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The Hyperoxic-Hypoxic Paradox

Hadanny, Amir, Efrati, Shai·2020·Biomolecules
DOI 10.3390/biom10060958
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Abstract

Effective metabolism is highly dependent on a narrow therapeutic range of oxygen. Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene expression, metabolic changes, and regenerative processes, including angiogenesis and stimulation of stem cell proliferation, migration, and differentiation. The sensing of decreased oxygen levels (hypoxia) or increased oxygen levels (hyperoxia), occurs through specialized chemoreceptor cells and metabolic changes at the cellular level, which regulate the response. Interestingly, fluctuations in the free oxygen concentration rather than the absolute level of oxygen can be interpreted at the cellular level as a lack of oxygen. Thus, repeated intermittent hyperoxia can induce many of the mediators and cellular mechanisms that are usually induced during hypoxia. This is called the hyperoxic-hypoxic paradox (HHP). This article reviews oxygen physiology, the main cellular processes triggered by hypoxia, and the cascade of events triggered by the HHP.

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Metadata

Authors
Hadanny, A., & Efrati, S.
Affiliations
The Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf-Harofeh) Medical Center, Zerifin 70300, Israel
ORCID
Efrati, Shai
Venue
Biomolecules
Publisher
MDPI AG
Published
2020-06-25
Volume
10
Issue
6
Pages
958
ISSN
2218-273X
DOI
10.3390/biom10060958
Cited by
204
References
16
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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