Using Extracellular Vesicles Released by GDNF-Transfected Macrophages for Therapy of Parkinson Disease

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Exosomes as drug delivery vehicles for Parkinson’s disease therapy

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Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

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GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

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Using exosomes, naturally-equipped nanocarriers, for drug delivery

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Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

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Neuroinflammation in Parkinson's disease and its potential as therapeutic target

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Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane Microdomain

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Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

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Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

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Characteristics of Compounds that Cross the Blood-Brain Barrier

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Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: In vitro and in vivo evaluations

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Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

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Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

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Activated Macrophages and Microglia Induce Dopaminergic Sprouting in the Injured Striatum and Express Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor

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Peripheral cytokines profile in parkinson’s disease

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Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

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Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

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CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport

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Is nose-to-brain transport of drugs in man a reality?

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Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges

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GDNF Secreting Human Neural Progenitor Cells Protect Dying Motor Neurons, but Not Their Projection to Muscle, in a Rat Model of Familial ALS

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Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson’s disease

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An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism

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Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery

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Macrophage-Derived Extracellular Vesicles as Drug Delivery Systems for Triple Negative Breast Cancer (TNBC) Therapy

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Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype

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A Macrophage−Nanozyme Delivery System for Parkinson's Disease

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Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

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Insights into Neuroinflammation in Parkinson’s Disease: From Biomarkers to Anti-Inflammatory Based Therapies

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Macrophage Delivery of Therapeutic Nanozymes in A Murine Model of Parkinson‘S Disease

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Prospects for exosomes in immunotherapy of cancer

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Nitric Oxide and Reactive Oxygen Species in Parkinson's Disease

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Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant α-Synuclein

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Carrier-mediated or specialized transport of drugs across the blood–brain barrier

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TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease

Haney, M. J., Klyachko, N. L., Harrison, E. B., Zhao, Y., Kabanov, A. V., & Batrakova, E. V. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801271 · Cited by 151 · see citing works

Exosomes and the blood–brain Barrier: Implications for Neurological Diseases

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Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations

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Distinct structural elements in GDNF mediate binding to GFRα1 and activation of the GFRα1–c‐Ret receptor complex

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Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring

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Macrophages Offer A Paradigm Switch for CNS Delivery of Therapeutic Proteins

Klyachko, N. L., Haney, M. J., Zhao, Y., Manickam, D. S., Mahajan, V., Suresh, P., Hingtgen, S. D., Mosley, R. L., Gendelman, H. E., Kabanov, A. V., et al. (2014) · Nanomedicine · doi:10.2217/nnm.13.115 · Cited by 92 · see citing works

Mesenchymal Stromal Cell-Based Therapy: New Perspectives and Challenges

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Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate and integrate after intracerebral transplantation in rats with transient forebrain ischemia

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Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine

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GDNF therapy for Parkinson’s disease

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Polyelectrolyte Complex Optimization for Macrophage Delivery of Redox Enzyme Nanoparticles

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Blood-Borne Macrophage–Neural Cell Interactions Hitchhike on Endosome Networks for Cell-Based Nanozyme Brain Delivery

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Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows

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GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinson’s disease in transgenic Parkin Q311X(A) mice

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Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease.

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GDNF-pretreatment enhances the survival of neural stem cells following transplantation in a rat model of Parkinson's disease

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Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS/MS in the sandwich cultured human hepatocyte model

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Extracellular Vesicles as Drug Carriers for Enzyme Replacement Therapy to Treat CLN2 Batten Disease: Optimization of Drug Administration Routes

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Pharmacokinetics and modeling of immune cell trafficking: quantifying differential influences of target tissues versus lymphocytes in SJL and lipopolysaccharide-treated mice

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Extracellular Vesicles as Drug Delivery System for the Treatment of Neurodegenerative Disorders: Optimization of the Cell Source

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Brain Targeting and Toxicological Assessment of the Extracellular Vesicle-Packaged Antioxidant Catalase-SKL Following Intranasal Administration in Mice

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Extracellular vesicles: a rising star for therapeutics and drug delivery

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Strategies for Engineering of Extracellular Vesicles

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Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics

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An Overview on the Physiopathology of the Blood–Brain Barrier and the Lipid-Based Nanocarriers for Central Nervous System Delivery

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Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging

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Myeloid cell-mediated drug delivery: From nanomedicine to cell therapy

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Intranasal delivery of extracellular vesicles: A promising new approach for treating neurological and respiratory disorders.

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Immune cells: potential carriers or agents for drug delivery to the central nervous system

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Stimuli-Responsive, Cell-Mediated Drug Delivery Systems: Engineering Smart Cellular Vehicles for Precision Therapeutics

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Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

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Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration

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Extracellular vesicle as therapeutic agents in anti-aging: Mechanistic insights and future potential

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Uncovering Novel Therapeutic Targets for Parkinson’s Disease

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Extracellular particles: emerging insights into central nervous system diseases

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Emerging role of extracellular vesicles in multiple sclerosis: From cellular surrogates to pathogenic mediators and beyond

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Cationized extracellular vesicles for gene delivery

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Extracellular vesicles as natural nanocarriers: From in vitro engineering to in situ generation in cancer therapy

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Brain-derived extracellular vesicles: A promising avenue for Parkinson’s disease pathogenesis, diagnosis, and treatment

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Extracellular Vesicles Released by Genetically Modified Macrophages Activate Autophagy and Produce Potent Neuroprotection in Mouse Model of Lysosomal Storage Disorder, Batten Disease

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Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation

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Navigating the brain: Harnessing endogenous cellular hitchhiking for targeting neoplastic and neuroinflammatory diseases

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Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia

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Therapeutic strategies based on macrophages and their derivatives: Targeted drug delivery platforms and disease treatment

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Insights into the Versatile Role of Extracellular Vesicles in the Treatment of CNS Disorders

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Genetically Mediated Cell Membrane Engineering Strategies and Their Scope in Biomedical Applications

Tollabi, M., Kheirandish, M. H., Mehrabi, A., Poursalehi, Z., Heidari, M., & Milan, P. B. (2025) · Springer eBooks · doi:10.1007/978-3-031-93425-4_6 · Cited by 2 · see citing works

Nanoparticle-Mediated Gene Therapy for Neurological Disorders

Modi, C. D., Arora, M., Dudhatra, B., Singh, A. K., Udhwani, N. H., Rana, H., & Prajapati, B. G. (2025) · Nanotechnology in the life sciences · doi:10.1007/978-3-031-80185-3_2 · Cited by 1 · see citing works

Cell-based immunotherapy for neurodegenerative disease: A promising avenue

Huerta, T. J., Urbina-Muñoz, V., Urra-Alvarez, V., Villablanca, C., Gómez‐Pérez, L. S., Saavedra, B., Contreras, T., & Vidal, R. L. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00816 · Cited by 1 · see citing works

The role of GDNF in neurodegenerative pathologies

Kolesnikova, A., Ushakova, V. M., Zorkina, Y., Andriushchenko, A., Zubkov, E. A., Chekhonin, V. P., & Kostyuk, G. (2026) · Discover Neuroscience · doi:10.1186/s13064-026-00234-z · Cited by 1 · see citing works

Autonomous intranasal delivery systems for central nervous system therapeutics

Shen, H., Srivastava, S. K., Aggarwal, N., & Chang, M. W. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01781-5 · Cited by 1 · see citing works

Engineering Cell Membrane-Derived Nanovesicles for Advanced Biomedical Applications

Hussain, Z., Ahmed, W., Gao, T., Zhang, Y., & Pei, R. (2025) · Springer eBooks · doi:10.1007/978-3-031-93425-4_2

Cell Membrane Engineering for Advanced Drug Delivery Against Neurodegenerative and Inflammatory Diseases

Rajeshkumar, R. R., Pandi, J. S., Murugesan, S., Pavadai, P., Theivendren, P., & Kunjiappan, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-93425-4_16

Investigating the inflammatory responses to organic biomaterials in models of Parkinson’s disease: a systematic review

Lafarge, E., Dowd, E., & McKernan, D. P. (2026) · International Journal of Polymeric Materials · doi:10.1080/00914037.2025.2610718

Role of astrocytes in the development and progression of major depressive disorder

Jing, P., Sun, C., Xiao-peng, Y. I. N., Liu, X.-C., Tian, Q., & (673328), X.-B. Z. (2026) · World Journal of Psychiatry · doi:10.5498/wjp.v16.i5.115794

Functionalization of extracellular vesicles for biomedical applications

Rani, S., Hussain, Z., & Pei, R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36641-3.00009-7

MAPK-dependent release of GDNF from Schwann cells mediates tumor-independent pain in neurofibromatosis 1

Raut, N. G. R., Sprague, K. L., Adlakha, A., Rupert, A. R., Hofmann, M. C., Queme, L. F., Ratner, N., & Jankowski, M. P. (2026) · Science Signaling · doi:10.1126/scisignal.aee5174

Microglial advances in Parkinson’s disease

Debasa‐Mouce, M., Ouro, A., Leon, J. D., Gulkarov, S., Reiss, A. B., & Bougea, A. M. (2026) · Advances in immunology · doi:10.1016/bs.ai.2026.06.003

Nanoparticle-Mediated Modulation of the PINK1/Parkin Mitophagy Pathway in Parkinson’s Disease: A Scoping ReviewPreprint

Kingsley, C., Ahad, N., Rodriguez, K., & Xiang, A. Q. (2026) · Research Square · doi:10.21203/rs.3.rs-10308858/v1

Nanoparticle-Mediated Modulation of the PINK1/Parkin Mitophagy Pathway in Parkinson’s Disease: A Scoping ReviewPreprint

Xiang, A. Q., Kingsley, C., Ahad, N., & Rodriguez, K. (2026) · Research Square · doi:10.21203/rs.3.rs-10308858/v2

Nanoparticle-Mediated Modulation of the PINK1/Parkin Mitophagy Pathway in Parkinson’s Disease: A Narrative ReviewPreprint

Xiang, A. Q., Kingsley, C., Ahad, N., & Rodriguez, K. (2026) · Research Square · doi:10.21203/rs.3.rs-10308858/v3

Using Extracellular Vesicles Released by GDNF-transfected Macrophages for Therapy of Parkinson’s DiseasePreprint

Zhao, Y., Haney, M. J., Fallon, J. K., Rodriguez, M., Swain, C. J., Arzt, C. J., Smith, P. C., Loop, M. S., Harrison, E. B., El‐Hage, N., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.25.493424 · Cited by 8 · see citing works

Cell Based Nano Therapeutic for Drug Delivery in a Parkinson’s Mouse Model (P5-3.010)

Stone, N., Martinez, M. R., & El‐Hage, N. (2025) · Neurology · doi:10.1212/wnl.0000000000211923

Extracellular Vesicles as Nanotherapeutics for Parkinson’s Disease

Leggio, L., Paternò, G., Vivarelli, S., L’Episcopo, F., Tirolo, C., Raciti, G., Pappalardo, F., Giachino, C., Caniglia, S., Serapide, M. F., et al. (2020) · Biomolecules · doi:10.3390/biom10091327 · Cited by 100 · see citing works

Macrophage-Derived Exosomes for the Delivery of GDNF in Parkinson’s Disease

Jin, Y. S. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/v8aw-yr55

From Bench to Brain: Translating EV and Nanocarrier Research into Parkinson’s Disease Therapies

Barathan, M., & Abdullah, N. A. H. (2025) · Biology · doi:10.3390/biology14101349 · Cited by 2 · see citing works