Cited by 236Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

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Neuroprotective Natural Products for Alzheimer’s Disease

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Chen, Xin, Drew, Joshua, Berney, Wren, Lei, Wei·2021·Cells

DOI 10.3390/cells10061309PMC PMC8225186

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Abstract

Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This review mainly focuses on the possible neuroprotective mechanisms from natural products that may be beneficial in AD treatment and the natural product mixtures or extracts from different sources that have demonstrated neuroprotective activity in preclinical and/or clinical studies. It is believed that natural product mixtures or extracts containing multiple bioactive compounds that can work additively or synergistically to exhibit multiple neuroprotective mechanisms might be an effective approach in AD drug discovery.

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Campos, M.R.S. (2019). Chapter 2—Phenolic Compounds: Structure, Classification, and Antioxidant Power. Bioactive Compounds, Woodhead Publishing.

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Authors: Chen, X., Drew, J., Berney, W., & Lei, W.
Affiliations: Campbell University (US)
Presbyterian College (US)
Corresponding author: Chen, Xin
ORCID: Chen, Xin
Lei, Wei
Venue: Cells
Publisher: MDPI AG
Published: 2021-05-25
Volume: 10
Issue: 6
Pages: 1309
ISSN: 2073-4409 (ISSN-L)
DOI: 10.3390/cells10061309
PMC: PMC8225186
OpenAlex: W3165481569
Cited by: 236
References: 314
Citations by year: 2026: 41 · 2025: 53 · 2024: 54 · 2023: 54 · 2022: 30 · 2021: 4
FWCI: 8.15
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cells (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: Alzheimer's disease, neuroprotection, natural products, natural product mixtures, plant extracts, neuroprotection mechanism
MeSH terms: Alzheimer Disease, Animals, Biological Products, Humans, Neuroprotective Agents, Drug Discovery

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Neuroprotective Natural Products for Alzheimer’s Disease

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