Bridging neurotrophic factors and bioactive peptides to Alzheimer’s disease

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Amyloid Beta: Structure, Biology and Structure-Based Therapeutic Development

Chen, G.-F., Xu, T.-H., Yan, Y., Zhou, Y.-R., Jiang, Y., Melcher, K., & Xu, H. E. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.28 · Cited by 1,965 · see citing works

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577 · see citing works

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity

Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359 · see citing works

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173 · see citing works

Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer

Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991 · see citing works

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Gonçalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0275-4 · Cited by 935 · see citing works

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel, N. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14116 · Cited by 893 · see citing works

Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease

Bai, R., Guo, J., Ye, X.-Y., Xie, Y., & Xie, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101619 · Cited by 813 · see citing works

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., Kim, E., Rompala, A., Oram, M. K., Asselin, C., et al. (2018) · Science · doi:10.1126/science.aan8821 · Cited by 802 · see citing works

The cost of Alzheimer's disease in China and re‐estimation of costs worldwide

Jia, J., Wei, C., Chen, S., Li, F., Tang, Y., Qin, W., Zhao, L., Jin, H., Xu, H., Wang, F., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.12.006 · Cited by 752 · see citing works

Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer’s disease

Peng, S., Wuu, J., Mufson, E. J., & Fahnestock, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03135.x · Cited by 691 · see citing works

Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism

Kumar, K. G., Trevaskis, J. L., Lam, D. D., Sutton, G. M., Koza, R. A., Chouljenko, V. N., Kousoulas, K. G., Rogers, P. M., Kesterson, R. A., Thearle, M. S., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.011 · Cited by 511 · see citing works

Amyloid toxicity in Alzheimer’s disease

Reiss, A. B., Arain, H. A., Stecker, M. M., Siegart, N. M., & Kasselman, L. J. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0063 · Cited by 447 · see citing works

Decreased Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Patients with Alzheimer’s Disease (AD): A Systematic Review and Meta-Analysis

Ng, T. K. S., Ho, C. S. H., Tam, W., Kua, E. H., & Ho, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020257 · Cited by 419 · see citing works

Regulation of hippocampal synaptic plasticity by BDNF

Leal, G., Afonso, P. M., Salazar, I. L., & Duarte, C. B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.019 · Cited by 410 · see citing works

Exercise hormone irisin is a critical regulator of cognitive function

Islam, M. R., Valaris, S., Young, M. F., Haley, E. B., Luo, R., Bond, S. F., Mazuera, S., Kitchen, R. R., Caldarone, B. J., Bettio, L. E. B., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00438-z · Cited by 403 · see citing works

Neuro-inflammation and anti-inflammatory treatment options for Alzheimer’s disease

Ozben, T., & Ozben, S. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2019.04.001 · Cited by 381 · see citing works

The complexity of tau in Alzheimer’s disease

Naseri, N. N., Wang, H., Guo, J. D., Sharma, M., & Luo, W. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.022 · Cited by 374 · see citing works

Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies

Han, L., & Jiang, C. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.11.023 · Cited by 358 · see citing works

Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases

Numakawa, T., Odaka, H., & Adachi, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113650 · Cited by 355 · see citing works

Plaque formation and the intraneuronal accumulation of β‐amyloid in Alzheimer's disease

Takahashi, R. H., Nagao, T., & Gouras, G. K. (2017) · Pathology International · doi:10.1111/pin.12520 · Cited by 354 · see citing works

Autocrine BDNF-TrkB signalling within a single dendritic spine

Harward, S. C., Hedrick, N. G., Hall, C. E., Parra-Bueno, P., Milner, T. A., Pan, E., Laviv, T., Hempstead, B. L., Yasuda, R., & McNamara, J. O. (2016) · Nature · doi:10.1038/nature19766 · Cited by 325 · see citing works

BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission

Waterhouse, E. G., An, J. J., Orefice, L. L., Baydyuk, M., Liao, G.-Y., Zheng, K., Lu, B., & Xu, B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0709-12.2012 · Cited by 287 · see citing works

Exercise sustains the hallmarks of health

Qiu, Y., Fernández-García, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otín, C., & Xiao, J. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.10.003 · Cited by 270 · see citing works

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway

Luo, H., Xiang, Y., Qu, X., Liu, H., Liu, C., Li, G., Han, L., & Qin, X. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00395 · Cited by 268 · see citing works

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

Wang, Z.-H., Xiang, J., Liu, X., Yu, S. P., Manfredsson, F. P., Sandoval, I. M., Wu, S., Wang, J.-Z., & Ye, K. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.054 · Cited by 238 · see citing works

Neuroprotective Natural Products for Alzheimer’s Disease

Chen, X., Drew, J., Berney, W., & Lei, W. (2021) · Cells · doi:10.3390/cells10061309 · Cited by 236 · see citing works

Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

Brown, B. M., Peiffer, J. J., Taddei, K., Lui, J. K., Laws, S. M., Gupta, V. B., Taddei, T., Ward, V. K., Rodrigues, M. A., Burnham, S., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.107 · Cited by 235 · see citing works

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Macdonald, R., Barnes, K., Hastings, C., & Mortiboys, H. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170501 · Cited by 216 · see citing works

Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease

Kirouac, L., Rajic, A. J., Cribbs, D. H., & Padmanabhan, J. (2017) · eneuro · doi:10.1523/eneuro.0149-16.2017 · Cited by 207 · see citing works

Melatonin Rescue Oxidative Stress-Mediated Neuroinflammation/ Neurodegeneration and Memory Impairment in Scopolamine-Induced Amnesia Mice Model

Muhammad, T., Ali, T., Ikram, M. A., Khan, A., Alam, S. I., & Kim, M. O. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9824-3 · Cited by 201 · see citing works

Conditional BDNF delivery from astrocytes rescues memory deficits, spine density and synaptic properties in the 5xFAD mouse model of Alzheimer disease

de Pins, B., Cifuentes-Díaz, C., Farah, A. T., López-Molina, L., Montalban, E., Sancho‐Balsells, A., López, A. V., Ginés, S., Delgado-Garcia, J. M., Alberch, J., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2121-18.2019 · Cited by 197 · see citing works

Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer’s dementia

Wang, R., & Holsinger, R. M. D. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.10.002 · Cited by 194 · see citing works

<scp>BDNF</scp> isoforms: a round trip ticket between neurogenesis and serotonin?

Foltran, R. B., & Diaz, S. L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13658 · Cited by 187 · see citing works

Exercise and BDNF reduce Aβ production by enhancing α‐secretase processing of APP

Nigam, S. M., Xu, S., Kritikou, J. S., Marosi, K., Brodin, L., & Mattson, M. P. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14034 · Cited by 186 · see citing works

Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease

Chen, C., Yang, C., Wang, J., Huang, X., Yu, H., Li, S., Li, S., Zhang, Z., Liu, J., Yang, X., et al. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12774 · Cited by 183 · see citing works

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

Pickett, E. K., Herrmann, A. G., McQueen, J., Abt, K., Dando, O., Tulloch, J., Jain, P., Dunnett, S., Sohrabi, S., Fjeldstad, M. P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.044 · Cited by 179 · see citing works

Cellular and molecular mechanisms regulating neuronal growth by brain‐derived neurotrophic factor

González‐Gutiérrez, A., Moya‐Alvarado, G., González-Billault, C. E., & Bronfman, F. C. (2016) · Cytoskeleton · doi:10.1002/cm.21312 · Cited by 154 · see citing works

The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer’s disease

Wu, H., Dunnett, S. L., Ho, J. Y. S., & Chang, R. C. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100764 · Cited by 151 · see citing works

Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease

Wang, M., Zhang, H., Liang, J., Huang, J., & Chen, N. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02753-6 · Cited by 149 · see citing works

Review: Apelin in disease

Antushevich, H., & Wójcik, M. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.05.012 · Cited by 148 · see citing works

Inhibitory Effects of Walnut ( Juglans regia ) Peptides on Neuroinflammation and Oxidative Stress in Lipopolysaccharide-Induced Cognitive Impairment Mice

Wang, S., Zheng, L. P., Zhao, T., Zhang, Q., Liu, Y., Sun, B., Su, G., & Zhao, M. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07670 · Cited by 142 · see citing works

Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction

Cefis, M., Chaney, R., Wirtz, J., Méloux, A., Quirié, A., Leger, C., Prigent‐Tessier, A., & Garnier, P. E. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1275924 · Cited by 130 · see citing works

Portal Absorption of Small Peptides in Rats under Unrestrained Conditions

Hara, H., Funabiki, R., Iwata, M., & Yamazaki, K. (1984) · Journal of Nutrition · doi:10.1093/jn/114.6.1122 · Cited by 129 · see citing works

Adropin Is a Brain Membrane-bound Protein Regulating Physical Activity via the NB-3/Notch Signaling Pathway in Mice

Wong, C., Wang, Y., Lee, J. T. H., Huang, Z. P., Wu, D., Xu, A., & Lam, K. S. L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.576058 · Cited by 127 · see citing works

Exercise-induced oxidative stress and melatonin supplementation: current evidence

Kruk, J., Aboul-Enein, B., & Duchnik, E. (2021) · Journal of Physiological Sciences · doi:10.1186/s12576-021-00812-2 · Cited by 125 · see citing works

Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer’s disease

Chen, S., Chen, S., Sun, Y., Xu, Z., Wang, Y., Yao, S., Yao, W., & Gao, X. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101133 · Cited by 119 · see citing works

Amyloid‐β protein (Aβ) Glu11 is the major β‐secretase site of β‐site amyloid‐β precursor protein‐cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis

Deng, Y., Wang, Z., Wang, R., Zhang, X., Zhang, S., Wu, Y., Staufenbiel, M., Cai, F., & Song, W. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12235 · Cited by 108 · see citing works

NGF steers microglia toward a neuroprotective phenotype

Rizzi, C., Tiberi, A., Giustizieri, M., Marrone, M. C., Gobbo, F., Carucci, N. M., Meli, G., Arisi, I., D’Onofrio, M., Marinelli, S., et al. (2018) · Glia · doi:10.1002/glia.23312 · Cited by 103 · see citing works

Walnut‐Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice

Wang, M., Amakye, W. K., Guo, L., Gong, C., Zhao, Y., Yao, M., & Ren, J. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900326 · Cited by 99 · see citing works

ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels

Ioannou, M. S., & Fahnestock, M. L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030599 · Cited by 93 · see citing works

High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair

Conroy, J. N., & Coulson, E. J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101568 · Cited by 93 · see citing works

Walnut (Juglans regia) Peptides Reverse Sleep Deprivation-Induced Memory Impairment in Rat via Alleviating Oxidative Stress

Wang, S., Su, G., Zhang, Q., Zhao, T., Liu, Y., Zheng, L. P., & Zhao, M. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03884 · Cited by 91 · see citing works

Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process

Zhang, H., Wu, X., Liang, J., Kirberger, M., & Chen, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101680 · Cited by 88 · see citing works

Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis

Cui, L., Hou, N.-N., Wu, H., Zuo, X., Lian, Y.-Z., Zhang, C., Wang, Z., Zhang, X., & Zhu, J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.603854 · Cited by 88 · see citing works

Melatonin levels in the Alzheimer’s disease continuum: a systematic review

Nous, A., Engelborghs, S., & Smolders, I. J. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00788-6 · Cited by 87 · see citing works

Potential mechanisms mediating the protective effects of a peptide from walnut ( Juglans mandshurica Maxim.) against hydrogen peroxide induced neurotoxicity in PC12 cells

Liu, C., Guo, Y., Zhao, F., Qin, H., Lu, H., Li, F., Wang, J., & Min, W. (2019) · Food & Function · doi:10.1039/c8fo02557f · Cited by 84 · see citing works

Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility

Li, C., McManus, F. P., Plutoni, C., Pascariu, C. M., Nelson, T., Delsin, L. E. A., Emery, G., & Thibault, P. (2020) · Nature Communications · doi:10.1038/s41467-020-14581-w · Cited by 81 · see citing works

Serum BDNF as a Potential Biomarker of Alzheimer's Disease: Verification Through Assessment of Serum, Cerebrospinal Fluid, and Medial Temporal Lobe Atrophy

Mori, Y., Tsuji, M., Oguchi, T., Kasuga, K., Kimura, A., Futamura, A., Sugimoto, A., Kasai, H., Kuroda, T., Yano, S., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.653267 · Cited by 80 · see citing works

Walnut-Derived Peptide Activates PINK1 via the NRF2/KEAP1/HO-1 Pathway, Promotes Mitophagy, and Alleviates Learning and Memory Impairments in a Mice Model

Zhao, F., Liu, C., Fang, L., Lu, H., Wang, J., Gao, Y., Gabbianelli, R., & Min, W. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07546 · Cited by 78 · see citing works

Neuroprotection by Walnut-Derived Peptides through Autophagy Promotion via Akt/mTOR Signaling Pathway against Oxidative Stress in PC12 Cells

Zhao, F., Wang, J., Lu, H., Li, F., Qin, H., Liu, C., & Min, W. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b08252 · Cited by 77 · see citing works

Protective role of Apelin-13 on amyloid β25–35-induced memory deficit; Involvement of autophagy and apoptosis process

Aminyavari, S., Zahmatkesh, M., Farahmandfar, M., Khodagholi, F., Dargahi, L., & Zarrindast, M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.005 · Cited by 74 · see citing works

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

Triaca, V., Sposato, V., Bolasco, G., Ciotti, M. T., Pelicci, P., Bruni, A. C., Cupidi, C., Maletta, R., Feligioni, M., Nisticò, R., et al. (2016) · Aging Cell · doi:10.1111/acel.12473 · Cited by 73 · see citing works

Neuroprotective Function of a Novel Hexapeptide QMDDQ from Shrimp via Activation of the PKA/CREB/BNDF Signaling Pathway and Its Structure–Activity Relationship

Wu, D., Zhang, S., Sun, N., Zhu, B., & Lin, S. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c02689 · Cited by 70 · see citing works

Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease

Chen, D., Lan, G., Li, R., Mei, Y., Shui, X., Gu, X., Wang, L., Zhang, T., Gan, C., Xia, Y., et al. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00302-4 · Cited by 68 · see citing works

Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology

Ginsberg, S. D., Malek-Ahmadi, M., Alldred, M. J., Chen, Y.-H., Chen, K.-W., Chao, M., Counts, S., & Mufson, E. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104540 · Cited by 68 · see citing works

Melatonin regulates the transcription of βAPP‐cleaving secretases mediated through melatonin receptors in human neuroblastoma SH‐SY5Y cells

Panmanee, J., Nopparat, C., Chavanich, N., Shukla, M., Mukda, S., Song, W., Vincent, B., & Govitrapong, P. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12260 · Cited by 68 · see citing works

The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease

Pentz, R., Iulita, M. F., Ducatenzeiler, A., Bennett, D. A., & Cuello, A. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-0797-2 · Cited by 68 · see citing works

Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies

Xiang, J., Wang, Z.-H., Ahn, E. H., Liu, X., Yu, S.-P., Manfredsson, F. P., Sandoval, I. M., Ju, G., Wu, S., & Ye, K. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901348116 · Cited by 67 · see citing works

Aluminum chloride-induced amyloid β accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin

Promyo, K., Iqbal, F., Chaidee, N., & Chetsawang, B. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111829 · Cited by 63 · see citing works

Melatonin protects against A β ‐induced neurotoxicity in primary neurons via miR‐132/PTEN/AKT/FOXO3a pathway

Zhao, Y., Zhao, R., Wu, J., Wang, Q., Pang, K., Shi, Q., Gao, Q., Hu, Y., Dong, X., Zhang, J., et al. (2018) · BioFactors · doi:10.1002/biof.1411 · Cited by 61 · see citing works

Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease

Chen, D., Mei, Y., Kim, N., Lan, G., Gan, C., Fan, F., Zhang, T., Xia, Y., Wang, L., Lin, C., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12665 · Cited by 59 · see citing works

Fermented rice peptides attenuate scopolamine-induced memory impairment in mice by regulating neurotrophic signaling pathways in the hippocampus

Corpuz, H. M., Fujii, H., Nakamura, S., & Katayama, S. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146322 · Cited by 57 · see citing works

Melatonin improves cognitive function by suppressing endoplasmic reticulum stress and promoting synaptic plasticity during chronic cerebral hypoperfusion in rats

Thangwong, P., Jearjaroen, P., Govitrapong, P., Tocharus, C., & Tocharus, J. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114980 · Cited by 55 · see citing works

The memory improving effects of round scad ( Decapterus maruadsi ) hydrolysates on sleep deprivation-induced memory deficits in rats via antioxidant and neurotrophic pathways

Zhang, Q., Su, G., Zhao, T., Wang, S., Sun, B., Zheng, L. P., & Zhao, M. (2019) · Food & Function · doi:10.1039/c9fo00855a · Cited by 54 · see citing works

BDNF inhibits neurodegenerative disease–associated asparaginyl endopeptidase activity via phosphorylation by AKT

Wang, Z.-H., Wu, W., Kang, S. S., Liu, X., Wu, Z., Peng, J., Yu, S. P., Manfredsson, F. P., Sandoval, I. M., Liu, X., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99007 · Cited by 52 · see citing works

Soybean-Derived Glycine–Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain

Shimizu, A., Mitani, T., Tanaka, S., Fujii, H., Maebuchi, M., Amiya, Y., Tanaka, M., Matsui, T., Nakamura, S., & Katayama, S. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b01581 · Cited by 51 · see citing works

Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913

Chen, X., Peng, M., Li, J., Tang, B.-L., Shao, X., Zhao, F., Liu, C., Zhang, X., Li, P., Shi, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15971-9 · Cited by 51 · see citing works

Key Peptides and Proteins in Alzheimer’s Disease

Penke, B., Bogár, F., Paragi, G., Gera, J., & Fülöp, L. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190103123434 · Cited by 50 · see citing works

Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease

Liao, J., Chen, C., Ahn, E. H., Liu, X., Li, H., Edgington‐Mitchell, L. E., Lu, Z., Ming, S., & Ye, K. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108737 · Cited by 50 · see citing works

Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons

Latina, V., Caioli, S., Zona, C., Ciotti, M. T., Amadoro, G., & Calissano, P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00068 · Cited by 50 · see citing works

Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway

Dezfouli, M. A., Zahmatkesh, M., Farahmandfar, M., & Khodagholi, F. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.02.016 · Cited by 49 · see citing works

Stability towards the gastrointestinal simulated digestion and bioactivity of PAYCS and its digestive product PAY with cognitive improving properties

Zhao, T., Zheng, L. P., Zhang, Q., Wang, S., Zhao, Q., Su, G., & Zhao, M. (2019) · Food & Function · doi:10.1039/c8fo02314j · Cited by 49 · see citing works

Intranasal delivery of BDNF rescues memory deficits in AD11 mice and reduces brain microgliosis

Braschi, C., Capsoni, S., Narducci, R., Poli, A., Sansevero, G., Brandi, R., Maffei, L., Cattaneo, A., & Berardi, N. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01646-5 · Cited by 49 · see citing works

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons

Afonso, P. M., Luca, P. D., Carvalho, R. D. S., Cortes, L., Pinheiro, P. S., Oliveiros, B., Almeida, R. D., Mele, M., & Duarte, C. B. (2019) · Science Signaling · doi:10.1126/scisignal.aav3577 · Cited by 47 · see citing works

The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation

Eu, W. Z., Chen, Y., Chen, W., Wu, K., Tsai, C., Cheng, S., Carter, R. N., & Huang, G. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01280-3 · Cited by 47 · see citing works

Long-term oral melatonin alleviates memory deficits, reduces amyloid-β deposition associated with downregulation of BACE1 and mitophagy in APP/PS1 transgenic mice

Sun, C., Qiu, X., Wang, Y., Liu, J., Li, Q., Jiang, H., Li, S., & Song, C. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135192 · Cited by 46 · see citing works

Neuroprotective Activity of Melittin—The Main Component of Bee Venom—Against Oxidative Stress Induced by Aβ25–35 in In Vitro and In Vivo Models

Nguyen, C. D., & Lee, G. (2021) · Antioxidants · doi:10.3390/antiox10111654 · Cited by 46 · see citing works

Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia

Xu, L., Dong, W., Zhao, J., & Xu, Y. (2015) · Marine Drugs · doi:10.3390/md13063653 · Cited by 46 · see citing works

Walnut-Derived Peptide Enhances Mitophagy via JNK-Mediated PINK1 Activation to Reduce Oxidative Stress in HT-22 Cells

Yang, J., Fang, L., Lu, H., Liu, C., Wang, J., Wu, D., & Min, W. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c00005 · Cited by 46 · see citing works

Innate Immunity and Cell Death in Alzheimer’s Disease

Lee, S., Cho, H., & Ryu, J. (2021) · ASN NEURO · doi:10.1177/17590914211051908 · Cited by 43 · see citing works

Apelin-13 regulates LPS-induced N9 microglia polarization involving STAT3 signaling pathway

Zhou, S., Guo, X., Chen, S., Xu, Z., Duan, W., & Zeng, B. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101938 · Cited by 43 · see citing works

Arginine-Containing Peptides Derived from Walnut Protein Against Cognitive and Memory Impairment in Scopolamine-Induced Zebrafish: Design, Release, and Neuroprotection

Wang, S., Su, G., Fan, J., Xiao, Z., Zheng, L. P., Zhao, M., & Wu, J. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05104 · Cited by 43 · see citing works

TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies

Xia, Y., Wang, Z.-H., Liu, P., Edgington‐Mitchell, L. E., Liu, X., Wang, X., & Ye, K. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00863-8 · Cited by 42 · see citing works

Effect and mechanism of oyster hydrolytic peptides on spatial learning and memory in mice

Wang, X., Yu, H., Xing, R., Liu, S., Chen, X., & Li, P. (2018) · RSC Advances · doi:10.1039/c7ra13139a · Cited by 38 · see citing works

Protective Effects of Fibroblast Growth Factor 21 Against Amyloid-Beta1–42-Induced Toxicity in SH-SY5Y Cells

Amiri, M., Braidy, N., & Aminzadeh, M. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9914-2 · Cited by 38 · see citing works

Exogenous Bioactive Peptides Have a Potential Therapeutic Role in Delaying Aging in Rodent Models

Wang, J., Wu, Y., Chen, Z., Chen, Y., Lin, Q., & Liang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031421 · Cited by 38 · see citing works

Neuroprotective effects of two selenium-containing peptides, TSeMMM and SeMDPGQQ, derived from selenium-enriched rice protein hydrolysates on Pb2+-induced oxidative stress in HT22 cells

Wu, J., Li, P., Shi, Y., Fang, Y., Zhu, Y., Fan, F., Pei, F., Xia, J., Xie, M., & Hu, Q. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110932 · Cited by 37 · see citing works

Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats

Kamsrijai, U., Wongchitrat, P., Nopparat, C., Satayavivad, J., & Govitrapong, P. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104601 · Cited by 35 · see citing works

Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons

Allard, S. T. M., Jacobs, M. L., Carmo, S. D., & Cuello, A. C. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.002 · Cited by 34 · see citing works

Protective effects of melatonin on mitochondrial biogenesis and mitochondrial structure and function in the HEK293-APPswe cell model of Alzheimer's disease.

Cf, W., Cy, S., Wang, X., Ly, H., Ding, M., Yang, H., Wang, P., Ll, X., Zh, X., & Jz, B. (2019) · PubMed · doi:10.26355/eurrev_201904_17723 · Cited by 34 · see citing works

Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation

Liu, Y., Hsu, W., Ma, Y., & Lee, E. H. Y. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.09.003 · Cited by 34 · see citing works

Effect of oral and intraperitoneal administration of walnut-derived pentapeptide PW5 on cognitive impairments in APPSWE/PS1ΔE9 mice

Wang, M., Amakye, W. K., Gong, C., Ren, Z., Yuan, E., & Ren, J. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.01.003 · Cited by 33 · see citing works

Elevated Levels of miR-144-3p Induce Cholinergic Degeneration by Impairing the Maturation of NGF in Alzheimer’s Disease

Zhou, L., Zhang, J., Tan, L., Huang, H., Zhou, Y., Liu, Z., Lu, Y., Zhu, L., Yao, C., & Liu, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.667412 · Cited by 33 · see citing works

Deer antler extracts reduce amyloid-beta toxicity in a Caenorhabditis elegans model of Alzheimer's disease

Du, F., Zhao, H., Yao, M., Yang, Y., Jiao, J., & Li, C. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114850 · Cited by 32 · see citing works

Anxiolytic impact of Apelin-13 in a rat model of Alzheimer's disease: Involvement of glucocorticoid receptor and FKBP5

Aminyavari, S., Zahmatkesh, M., Khodagholi, F., & Sanati, M. (2019) · Peptides · doi:10.1016/j.peptides.2019.170102 · Cited by 30 · see citing works

GPETAFLR, a peptide from Lupinus angustifolius L. prevents inflammation in microglial cells and confers neuroprotection in brain

Lemus‐Conejo, A., Millán-Linares, M. C., Toscano, R., Millán, F., Pedroche, J., Muriana, F. J. G., & la Paz, S. M. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1763058 · Cited by 30 · see citing works

Amelioration of walnut-derived novel peptides against d -galactose-induced cognitive impairment by modulating the gut microbiota composition

Li, T., Lin, L., Li, C., Zheng, J., Chen, B., Shen, Y., & Ren, D. (2023) · Food & Function · doi:10.1039/d2fo03775k · Cited by 30 · see citing works

Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease

Proulx, É., Fraser, P. E., McLaurin, J., & Lambe, E. K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4501-14.2015 · Cited by 29 · see citing works

Melatonin Ameliorates the Progression of Alzheimer’s Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity

Li, F., Xie, Z., Wang, X., Xu, Y., Xiao, Z., Xiaoyan, Z., Jieke, Y., & Lai, C. (2022) · BioMed Research International · doi:10.1155/2022/8099459 · Cited by 29 · see citing works

Neurotropin reduces memory impairment and neuroinflammation via BDNF/NF-κB in a transgenic mouse model of Alzheimer's disease.

Fang, W., Liao, W., Zheng, Y., Huang, X., Weng, X., Fan, S., Chen, X., Zhang, X., Chen, J., Xiao, S., et al. (2019) · Europe PMC (PubMed Central) · Cited by 28 · see citing works

Apelin attenuates streptozotocin-induced learning and memory impairment by modulating necroptosis signaling pathway

Nasseri, B., Zareian, P., & Alizade, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106546 · Cited by 28 · see citing works

Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling

Chen, B., Wu, J., Hu, S. H., Liu, Q., Yang, H., & You, Y. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03844-1 · Cited by 27 · see citing works

Effects of adropin on learning and memory in rats tested in the Morris water maze

Ozkan, A., Aslan, M., Sinen, O., Munzuroğlu, M., Derin, N., Parlak, H., Bulbul, M., & Agar, A. (2021) · Hippocampus · doi:10.1002/hipo.23403 · Cited by 27 · see citing works

Brain-Derived Neurotrophic Factor (BDNF) Preserves the Functional Integrity of Neural Networks in the β-Amyloidopathy Model in vitro

Mitroshina, Е. V., Yarkov, R. S., Mishchenko, T. A., Krut’, V. G., Gavrish, M. S., Epifanova, E. A., Babaev, A. A., & Vedunova, M. V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00582 · Cited by 26 · see citing works

NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

Latina, V., Caioli, S., Zona, C., Ciotti, M. T., Borreca, A., Calissano, P., & Amadoro, G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00487 · Cited by 26 · see citing works

A Review of Techniques for Biodelivery of Nerve Growth Factor (NGF) to the Brain in Relation to Alzheimer’s Disease

Mitra, S., Gera, R., Linderoth, B., Lind, G., Wahlberg, L. U., Almqvist, P. M., Behbahani, H., & Eriksdotter, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-74046-7_11 · Cited by 25 · see citing works

NGF but not BDNF overexpression protects hippocampal LTP from beta-amyloid-induced impairment

Ivanov, A. D., Тухбатова, Г. Р., Salozhin, S. V., & Markevich, V. A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.063 · Cited by 23 · see citing works

Mechanisms of melatonin binding and destabilizing the protofilament and filament of tau R3–R4 domains revealed by molecular dynamics simulation

Zhu, L., Gong, Y., Lju, H., Sun, G., Zhang, Q., & Qian, Z. (2021) · Physical Chemistry Chemical Physics · doi:10.1039/d1cp03142b · Cited by 23 · see citing works

Apamin Improves Prefrontal Nicotinic Impairment in Mouse Model of Alzheimer’s Disease

Proulx, É., Power, S. K., Oliver, D. K., Sargin, D., McLaurin, J., & Lambe, E. K. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz107 · Cited by 23 · see citing works

Apelin-13 protects human neuroblastoma SH-SY5Y cells against amyloid-beta induced neurotoxicity: Involvement of anti oxidant and anti apoptotic properties

Samandari-Bahraseman, M. R., & Elyasi, L. (2021) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2020-0294 · Cited by 23 · see citing works

Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer’s disease

Bi, J., Lai, H., Wang, P., Sui, H., Li, X., & Bai, L. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.295349 · Cited by 23 · see citing works

BDNF Induced Translation of Limk1 in Developing Neurons Regulates Dendrite Growth by Fine-Tuning Cofilin1 Activity

Ravindran, S., Nalavadi, V., & Muddashetty, R. S. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00064 · Cited by 22 · see citing works

Serum apelin‐13 levels and total oxidant/antioxidant status of patients with Alzheimer’s disease

Yıldız, Z., Eren, N., Orçun, A., Gokyigit, F. M., Turgay, F., & Çelebi, L. G. (2021) · Aging Medicine · doi:10.1002/agm2.12173 · Cited by 22 · see citing works

Antiapoptotic effects of velvet antler polypeptides on damaged neurons through the hypothalamic-pituitary-adrenal axis

Yang, Q., Lin, J., Sui, X., Li, H., Kan, M., Wang, J., Li, J., Zhang, Z., Liu, X., Ming, S., et al. (2020) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2020.03.167 · Cited by 20 · see citing works

Digging into the low molecular weight peptidome with the OligoNet web server

Liu, Y., Forcisi, S., Lucio, M., Harir, M., Bahut, F., Bou, M. D., Krieger-Weber, S., Gougeon, R. D., Alexandre, H., & Schmitt‐Kopplin, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-11786-w · Cited by 19 · see citing works

Adropin as an indicator of T2DM and its complications

Zhang, H., & Chen, N. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.06.002 · Cited by 19 · see citing works

Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein

Probst, S., Krüger, M., Kägi, L., Thöni, S., Schuppli, D., Nitsch, R. M., & Konietzko, U. (2020) · Journal of Cell Science · doi:10.1242/jcs.242917 · Cited by 18 · see citing works

Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction

Wei, W., Liu, Y., Dai, C., Baazaoui, N., Tung, Y. C., Liu, F., & Iqbal, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201599 · Cited by 17 · see citing works

Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro

Eriksdotter, M., Navarro-Oviedo, M., Mitra, S., Wahlberg, L. U., Linderoth, B., Tjernberg, L. O., & Behbahani, H. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.08.007 · Cited by 16 · see citing works

FE65: Roles beyond amyloid precursor protein processing

Chow, W. N. V., Cheung, H. N. M., Li, W., & Lau, K. (2015) · Cellular & Molecular Biology Letters · doi:10.1515/cmble-2015-0002 · Cited by 16 · see citing works

TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition

Franco, M. L., García-Carpio, I., Baro, R. C., Escribano-Saiz, J. J., Chávez‐Gutiérrez, L., & Vilar, M. (2021) · Life Science Alliance · doi:10.26508/lsa.202000844 · Cited by 15 · see citing works

Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation

Hu, S., Shen, P., Chen, B., Tian, S., & You, Y. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136850 · Cited by 15 · see citing works

Endonasal CNS Delivery System for Blood-Brain Barrier Impermeant Therapeutic Oligonucleotides Using Heterotopic Mucosal Engrafting

Pawar, G. N., Parayath, N. N., Sharma, A., Coito, C., Khorkova, O., Hsiao, J. H., Curry, W. T., Amiji, M. M., & Bleier, B. S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.660841 · Cited by 14 · see citing works

Viktor Mutt lecture: Peptides can cross the blood-brain barrier

Banks, W. A. (2023) · Peptides · doi:10.1016/j.peptides.2023.171079 · Cited by 14 · see citing works

Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults

Aggarwal, G., Morley, J. E., Vellas, B., Nguyen, A. D., Butler, A. A., for the MAPT/DSA Group, Guyonnet, S., Carrié, I., Brigitte, L., Faisant, C., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00824-3 · Cited by 13 · see citing works

Apelin–13 protects against memory impairment and neuronal loss, Induced by Scopolamine in male rats

Gazmeh, S., Azhir, M., Elyasi, L., Jahanshahi, M., Nikmahzar, E., & Jameie, S. B. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-021-00882-6 · Cited by 11 · see citing works

Focus on Alzheimer’s Disease: The Role of Fibroblast Growth Factor 21 and Autophagy

Yang, L., & Nao, J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.11.003 · Cited by 11 · see citing works

Velvet antler polypeptide is able to induce differentiation of neural stem cells towards neurons in vitro

Lihong, Z., Zhihong, Z., Yanan, S., Ma, S., Weifeng, Y., Hongtao, L., Junling, Z., Jingfeng, O., & Yi, W. (2017) · 中医杂志：英文版 · doi:10.1016/s0254-6272(17)30065-1 · Cited by 10 · see citing works

Melatonin Attenuates Methamphetamine-Induced Alteration of Amyloid β Precursor Protein Cleaving Enzyme Expressions via Melatonin Receptor in Human Neuroblastoma Cells

Nopparat, C., Boontor, A., Panmanee, J., & Govitrapong, P. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00522-6 · Cited by 8 · see citing works

proNGF Involvement in the Adult Neurogenesis Dysfunction in Alzheimer’s Disease

Olabiyi, B. F., Fleitas, C., Zammou, B., Ferrer, I., Rampon, C., Egea, J., & EspinetMestre, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910744 · Cited by 7 · see citing works

A sequential stimuli-responsive hydrogel promotes structural and functional recovery of severe spinal cord injury

Hu, C., Wang, W., Yang, Y., Zhang, B., Li, Z., Chen, L., Tu, Q., Zhang, T., Lin, D., Yi, H., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122995 · Cited by 56 · see citing works

Marine peptides as potential anti-aging agents: Preparation, characterization, mechanisms of action, and future perspectives

Yao, W., Zhang, Y., & Zhang, G. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140413 · Cited by 31 · see citing works

Research Progress on Treating Spinal Cord Injury by Modulating the Phenotype of Microglia

Yu, Q., Cai, Z., Liu, X., Lin, S., Li, P., Ruan, Y., Liang, J., He, X., & Lin, W. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2309171 · Cited by 17 · see citing works

GLP-1 agonists and exercise: the future of lifestyle prioritization

Codella, R., Senesi, P., & Luzi, L. (2025) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2025.1720794 · Cited by 16 · see citing works

Overcoming the blood‒brain barrier: nanomedicine strategies for targeted delivery and multimodal therapy in Alzheimer's disease

Li, J., Guo, L., Cai, W., Mei, J., Liu, J., & Liu, Y. (2026) · Drug Delivery · doi:10.1080/10717544.2026.2645830 · Cited by 14 · see citing works

Hippocampal Neurogenesis in Alzheimer’s Disease: Multimodal Therapeutics and the Neurogenic Impairment Index Framework

Ma, L., Wei, Q., Jiang, M., Wu, Y., Liu, X., Yang, Q., Bai, Z., & Yang, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136105 · Cited by 10 · see citing works

Lactobacillus plantarum LP104 improved intestinal and brain inflammation by modulating TLR4 pathway and gut flora in alcohol liver injury mice

Zhang, Y., Ma, Y., Fan, Y., Gao, Y., He, Y., Wang, Y., Nan, B., Liu, J., Liu, J., & Wang, Y. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105424 · Cited by 10 · see citing works

New BDNF and NT-3 Cyclic Mimetics Concur with Copper to Activate Trophic Signaling Pathways as Potential Molecular Entities to Protect Old Brains from Neurodegeneration

Magrì, A. L., Tomasello, B., Николаевна, Н. И., Tabbı̀, G., Cairns, W. R. L., Greco, V., Sciuto, S., Mendola, D. L., & Rizzarelli, E. (2024) · Biomolecules · doi:10.3390/biom14091104 · Cited by 9 · see citing works

Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseases

Giri, S., & Chandra, P. (2025) · Neuropeptides · doi:10.1016/j.npep.2025.102563 · Cited by 9 · see citing works

Nerve Growth Factor and Brain-Derived Neurotrophic Factor in COVID-19

Petrella, C., Ferraguti, G., Tarani, L., Tarani, F., Messina, M. P., & Fiore, M. (2024) · Biology · doi:10.3390/biology13110907 · Cited by 7 · see citing works

The Aggravating Role of Failing Neuropeptide Networks in the Development of Sporadic Alzheimer’s Disease

Jászberényi, M., Thurzó, B., Jayakumar, A., & Schally, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313086 · Cited by 4 · see citing works

Antimicrobial and Anti-Inflammatory Bioactive Peptides: Their Role in Potential Therapeutic Applications for Periodontitis—A Narrative Review

Tonolo, F., Silva, R. C. L., Bortoluzzi, M., Scarel‐Caminaga, R. M., & Vianello, F. (2025) · Nutrients · doi:10.3390/nu17193105 · Cited by 5 · see citing works

Viral vectors in neurodegenerative diseases: immune responses and therapeutic applications

Wang, Y., Mu, S., & Liu, F. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1603125 · Cited by 3 · see citing works

Isoliensinine confers neuroprotection and alleviates LPS-induced neuroinflammation in microglia by regulating the MAPK/NF-κB signaling

Yuan, M., Hu, J., Gao, L., Long, W., Wang, S., Tan, X., & Hu, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1675865 · Cited by 3 · see citing works

Active ingredients derived from plants, animals, and fungi promote central nervous system regeneration: a narrative review

Chen, S., Pei, H., Liang, H., Geng, J., Chen, W., Zong, Y., Zhao, Y. H., Du, R., & He, Z. (2025) · Regenerative medicine reports . · doi:10.4103/regenmed.regenmed-d-25-00017 · Cited by 3 · see citing works

Association Between Irisin Level and Cognitive Function: A Systematic Review and Meta‐Analysis

Han, C., Zhou, Z., Kong, L., Lü, J., & Li, X. (2025) · Brain and Behavior · doi:10.1002/brb3.70662 · Cited by 3 · see citing works

Molecular Mechanisms of Dietary Bioactive Peptides in Treating Alzheimer’s Disease and Mild Cognitive Impairment by Network Pharmacology and Molecular Docking Analysis

Li, R., Zi, J., Hu, Y., Li, X., Cao, Q., Li, Y., Wang, X., Xiong, J., & Cheng, G. (2025) · Rejuvenation Research · doi:10.1089/rej.2024.0092 · Cited by 2 · see citing works

Serum Irisin Levels are Inversely Correlated with Acute Ischaemic Stroke Incidence: Implications for Early Diagnosis in Southern China

Ouyang, F., Chen, S., Li, S., Liu, L., Guan, S., Yan, Z., Shumin, W., Zeng, Y., Liu, J., & Zhong, J. (2024) · International Journal of General Medicine · doi:10.2147/ijgm.s483793 · Cited by 2 · see citing works

Efficient Screening of Synergistic Antioxidant and AChE Inhibitory Peptides From Sea Cucumber (Stichopus japonicus) Using a Novel Approach Combining De Novo Sequencing and Parallel Peptide Synthesis

Li, Y., Gao, S., Zhang, X., Cao, Z., Guo, Y., Zhao, R., Li, L., Liu, Y., Qin, Q. P., Yi, B., et al. (2025) · Peptide Science · doi:10.1002/pep2.70002 · Cited by 1 · see citing works

From genetic roots to recent advancements in gene therapy targeting amyloid beta in Alzheimer’s disease

Peyvand, P., Allami, P., & Rezaei, N. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2025-0025 · Cited by 1 · see citing works

Relationship of Melatonin with the Hippocampus

Kılıç, K. D., Turgut, A. Ç., & Özyazıcı, A. T. (2025) · Springer eBooks · doi:10.1007/978-3-031-88907-3_20 · Cited by 1 · see citing works

Exploring the potential impact of GPC-enriched egg yolk derivatives on cognitive vitality in aging brains: A preliminary study

Yu, W., Gao, Q. H., Yang, Y., Chang, C., Hu, W., Su, Y., Gu, L., & Li, J. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107881 · Cited by 1 · see citing works

Trimethyl Chitosan-Engineered Cod Skin Peptide Nanosystems Alleviate Behavioral and Cognitive Deficits in D-Galactose-Induced Alzheimer’s Disease Model Mice

Kong, S., Lv, L., Guo, J., Lu, G., Li, D., & Zhou, X. (2025) · Marine Drugs · doi:10.3390/md23120472 · Cited by 1 · see citing works

Neurotrophic Factors: Emerging Biology and Therapeutic Applications for Cardiovascular Diseases

Liu, Y., Zhang, H., Yu, F., Liu, T., Jia, D., & Wang, R. (2026) · Metabolites · doi:10.3390/metabo16010058 · Cited by 1 · see citing works

Nanotherapeutic Macrophage‐Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis‐Induced Lung Injury and Neurologic Damage

Wang, W., Hai, Y., Lu, X., Chen, Y., Zhang, B., Fan, R., Dou, J., Yan, J., Fu, S., Zhang, W., et al. (2026) · Advanced Science · doi:10.1002/advs.202520665 · Cited by 1 · see citing works

Melatonin ameliorates tauopathy and ferroptosis in P301S Tau transgenic mice

Jia, M., Wang, L., Guo, S.-Q., Liang, X.-T., Liu, X., Guo, S.-J., Wang, T., Zhong, M., Gao, H., & Guo, C. (2025) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2024.40

Neurotrophins sensing nutrition: Molecular mechanisms regulating host lipid metabolism and prospects for clinical application

Zhang, M., Yin, J., Han, Q., & Yin, Y. (2026) · The Innovation Nutrition · doi:10.59717/j.xinn-nutri.2026.100012

Alzheimer’s disease and apitherapy: the therapeutic effect of various honeybee products

Rashwan, E. H., Elashal, M. H., Khalifa, S. A. M., El‐Wahed, A. A. A., Wang, D., Hussein, W. M., Wang, X., Cheng, G., Naggar, Y. A., Wang, H., et al. (2026) · Neurodegenerative Disease Management · doi:10.1080/17582024.2026.2664407

Traditional Chinese medicine ginseng regulates neurotrophic factors to improve neurodegenerative diseases: A potential strategy for Alzheimer's disease treatment

Huang, Q., Xie, Y., Zhang, X., Zuo, Y., Wang, L., Xu, H., Yu, M., & Liu, C. (2026) · Journal of Ginseng Research · doi:10.1016/j.jgr.2026.101078

Microgliopathy in poststroke depression: exploring mechanisms and therapeutic strategies

Yang, C., Wu, S., Cao, H., Yin, Y., Zhang, Y., Zhang, L., Chen, R., & Tao, X. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.08.046

Neurotrophic regulation of lipid metabolism in Alzheimer's disease: Mechanisms and therapeutic implications

Fan, D., Zhai, W., Zhang, Q., Li, J., Wang, Y., & Sun, L. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261499707

Brain peptides in Alzheimer’s disease - pathophysiology and therapeutic advances

Pahal, S., Gupta, A., Kumar, V., Singh, P. B. R. P., Kaushik, M., Pahal, V., Atluri, G., & Chaudhary, A. (2026) · Cell and Tissue Research · doi:10.1007/s00441-026-04055-8 · Cited by 2 · see citing works

Bioactive peptides as multipotent molecules bespoke and designed for Alzheimer's disease

Mesias, A., Borges, S., Pintado, M., & Baptista-Silva, S. (2025) · Neuropeptides · doi:10.1016/j.npep.2025.102515 · Cited by 11 · see citing works

Peptides Derived from Growth Factors to Treat Alzheimer’s Disease

Gascon, S., Jann, J., Langlois-Blais, C., Plourde, M., Lavoie, C. L., & Faucheux, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116071 · Cited by 24 · see citing works

Harnessing the Therapeutic Potential of Peptides for Synergistic Treatment of Alzheimer’s Disease by Targeting Aβ Aggregation, Metal-Mediated Aβ Aggregation, Cholinesterase, Tau Degradation, and Oxidative Stress

Singh, K., Kaur, A., Goyal, B., & Goyal, D. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00246 · Cited by 28 · see citing works

Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease

Ding, X., Chen, Y., Zhang, X., Duan, Y., Yuan, G., & Liu, C. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102457 · Cited by 7 · see citing works