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Neuroprotective Natural Products for Alzheimer’s Disease
Open accessAbstract
Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This review mainly focuses on the possible neuroprotective mechanisms from natural products that may be beneficial in AD treatment and the natural product mixtures or extracts from different sources that have demonstrated neuroprotective activity in preclinical and/or clinical studies. It is believed that natural product mixtures or extracts containing multiple bioactive compounds that can work additively or synergistically to exhibit multiple neuroprotective mechanisms might be an effective approach in AD drug discovery.
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“such evidence allows us to project a scenario where AD could have possible preventive treatments and/or have a slowing palliative effect in patients who already suffer from it [73,74,75].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [73]
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“Mixtures of drugs or plant extracts might have advantages over single drugs as they can impact different targets simultaneously, which could be a novel and more effective treatment option for AD (Chen et al., 2021).”
From Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease (2022) · cites this paper as Chen et al., 2021
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“Consequently, although the use of some herbs, such as those of C. longa and B. monnieri, have demonstrated slight clinical improvements, many natural products such as polyphenols remain of interest in the treatment of neurodegenerative disorders [203].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [203]
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Metadata
- Authors
- Chen, X., Drew, J., Berney, W., & Lei, W.
- Affiliations
- Campbell University (US)
- Presbyterian College (US)
- Corresponding author
- Chen, Xin
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2021-05-25
- Volume
- 10
- Issue
- 6
- Pages
- 1309
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC8225186
- OpenAlex
- W3165481569
- Cited by
- 236
- References
- 314
- Citations by year
- 2026: 41 · 2025: 53 · 2024: 54 · 2023: 54 · 2022: 30 · 2021: 4
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, neuroprotection, natural products, natural product mixtures, plant extracts, neuroprotection mechanism
- MeSH terms
- Alzheimer Disease, Animals, Biological Products, Humans, Neuroprotective Agents, Drug Discovery
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