Cited by 27Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

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Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

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Tizabi, Yousef, Getachew, Bruk, Hauser, Sheketha R., Tsytsarev, Vassiliy, Manhães, Alex C., da Silva, Victor Diogenes Amaral·2024·Brain Sciences

DOI 10.3390/brainsci14060558PMC PMC11201416

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Abstract

Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, it is only relatively recently that the role of glia in these disorders has attracted attention. Detailed understanding of the glial functions in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, the specific contributions of neurotrophic factors, neuroinflammation, and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes, and synantocytes) on phenotypic manifestation of mood disorders or SUD are emphasized. In addition, use of this knowledge in the potential development of novel therapeutics is touched upon.

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Figure 1 Schematic diagram depicting glial–neuron interaction, disruption of which by defects in neurotrophic factors or dysbiosis of the gut microbiota may lead to neuroinflammation and major depressive disorder (MDD).CC BY · PubMed Central

Figure 2 Schematic diagram depicting glial–neuron interaction, disruption of which by defects in neurotrophic factors or dysbiosis of the gut microbiota may lead to neuroinflammation and substance use disorder (SUD).CC BY · PubMed Central

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Authors: Tizabi, Y., Getachew, B., Hauser, S. R., Tsytsarev, V., Manhães, A. C., & da Silva, V. D. A.
Affiliations: Howard University (US)
Indiana University School of Medicine (US)
University of Maryland, Baltimore (US)
Universidade do Estado do Rio de Janeiro (BR)
Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador 40110-100, BA, Brazil
Corresponding author: Tizabi, Yousef
ORCID: Tizabi, Yousef
Getachew, Bruk
Hauser, Sheketha R.
Tsytsarev, Vassiliy
Manhães, Alex C.
da Silva, Victor Diogenes Amaral
Venue: Brain Sciences
Publisher: MDPI AG
Published: 2024-05-30
Volume: 14
Issue: 6
Pages: 558
ISSN: 2076-3425 (ISSN-L)
DOI: 10.3390/brainsci14060558
PMC: PMC11201416
OpenAlex: W4399175317
Cited by: 27
References: 269
Citations by year: 2026: 4 · 2025: 16 · 2024: 7
FWCI: 1.38
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Brain Sciences (publishedVersion, cc-by)
Preprints.org (acceptedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
IUScholarWorks (Indiana University) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: NIH/NIAAA (R03AA022479, 2 SO6 GM08016-39)
NIH/NIGMS (R03AA022479, 2 SO6 GM08016-39)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: glial cells, mood disorders, substance use disorders, drug addiction, microglia, astrocytes, oligodendrocytes, neurotrophic factors, neuroinflammation, gut microbiota, reward systems, mood regulation, new drugs

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Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

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