The DOI matches its Crossref record; 269 of the 269 references it cites were found in a registry or an index.
Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction
Open accessPublished version of a preprint
Abstract
Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, it is only relatively recently that the role of glia in these disorders has attracted attention. Detailed understanding of the glial functions in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, the specific contributions of neurotrophic factors, neuroinflammation, and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes, and synantocytes) on phenotypic manifestation of mood disorders or SUD are emphasized. In addition, use of this knowledge in the potential development of novel therapeutics is touched upon.
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Metadata
- Authors
- Tizabi, Y., Getachew, B., Hauser, S. R., Tsytsarev, V., Manhães, A. C., & da Silva, V. D. A.
- Affiliations
- Howard University (US)
- Indiana University School of Medicine (US)
- University of Maryland, Baltimore (US)
- Universidade do Estado do Rio de Janeiro (BR)
- Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador 40110-100, BA, Brazil
- Corresponding author
- Tizabi, Yousef
- ORCID
- Venue
- Brain Sciences
- Publisher
- MDPI AG
- Published
- 2024-05-30
- Volume
- 14
- Issue
- 6
- Pages
- 558
- ISSN
- 2076-3425 (ISSN-L)
- PMC
- PMC11201416
- OpenAlex
- W4399175317
- Cited by
- 27
- References
- 269
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 7
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain Sciences (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIH/NIAAA (R03AA022479, 2 SO6 GM08016-39)
- NIH/NIGMS (R03AA022479, 2 SO6 GM08016-39)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- glial cells, mood disorders, substance use disorders, drug addiction, microglia, astrocytes, oligodendrocytes, neurotrophic factors, neuroinflammation, gut microbiota, reward systems, mood regulation, new drugs
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