The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer
Open accessAbstract
It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter- and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral–gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral–gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral–gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment.
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Cites
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Cited by
Oral microbiome: a review of its impact on oral and systemic health
Rajasekaran, J. J., Krishnamurthy, H. K., Bosco, J., Jayaraman, V., Krishna, K., Wang, T., & Bei, K. (2024) · Microorganisms · doi:10.3390/microorganisms12091797 · Cited by 272
Promising dawn in tumor microenvironment therapy: engineering oral bacteria
Wang, Z., Sun, W., Hua, R., Wang, Y., Li, Y., & Zhang, H. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00282-3 · Cited by 97
Deciphering mechanisms and implications of bacterial translocation in human health and disease
Jin, S., Wetzel, D., & Schirmer, M. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102147 · Cited by 39
Dumitru, C. N., Dumitru, A. O., Popa, G. V., Marcu, T., Ursu, M., Nechita, A., & Matei, N. M. (2026) · Dentistry Journal · doi:10.3390/dj14050289 · Cited by 6
Metadata
- Authors
- Park, S.-Y., Hwang, B.-O., Lim, M., Ok, S.-H., Lee, S.-K., Chun, K.-S., Park, K.-K., Hu, Y., Chung, W.-Y., & Song, N.-Y.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2021-04-28
- Volume
- 13
- Issue
- 9
- Pages
- 2124
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W3145608327
- Cited by
- 232
- References
- 55
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- Park, S.-Y., Hwang, B.-O., Lim, M., Ok, S.-H., Lee, S.-K., Chun, K.-S., Park, K.-K., Hu, Y., Chung, W.-Y., & Song, N.-Y. (2021). Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer. Cancers. https://doi.org/10.3390/cancers13092124
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