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Exercise Benefits Brain Function: The Monoamine Connection
Open accessAbstract
The beneficial effects of exercise on brain function have been demonstrated in animal models and in a growing number of clinical studies on humans. There are multiple mechanisms that account for the brain-enhancing effects of exercise, including neuroinflammation, vascularization, antioxidation, energy adaptation, and regulations on neurotrophic factors and neurotransmitters. Dopamine (DA), noradrenaline (NE), and serotonin (5-HT) are the three major monoamine neurotransmitters that are known to be modulated by exercise. This review focuses on how these three neurotransmitters contribute to exercise affecting brain function and how it can work against neurological disorders.
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Metadata
- Authors
- Lin, T.-W., & Kuo, Y.-M.
- Affiliations
- National Cheng Kung University (TW)
- Corresponding author
- Kuo, Yu-Min
- Venue
- Brain Sciences
- Publisher
- MDPI AG
- Published
- 2013-01-11
- Volume
- 3
- Issue
- 1
- Pages
- 39-53
- ISSN
- 2076-3425 (ISSN-L)
- PMC
- PMC4061837
- OpenAlex
- W2153823980
- Cited by
- 392
- References
- 141
- Citations by year
- 2026: 33 · 2025: 54 · 2024: 48 · 2023: 58 · 2022: 55 · 2021: 33 · 2020: 35 · 2019: 24 · 2018: 13 · 2017: 13 · 2016: 7 · 2015: 8 · 2014: 8
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- physical activity, brain function, monoamines, dopamine, norepinephrine, serotonin, neuroinflammation, neurotrophic factors, neurotransmitters, neurological disorders
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