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Cited by 4Neuroscience and Neuropharmacology ResearchAxon Guidance and Neuronal SignalingNeurobiology and Insect Physiology Research

Cellular and Molecular Mechanisms Underlying Synaptic Subcellular Specificity

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Wang, Mengqing, Fan, Jiale, Shao, Zhiyong·2024·Brain Sciences
DOI 10.3390/brainsci14020155PMC PMC10886843
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Abstract

Chemical synapses are essential for neuronal information storage and relay. The synaptic signal received or sent from spatially distinct subcellular compartments often generates different outcomes due to the distance or physical property difference. Therefore, the final output of postsynaptic neurons is determined not only by the type and intensity of synaptic inputs but also by the synaptic subcellular location. How synaptic subcellular specificity is determined has long been the focus of study in the neurodevelopment field. Genetic studies from invertebrates such as Caenorhabditis elegans (C. elegans) have uncovered important molecular and cellular mechanisms required for subcellular specificity. Interestingly, similar molecular mechanisms were found in the mammalian cerebellum, hippocampus, and cerebral cortex. This review summarizes the comprehensive advances in the cellular and molecular mechanisms underlying synaptic subcellular specificity, focusing on studies from C. elegans and rodents.

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  • The final output of a neuron is determined not only by the type and intensity of synaptic inputs but also by their physical location on the neuron.

    “The final output of a neuron is determined not only by the type and intensity of synaptic inputs but also by their physical location on the neuron [86].”

    From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [86]

  • Synaptic diversity is evident in subcellular specificity, where specific presynaptic terminals precisely target particular postsynaptic subcellular domains.

    “Synaptic diversity is also evident in subcellular specificity, where specific presynaptic terminals precisely target particular postsynaptic subcellular domains [86].”

    From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [86]

  • Synaptic subcellular specificity can be regulated at various stages of neurodevelopment, including neurogenesis, neuronal migration, axon guidance, and synaptic targeting.

    “This specificity can be regulated at various stages of neurodevelopment, including neurogenesis, neuronal migration, axon guidance, and synaptic targeting.”

    From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [86]

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Authors
Wang, M., Fan, J., & Shao, Z.
Affiliations
Fudan University (CN)
Corresponding author
Shao, Zhiyong
ORCID
Venue
Brain Sciences
Publisher
MDPI AG
Published
2024-02-02
Volume
14
Issue
2
Pages
155
ISSN
2076-3425 (ISSN-L)
DOI
10.3390/brainsci14020155
PMC
PMC10886843
OpenAlex
W4391486312
Cited by
4
References
138
Citations by year
2026: 3 · 2025: 1
FWCI
0.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (32170828, 2021YFA0909300)
  • Ministry of Science and Technology, China (32170828, 2021YFA0909300)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
postsynaptic neurons, Caenorhabditis elegans, brain development, synaptic targeting, cerebellum, hippocampus, cerebral cortex

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