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Cited by 620Neuroscience and Neuropharmacology ResearchCell Adhesion Molecules ResearchGenetics and Neurodevelopmental Disorders

Cell adhesion molecules: signalling functions at the synapse

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Dalva, Matthew B., McClelland, Andrew C., Kayser, Matthew S.·2007·Nature Reviews Neuroscience
DOI 10.1038/nrn2075PMC PMC4756920
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Abstract

Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide a mechanical link between cells. In this review, we will discuss the roles these proteins have during development and at mature synapses. Synaptic adhesion proteins participate in the formation, maturation, function and plasticity of synaptic connections. Together with conventional synaptic transmission mechanisms, these molecules are an important element in the trans-cellular communication mediated by synapses.

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  • Postsynaptic EphBs and ephrin-Bs control multiple aspects of excitatory synaptogenesis, inducing dendritic spine formation and clustering of NMDARs and AMPARs.

    “Postsynaptic EphBs and ephrin-Bs control multiple aspects of excitatory synaptogenesis, inducing dendritic spine formation and clustering of NMDARs and AMPARs [78].”

    From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [78]

    The synaptogenesis passage (indexed as Abstract; page unavailable) says that postsynaptic EphBs control excitatory synaptogenesis and that activating EphB with an ephrin-B fusion protein induces spine formation and NMDAR and AMPAR clustering. It does not attribute those same effects to postsynaptic ephrin-Bs; the paper describes ephrin-B here as the ligand used to activate EphB. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Dalva, M. B., McClelland, A. C., & Kayser, M. S.
Affiliations
  • University of Pennsylvania (US)
  • University of Pennsylvania Health System (US)
Corresponding author
Dalva, Matthew B.
ORCID
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2007-02-14
Volume
8
Issue
3
Pages
206-220
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
DOI
10.1038/nrn2075
PMC
PMC4756920
OpenAlex
W2007487855
Cited by
620
References
6
Citations by year
2026: 28 · 2025: 28 · 2024: 38 · 2023: 26 · 2022: 15 · 2021: 27 · 2020: 29 · 2019: 21 · 2018: 35 · 2017: 24 · 2016: 32 · 2015: 35 · 2014: 34 · 2013: 46 · 2012: 41
FWCI
3.21
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (R01DA022727)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
adhesion molecules, synapses, synaptic development, synaptic plasticity, synaptic transmission, synapse maturation, axons and dendrites
MeSH terms
Animals, Models, Biological, Synapses, Signal Transduction, Cell Adhesion Molecules

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