Alcohol, Aldehydes, Adducts and Airways
Open accessAbstract
Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA. Acetaldehyde and malondialdehyde are the major aldehydes generated in high levels in the lung of subjects with alcohol use disorder who smoke cigarettes. In addition to the above aldehydes, several other aldehydes like 4-hydroxynonenal, formaldehyde and acrolein are also detected in the lung due to exposure to toxic gases, vapors and chemicals. These aldehydes react with nucleophilic targets in cells such as DNA, lipids and proteins to form both stable and unstable adducts. This adduction may disturb cellular functions as well as damage proteins, nucleic acids and lipids. Among several adducts formed in the lung, malondialdehyde DNA (MDA-DNA) adduct and hybrid malondialdehyde-acetaldehyde (MAA) protein adducts have been shown to initiate several pathological conditions in the lung. MDA-DNA adducts are pre-mutagenic in mammalian cells and induce frame shift and base-pair substitution mutations, whereas MAA protein adducts have been shown to induce inflammation and inhibit wound healing. This review provides an insight into different reactive aldehyde adducts and their role in the pathogenesis of lung disease.
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Free amino acid residues of proteins, lipids, nucleic acids, and nucleophilic molecules are major targets of adduct formation or covalent binding with reactive molecules such as acetaldehyde, acrolein, crotonaldehyde, formaldehyde, malondialdehyde, 4-hydroxynonenal, 8-hydroxydeoxyguanosine, N2-((furan-2-yl)methyl)-2′-deoxyguanosine, and N2-ethyl-2′-deoxyguanosine.
“Free amino acid residues of proteins, lipids, nucleic acids, and nucleophilic molecules are major targets of adduct formation or covalent binding with reactive molecules such as acetaldehyde, acrolein, crotonaldehyde, formaldehyde, malondialdehyde, 4-hydroxynonenal, 8-hydroxydeoxyguanosine, N2-((furan-2-yl)methyl)-2′-deoxyguanosine, and N2-ethyl-2′-deoxyguanosine164–166.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [164]
Chronic and/or excessive alcohol intake can cause ARDS and other types of pulmonary dysfunction characterized by reduced air exchange rates with increased lung epithelial barrier dysfunction, possibly through increased oxidative stress and MDA and 4-HNE adducts.
“Chronic and/or excessive alcohol intake can cause acute respiratory distress syndrome (ARDS) and other types of pulmonary dysfunction characterized by reduced air exchange rates with increased lung epithelial barrier dysfunction, possibly through increased oxidative stress and MDA and 4-HNE adducts164,234.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [164]
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Cites
Current Cigarette Smoking Among Adults — United States, 2016
Jamal, A., Phillips, E., Gentzke, A. S., Homa, D. M., Babb, S. D., King, B. A., & Neff, L. J. (2018) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6702a1 · Cited by 3,060 · see citing works
Current Cigarette Smoking Among Adults — United States, 2005–2014
Jamal, A., Homa, D. M., O’Connor, E., Babb, S. D., Caraballo, R. S., Singh, T., Hu, S., & King, B. A. (2015) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6444a2 · Cited by 2,544 · see citing works
Smoking and drinking in relation to oral and pharyngeal cancer.
Blot, W. J., McLaughlin, J. K., Winn, D. M., Austin, D. F., Greenberg, R. S., Preston‐Martin, S., Bernstein, L., Schoenberg, J. B., Stemhagen, A., & Fraumeni, J. F. (1988) · PubMed · Cited by 1,993 · see citing works
Marnett, L. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.361 · Cited by 1,887 · see citing works
A descriptive model of the cigarette epidemic in developed countries
López, A. D., Collishaw, N. E., & PIHA, T. (1994) · Tobacco Control · doi:10.1136/tc.3.3.242 · Cited by 1,186 · see citing works
Molecular mechanisms of alcohol-mediated carcinogenesis
Seitz, H. K., & Stickel, F. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2191 · Cited by 1,142 · see citing works
Economic costs of excessive alcohol consumption in the U.S., 2006
Bouchery, E. E., Harwood, H. J., Sacks, J. J., Simon, C. J., & Brewer, R. D. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.06.045 · Cited by 1,041 · see citing works
Valavanidis, A., Vlachogianni, T., Fiotakis, K., & Loridas, S. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10093886 · Cited by 910 · see citing works
Tobacco smoking and cancer: a brief review of recent epidemiological evidence
Sasco, A. J., Secretan, B., & Straíf, K. (2004) · Lung Cancer · doi:10.1016/j.lungcan.2004.07.998 · Cited by 806 · see citing works
Oxidative stress and air pollution exposure
Lodovici, M., & Bigagli, E. (2011) · Journal of Toxicology · doi:10.1155/2011/487074 · Cited by 720 · see citing works
Acute effects of cigarette smoke on inflammation and oxidative stress: a review
van der Vaart, H. (2004) · Thorax · doi:10.1136/thx.2003.012468 · Cited by 695 · see citing works
Negre‐Salvayre, A., Coatrieux, C., Ingueneau, C., & Salvayre, R. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707395 · Cited by 641 · see citing works
Protein-bound acrolein: Potential markers for oxidative stress
Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T., Hattori, N., Mizuno, Y., Suzuki, D., Miyata, T., Noguchi, N., Niki, E., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4882 · Cited by 632 · see citing works
Moderate Alcohol Intake and Cancer Incidence in Women
Allen, N. E., Beral, V., Casabonne, D., Kan, S. W., REEVES, G. K., Brown, A., Green, J., & Collaborators, O. B. O. T. M. W. S. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn514 · Cited by 600 · see citing works
Malondialdehyde, a Product of Lipid Peroxidation, Is Mutagenic in Human Cells
Niedernhofer, L. J., Daniels, J. S., Rouzer, C. A., Greene, R. E., & Marnett, L. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212549200 · Cited by 578 · see citing works
Oxidative Stress and Covalent Modification of Protein with Bioactive Aldehydes
Grimsrud, P. A., Xie, H., Griffin, T. J., & Bernlohr, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700019200 · Cited by 570 · see citing works
Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention
Hecht, S. S. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00815-x · Cited by 536 · see citing works
Epithelial antimicrobial peptides in host defense against infection
Bals, R. (2000) · Respiratory Research · doi:10.1186/rr25 · Cited by 499 · see citing works
Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.
Uchida, K., & Stadtman, E. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4544 · Cited by 492 · see citing works
Hunninghake, G. W., & Crystal, R. G. (1983) · PubMed · doi:10.1164/arrd.1983.128.5.833 · Cited by 452 · see citing works
Pathological aspects of lipid peroxidation
Nègre‐Salvayre, A., Augè, N., Ayala, V., Başağa, H., Boada, J., Brenke, R., Chapple, S. J., Cohen, G., Fehér, J., Grune, T., et al. (2010) · Free Radical Research · doi:10.3109/10715762.2010.498478 · Cited by 451 · see citing works
The health consequences of smoking: Cancer
Newcomb, P. A., & Carbone, P. P. (1992) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30355-8 · Cited by 449 · see citing works
Inflammation and Lung Cancer: Roles of Reactive Oxygen/Nitrogen Species
Azad, N., Rojanasakul, Y., & Vallyathan, V. (2008) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701436460 · Cited by 409 · see citing works
Health consequences of smoking
(2005) · Choice Reviews Online · doi:10.5860/choice.42-2842 · Cited by 406 · see citing works
DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis
Brooks, P. J., & Theruvathu, J. A. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.03.009 · Cited by 382 · see citing works
Detection of Endogenous Malondialdehyde-Deoxyguanosine Adducts in Human Liver
Chaudhary, A. K., Nokubo, M., Reddy, G. R., Yeola, S. N., Morrow, J. D., Blair, L. A., & Marnett, L. J. (1994) · Science · doi:10.1126/science.8079172 · Cited by 374 · see citing works
Hiura, T. S., Kaszubowski, M. P., Li, N., & Nel, A. E. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5582 · Cited by 334 · see citing works
The Macrophage in Chronic Obstructive Pulmonary Disease
Shapiro, S. D. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.supplement_1.9 · Cited by 324 · see citing works
Expression and Regulation of Xenobiotic-Metabolizing Cytochrome P450 (CYP) Enzymes in Human Lung
Hukkanen, J., Pelkonen, O., Hakkola, J., & Raunio, H. (2002) · Critical Reviews in Toxicology · doi:10.1080/20024091064273 · Cited by 319 · see citing works
Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction
Eiserich, J. P., van der Vliet, A., Handelman, G., Halliwell, B. B., & Cross, C. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1490s · Cited by 306 · see citing works
HNE interacts directly with JNK isoforms in human hepatic stellate cells.
Parola, M., Robino, G., Marra, F., Pinzani, M., Bellomo, G., Leonarduzzi, G., Chiarugi, P., Camandola, S., Poli, G., Waeg, G., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1413 · Cited by 297 · see citing works
Smoking-related DNA and protein adducts in human tissues
Phillips, D. H. (2002) · Carcinogenesis · doi:10.1093/carcin/23.12.1979 · Cited by 296 · see citing works
How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease
Office on Smoking (2010) · Cited by 288 · see citing works
Cellular and Mitochondrial Effects of Alcohol Consumption
Manzo‐Ávalos, S., & Saavedra-Molina, A. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7124281 · Cited by 283 · see citing works
DNA adducts with lipid peroxidation products
Blair, I. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700051200 · Cited by 253 · see citing works
Requena, J. R., Fu, M.-X., Ahmed, M., Jenkins, A. J., Lyons, T. J., & Thorpe, S. R. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/11.supp5.48 · Cited by 253 · see citing works
Yao, H., & Rahman, I. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.10.022 · Cited by 250 · see citing works
4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications
Parola, M., Bellomo, G., Robino, G., Barrera, G., & Dianzani, M. U. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.3-255 · Cited by 250 · see citing works
Macrophage Scavenger Receptor Class A
de Winther, M. P. J., van Dijk, K. W., Havekes, L. M., & Hofker, M. H. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.290 · Cited by 248 · see citing works
Schütt, F., Bergmann, M., Holz, F. G., & Kopitz, J. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0172 · Cited by 241 · see citing works
Aldehydes in Exhaled Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease
Corradi, M., Rubinstein, I., Andreoli, R., Manini, P., Caglieri, A., Poli, D., Alinovi, R., & Mutti, A. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200210-1253oc · Cited by 237 · see citing works
Rahman, I. (2005) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:43:1:167 · Cited by 233 · see citing works
Identification of DNA adducts of acetaldehyde
Wang, M., McIntee, E. J., Cheng, G., Shi, Y., Villalta, P. W., & Hecht, S. S. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000118t · Cited by 232 · see citing works
Pearson, T. A. (1996) · Circulation · doi:10.1161/01.cir.94.11.3023 · Cited by 223 · see citing works
Lipid peroxidation-induced putative malondialdehyde-DNA adducts in human breast tissues.
Wang, M., Dhingra, K., Hittelman, W. N., Liehr, J. G., de Andrade, M., & Li, D. (1996) · PubMed · Cited by 221 · see citing works
Tuma, D. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00742-0 · Cited by 211 · see citing works
Reactive Oxygen Species, Inflammation, and Lung Diseases
Rosanna, D. P., & Cuzzocrea, S. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802083716 · Cited by 209 · see citing works
Acetaldehyde adducts with proteins: Binding of [14C]acetaldehyde to serum albumin
Donohue, T. M., Tuma, D. J., & Sorrell, M. F. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90406-x · Cited by 209 · see citing works
Comorbid Cigarette and Alcohol Addiction
Miller, N. S., & Gold, M. S. (1998) · Journal of Addictive Diseases · doi:10.1300/j069v17n01_06 · Cited by 207 · see citing works
Nkadi, P. O., Merritt, T. A., & Pillers, D. M. (2009) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2009.01.015 · Cited by 206 · see citing works
Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva
Salaspuro, V., & Salaspuro, M. P. (2004) · International Journal of Cancer · doi:10.1002/ijc.20293 · Cited by 206 · see citing works
Toxicological and pathophysiological roles of reactive oxygen and nitrogen species
Roberts, R. A., Smith, R. A., Safe, S. H., Szabó, C., Tjalkens, R. B., & Robertson, F. M. (2010) · Toxicology · doi:10.1016/j.tox.2010.07.009 · Cited by 206 · see citing works
Focus on: Alcohol and the immune system.
Molina, P. E., Happel, K. I., Zhang, P., Kolls, J. K., & Nelson, S. (2010) · Europe PMC (PubMed Central) · Cited by 205 · see citing works
Determination of toxic carbonyl compounds in cigarette smoke
Fujioka, K., & Shibamoto, T. (2006) · Environmental Toxicology · doi:10.1002/tox.20153 · Cited by 197 · see citing works
Rehabilitation Decreases Exercise-induced Oxidative Stress in Chronic Obstructive Pulmonary Disease
Mercken, E. M., Hageman, G. J., Schols, A. M. W. J., Akkermans, M. A., Bast, A., & Wouters, E. F. �. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200411-1580oc · Cited by 194 · see citing works
Casini, A., Cunningham, M., Rojkind, M., & Lieber, C. S. (1991) · Hepatology · doi:10.1002/hep.1840130424 · Cited by 189 · see citing works
Dangerous byproducts of alcohol breakdown--focus on adducts.
(2003) · Europe PMC (PubMed Central) · Cited by 187 · see citing works
Kirkham, P., Caramori, G., Casolari, P., Papi, A. A., Edwards, M., Shamji, B. W. H., Triantaphyllopoulos, K. A., Hussain, F., Pinart, M., Khan, Y., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1605oc · Cited by 186 · see citing works
α,β-Unsaturated Aldehydes in Cigarette Smoke Release Inflammatory Mediators from Human Macrophages
Facchinetti, F., Amadei, F., Geppetti, P., Tarantini, F., Serio, C. D., Dragotto, A., Gigli, P. M., Catinella, S., Civelli, M., & Patacchini, R. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0130oc · Cited by 185 · see citing works
Protein Modification by Acrolein: Formation and Stability of Cysteine Adducts
Cai, J., Bhatnagar, A., & Pierce, W. M. J. (2009) · Chemical Research in Toxicology · doi:10.1021/tx800465m · Cited by 183 · see citing works
Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury,
Niemelä, O. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00744-4 · Cited by 181 · see citing works
Antibodies against acetaldehyde-modified protein epitopes in human alcoholics
Niemelä, O. J., Klajner, F., Orrego, H., Vidins, E. I., Blendis, L. M., & Israel, Y. (1987) · Hepatology · doi:10.1002/hep.1840070607 · Cited by 181 · see citing works
Linhart, K. B., Bartsch, H., & Seitz, H. K. (2014) · Redox Biology · doi:10.1016/j.redox.2014.08.009 · Cited by 180 · see citing works
Absorption, Diffusion, Distribution, and Elimination of Ethanol: Effects on Biological Membranes
Kalant, H. (1971) · Springer eBooks · doi:10.1007/978-1-4615-6525-3_1 · Cited by 175 · see citing works
Protein Adduct Formation as a Molecular Mechanism in Neurotoxicity
LoPachin, R. M., & DeCaprio, A. P. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi197 · Cited by 175 · see citing works
Alcohol and airways function in health and disease
Sisson, J. H. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.06.003 · Cited by 171 · see citing works
Rolla, R., Vay, D., Mottaran, E., Parodi, M., Traverso, N., Aricò, S., Sartori, M., Bellomo, G., Klassen, L. W., Thiele, G. M., et al. (2000) · Hepatology · doi:10.1053/he.2000.5373 · Cited by 163 · see citing works
Thiele, G. M., Duryee, M. J., Anderson, D. R., Klassen, L. W., Mohring, S. M., Young, K. A., Benissan‐Messan, D., Sayles, H. R., Dusad, A., Hunter, C. D., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38969 · Cited by 162 · see citing works
Rapidly Fatal Outcome of Bacteremic Klebsiella pneumoniae Pneumonia in Alcoholics
Jong, G.-M., Hsiue, T., Chen, C.-R., Chang, H.-Y., & Chen, C.-W. (1995) · CHEST Journal · doi:10.1378/chest.107.1.214 · Cited by 161 · see citing works
Covalent Binding of Acetaldehyde to Proteins: Participation of Lysine Residues
Tuma, D. J., Newman, M. R., Donohue, T. M., & Sorrell, M. F. (1987) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1987.tb00178.x · Cited by 155 · see citing works
Covalent adduction of nucleophilic amino acids by 4-hydroxynonenal and 4-oxononenal
Doorn, J. A., & Petersen, D. R. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00178-3 · Cited by 147 · see citing works
Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats
Guidot, D. M., Modelska, K., Lois, M., et al. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.1.l127 · Cited by 147 · see citing works
Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.
Brenner, D. A., & Chojkier, M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45434-8 · Cited by 142 · see citing works
Chepiga, T. A., Morton, M. J., MURPHY, P., et al. (2000) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(00)00086-7 · Cited by 141 · see citing works
Lung defences: an overview: TABLE 1—
Nicod, L. P. (2005) · European Respiratory Review · doi:10.1183/09059180.05.00009501 · Cited by 139 · see citing works
Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde
Theruvathu, J. A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki661 · Cited by 135 · see citing works
Alcohol abuse in the critically ill patient
Moss, M. M., & Burnham, E. L. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69490-7 · Cited by 133 · see citing works
Wang, M., Yu, N., Chen, L., Villalta, P. W., Hochalter, J. B., & Hecht, S. S. (2006) · Chemical Research in Toxicology · doi:10.1021/tx0502948 · Cited by 133 · see citing works
Cigarette smoke irreversibly modifies glutathione in airway epithelial cells
van der Toorn, M., Vries, M. P. S.-D., Slebos, D., de Bruin, H. G., Abello, N., van Oosterhout, A. J. M., Bischoff, R., & Kauffman, H. F. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00081.2007 · Cited by 131 · see citing works
Role of 4-Hydroxynonenal-Protein Adducts in Human Diseases
Barrera, G., Pizzimenti, S., Ciamporcero, E. S., Daga, M., Ullio, C., Arcaro, A., Cetrangolo, G. P., Ferretti, C., Dianzani, C., Lepore, A., et al. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6166 · Cited by 130 · see citing works
Immunohistochemical detection of malondialdehyde-DNA adducts in human oral mucosa cells
Zhang, Y. (2002) · Carcinogenesis · doi:10.1093/carcin/23.1.207 · Cited by 127 · see citing works
Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress
Niemelä, O. J. (1999) · Frontiers in bioscience · doi:10.2741/niemela · Cited by 124 · see citing works
The Role of Oxidative Stress in the Pathogenesis of COPD
Rahman, I. (2005) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200504030-00003 · Cited by 121 · see citing works
VanderVeen, L. A., Hashim, M. F., Shyr, Y., & Marnett, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2332176100 · Cited by 120 · see citing works
Shamoto‐Nagai, M., Maruyama, W., Hashizume, Y., Yoshida, M., Osawa, T., Riederer, P. F., & Naoi, M. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0789-2 · Cited by 118 · see citing works
Moretto, N., Facchinetti, F., Southworth, T. W., Civelli, M., Singh, D., & Patacchini, R. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90570.2008 · Cited by 117 · see citing works
Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production
Deshmukh, H. S., Shaver, C., Case, L. M., Dietsch, M., Wesselkamper, S. C., Hardie, W. D., Korfhagen, T. R., Corradi, M., Nadel, J. A., Borchers, M. T., et al. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0339oc · Cited by 117 · see citing works
Niemelä, O., Parkkila, S., Pasanen, M., Limuro, Y., Bradford, B., & Thurman, R. G. (1998) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb05925.x · Cited by 107 · see citing works
Alcoholic lung injury: Metabolic, biochemical and immunological aspects
Kaphalia, L., & Calhoun, W. J. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.07.016 · Cited by 105 · see citing works
Formation and Repair of Tobacco Carcinogen‐Derived Bulky DNA Adducts
Hang, B. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/709521 · Cited by 103 · see citing works
Population-Based Trends in Lung Cancer Incidence in Women
Egleston, B. L., Meireles, S. I., Flieder, D. B., & Clapper, M. L. (2009) · Seminars in Oncology · doi:10.1053/j.seminoncol.2009.09.003 · Cited by 96 · see citing works
Concurrent Alcohol and Tobacco Dependence: Mechanisms and Treatment
Drobes, D. J. (2002) · Europe PMC (PubMed Central) · Cited by 95 · see citing works
Hill, G. E., Miller, J. A., Baxter, B. T., Klassen, L. W., Duryee, M. J., Tuma, D. J., & Thiele, G. M. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00153-1 · Cited by 95 · see citing works
Studies of the reaction of acetaldehyde with deoxynucleosides
Vaca, C. E., Fang, J., & Schweda, E. K. H. (1995) · Chemico-Biological Interactions · doi:10.1016/0009-2797(95)03632-v · Cited by 93 · see citing works
Detection of circulating antibodies to malondialdehyde-acetaldehyde adducts in ethanol-fed rats
Xu, D., Thiele, G. M., Beckenhauer, J. L., Klassen, L. W., Sorrell, M. F., & Tuma, D. J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70148-9 · Cited by 87 · see citing works
Fenaille, F., Guy, P. A., & Tabet, J. (2003) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(02)00911-x · Cited by 85 · see citing works
Li, C., Nanji, A. A., Siakotos, A. N., & Lin, R. C. (1997) · Hepatology · doi:10.1002/hep.510260317 · Cited by 85 · see citing works
Investigation of the mechanism of alcohol-induced bronchial asthma
Shimoda, T., Kohno, S., Takao, A., Fujiwara, C., Matsuse, H., Sakai, H., Watanabe, T., Kohei, H. A. R. A., & Asai, S. (1996) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(96)70285-3 · Cited by 84 · see citing works
The Functional Implications of Acetaldehyde Binding to Cell Constituentsa
Sorrell, M. F., & Tuma, D. J. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb48652.x · Cited by 84 · see citing works
Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress
Sunil, V. R., Vayas, K. N., Shen, J., Laskin, J. D., & Laskin, D. L. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.06.009 · Cited by 84 · see citing works
Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease
Moretto, N., Volpi, G., Pastore, F., & Facchinetti, F. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06531.x · Cited by 82 · see citing works
4-Hydroxy-2-nonenal–Protein Adducts and Apoptosis in Murine Lung Cells after Acute Ozone Exposure
Kirichenko, A., Li, L., Morandi, M. T., et al. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0307 · Cited by 77 · see citing works
Alcohol-attributable deaths and years of potential life lost--11 States, 2006-2010.
Gonzales, K. R., Roeber, J., Kanny, D., et al. (2014) · PubMed · Cited by 76 · see citing works
The Interaction of Acetaldehyde With Tubulina
Tuma, D. J., Jennett, R. B., & Sorrell, M. F. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb48681.x · Cited by 75 · see citing works
Piadé, J.-J., Wajrock, S., Jaccard, G., et al. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.01.016 · Cited by 75 · see citing works
Jones, A. W. (1990) · Forensic Science International · doi:10.1016/0379-0738(90)90177-z · Cited by 74 · see citing works
DNA adducts in human tissues: biomarkers of exposure to carcinogens in tobacco smoke.
Phillips, D. H. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s3453 · Cited by 73 · see citing works
Epigenetic effects of ethanol on the liver and gastrointestinal system
Shukla, S. D. (2013) · Alcohol research · doi:10.35946/arcr.v35.1.06 · Cited by 71 · see citing works
Chavez, J. D., Chung, W., Miranda, C. L., Singhal, M., Stevens, J. F., & Maier, C. S. (2009) · Chemical Research in Toxicology · doi:10.1021/tx9002462 · Cited by 71 · see citing works
Elucidation of Reaction Scheme Describing Malondialdehyde−Acetaldehyde−Protein Adduct Formation
Tuma, D. J., Kearley, M. L., Thiele, G. M., Worrall, S., Haver, A. C., Klassen, L. W., & Sorrell, M. F. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000222a · Cited by 71 · see citing works
Cigarette Smoke Component Acrolein Modulates Chromatin Assembly by Inhibiting Histone Acetylation
Chen, D., Fang, L., Li, K., Tang, M., & Jin, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.476630 · Cited by 71 · see citing works
McCaskill, M. L., Kharbanda, K. K., Tuma, D. J., Reynolds, J. D., DeVasure, J. M., Sisson, J. H., & Wyatt, T. A. (2011) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01443.x · Cited by 70 · see citing works
Self-citationBronchial malondialdehyde DNA adducts, tobacco smoking, and lung cancer
Munnia, A., Bonassi, S., Verna, A., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.08.007 · Cited by 70 · see citing works
Bono, R., Romanazzi, V., Munnia, A., et al. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100083x · Cited by 70 · see citing works
The chemistry of acetaldehyde-protein adducts.
Tuma, D. J., Hoffman, T. D., & Sorrell, M. F. (1991) · PubMed · Cited by 69 · see citing works
Acute and Chronic Alcohol Abuse Modulate Immunity
Brown, L. A. S., Cook, R. T., Jerrells, T. R., et al. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00195.x · Cited by 67 · see citing works
Innate Immunity and the Lung: Defense at the Interface Between Host and Environment
Zaas, A. K., & Schwartz, D. A. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.07.001 · Cited by 65 · see citing works
Finkelstein, E. I., Ruben, J. M., Koot, C. W., Hristova, M., & van der Vliet, A. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00227.2005 · Cited by 65 · see citing works
Kershaw, C. D., & Guidot, D. M. (2008) · PubMed · Cited by 64 · see citing works
Epigenetic effects of ethanol on liver and gastrointestinal injury
Shukla, S. D. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i33.5265 · Cited by 64 · see citing works
Sampey, B. P., Stewart, B. J., & Petersen, D. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610602200 · Cited by 64 · see citing works
Duryee, M. J., Klassen, L. W., Freeman, T. L., Willis, M. S., Tuma, D. J., & Thiele, G. M. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000148115.90045.c5 · Cited by 64 · see citing works
Reactive Lipid Species from Cyclooxygenase-2 Inactivate Tumor Suppressor LKB1/STK11
Wagner, T. M., Mullally, J. E., & Fitzpatrick, F. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509723200 · Cited by 62 · see citing works
Ozone Exposure Increases Aldehydes in Epithelial Lining Fluid in Human Lung
Frampton, M. W., Pryor, W. A., Cueto, R., Cox, C., Morrow, P. E., & Utell, M. J. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.4.9807057 · Cited by 62 · see citing works
Detection of Aldehydes in Bronchoalveolar Lavage of Rats Exposed to Ozone
PRYOR, W. A. (1996) · Fundamental and Applied Toxicology · doi:10.1006/faat.1996.0185 · Cited by 58 · see citing works
Willis, M. S., Klassen, L. W., Tuma, D. J., Sorrell, M. F., & Thiele, G. M. (2002) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02436.x · Cited by 56 · see citing works
Araneda, O. F., Garcı́a, C., LAGOS, N., et al. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0047-y · Cited by 55 · see citing works
Role of Lipid Peroxidation-Derivedα,β-Unsaturated Aldehydes in Vascular Dysfunction
Lee, S. E., & Park, Y. S. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/629028 · Cited by 54 · see citing works
Liang, Y., Yeligar, S. M., & Brown, L. A. S. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/740308 · Cited by 53 · see citing works
Alcohol-related diseases of the mouth and throat
Riedel, F., GOESSLER, U. R., & Hörmann, K. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00019-2 · Cited by 53 · see citing works
Duryee, M. J., Freeman, T. L., Willis, M. S., Hunter, C. D., Hamilton, B. C., Suzuki, H., Tuma, D. J., Klassen, L. W., & Thiele, G. M. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.016121 · Cited by 51 · see citing works
Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats
Zheng, R., Dragomir, A.-C., Mishin, V. M., et al. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.04.026 · Cited by 47 · see citing works
Malondialdehyde–acetaldehyde-adducted protein inhalation causes lung injury
Wyatt, T. A., Kharbanda, K. K., McCaskill, M. L., Tuma, D. J., Yanov, D. A., DeVasure, J. M., & Sisson, J. H. (2011) · Alcohol · doi:10.1016/j.alcohol.2011.09.001 · Cited by 47 · see citing works
Self-citationBiomarkers of Induced Active and Passive Smoking Damage
Lodovici, M., & Bigagli, E. (2009) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph6030874 · Cited by 47 · see citing works
Peluso, M. E. M., Srivatanakul, P., Munnia, A., et al. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900907 · Cited by 43 · see citing works
Acetaldehyde-mediated cilia dysfunction in bovine bronchial epithelial cells
Sisson, J. H., Tuma, D. J., & Rennard, S. I. (1991) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1991.260.2.l29 · Cited by 43 · see citing works
Reaction of tobacco smoke aldehydes with human hemoglobin
Hoberman, H. D., & George, R. C. S. (1988) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.2570030205 · Cited by 42 · see citing works
Exocyclic malondialdehyde and aromatic DNA adducts in larynx tissues
Munnia, A., Amasio, M. E., & Peluso, M. E. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.024 · Cited by 42 · see citing works
Stable Acetaldehyde−Protein Adducts as Biomarkers of Alcohol Exposure
Birt, J. E. E. C., Shuker, D. E. G., & Farmer, P. B. (1998) · Chemical Research in Toxicology · doi:10.1021/tx970169z · Cited by 41 · see citing works
Alcohol-Induced Lung Damage and Increased Oxidative Stress
Aytaçoğlu, B. N., Çalıkoğlu, M. E., Tamer, L., et al. (2005) · Respiration · doi:10.1159/000088680 · Cited by 40 · see citing works
Galvin, J. R., & Franks, T. J. (2009) · Journal of Thoracic Imaging · doi:10.1097/rti.0b013e3181c1abb7 · Cited by 37 · see citing works
The Impact of Breathing Pattern and Lung Size on the Alcohol Breath Test
Hlastala, M. P., & Anderson, J. C. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-006-9216-3 · Cited by 37 · see citing works
Neutrophil elastase activity and superoxide production are diminished in neutrophils of alcoholics.
Sachs, C., Christensen, R. H., Pratt, P., & Lynn, W. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.5_pt_1.1249 · Cited by 35 · see citing works
Smoking and lung cancer—a new role for an old toxicant?
Hecht, S. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607811103 · Cited by 34 · see citing works
Wyatt, T. A., Kharbanda, K. K., Tuma, D. J., et al. (2001) · Alcohol · doi:10.1016/s0741-8329(01)00177-x · Cited by 34 · see citing works
Self-citationTobacco smoke and respiratory disease
Behr, J., & Nowak, D. (2002) · Cited by 32 · see citing works
Linhart, K. B., Glassen, K., Peccerella, T., Waldherr, R., Linhart, H., Bartsch, H., & Seitz, H. K. (2015) · PubMed Central · doi:10.3978/j.issn.2304-3881.2015.01.14 · Cited by 29 · see citing works
Kaphalia, L., Boroumand, N., Ju, H., Kaphalia, B. S., & Calhoun, W. J. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.02.018 · Cited by 28 · see citing works
DNA Adducts in Human Tissues: Biomarkers of Exposure to Carcinogens in Tobacco Smoke
Phillips, D. H. (1996) · Environmental Health Perspectives · doi:10.2307/3432803 · Cited by 28 · see citing works
Biological Basis of Alcohol-Induced Cancer
Vasiliou, V., Zakhari, S., Seitz, H. K., et al. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-09614-8 · Cited by 27 · see citing works
Gb, T. (1993) · PubMed · Cited by 27 · see citing works
Cigarette smoke and ozone effect on murine inflammatory responses
Gardi, C., & Valacchi, G. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06605.x · Cited by 26 · see citing works
Malondialdehyde–acetaldehyde adducts decrease bronchial epithelial wound repair
Wyatt, T. A., Kharbanda, K. K., Tuma, D. J., et al. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.06.002 · Cited by 25 · see citing works
Self-citationPROTEIN ADDUCT SPECIES IN MUSCLE AND LIVER OF RATS FOLLOWING ACUTE ETHANOL ADMINISTRATION
B. PATEL, V., WORRALL, S., EMERY, P. W., & PREEDY, V. R. (2005) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh196 · Cited by 25 · see citing works
Novitskiy, G., Ravi, R. K., Potter, J. J., Rennie-Tankersley, L., Wang, L., & Mezey, E. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh116 · Cited by 25 · see citing works
Inhaled frusemide does not affect lung mucociliary clearance in healthy and asthmatic subjects
Hasani, A. M., Pavia, D., Spiteri, M., et al. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07081497 · Cited by 22 · see citing works
Rukhsana Sultana, A., Raju, B. S. S., Sharma, V., Reddanna, P., & Babu, P. P. (2005) · Alcohol · doi:10.1016/j.alcohol.2004.12.004 · Cited by 22 · see citing works
Sapkota, M., Hottor, T., DeVasure, J. M., Wyatt, T. A., & McCaskill, M. L. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12439 · Cited by 21 · see citing works
Self-citationWorrall, S. (2000) · Alcohol and Alcoholism · doi:10.1093/alcalc/35.2.164 · Cited by 21 · see citing works
Guidot, D. M., Moss, M., Holguín, F., et al. (1999) · CHEST Journal · doi:10.1378/chest.116.suppl_1.82s · Cited by 20 · see citing works
Berger, J. P., Simet, S. M., DeVasure, J. M., et al. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.02.005 · Cited by 18 · see citing works
Effects of Acetaldehyde on Human Airway Constriction and Inflammation
Matsuse, H., Fukushima, C., Shimoda, T., et al. (2006) · Novartis Foundation symposium · doi:10.1002/9780470511848.ch7 · Cited by 17 · see citing works
Ethanol and the Liver: Mechanisms and Management
Sherman, D., Preedy, V. R., & WATSON, R. R. (2002) · Cited by 12 · see citing works
Carson, J. S., Xiong, W., Dale, M. A., et al. (2015) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2014.08.117 · Cited by 12 · see citing works
Wałaszek, Z. (2010) · Oncology Letters · doi:10.3892/ol.2010.221 · Cited by 10 · see citing works
Kaur, I., & Katyal, A. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.008 · Cited by 10 · see citing works
Alcohol, smoking and lung disease
Ström, K. (1999) · Addiction Biology · doi:10.1080/13556219971803 · Cited by 8 · see citing works
Acetaldehyde-mediated cilia dysfunction in bovine bronchial epithelial cells
Sisson, J. H., Tuma, D. J., & Rennard, S. I. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.262.6.1-a · Cited by 8 · see citing works
Detection of Aldehydes in Bronchoalveolar Lavage of Rats Exposed to Ozone
Pryor, W. A., Bermúdez, E., Cueto, R., et al. (1996) · Toxicological Sciences · doi:10.1093/toxsci/34.1.148 · Cited by 6 · see citing works
Sherman, D. H., & WATSON, R. R. (2002) · CRC Press eBooks · doi:10.3109/9780203301388 · Cited by 4 · see citing works
Al-Rubaye, F. G. (2011) · Indian Journal Of Applied Research · doi:10.15373/2249555x/june2014/13 · Cited by 1 · see citing works
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Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
Genome-wide mapping of genomic DNA damage: methods and implications
Amente, S., Scala, G., Majello, B., Azmoun, S., Tempest, H. G., Premi, S., & Cooke, M. S. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03923-6 · Cited by 33 · see citing works
- Authors
- Sapkota, M., & Wyatt, T.
- Affiliations
- University of Nebraska Medical Center (US)
- VA Nebraska Western Iowa Health Care System (US)
- Corresponding author
- Wyatt, Todd
- ORCID
- Wyatt, Todd
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2015-11-05
- Volume
- 5
- Issue
- 4
- Pages
- 2987-3008
- ISSN
- 2218-273X (ISSN-L)
- PMC
- PMC4693266
- OpenAlex
- W2111271266
- Cited by
- 72
- References
- 172
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 4 · 2022: 10 · 2021: 13 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 6
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomolecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- DHHS/NIH/NIAAA (R01AA017993)
- DHHS/CDC/NIOSH (U54OH010162)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- reactive aldehydes, acetaldehyde, malondialdehyde, 4-hydroxynonenal, formaldehyde, acrolein, aldehyde adducts, alcoholism, cigarette smoking, lung disease pathogenesis, DNA damage, protein adducts, lipid peroxidation, inflammation, wound healing
- MeSH terms
- Ethanol, Aldehydes, Animals, Humans, Respiratory Tract Diseases, Smoking, Tobacco Smoke Pollution, DNA Adducts
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