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Cited by 426Collagen: Extraction and CharacterizationSilk-based biomaterials and applicationsTissue Engineering and Regenerative Medicine

A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold

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Amirrah, Ibrahim N., Lokanathan, Yogeswaran, Zulkiflee, Izzat, Wee, M. F. Mohd Razip, Motta, Antonella, Fauzi, Mh Busra·2022·Biomedicines
DOI 10.3390/biomedicines10092307PMC PMC9496548
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Abstract

Collagen is the most abundant structural protein found in humans and mammals, particularly in the extracellular matrix (ECM). Its primary function is to hold the body together. The collagen superfamily of proteins includes over 20 types that have been identified. Yet, collagen type I is the major component in many tissues and can be extracted as a natural biomaterial for various medical and biological purposes. Collagen has multiple advantageous characteristics, including varied sources, biocompatibility, sustainability, low immunogenicity, porosity, and biodegradability. As such, collagen-type-I-based bioscaffolds have been widely used in tissue engineering. Biomaterials based on collagen type I can also be modified to improve their functions, such as by crosslinking to strengthen the mechanical property or adding biochemical factors to enhance their biological activity. This review discusses the complexities of collagen type I structure, biosynthesis, sources for collagen derivatives, methods of isolation and purification, physicochemical characteristics, and the current development of collagen-type-I-based scaffolds in tissue engineering applications. The advancement of additional novel tissue engineered bioproducts with refined techniques and continuous biomaterial augmentation is facilitated by understanding the conventional design and application of biomaterials based on collagen type I.

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  • Purified ECM scaffolds typically exhibit minimal immunogenicity, high biocompatibility, and reproducible fabrication because their isolation protocols eliminate or minimize other molecules, including DAMPs.

    “Purified ECM scaffolds typically exhibit minimal immunogenicity, high biocompatibility, and reproducible fabrication, as their isolation protocols eliminate or minimize other molecules, including DAMPs [117].”

    From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [117]

    Section 5.3 discusses biocompatibility as a requirement for bioscaffolds, not as an established property of purified ECM scaffolds. Section 6.2 reports immune responses to some transplanted scaffolds, but does not establish what is typical of purified ECM scaffolds. Searches for DAMPs, removal of other molecules, and reproducible fabrication found no passage supporting the claimed isolation-based explanation; page numbers were unavailable in our copy. (LLM, conf=0.72)

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Sorted by citations

Authors
Amirrah, I. N., Lokanathan, Y., Zulkiflee, I., Wee, M. F. M. R., Motta, A., & Fauzi, M. B.
Affiliations
  • National University of Malaysia (MY)
  • University of Trento (IT)
Corresponding author
Fauzi, Mh Busra
ORCID
Venue
Biomedicines
Publisher
MDPI AG
Published
2022-09-16
Volume
10
Issue
9
Pages
2307
ISSN
2227-9059 (ISSN-L)
DOI
10.3390/biomedicines10092307
PMC
PMC9496548
OpenAlex
W4296251990
Cited by
426
References
4
Citations by year
2026: 135 · 2025: 156 · 2024: 89 · 2023: 42 · 2022: 3 · 2020: 1
FWCI
4.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomedicines (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Trento) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Universiti Kebangsaan Malaysia (UKM-TR-006, IF0419Q1081, 101008041)
  • The Ministry of Science, Technology and Innovation (MOSTI; Malaysia) (UKM-TR-006, IF0419Q1081, 101008041)
  • The European Union (UKM-TR-006, IF0419Q1081, 101008041)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
type I collagen, tissue engineering, bioscaffolds, extracellular matrix, collagen synthesis, collagen cross-linking, collagen-based biomaterials, biocompatibility, biodegradability, collagen structure

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