Cited by 290Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroscience and Neuropharmacology Research

Genetic and activity-dependent mechanisms underlying interneuron diversity

Wamsley, Brie, Fishell, Gord·2017·Nature Reviews Neuroscience

Abstract

The proper construction of neural circuits requires the generation of diverse cell types, their distribution to defined regions, and their specific and appropriate wiring. A major objective in neurobiology has been to understand the molecular determinants that link neural birth to terminal specification and functional connectivity, a task that is especially daunting in the case of cortical interneurons. Considerable evidence supports the idea that an interplay of intrinsic and environmental signalling is crucial to the sequential steps of interneuron specification, including migration, selection of a settling position, morphogenesis and synaptogenesis. However, when and how these influences merge to support the appropriate terminal differentiation of different classes of interneurons remains uncertain. In this Review, we discuss a wealth of recent findings that have advanced our understanding of the developmental mechanisms that contribute to the diversification of interneurons and suggest areas of particular promise for further investigation.

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Crossref · 10.1038/nrn.2017.30

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  • Interneurons are generated from progenitors located in the ventral forebrain in transient structures called ganglionic eminences and migrate tangentially to the cortex through different migratory streams.

    “Interneurons are generated from progenitors located in the ventral forebrain in transient structures called ganglionic eminences and migrate tangentially to the cortex through different migratory streams85–87.”
  • Interneuron diversity does not emerge in response to activity-dependent mechanisms in the cortex, but is established early before cells reach the cortex by specific transcriptional programs that unfold over weeks.

    “This suggests that interneuron diversity does not emerge in response to activity-dependent mechanisms in the cortex (1, 9), but rather is established early, before these cells reach the cortex, by specific transcriptional programs that then unfold over the course of several weeks.”

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Authors
Wamsley, B., & Fishell, G.
Affiliations
New York University (US)
Corresponding author
Fishell, Gord
Venue
Nature Reviews Neuroscience
Published
2017-04-06
Volume
18
Issue
5
Pages
299-309
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2604871800
Cited by
290
References
107
Citations by year
2026: 15 · 2025: 18 · 2024: 32 · 2023: 28 · 2022: 31 · 2021: 40 · 2020: 38 · 2019: 44 · 2018: 33 · 2017: 11
FWCI
5.22
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (P01NS074972, T32NS086750)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
cortical interneurons, interneuron specification, interneuron diversity, neural development, interneuron migration, functional connectivity, synaptogenesis, morphogenesis, cell fate determination
MeSH terms
Animals, Cell Differentiation, Cerebral Cortex, Humans, Interneurons, Neural Pathways, Neurogenesis

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