Dysfunctional heteroreceptor complexes as novel targets for the treatment of major depressive and anxiety disorders

Pérez de la Mora, Miguel, Borroto-Escuela, Dasiel O., Crespo-Ramírez, Minerva, Rejón-Orantes, José del Carmen, Palacios-Lagunas, Daniel Alejandro, Martínez-Mata, Magda K., Sánchez-Luna, Daniela, Tesoro-Cruz, Emiliano +1 more·2022·Cells

DOI 10.3390/cells11111826

Cites (393)

Items 201–393 of 393

Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders
Herman M. van Praag, Jakob Korf, J.P.W.F. Lakke, Thijs Schut · 1975 · Psychological Medicine
Hippocampal dopamine/DRD1 signaling dependent on the ghrelin receptor
Kern, Andras, Mavrikaki, Maria, Ullrich, Celine, Albarran-Zeckler, Rosie, Brantley, Alicia Faruzzi, Smith, Roy G. · 2015 · Cell
Catecholamine metabolism in affective disorders: I.
Joseph J. Schildkraut, Edna K. Gordon, Jack Durell · 1965 · Journal of Psychiatric Research
The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components
Borroto-Escuela, Dasiel, Brito, Ismel, Romero-Fernandez, Wilber, Di Palma, Michael, Oflijan, Julia, Skieterska, Kamila, Duchou, Jolien, Van Craenenbroeck, Kathleen, Suárez-Boomgaard, Diana, Rivera, Alicia et al. · 2014 · International Journal of Molecular Sciences
Imaging protein interactions with bioluminescence resonance energy transfer (BRET) in plant and mammalian cells and tissues
Xiaodong Xu, Mohammed Soutto, Qiguang Xie, Stein V. Servick, Chitra Subramanian, Albrecht G. von Arnim, Carl Hirschie Johnson · 2007 · Proceedings of the National Academy of Sciences
Infusion of the dopamine D1 receptor antagonist SCH 23390 into the amygdala blocks fear expression in a potentiated startle paradigm
Elaine Waddington Lamont, Larry Kokkinidis · 1998 · Brain Research
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus
Xiaoying Lü, Alasdair M. Barr, Jefferson W. Kinney, Pietro Paolo Sanna, Bruno Conti, M. Margarita Behrens, Tamás Bartfai · 2005 · Proceedings of the National Academy of Sciences
Behavioral reactivity to stress
Habibeh Khoshbouei, Marco Cecchi, Stephanie Dove, Martin A. Javors, David A. Morilak · 2002 · Pharmacology Biochemistry and Behavior
Neuropeptide Y in the dentate gyrus
Günther Sperk, Trevor J. Hamilton, William F. Colmers · 2007 · Progress in brain research
Receptor-receptor interactions as an integrative mechanism in nerve cells
Michèle Zoli, Luigi F. Agnati, Peter B. Hedlund, Ximing Li, Sergi Ferré, Kjell Fuxé · 1993 · Molecular Neurobiology
Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers
Maud T Kamal, Florence Gbahou, Jean‐Luc Guillaume, Avais M. Daulat, Abla Benleulmi‐Chaachoua, Marine Luka, Patty B. Chen, Dina Kalbasi Anaraki, Marc Baroncini, Clotilde Mannoury la Cour et al. · 2015 · Journal of Biological Chemistry
New vistas on synaptic plasticity: the receptor mosaic hypothesis of the engram.
Luigi F. Agnati, Kjell Fuxé, Michèle Zoli, C Rondanini, Sven Ove Ögren · 1982 · PubMed
Biased signaling by endogenous opioid peptides
Ivone Gomes, Salvador Sierra, Lindsay M. Lueptow, Achla Gupta, Shawn Gouty, Elyssa B. Margolis, Brian M. Cox, Lakshmi A. Devi · 2020 · Proceedings of the National Academy of Sciences
Fibroblast Growth Factor Receptor 1– 5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity
Dasiel O. Borroto‐Escuela, Wilber Romero‐Fernandez, Giuseppa Mudò, Mileidys Pérez‐Alea, Francisco Ciruela, Alexander O. Tarakanov, Manuel Narváez, Valentina Di Liberto, Luigi F. Agnati, Natale Belluardo et al. · 2011 · Biological Psychiatry
Narcotic antagonistic potency of bivalent ligands which contain .beta.-naltrexamine. Evidence for simultaneous occupation of proximal recognition sites
Miriam Erez, Akira E. Takemori, Philip S. Portoghese · 1982 · Journal of Medicinal Chemistry
Depletion of catecholaminesin vivo induced by electrical stimulation of central monoamine pathways
Gordon William Arbuthnott, Timothy John Crow, Kjell Fuxé, Lars Olson, Urban Ungerstedt · 1970 · Brain Research
Oligomerisation of G-protein-coupled receptors
Graeme Milligan · 2001 · Journal of Cell Science
The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural–glial networks
Dasiel O. Borroto‐Escuela, Luigi F. Agnati, Karl Bechter, Anders Jansson, Alexander O. Tarakanov, Kjell Fuxé · 2015 · Philosophical Transactions of the Royal Society B Biological Sciences
In vivo characterization of high Basal signaling from the ghrelin receptor
Petersen, Pia Steen, Woldbye, David P. D., Madsen, Andreas Nygaard, Egerod, Kristoffer L., Jin, Chunyu, Lang, Manja, Rasmussen, Maria, Beck-Sickinger, Annette G., Holst, Birgitte · 2009 · Endocrinology
Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
Ahmed Hasbi, Brian F. O’Dowd, Susan R. George · 2011 · Molecular Brain
Anti-inflammatory neuropeptides: A new class of endogenous immunoregulatory agents
Mario Delgado, Doina Ganea · 2008 · Brain Behavior and Immunity
Fifty years of dopamine research
Anders Björklund, Stephen B. Dunnett · 2007 · Trends in Neurosciences
Differential Role of Galanin Receptors in the Regulation of Depression-Like Behavior and Monoamine/Stress-Related Genes at the Cell Body Level
E. Kuteeva, T. Wardi, L. Lundström, Ulla E. Sollenberg, Ü. Langel, T. Hökfelt, S. Ögren · 2008 · Neuropsychopharmacology
Lean mean fat reducing “ghrelin” machine: Hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity
Harriët Schellekens, Timothy G. Dinan, John F. Cryan · 2009 · Neuropharmacology
Anxiolytic-like action of centrally administered galanin
Ola Bing, Christian H Møller, Jörgen A. Engel, Bo Söderpalm, Markus A Heilig · 1993 · Neuroscience Letters
Interactions between NMDA and dopamine receptors: A potential therapeutic target
Min Wang, Albert H.C. Wong, Fang Liu · 2012 · Brain Research
Anxiogenic-Like Action of Galanin after Intra-Amygdala Administration in the Rat
C Möller · 1999 · Neuropsychopharmacology
Galanin and Its Receptors in Neurological Disorders
Linda Lundström, Anna Elmquist, Tamás Bartfai, Ülo Langel · 2005 · NeuroMolecular Medicine
The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects
Dasiel O. Borroto‐Escuela, Patrizia Ambrogini, Barbara Chruścicka, Maria Lindskog, Minerva Crespo‐Ramírez, Juan C. Hernández-Mondragón, Miguel Pérez de la Mora, Harriët Schellekens, Kjell Fuxé · 2021 · International Journal of Molecular Sciences
Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling
Céline M’Kadmi, Jean-Philippe Leyris, Lauriane Onfroy, Céline Galès, Aude Saulière, Didier Gagne, Marjorie Damian, Sophie Mary, Mathieu Maingot, Séverine Denoyelle et al. · 2015 · Journal of Biological Chemistry
Brain galanin system genes interact with life stresses in depression-related phenotypes
Gabriella Juhász, Gábor Hullám, Nóra Eszlári, Xénia Gonda, Péter Antal, Ian Muir Anderson, Tomas G. M. Hökfelt, J.F.W. Deakin, György Bagdy · 2014 · Proceedings of the National Academy of Sciences
The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice
Rose‐Marie Karlsson, Jessica S. Choe, Heather A. Cameron, Annika Thorsell, Jacqueline N. Crawley, Andrew Holmes, Markus A Heilig · 2007 · Psychopharmacology
Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze
Kathleen R. Bailey, Maria N. Pavlova, Alex D. Rohde, John G. Hohmann, Jacqueline N. Crawley · 2007 · Pharmacology Biochemistry and Behavior
Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour
Eugenia Kuteeva, Tomas G. M. Hökfelt, Tara Wardi, Sven Ove Ögren · 2010 · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions
Structure-guided development of heterodimer-selective GPCR ligands
Harald Hübner, Tamara Schellhorn, Marie Gienger, Carolin Schaab, Jonas M. Kaindl, Laurin Leeb, Timothy Clark, Dorothée Weikert, Peter Gmeiner · 2016 · Nature Communications
Moonlighting Proteins and Protein–Protein Interactions as Neurotherapeutic Targets in the G Protein-Coupled Receptor Field
Kjell Fuxé, Dasiel O. Borroto‐Escuela, Wilber Romero‐Fernandez, Miklós Palkovits, Alexander O. Tarakanov, Francisco Ciruela, Luigi F. Agnati · 2013 · Neuropsychopharmacology
Design Strategies for Bivalent Ligands Targeting GPCRs
Jeremy Shonberg, Peter J. Scammells, Ben Capuano · 2011 · ChemMedChem
Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats
Mary M. Torregrossa, Emily M. Jutkiewicz, Henry I. Mosberg, Gianfranco Balboni, Stanley J. Watson, James Henry Woods · 2005 · Brain Research
Targeting opioid dysregulation in depression for the development of novel therapeutics
Caroline A. Browne, Irwin Lucki · 2019 · Pharmacology & Therapeutics
The dopaminergic modulation of fear: Quinpirole impairs the recall of emotional memories in rats.
Karim Nader, Joseph E. LeDoux · 1999 · Behavioral Neuroscience
Biased G Protein–Coupled Receptor Signaling
James W. Wisler, Howard A. Rockman, Robert J. Lefkowitz · 2018 · Circulation
The dopaminergic modulation of fear: Quinpirole impairs the recall of emotional memories in rats.
Karim Nader, Joseph E. LeDoux · 1999 · Behavioral Neuroscience
Dimerization and oligomerization of G-protein-coupled receptors: debated structures with established and emerging functions
Laszlo K. Szidonya, Miklós Cserző, László Hunyady · 2008 · Journal of Endocrinology
Localization of 5-hydroxytryptamine uptake in rat brain after intraventricular injection
Kjell Fuxé, Urban Ungerstedt · 1967 · Journal of Pharmacy and Pharmacology
Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward
Harriët Schellekens, Timothy G. Dinan, John F. Cryan · 2013 · Frontiers in Neuroscience
Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y1 receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression
Patricia A. Jiménez-Vasquez, Zaida Dı́az-Cabiale, Laura Caberlotto, Inmaculada Bellido-Estévez, David H. Overstreet, Kjell Fuxé, Aleksander A. Mathé · 2006 · European Neuropsychopharmacology
Single ketamine infusion in bipolar depression resistant to antidepressants: are neurotrophins involved?
JANUSZ K. RYBAKOWSKI, Agnieszka Permoda‐Osip, Maria Skibińska, R. Adamski, Alicja Bartkowska‐Śniatkowska · 2012 · Human Psychopharmacology Clinical and Experimental
Galanin – 25 years with a multitalented neuropeptide
Eugenia Kuteeva, Tomas G. M. Hökfelt, Tara Wardi, Sven Ove Ögren · 2008 · Cellular and Molecular Life Sciences
On the mechanism of action of the antidepressant drugs amitriptyline and nortriptyline. Evidence for 5-hydroxytryptamine receptor blocking activity
Kjell Fuxé, Sven Ove Ögren, Luigi F. Agnati, Jan Åke Gustafsson, GÖSTA JONSSON · 1977 · Neuroscience Letters
Galanin Is a Potent In Vivo Modulator of Mesencephalic Serotonergic Neurotransmission
Ján Kehr · 2002 · Neuropsychopharmacology
Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors
Ahmed Hasbi, Tuan Nguyen, Haneen Rahal, Joshua D. Manduca, Sharon L. Miksys, Rachel Fynvola Tyndale, Bertha Kalifon Madras, Melissa L. Perreault, Susan R. George · 2020 · Biology of Sex Differences
Functional rescue of a constitutively desensitized β2AR through receptor dimerization
Elise Hébert, P. Thomas LOISEL, Lynda Adam, Nathalie Éthier, ST. Stephane ONGE, Michel Bouvier · 1998 · Biochemical Journal
Galanin as a modulator of anxiety and depression and a therapeutic target for affective disease
Rose‐Marie Karlsson, Andrew Holmes · 2006 · Amino Acids
Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
Emily M. Jutkiewicz, Kenner C. Rice, John R. Traynor, James Henry Woods · 2005 · Psychopharmacology
GPCR Heteromers and their Allosteric Receptor-Receptor Interactions
Kjell Fuxé, D. O. Borroto-Escuela, Daniel J. Marcellino, Wilber Romero‐Fernandez, Małgorzata Frankowska, Diego Guidolin, Małgorzata Filip, Luca Ferraro, Amina S. Woods, Alexander O. Tarakanov et al. · 2012 · Current Medicinal Chemistry
Galanin selectively modulates 5-hydroxytryptamine 1A receptors in the rat ventral limbic cortex
Kjell Fuxé, Gabriel von Euler, Luigi F. Agnati, Sven Ove Ögren · 1988 · Neuroscience Letters
Endomorphins have orexigenic and anxiolytic activities in mice
Akihiro Asakawa, Akio Inui, Kazuhiro Momose, Naohiko Ueno, Masayuki Fujino, Masato Kasuga · 1998 · Neuroreport
Polarized Synaptic Interactions Between Intercalated Neurons of the Amygdala
Sébastien Royer, Marzia Martina, Denis Paré · 2000 · Journal of Neurophysiology
Lowered endogenous mu-opioid receptor availability in subclinical depression and anxiety
Lauri Nummenmaa, Tomi Karjalainen, Janne Isojärvi, Tatu Kantonen, Jouni Tuisku, Valtteri Kaasinen, Juho Joutsa, Pirjo Nuutila, Kari K. Kalliokoski, Jussi Hirvonen et al. · 2020 · Neuropsychopharmacology
Relationships of 5-hydroxytryptamine immunoreactive terminal-like varicosities to 5-hydroxytryptamine-2A receptor-immunoreactive neuronal processes in the rat forebrain
A Jansson, Barbro Tinner, Mircea Bancila, Daniel Vergé, Harry W.M. Steinbusch, L.F. Agnati, Kjell Fuxé · 2001 · Journal of Chemical Neuroanatomy
Brain accessibility delineates the central effects of circulating ghrelin
Mario Perelló, Agustina Cabral, María Paula Cornejo, Pablo Nicolás De Francesco, Gimena Fernández, Maia Uriarte · 2018 · Journal of Neuroendocrinology
Distribution of dopamine D2-like receptors in the rat amygdala and their role in the modulation of unconditioned fear and anxiety
de la Mora, M. Perez, Gallegos-Cari, A., Crespo-Ramirez, M., Marcellino, D., Hansson, A.C., Fuxe, K. · 2012 · Neuroscience
Neuropeptide Y, neurokinin A and neurotensin in brain regions of Fawn Hooded “depressed”, wistar, and Sprague dawley rats. Effects of electroconvulsive stimuli
Aleksander A. Mathé, Patricia A. Jimenez, Elvar Theodorsson, Carina Stenfors · 1998 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
Oligomerization of opioid receptors with β 2 -adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation
Bryen A. Jordan, Nino Trapaidze, Ivone Gomes, Raju N. Nivarthi, Lakshmi A. Devi · 2000 · Proceedings of the National Academy of Sciences
Opioid agonist and antagonist bivalent ligands as receptor probes
Philip S. Portoghese, Giuseppe Ronsisvalle, Dennis L. Larson, C. B. Yim, Lawrence M. Sayre, Akira E. Takemori · 1982 · Life Sciences
2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-Protein Coupled Receptors. The Whole Is Greater Than the Sum of Its Parts
Amy Hauck Newman, Francisco O. Battiti, Alessandro Bonifazi · 2019 · Journal of Medicinal Chemistry
Molecular integration via allosteric interactions in receptor heteromers. A working hypothesis
Kjell Fuxé, Daniel J. Marcellino, Giuseppina Leo, Luigi F. Agnati · 2009 · Current Opinion in Pharmacology
Genetic epidemiology of migraine and depression
Yuanhao Yang, Lannie Ligthart, Gisela Marie Terwindt, Dorret Irene Boomsma, Astrid J. Rodriguez‐Acevedo, Dale R. Nyholt · 2016 · Cephalalgia
Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity
Alfonso B. Abizaid, James L. Hougland · 2019 · Trends in Endocrinology and Metabolism
In vitro expression and analysis of the 826 human G protein-coupled receptors
Xuechen Lv, Junlin Liu, Qiaoyun Shi, Qiwen Tan, Dong Wu, John J. Skinner, Angela L. Walker, Lixia Zhao, Xiang-Xiang Gu, Na Chen et al. · 2016 · Protein & Cell
Heterodimerization of Hypothalamic G-Protein-Coupled Receptors Involved in Weight Regulation
Anne Rediger, Patrick Tarnow, Annika Bickenbach, Michael Schaefer, Heiko Krude, Annette Gr uuml ters, Heike Biebermann · 2009 · Obesity Facts
Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats
Gregory V. Carr, Irwin Lucki · 2010 · Psychopharmacology
Galanin in the brain: chemoarchitectonics and brain cartography—a historical review
David M. Jacobowitz, Adelheid E. Kresse, Gerhard Skofitsch · 2004 · Peptides
On the existence and function of galanin receptor heteromers in the central nervous system
Kjell Fuxé, Dasiel O. Borroto‐Escuela, Wilber Romero‐Fernandez, Alexander O. Tarakanov, Feliciano Calvo, Pere Garriga, Mercé Tena, Manuel Narváez, Carmelo Millón, Concepción Parrado et al. · 2012 · Frontiers in Endocrinology
Comorbidity of Mood and Anxiety Disorders: The Rule, Not the Exception?
Charles B. Nemeroff · 2002 · American Journal of Psychiatry
GAL 3 receptor KO mice exhibit an anxiety-like phenotype
Susanne Maria Brunner, Aitak Farzi, Felix Sternberg, Barbara S. Holub, Meinrad Drexel, Florian Reichmann, Andreas A. Lang, Johannes Adalbert Mayr, J Vilches, Xavier Navarro et al. · 2014 · Proceedings of the National Academy of Sciences
Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning: Dissociation between anxiety, locomotion and non-emotional memory behavior
Gilliard Lach, Thereza Christina Monteiro de Lima · 2013 · Neurobiology of Learning and Memory
Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers
Imane Moutkine, Emily Quentin, Bruno Pierre Guiard, Luc Maroteaux, Stéphane Doly · 2017 · Journal of Biological Chemistry
Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats
Rebolledo-Solleiro, Daniela, Roldán-Roldán, Gabriel, Díaz, Daniel, Velasco, Myrian, Larqué, Carlos, Rico-Rosillo, Guadalupe, Vega-Robledo, Gloria Bertha, Zambrano, Elena, Hiriart, Marcia, Pérez de la Mora, Miguel · 2017 · PLoS ONE
Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress
Rhonda Denise Kineman, Manuel David Gahete, Raul Miguel Luque · 2007 · Journal of Molecular Endocrinology
Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat
de la Mora, Miguel Pérez, Pérez-Carrera, Diana, Crespo-Ramírez, Minerva, Tarakanov, Alexander, Fuxe, Kjell, Borroto-Escuela, Dasiel O. · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
A peptide targeting an interaction interface disrupts the dopamine D1‐D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism
Ahmed Hasbi, Melissa L. Perreault, Maurice Y.F. Shen, Lucia Zhang, Ryan To, Theresa Fan, Tuan Nguyen, Ji X, Brian F. O’Dowd, Susan R. George · 2014 · The FASEB Journal
Opioid δ agonists and endogenous enkephalins induce different emotional reactivity than μ agonists after injection in the rat ventral tegmental area
G Calenco, Valérie Daugé, G. Gacel, Jean Féger, Bernard Pierre Roques · 1991 · Psychopharmacology
On the distribution patterns of D1, D2, tyrosine hydroxylase and dopamine transporter immunoreactivities in the ventral striatum of the rat
A. Jansson, M. Goldstein, Barbro Tinner, Michèle Zoli, James H. Meador‐Woodruff, J. Lew, Allan I. Levey, Stanley J. Watson, L.F. Agnati, Kjell Fuxé · 1999 · Neuroscience
δ-Opioid Agonists: Differential Efficacy and Potency of SNC80, Its 3-OH (SNC86) and 3-Desoxy (SNC162) Derivatives in Sprague-Dawley Rats
Emily M. Jutkiewicz, Erik B. Eller, John E. Folk, Kenner C. Rice, John R. Traynor, James Henry Woods · 2004 · Journal of Pharmacology and Experimental Therapeutics
Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition
Dasiel O. Borroto‐Escuela, Xiang Li, Alexander O. Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade‐Talavera, Antonio Jimenez‐Beristain, Bartosz Pomierny, Zaida Dı́az-Cabiale et al. · 2017 · ACS Omega
Depressive Symptom Clusters Are Differentially Associated with General and Visceral Obesity
Radboud M. Marijnissen, Boudewijn A.A. Bus, Suzanne Holewijn, Barbara Franke, Nitin B. Purandare, Jacqueline d Graaf, Martin den Heijer, Jan K. Buitelaar, Richard C. Oude Voshaar · 2011 · Journal of the American Geriatrics Society
The intercalated paracapsular islands as a module for integration of signals regulating anxiety in the amygdala.
Elizabeth Palomares-Castillo, O. Hernández-Pérez, Diana Pérez-Carrera, Minerva Crespo-Ramírez, K. Fuxe, M. Pérez de la Mora · 2012 · Brain Research
Morphine Desensitization, Internalization, and Down-Regulation of the μ Opioid Receptor Is Facilitated by Serotonin 5-Hydroxytryptamine2A Receptor Coactivation
Juan F. López‐Giménez, M. Teresa Vilaró, Graeme Milligan · 2008 · Molecular Pharmacology
Update on GPCR-based targets for the development of novel antidepressants
Ioannis Mantas, Marcus Saarinen, Qing Xu, Per Svenningsson · 2021 · Molecular Psychiatry
Antidepressant-like and anxiolytic-like effects following activation of the μ-δ opioid receptor heteromer in the nucleus accumbens
Noufissa Kabli, Tuan Nguyen, Gianfranco Balboni, Brian F. O’Dowd, Susan R. George · 2013 · Molecular Psychiatry
A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction
Dasiel O. Borroto‐Escuela, Karolina Wydra, Małgorzata Filip, Kjell Fuxé · 2018 · Trends in Pharmacological Sciences
Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat
Eugenia Kuteeva, Tara Wardi, Tomas G. M. Hökfelt, Sven Ove Ögren · 2006 · European Neuropsychopharmacology
A Role for Galanin N-Terminal Fragment (1–15) in Anxiety- and Depression-Related Behaviors in Rats
Carmelo Millón, Antonio Flores‐Burgess, Manuel Narváez, Dasiel O. Borroto‐Escuela, Luis J. Santín, Concepción Parrado, José Ángel Narváez, Kjell Fuxé, Zaida Dı́az-Cabiale · 2015 · The International Journal of Neuropsychopharmacology
Dopamine D2 and serotonin 5‐ HT 1A receptor interaction in the context of the effects of antipsychotics – in vitro studies
Sylwia Łukasiewicz, Ewa Błasiak, Kinga Szafran‐Pilch, Marta Dziedzicka‐Wasylewska · 2016 · Journal of Neurochemistry
Reversal of Stress-Induced Social Interaction Deficits by Buprenorphine
Caroline A. Browne, Edgardo Falcón, Shivon A. Robinson, Olivier Berton, Irwin Lucki · 2017 · The International Journal of Neuropsychopharmacology
Ablation of Kappa-Opioid Receptors from Brain Dopamine Neurons has Anxiolytic-Like Effects and Enhances Cocaine-Induced Plasticity
Ashlee Van’t Veer, Anita J. Bechtholt, Sara Onvani, David N. Potter, Yujun Wang, Lee‐Yuan Liu‐Chen, Günther Schütz, Elena H. Chartoff, Uwe Rudolph, Bruce M. Cohen et al. · 2013 · Neuropsychopharmacology
Covalent crosslinking of angiotensin II to its binding sites in rat adrenal membranes.
Shoshana Paglin, James D. Jamieson · 1982 · Proceedings of the National Academy of Sciences
Correlation between oxytocin neuronal sensitivity and oxytocin-binding sites in the amygdala of the rat: electrophysiological and histoautoradiographic study
Miguel Condés‐Lara, Pierre Veinante, M. Rabai, Marie José Freund‐Mercier · 1994 · Brain Research
Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia
Dasiel O. Borroto‐Escuela, Julia Pintšuk, Thorsten Schäfer, Kristina Friedland, Luca Ferraro, Sergio Tanganelli, Fang Liu, Kjell Fuxé · 2016 · Therapeutic Advances in Psychopharmacology
Antagonistic A2a/D2 receptor interactions in the striatum as a basis for adenosine/dopamine interactions in the central nervous system
Kjell Fuxé, Sergi Ferré, Per Snaprud, Gabriel von Euler, Björn Axel Johansson, Bertil Ferdholm · 1993 · Drug Development Research
Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication
Kjell Fuxé, Dasiel O. Borroto‐Escuela · 2016 · Neural Regeneration Research
Differential effects of selective opioid peptide antagonists on the acquisition of Pavlovian fear conditioning
Michael S. Fanselow, Jeansok John Kim, Stacey L. Young, Daniel J. Calcagnetti, Joseph P. DeCola, Fred J. Helmstetter, J. Landeira-Fernández · 1991 · Peptides
Agonists at the δ‐opioid receptor modify the binding of µ‐receptor agonists to the µ–δ receptor hetero‐oligomer
Noufissa Kabli, Nancy A. Martin, T. Fan, Tuan Nguyen, Ahmed Hasbi, Gianfranco Balboni, Brian F. O’Dowd, S R George · 2010 · British Journal of Pharmacology
Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system
Carmelo Millón, Antonio Flores‐Burgess, Manuel Narváez, Dasiel O. Borroto‐Escuela, Luis J. Santín, Belén Gago, José Ángel Narváez, Kjell Fuxé, Zaida Dı́az-Cabiale · 2016 · Brain Structure and Function
Anxiolytic effects of intra-amygdaloid injection of the D1 antagonist SCH23390 in the rat
Miguel Pérez de la Mora, Linda Cárdenas-Cachón, Mariana Vázquez‐García, Minerva Crespo‐Ramírez, Kirsten Rosenmay Jacobsen, Malin Höistad, Luigi F. Agnati, Kjell Fuxé · 2004 · Neuroscience Letters
Design of bivalent ligands targeting putative GPCR dimers
Boshi Huang, Celsey M. St. Onge, Hongguang Ma, Yan Zhang · 2020 · Drug Discovery Today
Activation of 5-hydroxytryptamine1A receptors increases the affinity of galanin receptors in di- and telencephalic areas of the rat
Peter B. Hedlund, Gabriel von Euler, Kjell Fuxé · 1991 · Brain Research
Preferential activation by galanin 1–15 fragment of the GalR1 protomer of a GalR1–GalR2 heteroreceptor complex
Dasiel O. Borroto‐Escuela, Manuel Narváez, Michael Di Palma, Feliciano Calvo, David J. Rodriguez, Carmelo Millón, Jens Carlsson, Luigi F. Agnati, Pere Garriga, Zaida Dı́az-Cabiale et al. · 2014 · Biochemical and Biophysical Research Communications
Receptor–Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment
Dasiel O. Borroto‐Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero‐Fernandez, Yuniesky Andrade‐Talavera, Antonio Flores‐Burgess, Carmelo Millón, Belén Gago et al. · 2018 · Molecules
Heterodimerization of G-protein-coupled receptors in the CNS
Fiona H. Marshall · 2001 · Current Opinion in Pharmacology
Serotonin and hypothalamic control of hunger: a review
Fernanda de Matos Feijó, Marcello Casaccia Bertoluci, Cíntia Reis · 2011 · Revista da Associação Médica Brasileira (English Edition)
A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Wallace Fitzsimons, Shauna E., Chruścicka, Barbara, Druelle, Clementine, Stamou, Panagiota, Nally, Ken, Dinan, Timothy G., Cryan, John F., Schellekens, Harriët · 2019 · Neuropharmacology
Rapid anti-depressant and anxiolytic actions following dopamine D1–D2 receptor heteromer inactivation
Maurice Y.F. Shen, Melissa L. Perreault, Francis Rodriguez Bambico, Jace Jones-Tabah, Marco Cheung, Theresa Fan, José N. Nóbrega, Susan R. George · 2015 · European Neuropsychopharmacology
Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson’s disease and its treatment
Dasiel O. Borroto‐Escuela, Kjell Fuxé · 2019 · Journal of Neural Transmission
Evidence for the existence of FGFR1–5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system
Dasiel O. Borroto‐Escuela, Manuel Narváez, Mileidys Pérez‐Alea, Alexander O. Tarakanov, Antonio Jimenez‐Beristain, Giuseppa Mudò, Luigi F. Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fuxé · 2014 · Biochemical and Biophysical Research Communications
“Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats”
Marta Valenza, Eduardo R. Butelman, Mary Jeanne Kreek · 2017 · Psychopharmacology
Novel systemically active galanin receptor 2 ligands in depression‐like behavior
Indrek Saar, Jaanus Lahe, Kent Langel, Johan Runesson, Kristin Webling, Jaak Järv, Jussi Rytkönen, Ale T. O. Närvänen, Tamás Bartfai, Kaido Kurrikoff et al. · 2013 · Journal of Neurochemistry
In Situ Proximity Ligation Assay to Study and Understand the Distribution and Balance of GPCR Homo- and Heteroreceptor Complexes in the Brain
Dasiel O. Borroto‐Escuela, Beth Hagman, Miles Woolfenden, Luca Pinton, Antonio Jimenez‐Beristain, Julia Oflijan, Manuel Narváez, Michael Di Palma, Kristin Feltmann, Stefano Sartini et al. · 2016 · Neuromethods
Effects of bromocriptine on 3H-spiroperidol binding sites in rat striatum. Evidence for actions of dopamine receptors not linked to adenylate cyclase
Robert M. Schwarcz, Kjell Fuxé, Luigi F. Agnati, Jan-Ακε Gustafsson · 1978 · Life Sciences
Dopamine D2 heteroreceptor complexes and their receptor–receptor interactions in ventral striatum
Kjell Fuxé, Dasiel O. Borroto‐Escuela, Alexander O. Tarakanov, Wilber Romero‐Fernandez, Luca Ferraro, Sergio Tanganelli, Mileidys Pérez‐Alea, Michael Di Palma, Luigi F. Agnati · 2014 · Progress in brain research
Positive reinforcing effect of oxytocin microinjection in the rat central nucleus of amygdala
Kristóf László, Anita Kovács, Olga Zagorácz, Tamás Ollmann, László Péczely, Erika Kertes, D.G. Lacy, László Lénárd · 2015 · Behavioural Brain Research
Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus
Mercedes F. Paredes, Joel S. F. Greenwood, Scott C. Baraban · 2003 · Neuroscience Letters
One for all or one for one: does co-transmission unify the concept of a brain galanin “system” or clarify any consistent role in anxiety?
Gabe Barrera, David J. Echevarria, Jean-Francois Poulin, Sylvie Laforest, Guy Drolet, David A. Morilak · 2005 · Neuropeptides
Homobivalent Ligands of the Atypical Antipsychotic Clozapine: Design, Synthesis, and Pharmacological Evaluation
Fiona M. McRobb, Ian T. Crosby, Elizabeth Yuriev, J. Robert Lane, Ben Capuano · 2012 · Journal of Medicinal Chemistry
Morphine prevents the development of stress-enhanced fear learning
Jennifer L. Szczytkowski, Christina L. Lebonville, Donald T. Lysle · 2012 · Pharmacology Biochemistry and Behavior
Complementary roles for amygdala and periaqueductal gray in temporal-difference fear learning
Sindy Cole, Gavan P. McNally · 2008 · Learning & Memory
New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein‐coupled receptors
Reinhard Grisshammer · 2017 · Protein Science
The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders
Eva Maria Fritz, Nicolas Singewald, Dimitri De Bundel · 2020 · Frontiers in Synaptic Neuroscience
A Functional Role for Dopamine Transmission in the Amygdala during Condtioned Fear
Fay A. Guarraci, Russell J. Frohardt, S YOUNG, Bruce S. Kapp · 1999 · Annals of the New York Academy of Sciences
μ-opioid and 5-HT1A receptors heterodimerize and show signalling crosstalk via G protein and MAP-kinase pathways
Didier Cussac, Isabelle Rauly‐Lestienne, Peter Heusler, Frédéric Finana, Claudie Cathala, Sophie Bernois, Luc De Vries · 2012 · Cellular Signalling
International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?
Terry Kenakin, Luigi F. Agnati, Marc G. Caron, Bertil B. Fredholm, Diego Guidoli, Brian K. Kobilka, Robert J. Lefkowitz, Martin J. Lohse, Amina S. Woods, Kjell Fuxé · 2010 · Journal of Receptors and Signal Transduction
Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression
Dasiel O. Borroto‐Escuela, Mileidys Pérez‐Alea, Manuel Narváez, Alexander O. Tarakanov, Giuseppa Mudò, Antonio Jimenez‐Beristain, Luigi F. Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fuxé · 2015 · Biochemical and Biophysical Research Communications
Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo
Müzeyyen Ugur, Lyes Derouiche, Dominique Massotte · 2018 · Frontiers in Pharmacology
Efficacy of ketamine for major depressive episodes at 2, 4, and 6-weeks post-treatment: A meta-analysis
Conley, Ashley A., Norwood, Amber E. Q., Hatvany, Thomas C., Griffith, James D., Barber, Kathryn E. · 2021 · Psychopharmacology
Interaction of Intravenous Anesthetics with Recombinant Human M1-M3 Muscarinic Receptors Expressed in Chinese Hamster Ovary Cells
Kazuyoshi Hirota, Yoshio Hashimoto, David George Lambert · 2002 · Anesthesia & Analgesia
Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell
F. Liu, Rui Zhou, H. Yan, Haoran Yin, X. Wu, Y. Tan, L. Li · 2014 · Neuroscience
Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice.
Mingjun Xiang, Yuting Jiang, Zhiying Hu, Yang Yang, Xiaoxue Du, Benson O. A. Botchway, Marong Fang · 2019 · PubMed Central
Ketamine relieves depression-like behaviors induced by chronic postsurgical pain in rats through anti-inflammatory, anti-oxidant effects and regulating BDNF expression
Yang, Yitian, Song, Yuxiang, Zhang, Xuan, Zhao, Weixing, Ma, Tao, Liu, Yi, Ma, Penglei, Zhao, Yifan, Zhang, Hong · 2020 · Psychopharmacology
Intranasal Oxytocin as an Adjunct to Escitalopram in Major Depression
Gabrielle Scantamburlo, M. Ansseau, Vincent G. Geenen, Jean‐Jacques Legros · 2011 · Journal of Neuropsychiatry
Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes
Dasiel O. Borroto‐Escuela, Karolina Wydra, Julia Pintšuk, Manuel Narváez, Fidel Corrales, Magdalena Zaniewska, Luigi F. Agnati, Rafael Franco, Sergio Tanganelli, Luca Ferraro et al. · 2016 · Neural Plasticity
The neuropeptides Galanin and Galanin(1–15) in depression-like behaviours
Carmelo Millón, Antonio Flores‐Burgess, Manuel Narváez, Dasiel O. Borroto‐Escuela, Belén Gago, Luis J. Santín, Estela Castilla‐Ortega, José Ángel Narváez, Kjell Fuxé, Zaida Dı́az-Cabiale · 2017 · Neuropeptides
Galanin receptor 2 overexpressing mice display an antidepressive-like phenotype: possible involvement of the subiculum
Tara Wardi Le Maître, S. Xia, Erwan Le Maître, Xin‐Peng Dun, Jianqiang Lu, Elvar Theodorsson, Sven Ove Ögren, Tomas Hökfelt, Qing Xu · 2011 · Neuroscience
Attenuation of Oxytocin and Serotonin 2A Receptor Signaling through Novel Heteroreceptor Formation
Barbara Chruścicka, Shauna E. Wallace Fitzsimons, Dasiel O. Borroto‐Escuela, Clémentine M. Druelle, Panagiota Stamou, Kenneth Nally, Timothy G. Dinan, John F. Cryan, Kjell Fuxé, Harriët Schellekens · 2019 · ACS Chemical Neuroscience
Bitopic ligands: all-in-one orthosteric and allosteric
Maud Kamal, Ralf Jockers · 2009 · F1000 Biology Reports
Diversity and bias through dopamine D2R heteroreceptor complexes
Dasiel O. Borroto‐Escuela, Kjell Fuxé · 2016 · Current Opinion in Pharmacology
Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression
Dasiel O. Borroto‐Escuela, Caitlin M. DuPont, Xiang Li, David Savelli, Davide Lattanzi, Ipsit Srivastava, Manuel Narváez, Michael Di Palma, Elisa Barbieri, Yuniesky Andrade‐Talavera et al. · 2017 · Frontiers in Cellular Neuroscience
A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants
Chadi G. Abdallah, Kyung-Heup Ahn, Lynnette A. Averill, Samaneh Nemati, Christopher L. Averill, Samar Fouda, Mohini Ranganathan, PETER T. MORGAN, Deepak Cyril D’Souza, Daniel H. Mathalon et al. · 2020 · Neuropsychopharmacology
Dynamic modulation of FGFR1–5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2
Dasiel O. Borroto‐Escuela, Fidel Corrales, Manuel Narváez, Julia Oflijan, Luigi F. Agnati, Miklós Palkovits, Kjell Fuxé · 2013 · Biochemical and Biophysical Research Communications
Pharmacodynamic response profiles of anxiolytic and sedative drugs
Xia Chen, F. J. F. Broeyer, Marieke de Kam, Joke Baas, Adam F. Cohen, Joop van Gerven · 2016 · British Journal of Clinical Pharmacology
Serotonin and hypothalamic control of hunger: a review
Fernanda de Matos Feijó, Marcello Casaccia Bertoluci, Cíntia Reis · 2011 · Revista da Associação Médica Brasileira
Non-Monoaminergic Targets for the Development of Antidepressants: Focus on Neuropeptides
Mario Catena-Dell’Osso, Andrea M. Fagiolini, Donatella Marazziti, Stefano Baroni, Cesario Bellantuono · 2012 · Mini-Reviews in Medicinal Chemistry
Design, Synthesis, and Biological Evaluation of Bivalent Ligands Targeting Dopamine D2‐Like Receptors and the μ‐Opioid Receptor
Mingcheng Qian, Lakshmi Vasudevan, Jelle Huysentruyt, Martijn Risseeuw, Christophe Pol Stove, Patrick Vanderheyden, Kathleen Van Craenenbroeck, Serge Van Calenbergh · 2018 · ChemMedChem
Hetero-oligomers of α2A-adrenergic and μ-opioid receptors do not lead to transactivation of G-proteins or altered endocytosis profiles
Y.Q. Zhang, L E Limbird · 2004 · Biochemical Society Transactions
Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects
Manuel Narváez, Dasiel O. Borroto‐Escuela, Carmelo Millón, Belén Gago, Antonio Flores‐Burgess, Luis J. Santín, Kjell Fuxé, José Ángel Narváez, Zaida Dı́az-Cabiale · 2015 · Brain Structure and Function
Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test
Peng Huang, Julia Tunis, Christopher Parry, Ronald J. Tallarida, Lee‐Yuan Liu‐Chen · 2016 · European Journal of Pharmacology
Neuropeptides and central catecholamine systems: interactions in neuroendocrine and central cardiovascular regulation.
Kjell Fuxé, K. Andersson, Vittorio Locatelli, Viktor Mutt, Jesper Lundberg, Tomas G. M. Hökfelt, Agnati Lf, Peter H.E. Eneroth, Per Bolme · 1980 · PubMed
Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia—Relevance for Mental Diseases
Dasiel O. Borroto‐Escuela, Patrizia Ambrogini, Manuel Narváez, Valentina Di Liberto, Sarah Beggiato, Luca Ferraro, Ramón Fores‐Pons, Jose Erik Alvarez‐Contino, Alexander López‐Salas, Giuseppa Mudò et al. · 2021 · Cells
Heteromerization of dopaminergic receptors in the brain: Pharmacological implications
Desye Misganaw · 2021 · Pharmacological Research
Disruption of the dopamine transporter–dopamine D2 receptor interaction in schizophrenia
F. Lee, L. Pei, Fang Liu · 2009 · Synapse
Conventional and Novel Pharmacological Approaches to Treat Dopamine-Related Disorders: Focus on Parkinson’s Disease and Schizophrenia
Miguel Pérez de la Mora, Juan C. Hernández-Mondragón, Minerva Crespo‐Ramírez, José del Carmen Rejón-Orantes, Dasiel O. Borroto‐Escuela, Kjell Fuxé · 2019 · Neuroscience
Intranasal Oxytocin as an Adjunct to Escitalopram in Major Depression
Gabrielle Scantamburlo, Marc Ansseau, Vincent G. Geenen · 2011 · Journal of Neuropsychiatry
Changes in GABAAreceptors in status epilepticus
Günther Sperk · 2007 · Epilepsia
The recent progress in research on effects of anesthetics and analgesics on G protein-coupled receptors
Kouichiro Minami, Yasuhito Uezono · 2012 · Journal of Anesthesia
Altered explorative strategies and reactive coping style in the FSL rat model of depression
Salvatore Magara, Sarah Holst, Stina Lundberg, Erika Roman, Maria Lindskog · 2015 · Frontiers in Behavioral Neuroscience
Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling
Joseph Phan, Lamees Alhassen, Allan Argelagos, Wedad Alhassen, Benjamin Vachirakorntong, Zitong Lin, Nayna M. Sanathara, Amal Alachkar · 2020 · Scientific Reports
Molecular, biochemical and behavioural evidence for a novel oxytocin receptor and serotonin 2C receptor heterocomplex.
B. Chruścicka, C. Cowan, Shauna E. Wallace Fitzsimons, D. Borroto-Escuela, Clémentine Druelle, P. Stamou, Cristian A. Bergmann, T. Dinan, D. Slattery, K. Fuxe et al. · 2020 · Neuropharmacology
GABA-Dopamine Receptor-Receptor Interactions in Neostriatal Membranes of the Rat
Miguel Pérez de la Mora, Sergi Ferré, Kjell Fuxé · 1997 · Neurochemical Research
Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor
Lakshmi Vasudevan, Dasiel O. Borroto‐Escuela, Jelle Huysentruyt, Kjell Fuxé, Deepak Kumar Saini, Christophe Pol Stove · 2019 · Biomolecules
Novel Galanin Receptor Subtype Specific Ligand in Depression Like Behavior
Indrek Saar, Johan Runesson, Jaak Järv, Kaido Kurrikoff, Ülo Langel · 2012 · Neurochemical Research
A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats
Manuel Narváez, Dasiel O. Borroto‐Escuela, Luis J. Santín, Carmelo Millón, Belén Gago, Antonio Flores‐Burgess, Miguel Ángel Barbancho, Miguel Pérez de la Mora, José Ángel Narváez, Zaida Dı́az-Cabiale et al. · 2018 · Frontiers in Cellular Neuroscience
Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus
Dasiel O. Borroto‐Escuela, Mariana Pita-Rodríguez, Ramón Fores‐Pons, Miguel Ángel Barbancho, Kjell Fuxé, Manuel Narváez · 2020 · Journal of Cellular Physiology
Dopamine D2L Receptor Deficiency Causes Stress Vulnerability through 5-HT1A Receptor Dysfunction in Serotonergic Neurons
Norifumi Shioda, Yoshiki Imai, Yasushi Yabuki, Wataru Sugimoto, Kouya Yamaguchi, Yanyan Wang, Takatoshi Hikida, Toshikuni Sasaoka, Michihiro Mieda, Kohji Fukunaga · 2019 · Journal of Neuroscience
Opioid-dependent regulation of high and low fear responses in two inbred mouse strains
Klaudia Szklarczyk, Michał Korostyński, Przemysław Eligiusz Cieślak, Agnieszka Wawrzczak‐Bargieła, Ryszard Przewłocki · 2015 · Behavioural Brain Research
Chronic pentobarbital administration alters ?-aminobutyric acidA receptor ?6-subunit mRNA levels and diazepam-insensitive [3H]Ro15-4513 binding
Takehiko Ito, Toshihito Suzuki, Susan E. Wellman, Ing Kang Ho · 1996 · Synapse
The role of D2 dopamine receptors in oxytocin induced place preference and anxiolytic effect
László, K., Péczely, L., Géczi, F., Kovács, A., Zagoracz, O., Ollmann, T., Kertes, E., Kállai, V., László, B., Berta, B. et al. · 2020 · Hormones and Behavior
Galanin(1-15) Potentiates the Antidepressant-like Effects Induced by Escitalopram in a Rat Model of Depression
Laura García-Durán, Antonio Flores‐Burgess, Noelia Cantero-García, Araceli Puigcerver, José Ángel Narváez, Kjell Fuxé, Luis J. Santín, Carmelo Millón, Zaida Dı́az-Cabiale · 2021 · International Journal of Molecular Sciences
Molecular recognition of ketamine by a subset of olfactory G protein–coupled receptors
Jianghai Ho, Jose Manuel Perez‐Aguilar, Lu Gao, Jeffery G. Saven, Hiroaki Matsunami, Roderic G. Eckenhoff · 2015 · Science Signaling
Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept
Akiyoshi Saitoh, Hiroshi Nagase · 2016 · Handbook of experimental pharmacology
Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression
Antonio Flores‐Burgess, Carmelo Millón, Belén Gago, Laura García-Durán, Noelia Cantero-García, Araceli Puigcerver, José Ángel Narváez, Kjell Fuxé, Luis J. Santín, Zaida Dı́az-Cabiale · 2021 · The International Journal of Neuropsychopharmacology
In vivo neuronal co-expression of mu and delta opioid receptors uncovers new therapeutic perspectives
Eric Erbs, Lauren C. Faget, Pierre Veinante, Brigitte Lina Kieffer, Dominique Massotte · 2014 · Receptors & Clinical Investigation
Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing
Michael Di Palma, Stefano Sartini, Davide Lattanzi, Riccardo Cuppini, Mariana Pita-Rodríguez, Yoslandy Diaz-Carmenate, Manuel Narváez, Kjell Fuxé, Dasiel O. Borroto‐Escuela, Patrizia Ambrogini · 2020 · Mechanisms of Ageing and Development
Semagacestat, a γ-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor
Harriët Schellekens, Orla A. McNamara, Timothy G. Dinan, Justin V. McCarthy, Gerard P. McGlacken, John F. Cryan · 2012 · Journal of Pharmacy and Pharmacology
Candidate gene study reveals DRD1 and DRD2 as putative interacting risk factors for youth depression
Eyleen Corrales, Arcadi Navarro, Patricia Cuenca, Domingo Campos · 2016 · Psychiatry Research
Brain-derived neurotrophic factor-TrkB signaling and the mechanism of antidepressant activity by ketamine in mood disorders
Kenji Hashimoto · 2020 · European Archives of Psychiatry and Clinical Neuroscience
Detection, Analysis, and Quantification of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay
Dasiel O. Borroto‐Escuela, Manuel Narváez, Ismael Valladolid‐Acebes, Kirill Shumilov, Michael Di Palma, Karolina Wydra, Thorsten Schaefer, Irene Reyes‐Resina, Gemma Navarro, Giuseppa Mudò et al. · 2018 · Neuromethods
Direct inhibition of G protein signaling by cross‐conformational switches between α 2A ‐adrenergic and μ‐opioid receptors
Jean‐Pierre Vilardaga, Viacheslav O. Nikolaev, Kristina Lorenz, Sébastien Ferrandon, Martin J. Lohse · 2008 · The FASEB Journal
Increased Ethanol Self-Administration in ??-Opioid Receptor Knockout Mice
Amanda J. Roberts, Lisa H. Gold, Ilham Y. Polis, Jeffrey S. McDonald, Dominique Filliol, Brigitte Lina Kieffer, George F. Koob · 2001 · Alcoholism Clinical and Experimental Research
Methods to Identify the Signature of Trimers Formed by Three G Protein-Coupled Receptors or by Two G Protein-Coupled and One Ionotropic Receptor with Special Emphasis in the Functional Role in the Central Nervous System
Irene Reyes‐Resina, Eva Martínez‐Pinilla, Dasiel O. Borroto‐Escuela, Kjell Fuxé, Gemma Navarro, Rafael Franco · 2018 · Neuromethods
Characterizing the binding of dopamine D1–D2 receptors in vitro and in temporal and frontal lobe tissue total protein
Deborah Heyl, Margaret Champion, Robert Muterspaugh, Megan Connolly, Adam Baraka, Pouya Khazaei, Briana Moe, Zeinab Al‐Sheemary, Nael Jaber, Hedeel Guy‐Evans · 2019 · FEBS Letters
P.1.g.067 The GalR1–GalR2 heteroreceptor complex can be the receptor for galanin fragment 1–15
D.O. Borroto Escuela, Feliciano Calvo, Manuel Narváez, Wilber Romero‐Fernandez, Carmelo Millón, Michael Di Palma, Mileidys Pérez‐Alea, Mercé Tena, L.F. Agnati, Alexander O. Tarakanov et al. · 2014 · European Neuropsychopharmacology
A Biophysical Approach for the Study of Dopamine Receptor Oligomerization
Sylwia Łukasiewicz, Agata Faron‐Górecka, Marta Dziedzicka‐Wasylewska · 2012 · Methods in molecular biology
Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders
2000