Recent trends of natural based therapeutics for mitochondria targeting in Alzheimer’s disease
Abstract
Alzheimer's disease (AD) is the most ubiquitous neurodegenerative disorder with impaired cognitive functionality. Till date, the specific pathophysiology related to AD is still elusive. Recent reports suggest mitochondrial dysfunctionality like oxidative stress, Ca 2+ disbalance, apoptosis, decrease energy and its metabolism plays an important. Recent reports about mitochondrial mechanisms and dynamics in AD unravelled new insights of molecular targets. Targeting multi-pathway via natural products may attenuate and prevent the mitochondria dysfunctionality. In this review, we have focused on the pathophysiology events of mitochondrial dysfunction in AD as well as mitochondrial fusion and fission mechanisms, role of aging in multicellular organisms, and how these connect to cell cycle regulation, and transmission of energy status.
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Glycyrrhizin reduces oxidative stress and degeneration of brain cells in Alzheimer's disease and dementia patients.
“Glycyrrhizin, a triterpenoidal saponin with isoliquiritigenin as a phenolic component, reduces oxidative stress and degeneration of brain cells in AD and dementia patients [117].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [117]
Glycyrrhiza glabra has antioxidant, anti-inflammatory, and neuroprotective effects in managing neurodegenerative disorders related to dementia.
“Moreover, GB has been found to have antioxidant, anti-inflammatory, and neuroprotective effects in the management of neurodegenerative disorders related to dementia [117,118].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [117]
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Triphenylphosphine-Based Mitochondrial Targeting Nanocarriers: Advancing Cancer Therapy
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Indole therapeutics: Latest FDA updates, ongoing trials, and future directions
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Clinical application and future consideration and potential of cannabis
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Mitochondria as a therapeutic target for the treatment of Alzheimer's disease
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- Authors
- Dhiman, A., Handa, M., Ruwali, M., Singh, D. P., Kesharwani, P., & Shukla, R.
- Affiliations
- National Institute of Pharmaceutical Education and Research (IN)
- Amity University Gurugram (IN)
- National Institute of Occupational Health (IN)
- Jamia Hamdard (IN)
- Corresponding author
- Kesharwani, Prashant
- Shukla, Rahul
- Venue
- Mitochondrion
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 64
- Pages
- 112-124
- ISSN
- 1567-7249 (ISSN-L)
- OpenAlex
- W4220933483
- Cited by
- 21
- References
- 96
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mitochondrion (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, mitochondrial dysfunction, natural products, oxidative stress, calcium imbalance, apoptosis, mitochondrial dynamics, mitochondrial fission and fusion, aging, energy metabolism, cell cycle regulation
- MeSH terms
- Aging, Alzheimer Disease, Humans, Mitochondria, Oxidative Stress, Mitochondrial Dynamics
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