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Inflammation and cancer
Open accessAbstract
Inflammation is often associated with the development and progression of cancer. The cells responsible for cancer-associated inflammation are genetically stable and thus are not subjected to rapid emergence of drug resistance; therefore, the targeting of inflammation represents an attractive strategy both for cancer prevention and for cancer therapy. Tumor-extrinsic inflammation is caused by many factors, including bacterial and viral infections, autoimmune diseases, obesity, tobacco smoking, asbestos exposure, and excessive alcohol consumption, all of which increase cancer risk and stimulate malignant progression. In contrast, cancer-intrinsic or cancer-elicited inflammation can be triggered by cancer-initiating mutations and can contribute to malignant progression through the recruitment and activation of inflammatory cells. Both extrinsic and intrinsic inflammations can result in immunosuppression, thereby providing a preferred background for tumor development. The current review provides a link between inflammation and cancer development.
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Nuclear factor-κB in cancer development and progression
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Cited by
Twarda-Clapa, A., Olczak, A., Białkowska, A. M., & Koziołkiewicz, M. (2022) · Cells · doi:10.3390/cells11081312 · Cited by 746
The Role of Exercise in Cancer-Related Sarcopenia and Sarcopenic Obesity
Papadopetraki, A., Giannopoulos, A., Maridaki, M., Zagouri, F., Droufakou, S., Koutsilieris, M., & Philippou, A. (2023) · Cancers · doi:10.3390/cancers15245856 · Cited by 34
Chemistry and Biological Activities of Cannflavins of the Cannabis Plant
Abdel-Kader, M. S., Radwan, M. M., Metwaly, A. M., Eissa, I. H., Hazekamp, A., & ElSohly, M. A. (2023) · Cannabis & Cannabinoid Research · doi:10.1089/can.2023.0128 · Cited by 28
Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways
Rahmani, A. H., Almatroudi, A., Allemailem, K. S., Alharbi, H. O. A., Alwanian, W. M., Alhunayhani, B. A., Algahtani, M., Theyab, A., Almansour, N. M., Algefary, A. N., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11123205 · Cited by 22
Sarfraz, M., Khan, A., Batiha, G. E.-S., Akhtar, M. F., Saleem, A., Ajiboye, B. O., Kamal, M., Ali, A., Alotaibi, N. M., Aaghaz, S., et al. (2023) · Cancers · doi:10.3390/cancers15164194 · Cited by 20
Metadata
- Authors
- Singh, N., Baby, D., Rajguru, J., Patil, P., Thakkannavar, S., & Pujari, V.
- Venue
- Annals of African Medicine
- Publisher
- Medknow
- Published
- 2019
- Volume
- 18
- Issue
- 3
- Pages
- 121
- ISSN
- 0975-5764 (ISSN-L)
- 1596-3519
- OpenAlex
- W2968972266
- Cited by
- 1,333
- References
- 4
- FWCI
- 31.16
- Type
- journal article
- Language
- en
- Open access
- green
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