:10.1155/2023/5209480 · Cited by 9 · see citing works
Sebarchievici, I., Țăranu, B.-O., Rus, F. Ș., & Făgădar-Cosma, E. (2020) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2020.114127 · Cited by 9 · see citing works
Testa, U., Pelosi, E., & Castelli, G. (2020) · Hematology/Oncology and Stem Cell Therapy · doi:10.1016/j.hemonc.2020.11.002 · Cited by 8 · see citing works
Vollbracht, C., Gündling, P. W., Kraft, K., & Friesecke, I. (2019) · Journal of International Medical Research · doi:10.1177/0300060519875370 · Cited by 8 · see citing works
Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and LymphomaPreprint
Stahl, M. F., Epstein-Peterson, Z. D., & Intlekofer, A. M. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035477 · Cited by 8 · see citing works
Kim, H. S., Kwon, S., Choi, O. K., & Lim, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1512605 · Cited by 7 · see citing works
Vitamin requirements during stem cell transplantation: a systematic review
Segon, B., Lam, L., Chan, H. Y., Andersen, S., Brown, T. E., Kenway, D., & Bauer, J. D. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07409-4 · Cited by 6 · see citing works
Milbar, H. C., Caplan, A., Schwab, R. D., Coromilas, A. J., Baumrin, E., Forrestel, A., Steele, K. T., Micheletti, R. G., Perl, A., & Rosenbach, M. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023009923 · Cited by 6 · see citing works
Beyond genetics: integrative oncology and the metabolic perspective on cancer treatment
Nair, P. M. K., Silwal, K., Ramalakshmi, R., Devibala, M., Saranya, M., Sivaranjani, S., Ramasamy, T., Palanisamy, A., & Mahalingam, M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1455022 · Cited by 5 · see citing works
Potential Health Benefits of Vitamin C: An Update
Ara, Z., Waliullah, S., Rastogi, D., Al-Otaibi, M. L., Pant, S., Nawati, M., Roy, R., Ansari, K. A., & Khan, A. A. (2025) · Food science and nutrition · doi:10.5772/intechopen.1007674 · Cited by 4 · see citing works
Zhang, T., Tao, Q., Chen, R., Xu, W., Xu, J., & Wang, X. (2025) · Microchimica Acta · doi:10.1007/s00604-025-07435-z · Cited by 4 · see citing works
Yuan, J., Zhang, Y., Hua, X., Hong, H., Shi, W., Liu, K., Liu, Z., & Huang, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1177580 · Cited by 4 · see citing works
Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation
Leesang, T. E., Brabson, J. P., Yap, Y. S., Barbieri, D. A., Klimas, A. S., Pinzone, J., Ahearn, E. L., Lam, M. Q., Lyon, P. D., Swirski, A., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116379 · Cited by 3 · see citing works
Vitamin C: Is it Relevant or Obsolete in the Modern Era?
Ramanujan, S., Yadav, S. R., Adler, A., Bewley, S., & Radhakrishnan, K. R. (2024) · Current Pediatrics Reports · doi:10.1007/s40124-024-00315-9 · Cited by 3 · see citing works
The physiological functions of ascorbate in the development of cancer
Agathocleous, M. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052201 · Cited by 4 · see citing works
Ang, A. D., Vissers, M. C. M., Burgess, E. R., Currie, M. J., & Dachs, G. U. (2021) · Antioxidants · doi:10.3390/antiox10030430 · Cited by 3 · see citing works
Jin, W., Yao, H., Wang, X., Li, M., Gao, X., Chen, W., & Zhang, Y. (2025) · Journal of Materials Chemistry C · doi:10.1039/d4tc04412f · Cited by 3 · see citing works
Nakamura, Z. M., Deal, A. M., Rosenstein, D. L., Quillen, L. J., Chien, S. A., Wood, W. A., Shea, T. C., & Park, E. M. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.106076 · Cited by 3 · see citing works
Carr, A. C. (2017) · Antioxidants · doi:10.3390/antiox6040094 · Cited by 2 · see citing works
L-Ascorbic Acid in the Epigenetic Regulation of Cancer Development and Stem Cell Reprogramming
Kovina, A. P., Petrova, N. V., Razin, S. V., & Kantidze, O. L. (2020) · Acta Naturae · doi:10.32607/actanaturae.11060 · Cited by 2 · see citing works
Lessons Learned from Cancer Metabolism for Physiology and DiseasePreprint
Campbell, S. L., & Christofk, H. R. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041554 · Cited by 2 · see citing works
The Vitamin C Level in Cases with Hematological Malignancies
Sincan, G., Erdem, F., & Kızıltunç, A. (2024) · Harran Üniversitesi Tıp Fakültesi Dergisi · doi:10.35440/hutfd.1458028 · Cited by 1 · see citing works
Lazarow, H., Carulli, A., McWilliams, T. L., Kucharczuk, C., Hollander, L., Catania, C. J., Munshi, P. N., Gabriel, P. E., Loren, A. W., Porter, D. L., et al. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-09778-y · Cited by 1 · see citing works
Heidari, S., Shahrami, B., Rad, S., Sadeghi, K., Aliabadi, L. S., Hadjibabaei, M., & Vaezi, M. (2026) · Supportive Care in Cancer · doi:10.1007/s00520-026-10434-2 · Cited by 1 · see citing works
Vitamin C: Current Concepts in Human Physiology
Carr, A. C., & Natarajan, R. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-295-2 · Cited by 1 · see citing works
Goncharova, P. S., Davydova, T. K., & Жукова, Н. Г. (2021) · Personalized Psychiatry and Neurology · doi:10.52667/2712-9179-2021-1-2-63-82 · Cited by 1 · see citing works
Effect of Vitamin C on Cancer Process
HEMDAN, O. A. M., Girgin, G., & Baydar, T. (2024) · Hacettepe University Journal of the Faculty of Pharmacy · doi:10.52794/hujpharm.1484625 · Cited by 1 · see citing works
Diagnostics and mechanisms of hemostasis
Heubel-Moenen, F. C. J. I. (2021) · doi:10.26481/dis.20220131fm
Western, P. S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726696342.793554069
Schellhorn, H. E. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.729069935.793537498
Ascorbic Acid Therapy in Hematological Malignancies - The Current Knowledge and Future DirectionsPreprint
Lam, W. K., Ha, C. Y., & Yip, S. F. (2022) · doi:10.32388/pmlz1t.2
Ascorbic Acid Therapy in Hematological Malignancies - The Current Knowledge and Future DirectionsPreprint
Lam, W. K., Ha, C. Y., & Yip, S. F. (2022) · doi:10.32388/pmlz1t
Ascorbic Acid Therapy in Hematological Malignancies - The Current Knowledge and Future DirectionsPreprint
Lam, W. K., Ha, C. Y., & Yip, S. F. (2022) · doi:10.32388/pmlz1t.3
Ascorbic Acid Therapy in Hematological Malignancies - The Current Knowledge and Future DirectionsPreprint
Lam, W. K., Ha, C. Y., & Yip, S. F. (2022) · doi:10.32388/pmlz1t.4
Ascorbic Acid Therapy in Hematological Malignancies - The Current Knowledge and Future DirectionsPreprint
Lam, W. K., Ha, C. Y., & Yip, S. F. (2022) · doi:10.32388/pmlz1t.5
Improving outcome of haematopoietic stem cell transplantation
van Gorkom, G. N. Y. (2022) · doi:10.26481/dis.20220616gg
Ojha, A., Sahani, P., Shekhar, S., & Mishra, S. K. (2024) · Journal of Environmental Biology · doi:10.22438/jeb/45/2/mrn-5226
Fu, Y., Xu, F., Jiang, L., Miao, Z., Liang, X., Yang, J., Larsson, S. C., & Zheng, J. (2021) · Figshare · doi:10.6084/m9.figshare.15079687
Topham, B., de Vries, M., Nonis, M., van Berkel, R., Pullar, J. M., Magon, N. J., Vissers, M. C. M., Currie, M. J., Robinson, B. A., Gibbs, D., et al. (2024) · Epigenomes · doi:10.3390/epigenomes8020017
- Authors
- Huijskens, M. J. A. J., Wodzig, W. K. W. H., Walczak, M., Germeraad, W. T. V., & Bos, G. M. J.
- Affiliations
- Maastricht University Medical Centre (NL)
- Corresponding author
- Germeraad, Wilfred T.V.
- ORCID
- Bos, Gerard M.J.
- Venue
- Results in Immunology
- Publisher
- Elsevier BV
- Published
- 2016
- Volume
- 6
- Pages
- 8-10
- ISSN
- 2211-2839 (ISSN-L)
- PMC
- PMC4792862
- OpenAlex
- W2249055939
- Cited by
- 106
- References
- 12
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 14 · 2021: 17 · 2020: 15 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 2
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Results in Immunology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by-nc-nd)
- Research Publications (Maastricht University) (submittedVersion, cc-by-nc-nd)
- Funders
- Dutch Cancer Society KWF (UM2010-4671)
- Cancer Research Fund
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- vitamin C, serum vitamin C, hematologic malignancies, chemotherapy, hematopoietic stem cell transplantation, T cell proliferation, vitamin C supplementation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
