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A Review on Surface-Enhanced Raman Scattering

Open access
Pilot, Roberto, Signorini, Raffaella, Durante, Christian, Orian, Laura, Bhamidipati, Manjari, Fabris, Laura·2019·Biosensors

Abstract

Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.

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Metadata

Authors
Pilot, R., Signorini, R., Durante, C., Orian, L., Bhamidipati, M., & Fabris, L.
Venue
Biosensors
Publisher
MDPI AG
Published
2019-04-17
Volume
9
Issue
2
Pages
57
ISSN
2079-6374 (ISSN-L)
OpenAlex
W2938789811
Cited by
1,010
References
17
FWCI
31.89
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: A Review on Surface-Enhanced Raman Scattering. https://app.cochat.ai/papers/10.3390/bios9020057
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Pilot, R., Signorini, R., Durante, C., Orian, L., Bhamidipati, M., & Fabris, L. (2019). A Review on Surface-Enhanced Raman Scattering. Biosensors. https://doi.org/10.3390/bios9020057

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