The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review
Open accessAbstract
Many cancer patients on intensive chemotherapy lack vitamin C. Vitamin C stimulates the production and activation of immune cells, so perhaps supplementation could be used to improve the immunity in those patients. This review assesses the effectiveness and safety of vitamin C administration in cancer. The PubMed and EMBASE databases were searched and all study designs except for phase I studies, and case reports were included in this review. A total of 19 trials were included. In only 4 trials randomization was used to determine if patients received vitamin C or a placebo. The result of this review does not prove that there is a clinically relevant positive effect of vitamin C supplementation in cancer patients in general on the overall survival, clinical status, quality of life (QOL) and performance status (PS), since the quality of the studies published is low. Interventions and patient groups are very diverse, hence an effect in some patient groups is possible. There seems to be a better effect with intravenous than oral administration. Nevertheless, treatment with vitamin C is safe with minimal side effects. Thereby, we think it is safe to examine the effects of vitamin C on specific groups of patients in a randomized controlled setting.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Vitamin C (ascorbic acid) is a powerful antioxidant that can have beneficial effects on delaying the aging process and age-related diseases through its action on redox oxidative and mitochondrial pathways, immune system, inflamm-aging, endothelial integrity, and lipoprotein metabolism.
“Vitamin C or ascorbic acid (AA) is a powerful antioxidant that can have beneficial effects on delaying the aging process and age-related diseases thorough its action on redox oxidative and mitochondrial pathways, on the immune system, on inflamm-aging, on endothelial integrity, and on lipoprotein metabolism [114,115,116,117,118,119,120,121].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [121]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,577 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Italian Journal of Public Health · doi:10.2427/5768 · Cited by 3,374 · see citing works
Vitamin C pharmacokinetics: Implications for oral and intravenous use
Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992 · see citing works
Systems to rate the strength of scientific evidence.
West, S. L., King, V., Carey, T. S., Lohr, K. N., Mckoy, N. A., Sutton, S. F., & Lux, L. J. (2002) · PubMed Central · Cited by 873 · see citing works
Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., Khosh, D. B., Drisko, J., & Levine, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804226105 · Cited by 854 · see citing works
Cameron, E., & Pauling, L. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3685 · Cited by 710 · see citing works
Moertel, C. G., Fleming, T. R., Creagan, E. T., Rubin, J., O'Connell, M. J., & Ames, M. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120301 · Cited by 637 · see citing works
Creagan, E. T., Moertel, C. G., O'Fallon, J. R., Schutt, A. J., O'Connell, M. J., Rubin, J., & Frytak, S. (1979) · New England Journal of Medicine · doi:10.1056/nejm197909273011303 · Cited by 584 · see citing works
Ma, Y., Chapman, J., Levine, M., Polireddy, K., Drisko, J., & Chen, Q. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007154 · Cited by 501 · see citing works
Cameron, E., & Pauling, L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4538 · Cited by 476 · see citing works
Cameron, E., & Campbell, A. (1974) · Chemico-Biological Interactions · doi:10.1016/0009-2797(74)90019-2 · Cited by 344 · see citing works
Regulation of the epigenome by vitamin C
Young, J. I., Züchner, S., & Wang, G. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034228 · Cited by 319 · see citing works
Kurbacher, C. M., Wagner, U. A. G., Kolster, B., Andreotti, P. E., Krebs, D., & Bruckner, H. W. (1996) · Cancer Letters · doi:10.1016/0304-3835(96)04212-7 · Cited by 235 · see citing works
Vitamin C deficiency in cancer patients
Mayland, C. R., Bennett, M. I., & Allan, K. (2005) · Palliative Medicine · doi:10.1191/0269216305pm970oa · Cited by 199 · see citing works
Effect of high-dose intravenous vitamin C on inflammation in cancer patients
Mikirova, N. A., Casciari, J. J., Rogers, A. S., & Taylor, P. R. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-189 · Cited by 193 · see citing works
Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone
Timoshnikov, V. A., Kobzeva, T. V., Polyakov, N. E., & Kontoghiorghes, G. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113967 · Cited by 181 · see citing works
Pawłowska, E., Szczepańska, J., & Błasiak, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7286737 · Cited by 174 · see citing works
Yeom, C. H., Jung, G. C., & Song, K. J. (2007) · Journal of Korean Medical Science · doi:10.3346/jkms.2007.22.1.7 · Cited by 149 · see citing works
Vollbracht, C., Schneider, B., Leendert, V., Weiß, G., Auerbach, L., & Beuth, J. (2011) · PubMed · Cited by 145 · see citing works
Influence of Vitamin C on Lymphocytes: An Overview
Van Gorkom, G., Klein Wolterink, R., Van Elssen, C., Wieten, L., Germeraad, W., & Bos, G. (2018) · Antioxidants · doi:10.3390/antiox7030041 · Cited by 139 · see citing works
Self-citationHoffer, L. J., Robitaille, L., ZAKARIAN, R. J., Melnychuk, D., Kavan, P., Agulnik, J. S., Cohen, V., Small, D. I., & Miller, W. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120228 · Cited by 123 · see citing works
A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients.
Riordan, H. D., Casciari, J. J., González, M. J., Riordan, N. H., Miranda-Massari, J. R., Taylor, P. R., & Jackson, J. A. (2005) · PubMed · Cited by 116 · see citing works
Zhao, H., Zhu, H., Huang, J., Zhu, Y., Hong, M., Zhu, H., Zhang, J., Li, S., Yang, L., Lian, Y., et al. (2018) · Leukemia Research · doi:10.1016/j.leukres.2017.12.009 · Cited by 112 · see citing works
Huijskens, M. J. A. J., Walczak, M., Koller, N., Briedé, J. J., Senden-Gijsbers, B. L. M. G., Schnijderberg, M. C. A., Bos, G. M. J., & Germeraad, W. T. V. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1ta0214-121rr · Cited by 109 · see citing works
Self-citationAscorbic acid serum levels are reduced in patients with hematological malignancies
Huijskens, M. J. A. J., Wodzig, W. K. W. H., Walczak, M., Germeraad, W. T. V., & Bos, G. M. J. (2016) · Results in Immunology · doi:10.1016/j.rinim.2016.01.001 · Cited by 106 · see citing works
Self-citationAttia, M., Essa, E. A., Zaki, R. M., & Elkordy, A. (2020) · Antioxidants · doi:10.3390/antiox9050359 · Cited by 106 · see citing works
Huijskens, M. J. A. J., Walczak, M., Sarkar, S., Atrafi, F., Senden-Gijsbers, B. L. M. G., Tilanus, M. G. J., Bos, G. M. J., Wieten, L., & Germeraad, W. T. V. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.01.004 · Cited by 91 · see citing works
Self-citationMurata, A., Morishige, F., & Yamaguchi, H. (1982) · PubMed · Cited by 75 · see citing works
High-dose intravenous vitamin C improves quality of life in cancer patients
Takahashi, H., Mizuno, H., & Yanagisawa, A. (2012) · Personalized Medicine Universe · doi:10.1016/j.pmu.2012.05.008 · Cited by 68 · see citing works
Nielsen, T. K., Højgaard, M., Andersen, J. T., Jørgensen, N. R., Zerahn, B., Kristensen, B., & Henriksen, T. (2017) · Translational Andrology and Urology · doi:10.21037/tau.2017.04.42 · Cited by 55 · see citing works
Cameron, E., & Campbell, A. S. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90127-k · Cited by 48 · see citing works
Jung, S.-A., Lee, D.-H., Moon, J.-H., Hong, S.-W., Shin, J.-S., Hwang, I. Y., Shin, Y. J., Kim, J. H., Gong, E.-Y., Kim, S.-M., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.009 · Cited by 47 · see citing works
Vitamins C and K3 Sensitize Human Urothelial Tumors to Gemcitabine
Kassouf, W., Highshaw, R. A., Nelkin, G. M., Dinney, C. P., & Kamat, A. M. (2006) · The Journal of Urology · doi:10.1016/j.juro.2006.06.042 · Cited by 43 · see citing works
Bayır, A. G., & Kızıltan, H. Ş. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1055366 · Cited by 38 · see citing works
Bazzan, A. J., Zabrecky, G. P., Wintering, N., Newberg, A. B., & Monti, D. (2018) · Integrative Cancer Therapies · doi:10.1177/1534735418775809 · Cited by 34 · see citing works
Choi, Y. K., Kang, J.-I., Han, S. H., Kim, Y. R., Jo, J., Kang, Y. W., Choo, D. R., Hyun, J. W., Koh, Y. S., Yoo, E.-S., et al. (2020) · Nutrients · doi:10.3390/nu12051351 · Cited by 30 · see citing works
Bober, P., Alexovič, M., Talian, I., Tomková, Z., Viscorova, Z., Bencková, M., Andrašina, I., Ciccocioppo, R., Petrovič, D., Adamek, M., et al. (2016) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-016-2259-4 · Cited by 26 · see citing works
Ascorbic acid supplementation and five year survival rates in women with early breast cancer.
Jm, P., Wf, W., & Jw, D. (1984) · PubMed · Cited by 21 · see citing works
Kalita, S., Verma, A. K., & Prasad, S. B. (2014) · PubMed · Cited by 13 · see citing works
Kırpınar, İ., Deveci, E., Kılıç, A., & Çamur, D. Z. (2016) · Nutrition and Cancer · Cited by 13 · see citing works
Integrative Cancer Therapies: Learning From COVID-19
Block, K. I. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420932652 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03696-4 · Cited by 1,445 · see citing works
Cancer immunotherapy with γδ T cells: many paths ahead of us
Kabelitz, D., Serrano, R., Kouakanou, L., Peters, C., & Kalyan, S. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0504-x · Cited by 295 · see citing works
Immunomodulatory and antimicrobial effects of vitamin C
Mousavi, S., Bereswill, S., & Heimesaat, M. M. (2019) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2019.00016 · Cited by 268 · see citing works
Immune cell - produced ROS and their impact on tumor growth and metastasis
Kennel, K. B., & Greten, F. R. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101891 · Cited by 209 · see citing works
Kontoghiorghes, G. J., & Kontoghiorghe, C. (2020) · Cells · doi:10.3390/cells9061456 · Cited by 197 · see citing works
Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone
Timoshnikov, V. A., Kobzeva, T. V., Polyakov, N. E., & Kontoghiorghes, G. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113967 · Cited by 181 · see citing works
Pawłowska, E., Szczepańska, J., & Błasiak, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7286737 · Cited by 174 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Wierzejska, R. E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18178897 · Cited by 120 · see citing works
Kontoghiorghes, G. J., Kolnagou, A., Kontoghiorghe, C., Mourouzidis, L., Timoshnikov, V. A., & Polyakov, N. E. (2020) · Medicines · doi:10.3390/medicines7080045 · Cited by 112 · see citing works
Biernacka, P., Adamska, I., & Felisiak, K. (2023) · Molecules · doi:10.3390/molecules28103993 · Cited by 112 · see citing works
Attia, M., Essa, E. A., Zaki, R. M., & Elkordy, A. (2020) · Antioxidants · doi:10.3390/antiox9050359 · Cited by 106 · see citing works
Antioxidants for the Treatment of Breast Cancer: Are We There Yet?
Griñán‐Lisón, C., Blaya-Cánovas, J. L., López-Tejada, A., Ávalos-Moreno, M., Navarro-Ocón, A., Cara, F. E., González-González, A., Lorente, J. A., Marchal, J. A., & Granados-Principal, S. M. (2021) · Antioxidants · doi:10.3390/antiox10020205 · Cited by 98 · see citing works
Timoshnikov, V. A., Selyutina, O. Y., Polyakov, N. E., Didichenko, V., & Kontoghiorghes, G. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031247 · Cited by 97 · see citing works
Vo, T. K., Ta, Q. T. H., Chu, Q. T., Nguyen, T. T., & Giau, V. V. (2020) · Molecules · doi:10.3390/molecules25133021 · Cited by 77 · see citing works
Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression
Jomová, K., Alomar, S. Y., Valko, R., Fresser, L., Nepovimová, E., Kuča, K., & Valko, M. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04146-5 · Cited by 88 · see citing works
The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review
Villagrán, M., Ferreira, J. L., Martorell, M., & Mardones, L. (2021) · Antioxidants · doi:10.3390/antiox10121894 · Cited by 73 · see citing works
Ma, Z., Yang, M., Foda, M. F., Zhang, K., Li, S., Liang, H., Zhao, Y., & Han, H. (2022) · ACS Nano · doi:10.1021/acsnano.2c08446 · Cited by 71 · see citing works
Wang, F., He, M.-M., Xiao, J., Zhang, Y., Yuan, X., Fang, W. J., Zhang, Y., Wang, W., Hu, X.-H., Ma, Z., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-0655 · Cited by 64 · see citing works
Talib, W. H., Jum'Ah, D., Attallah, Z. S., Jallad, M. S., Kury, L. T. A., Hadi, R. W., & Mahmod, A. I. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1281879 · Cited by 57 · see citing works
Sacks, B., Onal, H., Martorana, R. M., Sehgal, A., Harvey, A., Wastella, C. M., Ahmad, H., Ross, E. N., Pjetergjoka, A., Prasad, S., et al. (2021) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-021-00518-6 · Cited by 56 · see citing works
Chaturvedi, S., Khan, S., Bhunia, R. K., Kaur, K., & Tiwari, S. (2022) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-022-01172-w · Cited by 56 · see citing works
Evaluation of antibacterial activity of vitamin C against human bacterial pathogens
Mumtaz, S., Mumtaz, S., Ali, S., Tahir, H. M., Kazmi, S. A. R., Mughal, T. A., & Younas, M. (2021) · Brazilian Journal of Biology · doi:10.1590/1519-6984.247165 · Cited by 52 · see citing works
Tang, C., Long, R., Tong, X., Guo, Y., Tong, C., & Shi, S. (2021) · Microchemical Journal · doi:10.1016/j.microc.2021.106000 · Cited by 50 · see citing works
Woldeselassie, M., & Tamene, A. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1480780 · Cited by 44 · see citing works
Susa, F., & Pisano, R. (2023) · Processes · doi:10.3390/pr11113167 · Cited by 41 · see citing works
Cortez-Trejo, M. C., Olivas-Aguirre, F. J., Dufoo‐Hurtado, E., Castañeda, R., Villegas-Quintero, H., Medina‐Franco, J. L., Mendoza, S., & Wall‐Medrano, A. (2022) · Biomolecules · doi:10.3390/biom12111649 · Cited by 39 · see citing works
Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis
Ghanem, A., Melzer, A. M., Zaal, E. A., Neises, L., Baltissen, D., Matar, O., Glennemeier-Marke, H., Almouhanna, F., Theobald, J., el Maaty, M. A. A., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.012 · Cited by 38 · see citing works
Rowanberry—A Source of Bioactive Compounds and Their Biopharmaceutical Properties
Arvinte, O., Senila, L. R., Becze, A., & Amariei, S. (2023) · Plants · doi:10.3390/plants12183225 · Cited by 35 · see citing works
The key metabolites associated with nutritional components in purple glutinous rice
Xiong, Q., Zhang, J., Shi, Q., Zhang, Y., Sun, C., Li, A., Lu, W.-J., Hu, J., Zhou, N., Wei, H., et al. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111686 · Cited by 31 · see citing works
Choi, Y. K., Kang, J.-I., Han, S. H., Kim, Y. R., Jo, J., Kang, Y. W., Choo, D. R., Hyun, J. W., Koh, Y. S., Yoo, E.-S., et al. (2020) · Nutrients · doi:10.3390/nu12051351 · Cited by 30 · see citing works
Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics
White, R., Nonis, M., Pearson, J. F., Burgess, E. R., Morrin, H. R., Pullar, J. M., Spencer, E. S., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2020) · Nutrients · doi:10.3390/nu12082338 · Cited by 30 · see citing works
Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment
Maekawa, T., Miyake, T., Tani, M., & Üemoto, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.981547 · Cited by 32 · see citing works
Kontoghiorghes, G. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094654 · Cited by 31 · see citing works
Bioactives From Brown Algae: Antioxidant, Anti‐Inflammatory, Anticancer, and Antimicrobial Potential
Fonseca‐Barahona, I., Shahbaz, K., & Baroutian, S. (2025) · ChemBioEng Reviews · doi:10.1002/cben.70007 · Cited by 34 · see citing works
Isola, S., Gammeri, L., Furci, F., Gangemi, S., Pioggia, G., & Allegra, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137284 · Cited by 27 · see citing works
Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance
Ciebiera, M., Ali, M. K., Zgliczyńska, M., Skrzypczak, M., & Al-Hendy, A. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155528 · Cited by 28 · see citing works
Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back
González‐Montero, J., Chichiarelli, S., Eufemi, M., Fabio Altieri, F., Saso, L., & Rodrigo, R. (2022) · Molecules · doi:10.3390/molecules27123818 · Cited by 27 · see citing works
Kim, J. H., Hwang, S., Lee, J., Im, S. S., & Son, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012249 · Cited by 26 · see citing works
Why Vitamin C Could Be an Excellent Complementary Remedy to Conventional Therapies for Breast Cancer
Codini, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218397 · Cited by 26 · see citing works
Microbiome Modulation for the Treatment of Solid Neoplasms
Barragán-Carrillo, R., Zengin, Z. B., & Pal, S. K. (2025) · Journal of Clinical Oncology · doi:10.1200/jco-25-00374 · Cited by 24 · see citing works
The Result of Vitamin C Treatment of Patients with Cancer: Conditions Influencing the Effectiveness
Hunyady, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084380 · Cited by 28 · see citing works
Recommendations for Nutritional Supplementation in Pediatric Oncology: A Compilation of the Facts
Podpeskar, A., Crazzolara, R., Kropshofer, G., Hetzer, B., Rabensteiner, E., Meister, B., Obexer, P., & Salvador, C. (2023) · Nutrients · doi:10.3390/nu15143239 · Cited by 23 · see citing works
Rao, S., Xiao, X., Wang, Y., Xiong, Y., Cheng, H., Li, L., & Cheng, S. (2022) · Folia Horticulturae · doi:10.2478/fhort-2022-0017 · Cited by 21 · see citing works
Butkevičiūtė, A., Viškelis, J., Viškelis, P., Liaudanskas, M., & Janulis, V. (2021) · Applied Sciences · doi:10.3390/app11136215 · Cited by 20 · see citing works
Selyutina, O. Y., Kononova, P. A., Koshman, V. E., Fedenok, L. G., & Polyakov, N. E. (2022) · Antioxidants · doi:10.3390/antiox11020376 · Cited by 20 · see citing works
An Infrared Evanescent Wave Sensor for Detection of Ascorbic Acid in Food and Drugs
You, T., Zhao, Y., Xu, Y., Guo, H., Zhu, J., Tao, H., Zhang, X., & Xu, Y. (2024) · Journal of Lightwave Technology · doi:10.1109/jlt.2024.3357491 · Cited by 20 · see citing works
Daily Lifestyle Modifications to Improve Quality of Life and Survival in Glioblastoma: A Review
Travers, S. S., & Litofsky, N. S. (2021) · Brain Sciences · doi:10.3390/brainsci11050533 · Cited by 19 · see citing works
Soozanipour, A., Taheri‐Kafrani, A., Razmjou, A., & Asadnia, M. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2021.118111 · Cited by 19 · see citing works
Bahadoran, Z., Mirmiran, P., Kashfi, K., & Ghasemi, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094735 · Cited by 19 · see citing works
Sularz, O., Koronowicz, A. A., Smoleń, S., Kowalska, I., Skoczylas, Ł., Liszka‐Skoczylas, M., Tabaszewska, M., & Pitala, J. (2021) · RSC Advances · doi:10.1039/d1ra04679a · Cited by 19 · see citing works
Vitamin C protects carboplatin-exposed oocytes from meiotic failure
Zhou, C., Zhang, X., Zhang, Y., ShiYang, X., Yu, L., Shi, X., & Xiong, B. (2019) · Molecular Human Reproduction · doi:10.1093/molehr/gaz046 · Cited by 17 · see citing works
Vitamin C and β-carotene co-loaded in marine and egg nanoliposomes
Hamadou, A. H., Zhang, J., Chen, C., Xu, J., & Xu, B. (2022) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2022.111315 · Cited by 16 · see citing works
El‐Malla, S. F., Mansour, F. R., Elattar, R. H., & Kamal, A. H. (2022) · Journal of AOAC International · doi:10.1093/jaoacint/qsac141 · Cited by 16 · see citing works
Akbar, M., Haroon, U., Ali, M., Tahir, K., Chaudhary, H. J., & Munis, M. F. H. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15483 · Cited by 16 · see citing works
Singh, R., Zeng, Q., Cheng, S., & Kumar, S. (2022) · IEEE Sensors Journal · doi:10.1109/jsen.2022.3168301 · Cited by 16 · see citing works
Ni 3 V 2 O 8 nanoflower mimetic enzyme constructs a dual-signal system for ascorbic acid detection
Yang, J., Chen, B., Qiu, H., Meng, S. M., & Yang, Y. (2023) · RSC Advances · doi:10.1039/d3ra04202b · Cited by 15 · see citing works
Non-pharmaceutical interventions to optimize cancer immunotherapy
Boesch, M., Baty, F., Rassouli, F., Kowatsch, T., Joerger, M., Früh, M., & Brutsche, M. H. (2023) · OncoImmunology · doi:10.1080/2162402x.2023.2255459 · Cited by 15 · see citing works
Tian, T., Shao, J., Shen, Z., Sun, X., Liu, Y., Cao, L., Geng, Y., & Song, B. (2022) · Nutrition · doi:10.1016/j.nut.2022.111696 · Cited by 15 · see citing works
Angiostatic effects of ascorbic acid: current status and future perspectives
Islam, M. T. (2020) · Angiogenesis · doi:10.1007/s10456-020-09719-9 · Cited by 14 · see citing works
Ostróżka-Cieślik, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063141 · Cited by 14 · see citing works
Effect of vitamins C and E on cancer survival; a systematic review
Mohseni, S., Tabatabaei‐Malazy, O., Ejtahed, H., Qorbani, M., Azadbakht, L., Khashayar, P., & Larijani, B. A. (2022) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-022-00451-x · Cited by 15 · see citing works
Jiang, C., Xie, L., Yan, F., Liang, Z., Liang, J., Huang, K., Li, H., Wang, Y., Luo, L., Li, T., et al. (2023) · Analytical Methods · doi:10.1039/d3ay00806a · Cited by 13 · see citing works
Akbar, M., Ali, N., Imran, M., Hussain, A., Hassan, S. W., Haroon, U., Kamal, A., Farhana, Chaudhary, H. J., & Munis, M. F. H. (2023) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2023.110508 · Cited by 13 · see citing works
Huang, Y.-X., Wu, J., Zhao, Y., Sui, W., Tian, T., Han, W., & Ni, J. (2024) · Preventive Medicine · doi:10.1016/j.ypmed.2024.108147 · Cited by 14 · see citing works
Apoptosis induction in ascorbic acid treated human colorectal cancer cell lines (Caco-2)
Mustafa, N. N., El-Desouky, M. A., Shawush, N. A., & Hanna, D. H. (2025) · Journal of Biologically Active Products from Nature · doi:10.1080/22311866.2025.2465679 · Cited by 14 · see citing works
Liao, C., Wang, X., Zhou, X., Wang, D., Zhang, Z., Liu, Y., Wu, X., Chen, Y., Tan, Y., Dai, X., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c12043 · Cited by 13 · see citing works
van Gorkom, G. N. Y., Boerenkamp, L. S., Senden-Gijsbers, B. L. M. G., van Ojik, H. H., Wodzig, W. K. W. H., Wieten, L., van Elssen, C. H. M. J., & Bos, G. M. J. (2022) · Nutrients · doi:10.3390/nu14224784 · Cited by 13 · see citing works
Self-citationEnzymatic synthesis of phenolic acid glucosyl esters to test activities on cholangiocarcinoma cells
Suyanto, E., Gorantla, J. N., Santi, M., Fatchiyah, F., Ketudat‐Cairns, M., Talabnin, C., & Cairns, J. R. K. (2024) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12895-5 · Cited by 12 · see citing works
Kontoghiorghes, G. J. (2024) · Antioxidants · doi:10.3390/antiox14010029 · Cited by 11 · see citing works
Amaral, A. R., Finardi, G. L. F., Marchi, P. H., de Oliveira, N. M. C., Príncipe, L. D. A., Teixeira, N., Pappalardo, M. C. F., Lima, L. O. C., Cirillo, J. V., Balieiro, J. C. D. C., et al. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1490290 · Cited by 11 · see citing works
Complementary Methods in Cancer Treatment—Cure or Curse?
Michalczyk, K., Pawlik, J., Czekawy, I., Kozłowski, M., & Cymbaluk‐Płoska, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18010356 · Cited by 11 · see citing works
Song, F., Wu, Y., Lin, X., Xue, D., & Wang, Y. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11653 · Cited by 11 · see citing works
Kalaycıoğlu, G. D. (2020) · MethodsX · doi:10.1016/j.mex.2020.101147 · Cited by 10 · see citing works
Li, G., Luo, L., Feng, S., Wang, H., Zhu, M., Li, R., & Lv, Z. (2022) · Sustainable Chemistry and Pharmacy · doi:10.1016/j.scp.2022.100704 · Cited by 10 · see citing works
Allegra, A., Casciaro, M., Presti, E. L., Musolino, C., & Gangemi, S. (2022) · Biomolecules · doi:10.3390/biom12060754 · Cited by 10 · see citing works
Farhana, Ali, M., Akbar, M., Chaudhary, H. J., & Munis, M. F. H. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106207 · Cited by 10 · see citing works
The therapeutic role of γδT cells in TNBC
Li, W., Zhao, X., Ren, C., Gao, S., Han, Q., Lu, M. M., & Li, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1420107 · Cited by 9 · see citing works
Ezim, O. E., & Abarikwu, S. O. (2023) · Andrologia · doi:10.1155/2023/5209480 · Cited by 9 · see citing works
Lee, W., Lee, Y.-B., Huh, M. H., & Choi, J. K. (2022) · Journal of Food Quality · doi:10.1155/2022/1619936 · Cited by 9 · see citing works
Kontoghiorghes, G. J. (2025) · Nutrients · doi:10.3390/nu17203270 · Cited by 9 · see citing works
El-Far, M., Essam, A., El‐Senduny, F. F., El‐Azim, A. O. A., Yahia, S., & El-sherbiny, I. M. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103920 · Cited by 8 · see citing works
Melanin Treatment Effect of Vacuoles-Zinc Oxide Nanoparticles Combined with Ascorbic Acid
Jeon, G., Choi, H., Park, D.-J., Nguyen, N., Kim, Y., & Min, J. (2022) · Molecular Biotechnology · doi:10.1007/s12033-022-00608-8 · Cited by 8 · see citing works
Chen, Z., Higashi, K., Shidara, R., Ueda, K., Morita, T., Limwikrant, W., Yamamoto, K., & Moribe, K. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120599 · Cited by 8 · see citing works
The Association Between Vitamin C and Cancer: A Two-Sample Mendelian Randomization Study
Chen, H., Du, Z., Zhang, Y., Li, M., Gao, R., Qin, L., & Wang, H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.868408 · Cited by 8 · see citing works
Integrative Cancer Therapies: Learning From COVID-19
Block, K. I. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420932652 · Cited by 7 · see citing works
Effects of Vitamin C and E Against Oxidative Stress: Is Antioxidant Supplementation Efficient?
Merzouk, A. S., Loukidi, B., Bettioui, R., & Merzouk, H. (2020) · Current Nutraceuticals · doi:10.2174/2665978601666200220094112 · Cited by 7 · see citing works
Samie, K. A., Dayer, D., & Eshkiki, Z. S. (2022) · Current Molecular Medicine · doi:10.2174/1566524022666220616141725 · Cited by 7 · see citing works
Zuberi, S. A., Sheraz, M. A., Ali, S. A., Shah, M. R., Mujahid, S., Ahmed, S., & Anwar, Z. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220816093123 · Cited by 7 · see citing works
Kadar, C. B., Păucean, A., Simon, E., Vodnar, D. C., Ranga, F., Rusu, I. E., Vișan, V.-G., Simona, M. A. N., Chiș, M. S., & Drețcanu, G. (2022) · Plants · doi:10.3390/plants11081080 · Cited by 7 · see citing works
Osmani, N. E., Prévostel, C., Lasorsa, L., El-Harakeh, M., Radwan, Z., Mawlawi, H., El-Sabban, M. E., Shirinian, M., & Dassouki, Z. (2024) · Epigenetics · doi:10.1080/15592294.2024.2337142 · Cited by 6 · see citing works
Vitamin C in the Management of Thyroid Cancer: A Highway to New Treatment?
Gorini, F., & Tonacci, A. (2024) · Antioxidants · doi:10.3390/antiox13101242 · Cited by 6 · see citing works
Electrochemical Detection of Ascorbic Acid by Fe₂O₃ Nanoparticles Modified Glassy Carbon Electrode
Sikaria, S., Celshia, S., Selvamani, M., Suresh, V., & Hussein, M. A. (2024) · Cureus · doi:10.7759/cureus.64688 · Cited by 6 · see citing works
Dantas, K. C. F., da Fonseca, P. H. M. L., Silva, K. M. M. N., & Silva, P. P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141372 · Cited by 5 · see citing works
The Role of Antioxidant on Health and Age-Related Diseases in Aging
Tan, B. L., & Norhaizan, M. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-82859-2_7 · Cited by 5 · see citing works
A sensing platform for ascorbic acid based on the spatial confinement of covalent organic frameworks
Yang, J., Qiu, H., Meng, S., & Yang, Y. (2023) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2023.123687 · Cited by 5 · see citing works
Macronutrients and micronutrients in cancer prevention and treatment
Ortega, A. M. M., & Campos, M. R. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819828-5.00003-6 · Cited by 7 · see citing works
Sun, H., Jiang, Y., Luo, K., Xing, D. H., Zhai, Y., He, X., Wu, W., & Zhao, Z. (2025) · Human & Experimental Toxicology · doi:10.1177/09603271251345656 · Cited by 4 · see citing works
Vitamin C in Cancer Management: Clinical Evidence and Involvement of Redox Role
Bhattacharya, S. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_161 · Cited by 4 · see citing works
Review Article a Multidisciplinary Evaluation for Advanced Supportive Care of Breast Cancer Patients
Petrone, A., Carlesimo, M., Fortuna, M. C., Peccatori, F. A., Codacci-Pisanelli, G., Barbara, R., Cruciani, S., Serra, P. A., Maioli, L., Maioli, M., et al. (2022) · Breast Care · doi:10.1159/000528280 · Cited by 4 · see citing works
- Authors
- van Gorkom, G. N. Y., Lookermans, E. L., Van Elssen, C. H. M. J., & Bos, G. M. J.
- Affiliations
- Division of Hematology, Department of Internal Medicine, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands
- Maastricht University Medical Centre (NL)
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-04-28
- Volume
- 11
- Issue
- 5
- Pages
- 977
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6566697
- OpenAlex
- W2942117124
- Cited by
- 159
- References
- 43
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 23 · 2023: 21 · 2022: 45 · 2021: 24 · 2020: 17 · 2019: 3
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Keywords
- vitamin C, cancer, vitamin C supplementation, chemotherapy, immune function, intravenous administration, oral administration, overall survival, quality of life, performance status, safety
- MeSH terms
- Ascorbic Acid, Drug Administration Routes, Humans, Neoplasms, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
