Cited by 21Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Dysfunctional heteroreceptor complexes as novel targets for the treatment of major depressive and anxiety disorders

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Pérez de la Mora, Miguel, Borroto-Escuela, Dasiel O., Crespo-Ramírez, Minerva, Rejón-Orantes, José del Carmen, Palacios-Lagunas, Daniel Alejandro, Martínez-Mata, Magda K., Sánchez-Luna, Daniela, Tesoro-Cruz, Emiliano +1 more·2022·Cells

Abstract

Among mental diseases, major depressive disorder (MDD) and anxiety deserve a special place due to their high prevalence and their negative impact both on society and patients suffering from these disorders. Consequently, the development of novel strategies designed to treat them quickly and efficiently, without or at least having limited side effects, is considered a highly important goal. Growing evidence indicates that emerging properties are developed on recognition, trafficking, and signaling of G-protein coupled receptors (GPCRs) upon their heteromerization with other types of GPCRs, receptor tyrosine kinases, and ionotropic receptors such as N-methyl-D-aspartate (NMDA) receptors. Therefore, to develop new treatments for MDD and anxiety, it will be important to identify the most vulnerable heteroreceptor complexes involved in MDD and anxiety. This review focuses on how GPCRs, especially serotonin, dopamine, galanin, and opioid heteroreceptor complexes, modulate synaptic and volume transmission in the limbic networks of the brain. We attempt to provide information showing how these emerging concepts can contribute to finding new ways to treat both MDD and anxiety disorders.

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  1. [15]Belon J.P. L’anxiété et Les Troubles Anxieux (Anxiety and Anxiety Disorders) Actual. Pharm. 2019 58 18 22 10.1016/J.ACTPHA.2019.09.005 · DOI
  2. [91]Fuxe K. Agnati L.F. Two Principal Modes of Electrochemical Communication in the Brain: Volume Versus Wiring Transmission Volume Transmission in the Brain: Novel Mechanisms for Neural Transmission Fuxe K. Agnati L.F. Raven Press New York, NY, USA 1991 1 9
  3. [113]Flores-Burgess A. Millón C. Gago B. Narváez J.A. Fuxe K. Díaz-Cabiale Z. Small Interference RNA Knockdown Rats in Behavior Neuromethods Wolfgang W. Springer Nature Basel, Switzerland 2018 133 148 9781493989447

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Authors
Pérez de la Mora, M., Borroto-Escuela, D. O., Crespo-Ramírez, M., Rejón-Orantes, J. D. C., Palacios-Lagunas, D. A., Martínez-Mata, M. K., Sánchez-Luna, D., Tesoro-Cruz, E., & Fuxe, K.
Affiliations
  • Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
  • Department of Neuroscience, Karolinska Institutet, Biomedicum, Solnavägen 9., 17177 Stockholm, Sweden
  • Universidad Autónoma de Chiapas (MX)
  • Universidad Nacional Autónoma de México (MX)
  • Mexican Social Security Institute (MX)
Venue
Cells
Publisher
MDPI AG
Published
2022-06-02
Volume
11
Issue
11
Pages
1826
ISSN
2073-4409 (ISSN-L)
OpenAlex
W4281758282
Cited by
21
References
393
Citations by year
2026: 4 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 2
FWCI
0.44
Type
journal article
Language
en
Open access
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Dirección General de Asuntos del Personal Académico (DGAPA) (IN206820, FIS/IMSS/PROT/G14/1320 ET-C, EMERGIA 2020-39318)
  • Stiftelsen Olle Engkvist Byggmästare, Stockholm, Sweden, Swedish Medical Research Council (IN206820, FIS/IMSS/PROT/G14/1320 ET-C, EMERGIA 2020-39318)
  • Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020) (IN206820, FIS/IMSS/PROT/G14/1320 ET-C, EMERGIA 2020-39318)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
major depressive disorder, anxiety disorders, serotonin receptors, dopamine receptors, galanin receptors, opioid receptors, NMDA receptor, synaptic transmission, volume transmission, limbic system, novel therapeutic targets
MeSH terms
Anxiety Disorders, Major Depressive Disorder, Humans, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Receptors, G-Protein-Coupled

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