The DOI matches its Crossref record; 243 of the 243 references it cites were found in a registry or an index.
Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs
Open accessAbstract
Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse group of compounds formed either exogeneously or endogeneously on the course of various pathways in the human body. In general, they are formed non-enzymatically by condensation between carbonyl groups of reducing sugars and free amine groups of nucleic acids, proteins, or lipids, followed by further rearrangements yielding stable, irreversible end-products. In the last decades, AGEs have aroused the interest of the scientific community due to the increasing evidence of their involvement in many pathophysiological processes and diseases, such as diabetes, cancer, cardiovascular, neurodegenerative diseases, and even infection with the SARS-CoV-2 virus. They are recognized by several cellular receptors and trigger many signaling pathways related to inflammation and oxidative stress. Despite many experimental research outcomes published recently, the complexity of their engagement in human physiology and pathophysiological states requires further elucidation. This review focuses on the receptors of AGEs, especially on the structural aspects of receptor–ligand interaction, and the diseases in which AGEs are involved. It also aims to present AGE classification in subgroups and to describe the basic processes leading to both exogeneous and endogeneous AGE formation.
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Inflammation and nutrition: friend or foe?
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Hong, B., Bea, S., Ko, H. Y., Kim, W. J., Cho, Y. M., & Shin, J.-Y. (2024) · Annals of Internal Medicine · doi:10.7326/m23-3220 · Cited by 33
Flores-López, L. A., De la Mora-De la Mora, I., Malagón-Reyes, C. M., García-Torres, I., Martínez-Pérez, Y., López-Herrera, G., Hernández-Alcántara, G., León-Avila, G., López-Velázquez, G., Olaya-Vargas, A., et al. (2024) · Biomolecules · doi:10.3390/biom14101295 · Cited by 6
Proteomic Profiling of Plasma- and Gut-Derived Extracellular Vesicles in Obesity
Baptista Pereira, P., Torrejón, E., Ferreira, I., Carvalho, A. S., Teshima, A., Sousa-Lima, I., Beck, H. C., Costa-Silva, B., Matthiesen, R., Macedo, M. P., et al. (2024) · Nutrients · doi:10.3390/nu16050736 · Cited by 6
Metadata
- Authors
- Twarda-Clapa, A., Olczak, A., Białkowska, A. M., & Koziołkiewicz, M.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2022-04-12
- Volume
- 11
- Issue
- 8
- Pages
- 1312
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W4223542076
- Cited by
- 746
- References
- 243
- FWCI
- 73.29
- Type
- journal article
- Language
- en
- Open access
- gold
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- Twarda-Clapa, A., Olczak, A., Białkowska, A. M., & Koziołkiewicz, M. (2022). Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs. Cells. https://doi.org/10.3390/cells11081312
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