The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo
Open accessAbstract
Antibiotic resistance is projected as one of the greatest threats to human health in the future and hence alternatives are being explored to combat resistance. Antimicrobial peptides (AMPs) have shown great promise, because use of AMPs leads bacteria to develop no or low resistance. In this review, we discuss the diversity, history and the various mechanisms of action of AMPs. Although many AMPs have reached clinical trials, to date not many have been approved by the US Food and Drug Administration (FDA) due to issues with toxicity, protease cleavage and short half-life. Some of the recent strategies developed to improve the activity and biocompatibility of AMPs, such as chemical modifications and the use of delivery systems, are also reviewed in this article.
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Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
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An anti-infective peptide that selectively modulates the innate immune response
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Oral delivery of peptides and proteins using lipid-based drug delivery systems
Li, P., Nielsen, H. M., & Müllertz, A. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.717068 · Cited by 116
Cited by
Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
Mohammad, S., & Thiemermann, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594150 · Cited by 585
Antimicrobial peptides: Structure, mechanism, and modification
Chen, N., & Jiang, C. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115377 · Cited by 279
Lima, P. G., Oliveira, J. T. A., Amaral, J. L., Freitas, C. D. T., & Souza, P. F. N. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119647 · Cited by 170
Bioactive materials for caries management: a literature review
Zhang, O. L., Niu, J. Y., Yin, I. X., Yu, O. Y., Mei, M. L., & Chu, C. H. (2023) · Dentistry Journal · doi:10.3390/dj11030059 · Cited by 62
(2024) · doi:10.1002/advs.202406305 · Cited by 55
Metadata
- Authors
- Kumar, P., Kizhakkedathu, J., & Straus, S.
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2018-01-19
- Volume
- 8
- Issue
- 1
- Pages
- 4
- ISSN
- 2218-273X (ISSN-L)
- OpenAlex
- W2788314593
- Cited by
- 1,227
- References
- 6
- FWCI
- 76.37
- Type
- journal article
- Language
- en
- Open access
- gold
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