The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities
Open accessAbstract
Naringin and naringenin are the main bioactive polyphenols in citrus fruits, the consumption of which is beneficial for human health and has been practiced since ancient times. Numerous studies have reported these substances’ antioxidant and antiandrogenic properties, as well as their ability to protect from inflammation and cancer, in various in vitro and in vivo experimental models in animals and humans. Naringin and naringenin can suppress cancer development in various body parts, alleviating the conditions of cancer patients by acting as effective alternative supplementary remedies. Their anticancer activities are pleiotropic, and they can modulate different cellular signaling pathways, suppress cytokine and growth factor production and arrest the cell cycle. In this narrative review, we discuss the effects of naringin and naringenin on inflammation, apoptosis, proliferation, angiogenesis, metastasis and invasion processes and their potential to become innovative and safe anticancer drugs.
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3 retracted
Khan, U. M., Sameen, A., Aadil, R. M., Shahid, M., Sezen, S., Zarrabi, A., Özdemir, B., Sevindik, М., Kaplan, D. N., Selamoğlu, Z., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/2488804 · Cited by 117
RetractedShi, X., Luo, X., Chen, T., Guo, W., Liang, C., Tang, S., & Mo, J. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16226 · Cited by 71
RetractedLian, G., Wang, Q., Mak, T. S., Huang, X., Yu, X., & Lan, H. Y. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.01.006 · Cited by 67
RetractedApoptosis: A Review of Programmed Cell Death
Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853
Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.41 · Cited by 5,298
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219
An Overview of Autophagy: Morphology, Mechanism, and Regulation
Parzych, K. R., & Klionsky, D. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5371 · Cited by 2,521
Tumor cell metabolism: cancer's Achilles' heel
Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337
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The Immunomodulatory and Anti-Inflammatory Role of Polyphenols
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Metadata
- Authors
- Stabrauskiene, J., Kopustinskiene, D. M., Lazauskas, R., & Bernatoniene, J.
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2022-07-13
- Volume
- 10
- Issue
- 7
- Pages
- 1686
- ISSN
- 2227-9059 (ISSN-L)
- OpenAlex
- W4285391797
- Cited by
- 300
- References
- 83
- FWCI
- 28.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Stabrauskiene, J., Kopustinskiene, D. M., Lazauskas, R., & Bernatoniene, J. (2022). Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities. Biomedicines. https://doi.org/10.3390/biomedicines10071686
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
