Cited by 916Antioxidant Activity and Oxidative StressRedox biology and oxidative stressExercise and Physiological Responses

The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.

Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives

Open access

Hajam, Younis Ahmad, Rani, Raksha, Ganie, Shahid Yousuf, Sheikh, Tariq Ahmad, Javaid, Darakhshan, Qadri, Syed Sanober, Pramodh, Sreepoorna, Alsulimani, Ahmad, Alkhanani, Mustfa F., Harakeh, Steve, Hussain, Arif, Haque, Shafiul, Reshi, Mohd Salim·2022·Cells

DOI 10.3390/cells11030552PMC PMC8833991

Open this paper in CoChat — free account Open PDF

Abstract

Reactive oxygen and nitrogen species (RONS) are generated through various endogenous and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic antioxidants. An imbalance between the generation and neutralization of oxidants results in the progression to oxidative stress (OS), which in turn gives rise to various diseases, disorders and aging. The characteristics of aging include the progressive loss of function in tissues and organs. The theory of aging explains that age-related functional losses are due to accumulation of reactive oxygen species (ROS), their subsequent damages and tissue deformities. Moreover, the diseases and disorders caused by OS include cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases and cancer. OS, induced by ROS, is neutralized by different enzymatic and non-enzymatic antioxidants and prevents cells, tissues and organs from damage. However, prolonged OS decreases the content of antioxidant status of cells by reducing the activities of reductants and antioxidative enzymes and gives rise to different pathological conditions. Therefore, the aim of the present review is to discuss the mechanism of ROS-induced OS signaling and their age-associated complications mediated through their toxic manifestations in order to devise effective preventive and curative natural therapeutic remedies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/cells11030552

Cites

218 of 218 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Apoptosis: A Review of Programmed Cell Death
Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Free radicals, antioxidants and functional foods: impact on human health
Lobo, V, Patil, A., Phatak, A., & Chandra, N. (2010) · Pharmacognosy Reviews · doi:10.4103/0973-7847.70902 · Cited by 5,435

Flagged first, then by citations

Show all 218 references

Research works printed but not linked: 1

Hajam, 2017, Retrieval of reproductive complications by exogenous melatonin treatment in streptozotocin induced diabetic rat model, Res. Rev. J. Zool. Sci., 5, 96

Sorted by citations

Items 301–400 of 916

Elucidating the Mechanism of Large-Diameter Titanium Dioxide Nanotubes in Protecting Osteoblasts Under Oxidative Stress Environment: The Role of Fibronectin and Albumin Adsorption
Xiang, Y., Lin, D., Zhou, Q., Luo, H., Zhou, Z., Wu, S., Xu, K., Tang, X., Ma, P., Cai, C.-Y., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s488154 · Cited by 7
Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents
Araújo, E. M., Coelho‐Júnior, H. J., Sousa, C. V., Rosa, T. D. S., Neto, I. V. D. S., Marzetti, E., Franco, O. L., & Aguiar, S. D. S. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112662 · Cited by 7
Long-chain chlorinated paraffins (LCCPs) exposure causes senescence and inflammatory damage in cardiomyocytes
Zhang, R., Zhang, M., Wang, G., Wu, D., Kong, Y., Deng, H., Li, J., Lan, H., & Wu, M. (2025) · Journal of Environmental Management · doi:10.1016/j.jenvman.2025.124166 · Cited by 7
Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment
Aleksandrova, Y. R., & Неганова, М. Е. (2025) · Antioxidants · doi:10.3390/antiox14020199 · Cited by 8
Exercise alleviates osteoporosis by regulating the secretion of the Senescent Associated Secretory Phenotype
Weng, K., He, Y., Weng, X., & Yuan, Y. J. (2025) · Bone · doi:10.1016/j.bone.2025.117485 · Cited by 8
Oxidative stress and inflammation mediate the association between Life's Crucial 9 and biological ageing: A secondary analysis of two observational studies
Wang, H., Zhang, J., Ning, J., Cui, Y., Hou, H., Liu, M. R., Liu, J., Tang, R., & Wang, J. (2025) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2025.100575 · Cited by 8
Mechanism study on the regulation of autophagy and oxidative stress through SIRT1/PI3K/AKT pathway by Liuwei Dihuang pill to improve ovarian function
Zhong, J., Lan, G., Ma, X., Zhang, W., Jiang, B., Qin, L., Li, X., & Nian, Y. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01689-0 · Cited by 7
Metabolite profiling and cytotoxicity of Tragopogon dubius fractions against MCF-7 cells
Ahmad, S. S., Garg, C., & Kaur, S. (2025) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2025.105065 · Cited by 7
Pomegranate Extract Modulates Oxidative Stress by Reducing Basal ROS Levels and Protecting White Blood Cells from Induced Oxidative Damage in Aging Mice
Verdú, D., Valls, A., Serna‐García, M., Herrera, G., Ezzeddin-Ayoub, M., Mauricio, M. D., Viña, J., & Serna, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26135957 · Cited by 7
The pathogenesis of benign prostatic hyperplasia and the roles of Prdx3, oxidative stress, pyroptosis and autophagy:a review
Xiang, J., Zheng, Y., Chen, D., Zeng, Y., Zhang, J., Chang, D., & Chang, C. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1579539 · Cited by 12
Antioxidants and Their Physiological Role in Free Radical Scavenging
Mukherjee, B., Hoque, A. A., Hota, S. H., Gope, S., Ray, M., Barman, M., Bhattacharya, S., Chakraborty, S., & Das, L. (2025) · Springer eBooks · doi:10.1007/978-981-96-8622-3_12 · Cited by 9
Beneficial effects of proanthocyanidins on skin aging: a review
Ye, H., Sun, J., He, L., Ai, C., Jin, W., & El‐Aty, A. M. A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1650328 · Cited by 8
Selenium improves behavioral performance in a rat model of autism spectrum disorder by mitigating oxidative stress and modulating the Sirt1/Keap1/Nrf2/HO-1 signaling pathway
Shu, Y., Yang, J., Zhang, P., Zhang, X., Zhao, X., Yan, J., Zhang, B., & Du, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115556 · Cited by 7
Accelerated biological aging mediates the associations of stress hyperglycemia ratio (SHR) with mortality in type 2 diabetes and obesity (diabesity)
Xu, J., Zhou, H., & Wang, Z. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02931-1 · Cited by 7
Ultra-Processed Foods and Cardiometabolic Health: A Review of Current Evidence
Gövez, N. E., & Köksal, E. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00703-7 · Cited by 11
Thiol/Disulfide Homeostasis as a New Oxidative Stress Marker in Patients with COPD
Karaoğlanoğlu, S., & Erdal, H. (2025) · Diagnostics · doi:10.3390/diagnostics15202584 · Cited by 7
Progression of Carotid Intima-Media Thickness Partly Indicates the Prevention of Hypertension among Older Individuals in the General Population
Shimizu, Y. (2023) · Life · doi:10.3390/life13071588 · Cited by 7
Research progress on gas signal molecular therapy for Parkinson’s disease
Wang, L., Dan, Q., Xu, B., Chen, Y., & Zheng, T. (2023) · Open Life Sciences · doi:10.1515/biol-2022-0658 · Cited by 7
The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
Rogóż, W., Mac, K., Owczarzy, A., Kulig, K., Pożycka, J., & Maciążek-Jurczyk, M. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00529-6 · Cited by 7
Lipid Peroxidation, Reduced Glutathione, and Glutathione Peroxidase Levels in Intervertebral Discs of Patients with Lumbar Degenerative Disc Disease
Morales, N. P., Loahachanwanich, W., Korwutthikulrangsri, E., Ruangchainikom, M., & Sutipornpalangkul, W. (2024) · Medical Science Monitor · doi:10.12659/msm.944335 · Cited by 7
Underlying Mechanisms of the Protective Effects of Lifestyle Factors On Age-Related Diseases
Alcaraz, N., Salcedo‐Tello, P., González‐Barrios, R., Torres‐Arciga, K., & Guzmán-Ramos, K. R. (2024) · Archives of Medical Research · doi:10.1016/j.arcmed.2024.103014 · Cited by 9
Ischemia‐modified albumin in rheumatic diseases: A systematic review and meta‐analysis
Mangoni, A. A., & Zinellu, A. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1324 · Cited by 7
The association between composite dietary antioxidant index and diabetic retinopathy in type 2 diabetic patients: evidence from the NHANES
Liu, S., Zhu, Z., Yu, K., Zhang, W., Pu, J., Lv, Y., Tang, Z., Liu, F., & Sun, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1399763 · Cited by 7
The role of GDF15 in attenuating noise-induced hidden hearing loss by alleviating oxidative stress
Jiang, Y., Zheng, Z., Zhu, J., Zhang, P., Li, S., Fu, Y., Wang, F., Zhang, Z., Tong, C., Zhang, M., et al. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09912-2 · Cited by 7
Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003–2018 data
Zeng, Q., Liao, M., Li, Y., She, F., & Ping, Z. (2024) · International Journal of Cardiology Cardiovascular Risk and Prevention · doi:10.1016/j.ijcrp.2024.200340 · Cited by 9
Zebrafish Model Insights into Mediterranean Diet Liquids: Olive Oil and Wine
Silva, P., Rodríguez-Pérez, M., & Burgos‐Ramos, E. (2023) · Antioxidants · doi:10.3390/antiox12101843 · Cited by 7
New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists
Scarano, N., Palma, F. D., Origlia, N., Musumeci, F., Schenone, S., Spinelli, S., Passalacqua, M., Zocchi, E., Sturla, L., Cichero, E., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122754 · Cited by 7
Cross Talks between CNS and CVS Diseases: An Alliance to Annihilate
Chib, S., Devi, S., Chalotra, R., Mittal, N., Singh, T. G., Kumar, P., & Singh, R. (2024) · Current Cardiology Reviews · doi:10.2174/011573403x278550240221112636 · Cited by 7
Citrus aurantifolia (Christm.) swingle extract ameliorates oxidative stress, dyslipidemia, and inflammation in galactose-induced aging in female rats
Bankole, H. A., Kazeem, M. I., Fatai, A. A., Lawal, R. A., Lawanson, S. O., Ogunyemi, R. T., Ajiboye, T. O., & Olayemi, R. O. (2024) · South African Journal of Botany · doi:10.1016/j.sajb.2024.03.027 · Cited by 8
Nonsurgical therapy for lumbar spinal stenosis caused by ligamentum flavum hypertrophy: A review
Fang, N., Wang, Z., Jiang, J., Yang, A., Mao, T., Wang, Z., & Chen, Q. (2024) · Medicine · doi:10.1097/md.0000000000038782 · Cited by 6
Plasma biomarkers in patients with age-related sarcopenia: a proteomic exploration and experimental validation
Lin, Q., Li, K., Li, L., Guan, L., Zeng, Y., Cai, D., Zhou, J., & Xu, L. (2024) · Aging Clinical and Experimental Research · doi:10.1007/s40520-024-02903-7 · Cited by 6
Purification, Structural Analysis and Bioactivity of Pueraria montana Polysaccharide
Chen, D., Yao, H., Qiu, X., Xu, L., Ou, Y., Xin, J., Lu, S., Li, M., Geng, Y., Zhang, Y., et al. (2025) · Foods · doi:10.3390/foods14081359 · Cited by 6
Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study
Shi, X., Wang, Y., Yang, F., Yi, Y., Hu, Q., Xie, T., Li, B., & Ma, K. (2025) · BMC Public Health · doi:10.1186/s12889-025-22374-3 · Cited by 7
Aqueous extract of Cissus quadrangularis L. alleviates heavy metal toxicity in Saccharomyces cerevisiae by limiting metal uptake and enhancing detoxification mechanisms
Limcharoensuk, T., Chumsawat, W., Siraj, U., Krobthong, S., Pitchayawat, P., Hamkrasri, A., Kerdsomboon, K., & Auesukaree, C. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118408 · Cited by 6
Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A review
El-Hack, M. E. A., Rudayni, H. A., Aldhalmi, A. K., Alawam, A. S., Allam, A. A., Khan, M. M. H., & Khafaga, A. F. (2025) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2025.100958 · Cited by 6
Systematic Characterization of Antioxidant Shielding Capacity Against Oxidative Stress of Aerial Part Extracts of Anacardium occidentale
Ponce‐Mora, A., Gimeno-Mallench, L., Lavandera, J. L., Giebelhaus, R. T., Domenech‐Bendaña, A., Locascio, A., Gutiérrez-Rojas, I., Sauro, S., de la Mata, A. P., Nam, S. L., et al. (2025) · Antioxidants · doi:10.3390/antiox14080935 · Cited by 7
Food-Derived Phytochemicals: Multicultural Approaches to Oxidative Stress and Immune Response
Gliozheni, E., Salem, Y., Cho, E., Wahlstrom, S., Olbrich, D., Shams, B., Alexander, M., & Ichii, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157316 · Cited by 6
Mechanism of lidocaine-induced ROS generation triggering DNA double-strand breaks and promoting intervertebral disc cell senescence via the MYC-DUSP1-P53 axis
Zhou, R., Wang, X., Jin, Y., Chen, B., Liu, H., Zhao, X., Jing, D., & Zhao, B. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.08.049 · Cited by 7
Unlocking the Ilex guayusa Potential: Volatile Composition, Antioxidant, Antidiabetic, and Hemolytic Activities, with In Silico Molecular Docking and ADMET Analysis of Hydroethanolic Extracts
Monteros‐Silva, N. E. D. L., Martínez-Palacios, K., Jiménez, A. M., Ochoa-Ocampo, M. A., Garzón, T., Carrillo-Vásconez, T., Radice, M., Yanez, E. V., Rea, J., Niño, Z., et al. (2025) · Molecules · doi:10.3390/molecules30193885 · Cited by 7
Mechanotransduction as a therapeutic target in tendinopathy: molecular pathways and exercise implications
Kim, D., Moon, H. Y., & Lee, M. C. (2025) · Research in Sports Medicine · doi:10.1080/15438627.2025.2568936 · Cited by 6
Ganoderma lucidum polysaccharides target the gut-brain axis: Unveiling a novel mechanism for ameliorating aging-induced cognitive impairment and oxidative stress
Chen, Y., Zeng, X., Gong, X., Chen, Y., Zhang, X., & Luo, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149519 · Cited by 7
Extracellular Redox Balance as a Determinant of Immune Regulation and Tissue Inflammation
Seitz, R., Müller, M. A., & Gülow, K. (2026) · Antioxidants · doi:10.3390/antiox15030280 · Cited by 8
Protective potential of pterostilbene against cyclophosphamide-induced nephrotoxicity and cystitis in rats
Keri̇moğlu, G., Arıcı, T., Bıyık, A. F., Kulaber, A., Alemdar, N. T., Demir, S., Aliyazıcıoğlu, Y., & Yeni̇lmez, E. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03735-6 · Cited by 6
Src Tyrosine Kinase Inhibitory and Antioxidant Activity of Black Chokeberry and Bilberry Fruit Extracts Rich in Chlorogenic Acid
Vladimir‐Knežević, S., Štefan, M. B., Blažeković, B., Jelić, D., Petković, T., Mandić, M., Šprajc, E., & Lovković, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115512 · Cited by 6
Antiproliferative effect of phenolic compounds extracted from winery pomace on TPC-1 thyroid cancer cells
Bohn, L. R., Dresch, A. P., Manica, D., Fogolari, O., Bagatini, M. D., Bender, J. P., Mibielli, G. M., & Teleken, J. G. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104457 · Cited by 6
Hepatoprotective effect of date fruit extract against ethanol-induced apoptosis in human hepatoma (HepG2) cells
Al-Sheddi, E. S., Farshori, N. N., Al-Oqail, M. M., Alblwi, F., Ahmad, J., Al-Khedhairy, A. A., & Siddiqui, M. A. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102519 · Cited by 6
Astaxanthin mediated repair of tBHP-Induced cellular injury in chondrocytes
Liang, W.-W., Liu, G., Zhou, W., Chen, W., Lu, Y., Wu, H., Yao, Q., & Zhu, C. (2024) · Redox Report · doi:10.1080/13510002.2024.2422271 · Cited by 5
Caftaric acid attenuates kidney and remote organ damage induced by renal ischemia-reperfusion injury
Akdemi̇r, F. N. E., Güler, M. C., Eraslan, E., Tanyeli̇, A., & Yıldırım, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-82912-8 · Cited by 6
Exploring Triptolide's Dual Role in Inflammation and Oxidative Stress: Responses of Organelles
Xiao, H., Liu, Y., Liu, D., Xiang, Y., & Zhang, W. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70371 · Cited by 6
Antifatigue and Anti-Inflammatory Effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge Complex Extracts in Physically Fatigued Mice
Huang, W. Y., Pan, J. H., Jeong, I., Oh, S. J., Hyun, Y. G., Kim, M. S., Han, B. K., Hong, J., Koo, Y. T., Lee, K. W., et al. (2022) · Journal of Medicinal Food · doi:10.1089/jmf.2022.k.0103 · Cited by 6
Reciprocal REGγ-Nrf2 Regulation Promotes Long Period ROS Scavenging in Oxidative Stress-Induced Cell Aging
Kibreab, S., Wang, Z., Zhu, X., Ren, Y., Jing, Y., Li, X., Li, L., & Zhang, B. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/4743885 · Cited by 6
Aging-Related Accumulation of Truncated Oxidized Phospholipids Augments Infectious Lung Injury and Endothelial Dysfunction via Cluster of Differentiation 36-Dependent Mechanism
Ke, Y., Karki, P., Li, Y., Promnares, K., Zhang, C., Eggerman, T. L., Bocharov, A. V., Birukova, A. A., & Birukov, K. G. (2023) · Cells · doi:10.3390/cells12151937 · Cited by 6
Attenuation of Benzo[a]Pyrene-Induced Oxidative Stress and Cell Apoptosis in Albino Rats by Wild Milk Thistle (Silybum Marianum L.) Seeds Extract
Mahran, M., & Elhassaneen, Y. A. (2023) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2023.214010.8042 · Cited by 9
Low-Dose Exposure of WS2 Nanosheets Induces Differential Apoptosis in Lung Epithelial Cells
Coreas, R., Li, Z., Chen, J., & Zhong, W. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c01843 · Cited by 6
Novel gramine-based bioconjugates obtained by click chemistry as cytoprotective compounds and potent antibacterial and antifungal agents
Berdzik, N., Jasiewicz, B., Ostrowski, K., Sierakowska, A., Szlaużys, M., Nowak, D., & Mrówczyńska, L. (2023) · Natural Product Research · doi:10.1080/14786419.2023.2261139 · Cited by 6
Effects of an Intervention with Selenium and Coenzyme Q10 on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect—A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial
Alehagen, U., Alexander, J., Aaseth, J., Larsson, A. O., Svensson, E., & Opstad, T. B. (2023) · Cells · doi:10.3390/cells12131773 · Cited by 8
Constituents of the fruits of Rubus chingii Hu and their neuroprotective effects on human neuroblastoma SH-SY5Y cells
Wang, J., Zhang, X., Yu, J., Du, J., Wu, X., Chen, L., Wang, R., Wu, Y., & Li, Y. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113255 · Cited by 6
Prolonged Copper Supplementation Modified Minerals in the Kidney, Liver and Blood, and Potentiated Oxidative Stress and Vasodilation of Isolated Aortic Rings in Young Wistar Rats
Kitala–Tańska, K., Hańć, A., Juśkiewicz, J., & Majewski, M. S. (2024) · Nutrients · doi:10.3390/nu16193230 · Cited by 5
One-Year Impact of Occupational Exposure to Polycyclic Aromatic Hydrocarbons on Sperm Quality
Peña-García, M. V., Moyano-Gallego, M. J., Gómez-Melero, S., Molero-Payan, R. M., Rodríguez-Cantalejo, F., & Caballero‐Villarraso, J. (2024) · Antioxidants · doi:10.3390/antiox13101181 · Cited by 5
Is castration leading to biological aging in dogs? Assessment of lipid peroxidation, inflammation, telomere length, mitochondrial DNA copy number, and expression of telomerase and age-related genes
Hassanpour, H., Javdani, M., Changaniyan-Khorasgani, Z., Rezazadeh, E., Jalali, R., & Mojtahed, M. (2024) · BMC Veterinary Research · doi:10.1186/s12917-024-04337-9 · Cited by 5
Oleuropein: a narrative review on its role in neurodegenerative diseases
Riquelme, C. V., & Pando, M. E. (2025) · Aging advances. · doi:10.4103/agingadv.agingadv-d-25-00002 · Cited by 5
Astragalus Polysaccharide Alleviates Cognitive Decline in D-Galactose-Induced Aging
Tian, J., Huo, R., Wang, Y., Wang, J., Fang, F., & Fang, C. (2025) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00524 · Cited by 5
The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster
Ramalho, D. L., Silva, J. R., dos Santos, M. E. M. M., Soares, M. E. S., Jesus, A. A. T., Alves, T. H. O., Brugnera, M. F., Moura, S., & Souza, A. O. (2025) · Scientific Reports · doi:10.1038/s41598-025-86413-0 · Cited by 5
Comprehensive review of the electrochemical detection, redox mechanism, and mitigation of the adverse effects of pharmaceutical xenobiotics via photocatalytic degradation
Riffat, I., Shah, A., Muhammad, H., & Shah, I. (2025) · Discover Sustainability · doi:10.1007/s43621-025-01384-6 · Cited by 5
Klotho Regulates the Extracellular Matrix Metabolism via TGF‐β1/Wnt Signaling Pathway of Fibroblasts in Pelvic Organ Prolapse
Zhou, Z., Fang, M., Luo, J., Fan, X., & Zhao, Y. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70358 · Cited by 5
Dendritic spine degeneration is associated with age-related decline in recognition and spatial memory in male mice
Monroy, E., Aguilar‐Hernández, L., de la Cruz‐López, F., Flores, G., & Morales‐Medina, J. C. (2025) · Brain Structure and Function · doi:10.1007/s00429-025-03002-7 · Cited by 5
Fibroblast growth factor 19 regulates polycystic ovary syndrome progression via FGFR4-ERK-NRF2 pathway
Qu, J., Qiu, M., Wang, J., Chen, Z., Chen, M., Teng, X., & Li, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1626938 · Cited by 5
Silibinin Alleviates Liver Oxidative Stress in D-Galactose-Treated Kunming Mice via Microbiota Homeostasis in a Microbiota-Dependent Manner
Dong, A., Zhang, X., Ma, J., Cao, J., Diene, G., Xu, Y., Yin, X., Li, Y., & Zhang, Y. (2025) · Antioxidants · doi:10.3390/antiox14091087 · Cited by 5
Efficacy of extracellular vesicles derived from mesenchymal stromal cells in regulating senescence: In vitro and in vivo insights
Yang, S.-S., Chen, S., Zhuang, W.-Y., Han, J., Liu, Y., Deng, L., Guo, H., Ma, H.-R., & Tan, Y. (2025) · World Journal of Stem Cells · doi:10.4252/wjsc.v17.i10.110445 · Cited by 4
The intricacies of advanced glycation end products (AGEs) in diabetic neuropathy
Rao, W., Hussain, M. S., Naseem, N., & Siddiqui, W. A. (2025) · 3 Biotech · doi:10.1007/s13205-025-04652-4 · Cited by 6
Caloric restriction attenuates oxidative and inflammatory markers of aging, while compromising germinative epithelium homeostasis in the rat aged testis
Bossio, S., Russa, D. L., Antonucci, G., Lofaro, D., Urlandini, L., Mandalà, M., Conforti, F., Dio, M. D., Aversa, A., Rago, V., et al. (2026) · Journal of Endocrinological Investigation · doi:10.1007/s40618-025-02806-y · Cited by 5
Next-Generation Dietary Antioxidants in Women’s Reproductive Health: Mechanisms, Reproductive Outcomes, and Therapeutic Potential
Rahman, A., Jalouli, M., Al-Zharani, M. M., & Harrath, A. H. (2026) · Antioxidants · doi:10.3390/antiox15030319 · Cited by 7
SIRT1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis
Duan, Y., Luo, Y., Han, X., Yu, H., Liu, H., Zhou, Y., Gao, Y., Xu, Q., Wei, Y., Min, R., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08634-z · Cited by 5
Fermentation characteristics and radical scavenging capacities of ginseng berry kombucha fermented by Saccharomyces cerevisiae and Gluconobacter oxydans
Choi, E. J., Song, H. H., Ko, K. Y., Hong, K., Suh, H. J., & Ahn, Y. (2023) · Applied Biological Chemistry · doi:10.1186/s13765-023-00785-3 · Cited by 5
Differentiation of hemispheric white matter lesions in migraine and multiple sclerosis with similar radiological features using advanced MRI
John, F., Kis-Jakab, G., Komáromy, H., Perlaki, G., Orsi, G., Bosnyák, E., Rozgonyi, R., Trauninger, A., Eklics, K., Kamson, D. O., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1384073 · Cited by 9
Shiitake mushroom powder supplementation increase antioxidative activity in dogs
Kusaba, A., & Arai, T. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1355560 · Cited by 5
Antioxidant Effects of Cactus Seed Oil against Iron-Induced Oxidative Stress in Mouse Liver, Brain and Kidney
Bouchab, H., Ishaq, A., Limami, Y., Saretzki, G. C., Nasser, B., & Kebbaj, R. E. (2024) · Molecules · doi:10.3390/molecules29184463 · Cited by 5
Family Identification and Functional Study of Copper Transporter Genes in Pleurotus ostreatus
Guo, L., Li, T., Zhang, B., Yan, K., Meng, J., Chang, M., & Hou, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212154 · Cited by 5
Supplementing the standard diet with brown rice bran powder might effectively improve the metabolic syndrome characteristics and antioxidant status: an open label randomized controlled trial
Ghorbani, Z., Shoaibinobarian, N., Zamani, E., Salari, A., Mahdavi‐Roshan, M., Porteghali, P., & Ahmadnia, Z. (2024) · Food & Function · doi:10.1039/d4fo03642e · Cited by 6
Preparation, structural property, and antioxidant activities of a novel pectin polysaccharide from the flowers of Hibiscus syriacus Linn.
Chen, J., Ye, C., Zhang, L., Xie, Z., Zhu, J., & Zhang, Z. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1524846 · Cited by 5
The Aging Substantia Nigra is Characterized by ROS Accumulation Potentially Resulting in Increased Neuroinflammation and Cytoskeletal Remodeling
Eggers, B., Steinbach, S., Aldea, I. G., Keers, S. M., Molina, M., Grinberg, L. T., Heinsen, H., Leite, R. E. P., Attems, J., May, C., et al. (2025) · Advanced Biology · doi:10.1002/adbi.202400814 · Cited by 5
Bibliometric and graphical analysis of ferroptosis and aging research: Trends, gaps, and future directions
Cao, S., Pang, Y., Wei, Y., Wang, D., Xiong, A., Yan, J., & Zeng, H. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.155949 · Cited by 5
Effects of adenosine triphosphate and coenzyme Q10 on potential hydroxychloroquine-induced retinal damage in rats.
Özbay, A. D., Somuncu, A. M., Cicek, I., Yavuzer, B., Bulut, S., Huseynova, G., Tastan, T. B., Gülaboğlu, M., & Süleyman, H. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110387 · Cited by 5
In vitro senescence and senolytic functional assays
Ryan, P., & Lee, J. (2025) · Biomaterials Science · doi:10.1039/d4bm01684j · Cited by 7
Understanding the Intricate Role of Exosomes in Pathogenesis of Alzheimer’s Disease
Chauhan, S., Behl, T., Sehgal, A., Singh, S., Sharma, N., Gupta, S., Albratty, M., Najmi, A., Meraya, A. M., & Alhazmi, H. A. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00621-4 · Cited by 6
Esculin protects human blood cells from bioallethrin-induced toxicity: An ex vivo study
Arif, A., Quds, R., Salam, S., & Mahmood, R. (2023) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2023.105375 · Cited by 5
Paclitaxel Overload Supramolecular Oxidative Stress Nanoamplifier with a CDK12 Inhibitor for Enhanced Cancer Therapy
Zhang, H., Xing, C., Yan, B., Lei, H., Guan, Y., Zhang, S., Kang, Y., & Pang, J. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00260 · Cited by 5
As healthy as invasive: Charybdis natator shell extract reveals beneficial metabolites with promising antioxidant and anti-inflammatory potentials
Galal‐Khallaf, A., Aboali, E. S., El‐Nabi, S. H., El-Tantawy, A. I., Schott, E. J., & Mohammed-Geba, K. (2024) · Frontiers in Marine Science · doi:10.3389/fmars.2024.1376768 · Cited by 5
Determination of Antioxidant and Antimicrobial Activities of Cell-Free Supernatant (CFSKC27L) and Exopolysaccharide (EPSKC27L) obtained from Ligilactobacillus salivarius KC27L
Çelik, K., Yüksekdağ, Z., Acar, B. Ç., & Kara, F. (2024) · Tekirdağ Ziraat Fakültesi Dergisi · doi:10.33462/jotaf.1370839 · Cited by 5
Botanical Bioflavonoid Composition from Scutellaria baicalensis- and Acacia catechu-Protected Mice against D-Galactose-Induced Immunosenescence, and Cyclophosphamide Induced Immune Suppression
Yimam, M., Horm, T., O’Neal, A. G., Chua, P., Jiao, P., Hong, M., & Jia, Q. (2024) · Nutrients · doi:10.3390/nu16183144 · Cited by 5
The alcohol exposome
Sabet, N. H., & Wyatt, T. A. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.12.003 · Cited by 6
Multi-omics perspective on Huoluo Xiaoling Pellet: key bioactive compounds and related mechanisms for the treatment of knee osteoarthritis
Zhang, J., Liu, L., Lao, Z., Li, L., Xu, H. Z., Wang, X., Lin, N., Guo, X., Yang, J., & Tang, L. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119761 · Cited by 5
Polynucleotide HPTTM-Based Hydrogels Exhibit Scavenging Activity Against Reactive Oxygen Species
Colangelo, M. T., Belletti, S., Guizzardi, S., & Galli, C. (2025) · Antioxidants · doi:10.3390/antiox14091089 · Cited by 5
The Toxicity of a New Monophenolic Synthetic Inducer of Keap1/Nrf2/ARE Redox-Sensitive Signaling System In Vitro and In Vivo
Валерьевна, Х. М., Khrapov, S. E., Владимирович, Ч. А., Kozhin, P. M., Romakh, L. P., Евгеньевна, С. А., Викторович, Х. С., Кандалинцева, Н. В., & Брониславовна, М. Е. (2023) · Cell and Tissue Biology · doi:10.1134/s1990519x23030069 · Cited by 5
A Comprehensive Review of Membrane Transporters and MicroRNA Regulation in Alzheimer’s Disease
Mishra, S., Stany, B. K., Das, A., Deepankumar, K., & Vijayan, M. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04135-2 · Cited by 5
Antihemolytic and antioxidant activities of aerial parts extracts of Zygophyllum album L. and Globularia alypum L. from Algeria
Ouffai, K., Azzi, R., Abbou, F., & LAHFA, F. B. (2022) · Journal of Natural Product Research and Applications · doi:10.46325/jnpra.v1i03.27 · Cited by 5
The effect of indoor air filtration on biomarkers of inflammation and oxidative stress: a review and meta-analysis of randomized controlled trials
Ren, J., Zhang, Z., Li, R., Tian, H., Guo, Z., Xue, W., Zhang, Y., Chen, F., Deng, Y., & Ma, Y. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-33414-7 · Cited by 5
Growth and production of water-stress indicators modified by zinc oxide nanoparticles as nanofertilizers under water-regulated conditions on tomatoes (Solanum lycopersicum L.)
Ojewumi, A. W., Osifeko, O. L., Keshinro, O. M., Osundinakin, M., Tope-Akinyetun, R. O., Ayoola, A. S., Husaini, M. A., Sejero, M. G., Adelugba, D. O., & Ojekale, A. B. (2025) · Plant Nano Biology · doi:10.1016/j.plana.2025.100168 · Cited by 4
Exploring Individual Factors Affecting Endothelial Function Response Variability in Aging: Implications for Precision Nutrition
Woolf, E. K., & Redman, L. M. (2025) · Nutrients · doi:10.3390/nu17142285 · Cited by 4
Toxic Effects of the Most Common Components of Energetic Co-Crystals
Peng, X., Li, C., Li, H., Deng, H., Lv, X., Gao, T., Shen, J., Zhao, B., Liu, Z.-Y., & Gao, J. (2025) · Molecules · doi:10.3390/molecules30153234 · Cited by 4

Authors: Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., Hussain, A., Haque, S., & Reshi, M. S.
Affiliations: Career Point University (IN)
Baba Ghulam Shah Badshah University (IN)
Zayed University (AE)
Jazan University (SA)
Almaarefa University (SA)
King Abdulaziz University (SA)
Manipal Academy of Higher Education, Dubai (AE)
Bursa Uludağ Üni̇versi̇tesi̇ (TR)
Corresponding author: Hussain, Arif
Haque, Shafiul
Reshi, Mohd Salim
ORCID: Hajam, Younis Ahmad
Qadri, Syed Sanober
Pramodh, Sreepoorna
Alsulimani, Ahmad
Alkhanani, Mustfa F.
Harakeh, Steve
Hussain, Arif
Haque, Shafiul
Reshi, Mohd Salim
Venue: Cells
Publisher: MDPI AG
Published: 2022-02-05
Volume: 11
Issue: 3
Pages: 552
ISSN: 2073-4409 (ISSN-L)
DOI: 10.3390/cells11030552
PMC: PMC8833991
OpenAlex: W4210796776
Cited by: 915
References: 218
Citations by year: 2026: 165 · 2025: 330 · 2024: 226 · 2023: 150 · 2022: 44
FWCI: 16.63
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cells (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Bursa Uludag University - AVESIS (submittedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
Funders: Jazan University
University Grants Commission (/2018)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: oxidative stress, reactive oxygen species, reactive nitrogen species, antioxidants, aging, age-related diseases, cardiovascular disease, chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, cancer, antioxidant enzymes, oxidative stress signaling
MeSH terms: Aging, Humans, Reactive Oxygen Species, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks