Distribution of dopamine D2-like receptors in the rat amygdala and their role in the modulation of unconditioned fear and anxiety
Abstract
Amygdaloid dopamine D(2) receptors play an important role in the modulation of fear/anxiety. Their topographical distribution within the amygdala is however unclear, and their role in unconditioned fear/anxiety remains largely unknown. The aim of this paper was to study the intra-amygdaloid distribution of D(2) receptors and to ascertain their role in unconditioned anxiety. Chemical anatomical studies in the rat, using D(2) and D(3)in situ hybridization, quantitative receptor autoradiography with either [(3)H]raclopride or [(125)I]sulpiride, and D(2)-like immunocytochemistry showed that the highest density of dopamine D(2) receptors is present in the central amygdaloid nucleus, particularly within its latero-capsular division, in which a D(2) but not a D(3) mRNA signal was observed. However, although at considerably reduced densities dopamine D(2) receptors were also found in other locations within the amygdala, including the basolateral nucleus. Behaviorally, the infusion of raclopride (0.75-4 μg/side) in the area of the central amygdaloid nucleus resulted at low doses in the appearance of anxiogenic-like effects in the Shock-Probe Burying test, whereas no effects of raclopride treatment were found at any dose in the Elevated Plus-Maze and the Open-Field test. Our results indicate that amygdaloid dopamine D(2)-like receptors have a topographically differentiated distribution within the rat amygdala, the major location being in the central amygdaloid nucleus. D(2)-like receptors play a role in the modulation of anxiety responses involving a potential differential function of D(2)-like receptors in the central amygdaloid nucleus versus the basolateral amygdaloid nucleus.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Local infusion of D2R antagonists triggers anxiogenic nonconditioned responses and a reduction in contextual conditioned fear.
“Thus, it has been demonstrated that local infusion of D2R antagonists triggers both anxiogenic nonconditioned responses (Perez de la Mora et al., 2012) and a reduction in contextual conditioned fear (de Souza Caetano et al., 2013).”
From Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions (2023) · cites this paper as Perez de la Mora et al., 2012
The paper proposes that D2R-OXTR heterocomplexes may exist in the basolateral amygdala and in the central nucleus of the amygdala, including the contralateral (CeL) and centro medial (CeM) amygdala.
“We propose that in the basolateral amygdala (Perez de la Mora et al., 2012) as well as in the central nucleus of the amygdala, including the contralateral (CeL) and centro medial (CeM) amygdala, D2R–OXTR heterocomplexes may exist.”
From Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions (2023) · cites this paper as Perez de la Mora et al., 2012
D2R blockade within CeA in the shock-probe burying test and elevated plus maze test produced anxiogenic and lack of effects, respectively, in our work.
“although both anxiogenic and lack of effects have been reported in our work (Perez de la Mora et al., 2012) following the D2R blockade within the CeA in the shock-probe burying test and the elevated plus maze test, respectively”
From Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions (2023) · cites this paper as Perez de la Mora et al., 2012
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822 · see citing works
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
Prut, L., & Belzung, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01272-x · Cited by 3,190 · see citing works
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · see citing works
Evidence for the existence of monoamine neurons in the central nervous system
Fuxé, K. (1965) · Cell and Tissue Research · doi:10.1007/bf00337069 · Cited by 1,567 · see citing works
Fuxé, K. (1965) · PubMed · Cited by 1,544 · see citing works
Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289 · see citing works
The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction
Scheel-Krüger, J. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90037-5 · Cited by 1,277 · see citing works
Abercrombie, E. D., Keefe, K. A., DiFrischia, D. S., & Zigmond, M. J. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09224.x · Cited by 1,106 · see citing works
Dopamine receptor pharmacology
Seeman, P. M., & Tol, H. H. M. V. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90323-9 · Cited by 969 · see citing works
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works
Quirk, G. J., Likhtik, E., Pelletier, J. G., & Paré, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08800.2003 · Cited by 927 · see citing works
Amygdala inhibitory circuits and the control of fear memory
Ehrlich, I., Humeau, Y., Grenier, F., Ciocchi, S., Herry, C., & Lüthi, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.026 · Cited by 878 · see citing works
New Vistas on Amygdala Networks in Conditioned Fear
Paré, D., Quirk, G. J., & Ledoux, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00153.2004 · Cited by 841 · cited 1× · see citing works
“…shown that BLA neurons target CeA output neurons, 4 both directly and via GABAergic interneurons located at different inhibitory interfaces (see Paré et al., 2004; Pérez de la Mora et al., 2008, 2010), and that both anxiogenic and anxiolytic effects on unconditioned tests of anxiety i the…”
Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
Yin, H. H., Mulcare, S. P., Hilário, M. R. F., Clouse, E., Holloway, T., Davis, M. I., Hansson, A. C., Lovinger, D. M., & Costa, R. M. (2009) · Nature Neuroscience · doi:10.1038/nn.2261 · Cited by 818 · see citing works
Self-citationVasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
Zahrt, J., Taylor, J. R., Mathew, R. G., & Arnsten, A. F. T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08528.1997 · Cited by 796 · see citing works
Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala
Killcross, S., Robbins, T., & Everitt, B. (1997) · Nature · doi:10.1038/41097 · Cited by 697 · see citing works
Anxiogenic stimuli in the elevated plus-maze
Treit, D., Menard, J., & Royan, C. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90492-c · Cited by 628 · see citing works
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning
Blair, H. T., Schafe, G. E., Bauer, E. P., Rodrigues, S. M., & LeDoux, J. E. (2001) · Learning & Memory · doi:10.1101/lm.30901 · Cited by 610 · see citing works
Pain pathways and parabrachial circuits in the rat.
Gauriau, C., & Bernard, J. (2002) · Experimental Physiology · doi:10.1113/eph8702357 · Cited by 572 · see citing works
Granon, S., Passetti, F., Thomas, K. L., Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01208.2000 · Cited by 546 · see citing works
Parallel circuits mediating distinct emotional coping reactions to different types of stress
Keay, K. A., & Bandler, R. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00049-5 · Cited by 512 · see citing works
Mesolimbic dopaminergic pathways in fear conditioning
Pezze, M. A., & Feldon, J. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.004 · Cited by 510 · see citing works
A multiple-test study of anxiety-related behaviours in six inbred rat strains
Ramos, A., Berton, O., Mormède, P., & Chaouloff, F. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)00164-7 · Cited by 493 · see citing works
Catecholamine regulation of the prefrontal cortex
Arnsten, A. F. T. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100208 · Cited by 489 · see citing works
Neuronal circuits of fear extinction
Herry, C., Ferraguti, F., Singewald, N., Letzkus, J. J., Ehrlich, I., & Lüthi, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07101.x · Cited by 484 · see citing works
Gurevich, E. V. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00066-9 · Cited by 432 · see citing works
The role of the amygdala in fear-potentiated startle: implications for animal models of anxiety
Davis, M. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90014-w · Cited by 427 · see citing works
Everitt, B. J., Cardinal, R. N., Parkinson, J. A., & Robbins, T. W. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07085.x · Cited by 416 · see citing works
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Bissière, S., Humeau, Y., & Lüthi, A. (2003) · Nature Neuroscience · doi:10.1038/nn1058 · Cited by 415 · see citing works
Rosenkranz, J. A., & Grace, A. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00324.2002 · Cited by 392 · see citing works
Defensive burying in rodents: ethology, neurobiology and psychopharmacology
de Boer, S. F., & Koolhaas, J. M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01278-0 · Cited by 391 · see citing works
Appetitive behavior: impact of amygdala-dependent mechanisms of emotional learning.
Everitt, B. J., Cardinal, R. N., Parkinson, J. A., & Robbins, T. W. (2003) · PubMed · Cited by 386 · see citing works
Yang, C., & Seamans, J. K. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01922.1996 · Cited by 369 · see citing works
Burying as a defensive response in rats.
Pinel, J. P. J., & Treit, D. (1978) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077494 · Cited by 365 · see citing works
Bouthenet, M.-L., Martres, M., Salès, N., & Schwartz, J. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90008-x · Cited by 356 · see citing works
Neugebauer, V., Galhardo, V., Maione, S., & Mackey, S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.014 · Cited by 353 · see citing works
Burying as a defensive response in rats
Treit, D. (2010) · cIRcle (University of British Columbia) · doi:10.14288/1.0100236 · Cited by 349 · see citing works
Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning
Rosenkranz, J. A., & Grace, A. A. (2002) · Nature · doi:10.1038/417282a · Cited by 348 · see citing works
A Specialized Subclass of Interneurons Mediates Dopaminergic Facilitation of Amygdala Function
Marowsky, A., Yanagawa, Y., Obata, K., & Vogt, K. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.029 · Cited by 328 · see citing works
Dopaminergic Innervation of the Amygdala Is Highly Responsive to Stress
Inglis, F., & Moghaddam, B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721088.x · Cited by 310 · see citing works
de la Mora, M. P., Gallegos-Cari, A., Arizmendi-García, Y., Marcellino, D., & Fuxe, K. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.010 · Cited by 296 · see citing works
Self-citationRosenkranz, J. A., & Grace, A. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-11027.1999 · Cited by 253 · see citing works
Hansson, A. C., Cippitelli, A., Sommer, W. H., Fedeli, A., Björk, K., Soverchia, L., Terasmaa, A., Massi, M. N., Heilig, M. A., & Ciccocioppo, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604419103 · Cited by 251 · see citing works
Self-citationBernard, J., Huang, G.-F., & Besson, J. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.2.551 · Cited by 230 · see citing works
Pesold, C., & Treit, D. (1995) · Brain Research · doi:10.1016/0006-8993(94)01318-c · Cited by 208 · see citing works
Amygdaloid D1 dopamine receptor involvement in Pavlovian fear conditioning
Guarraci, F. A., Frohardt, R. J., & Kapp, B. S. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01291-3 · Cited by 207 · see citing works
Dopamine Modulates Excitability of Basolateral Amygdala Neurons In Vitro
Kröner, S., Rosenkranz, J. A., Grace, A. A., & Barrionuevo, G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00843.2004 · Cited by 202 · see citing works
Nader, K., & LeDoux, J. E. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.5.891 · Cited by 194 · see citing works
Basso, A. M., Spina, M. G., Rivier, J., Vale, W., & Koob, G. F. (1999) · Psychopharmacology · doi:10.1007/s002130051028 · Cited by 190 · see citing works
Nader, K., & LeDoux, J. E. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.891 · Cited by 174 · see citing works
Pezze, M.-A., Dalley, J. W., & Robbins, T. W. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301073 · Cited by 170 · see citing works
Greba, Q., Gifkins, A., & Kokkinidis, L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02243-0 · Cited by 160 · see citing works
Distribution of GABA immunoreactivity in the amygdaloid complex of the cat
Paré, D., & Smith, Y. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90049-l · Cited by 152 · see citing works
Guarraci, F. A., Frohardt, R. J., Falls, W. A., & Kapp, B. S. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.3.647 · Cited by 140 · see citing works
Guarraci, F. A., Frohardt, R. J., Falls, W. A., & Kapp, B. S. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.3.647 · Cited by 140 · see citing works
Burstein, R., & Potrebic, S. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903350402 · Cited by 137 · see citing works
Lamont, E. W., & Kokkinidis, L. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00281-9 · Cited by 132 · see citing works
Yokoyama, M., Suzuki, E., Sato, T., Maruta, S., Watanabe, S., & Miyaoka, H. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2004.12.047 · Cited by 128 · see citing works
Economidou, D., Hansson, A. C., Weiss, F., Terasmaa, A., Sommer, W. H., Cippitelli, A., Fedeli, A., Martin-Fardon, R., Massi, M., Ciccocioppo, R., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.004 · Cited by 120 · see citing works
Self-citationScibilia, R. J., Lachowicz, J. E., & Kilts, C. D. (1992) · Synapse · doi:10.1002/syn.890110208 · Cited by 118 · see citing works
Functional mapping of GABAA receptor subtypes in the amygdala
Marowsky, A., Fritschy, J., & Vogt, K. E. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03574.x · Cited by 107 · see citing works
Opposing Roles for Dopamine D2 and D3 Receptors on Neurotensin mRNA Expression in Nucleus Accumbens
Díaz, J., Lévesque, D., Griffon, N., Lammers, C.-H., Martres, M., Sokoloff, P., & Schwartz, J. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00329.x · Cited by 102 · see citing works
de Oliveira, A. R., Reimer, A. E., de Macedo, C. E. A., de Carvalho, M. C., Silva, M. A. D. S., & Brandão, M. L. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.10.005 · Cited by 101 · see citing works
Fuxé, K., Jacobsen, K. X., Höistad, M., Tinner, B., Jansson, A., Staines, W. A., & Agnati, L. F. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00148-9 · Cited by 96 · see citing works
Lalonde, R., & Strazielle, C. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.02.003 · Cited by 94 · see citing works
Engin, E., & Treit, D. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.03.020 · Cited by 90 · see citing works
Diaz, M. R., Chappell, A. M., Christian, D., Anderson, N., & McCool, B. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.246 · Cited by 89 · see citing works
Engin, E., & Treit, D. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282d28f6f · Cited by 78 · see citing works
Dopaminergic innervation of interneurons in the rat basolateral amygdala
Pinard, C. R., Muller, J. F., Mascagni, F., & McDonald, A. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.043 · Cited by 75 · see citing works
Rezayof, A., Hosseini, S.-S., & Zarrindast, M. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.030 · Cited by 68 · see citing works
Fernández‐Guasti, A., Ferreira, A., & Picazo, O. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00586-x · Cited by 68 · see citing works
Jansson, A., Goldstein, M., Tinner, B., Zoli, M., Meador‐Woodruff, J. H., Lew, J., Levey, A. I., Watson, S. J., Agnati, L. F., & Fuxé, K. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00317-0 · Cited by 61 · see citing works
de la Mora, M. P., Lara‐García, D., Jacobsen, K. X., Vázquez‐García, M., Crespo‐Ramírez, M., Flores‐Gracia, C., Escamilla-Marván, E., & Fuxé, K. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04798.x · Cited by 59 · see citing works
Anxiolytic effects of intra-amygdaloid injection of the D1 antagonist SCH23390 in the rat
de la Mora, M. P., Cárdenas-Cachón, L., Vázquez‐García, M., Crespo‐Ramírez, M., Jacobsen, K. R., Höistad, M., Agnati, L. F., & Fuxé, K. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.079 · Cited by 51 · see citing works
Dopamine release in the amygdaloid complex of the rat, studied by brain microdialysis
Young, A. M. J., & Rees, K. R. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00390-5 · Cited by 49 · see citing works
Stereological analysis of forebrain regions in kainate-treated epileptic rats
Chen, S., & Buckmaster, P. S. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.058 · Cited by 45 · see citing works
de la Mora, M. P., Hernandez-Gómez, A.-M., Arizmendi‐García, Y., Jacobsen, K. X., Lara‐García, D., Flores‐Gracia, C., Crespo‐Ramírez, M., Gallegos‐Cari, A., Nuche‐Bricaire, A., & Fuxé, K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05963.x · Cited by 43 · see citing works
Self-citationAsan, E. (1993) · Histochemistry · doi:10.1007/bf00274095 · Cited by 41 · see citing works
Maltais, S., Côté, S., Drolet, G., & Falardeau, P. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00125-1 · Cited by 41 · see citing works
Netto, C. F., Borelli, K. G., & Brandão, M. L. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.12.023 · Cited by 32 · see citing works
Wiring and Volume Transmission in Rat Amygdala. Implications for Fear and Anxiety
de la Mora, M. P., Jacobsen, K. X., Crespo‐Ramírez, M., Flores‐Gracia, C., & Fuxé, K. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9722-9 · Cited by 27 · see citing works
James, T. A., & Starr, M. S. (1978) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(78)90049-9 · Cited by 19 · see citing works
[Convergence of nociceptive information on the parabrachio-amygdala neurons in the rat].
Bernard, J., & Besson, J. (1988) · PubMed · Cited by 17 · see citing works
Sandbak, T. (2001) · Alcohol and Alcoholism · doi:10.1093/alcalc/36.1.48 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390 · see citing works
“In concert with D2-like receptors in the CeL/CeC (Perez de la Mora et al., 2012), DAergic signaling exerts tight control over CeM-mediated expression of fear.”
Anderberg, R. H., Richard, J. E., Hansson, C., Nissbrandt, H., Bergquist, F., & Skibicka, K. P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.021 · Cited by 170 · see citing works
De Bundel, D., Zussy, C., Espallergues, J., Gerfen, C. R., Girault, J.-A., & Valjent, E. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.210 · Cited by 112 · see citing works
Fuxe, K., Borroto-Escuela, D. O., Romero-Fernandez, W., Ciruela, F., Manger, P., Leo, G., Díaz-Cabiale, Z., & Agnati, L. F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.062 · Cited by 81 · see citing works
Self-citationIncreased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats
Rebolledo-Solleiro, D., Roldán-Roldán, G., Díaz, D., Velasco, M., Larqué, C., Rico-Rosillo, G., Vega-Robledo, G. B., Zambrano, E., Hiriart, M., & Pérez de la Mora, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176554 · Cited by 64 · see citing works
de la Mora, M. P., Pérez-Carrera, D., Crespo-Ramírez, M., Tarakanov, A., Fuxe, K., & Borroto-Escuela, D. O. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.004 · Cited by 63 · see citing works
Self-citationPérez de la Mora, M., Borroto-Escuela, D. O., Crespo-Ramírez, M., Rejón-Orantes, J. D. C., Palacios-Lagunas, D. A., Martínez-Mata, M. K., Sánchez-Luna, D., Tesoro-Cruz, E., & Fuxe, K. (2022) · Cells · doi:10.3390/cells11111826 · Cited by 21 · see citing works
The role of D2 dopamine receptors in oxytocin induced place preference and anxiolytic effect
László, K., Péczely, L., Géczi, F., Kovács, A., Zagoracz, O., Ollmann, T., Kertes, E., Kállai, V., László, B., Berta, B., et al. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104777 · Cited by 18 · see citing works
Hernández-Mondragón, J. C., Hernández-Hernández, D. A., Crespo-Ramírez, M., Prospero-García, O., Rocha-Arrieta, L., Fuxe, K., Borroto-Escuela, D. O., & Perez de la Mora, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1251922 · Cited by 17 · see citing works
Self-citation
- Authors
- de la Mora, M. P., Gallegos-Cari, A., Crespo-Ramirez, M., Marcellino, D., Hansson, A. C., & Fuxe, K.
- Affiliations
- Karolinska Institutet (SE)
- Central Institute of Mental Health (DE)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 201
- Pages
- 252-266
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2020505550
- Cited by
- 81
- References
- 86
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 2 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 5
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (HA 6102/1-1)
- Deutsche Forschungsgemeinschaft
- Medicinska Forskningsrådet (04X-715)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D2 receptor, dopamine D3 receptor, amygdala, central amygdala, unconditioned fear, raclopride, sulpiride, receptor distribution, anxiogenic effects
- MeSH terms
- Amygdala, Analysis of Variance, Animals, Anxiety, Autoradiography, Conditioning, Psychological, Dose-Response Relationship, Drug, Electroshock, Exploratory Behavior, Fear, Gene Expression Regulation, Male, RNA, Messenger, Rats, Wistar, Receptors, Dopamine D2, Dopamine Antagonists, Maze Learning, Raclopride, Receptors, Dopamine D3, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
