Cited by 392Physical Activity and HealthNeurotransmitter Receptor Influence on BehaviorExercise and Physiological Responses

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Exercise Benefits Brain Function: The Monoamine Connection

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Lin, Tzu-Wei, Kuo, Yu-Min·2013·Brain Sciences

DOI 10.3390/brainsci3010039PMC PMC4061837

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Abstract

The beneficial effects of exercise on brain function have been demonstrated in animal models and in a growing number of clinical studies on humans. There are multiple mechanisms that account for the brain-enhancing effects of exercise, including neuroinflammation, vascularization, antioxidation, energy adaptation, and regulations on neurotrophic factors and neurotransmitters. Dopamine (DA), noradrenaline (NE), and serotonin (5-HT) are the three major monoamine neurotransmitters that are known to be modulated by exercise. This review focuses on how these three neurotransmitters contribute to exercise affecting brain function and how it can work against neurological disorders.

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Authors: Lin, T.-W., & Kuo, Y.-M.
Affiliations: National Cheng Kung University (TW)
Corresponding author: Kuo, Yu-Min
ORCID: Lin, Tzu-Wei
Kuo, Yu-Min
Venue: Brain Sciences
Publisher: MDPI AG
Published: 2013-01-11
Volume: 3
Issue: 1
Pages: 39-53
ISSN: 2076-3425 (ISSN-L)
DOI: 10.3390/brainsci3010039
PMC: PMC4061837
OpenAlex: W2153823980
Cited by: 392
References: 141
Citations by year: 2026: 33 · 2025: 54 · 2024: 48 · 2023: 58 · 2022: 55 · 2021: 33 · 2020: 35 · 2019: 24 · 2018: 13 · 2017: 13 · 2016: 7 · 2015: 8 · 2014: 8
FWCI: 5.34
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Brain Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: physical activity, brain function, monoamines, dopamine, norepinephrine, serotonin, neuroinflammation, neurotrophic factors, neurotransmitters, neurological disorders

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Exercise Benefits Brain Function: The Monoamine Connection

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