Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: In vitro and in vivo evaluations
Open accessAbstract
Exosomes have recently emerged as a promising drug delivery system with low immunogenicity, high biocompatibility, and high efficacy of delivery. We demonstrated earlier that macrophage-derived exosomes (exo) loaded with a potent anticancer agent paclitaxel (PTX) represent a novel nanoformulation (exoPTX) that shows high anticancer efficacy in a mouse model of pulmonary metastases. We now report the manufacture of targeted exosome-based formulations with superior structure and therapeutic indices for systemic administration. Herein, we developed and optimized a formulation of PTX-loaded exosomes with incorporated aminoethylanisamide-polyethylene glycol (AA-PEG) vector moiety to target the sigma receptor, which is overexpressed by lung cancer cells. The AA-PEG-vectorized exosomes loaded with PTX (AA-PEG-exoPTX) possessed a high loading capacity, profound ability to accumulate in cancer cells upon systemic administration, and improved therapeutic outcomes. The combination of targeting ability with the biocompatibility of exosome-based drug formulations offers a powerful and novel delivery platform for anticancer therapy.
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AA-modified PTX-loaded exosomes had better loading capacity and therapeutic efficiency in vivo.
“Their result showed that AA-modified vesicles had a better loading capacity and therapeutic efficiency in vivo [26].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [26]
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Self-citation
- Authors
- Kim, M. S., Haney, M. J., Zhao, Y., Yuan, D., Deygen, I., Klyachko, N. L., Kabanov, A. V., & Batrakova, E. V.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Batrakova, Elena V.
- Venue
- Nanomedicine Nanotechnology Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 14
- Issue
- 1
- Pages
- 195-204
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2764044430
- Cited by
- 663
- References
- 40
- Citations by year
- 2026: 40 · 2025: 75 · 2024: 97 · 2023: 96 · 2022: 114 · 2021: 89 · 2020: 79 · 2019: 50 · 2018: 23
- FWCI
- 16.97
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Russian Science Foundation (14-13-00731, RSF-14-13-00731)
- National Institutes of Health (RR021937)
- National Institute of Neurological Disorders and Stroke (R01NS057748)
- National Center for Advancing Translational Sciences
- UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- macrophage-derived exosomes, paclitaxel, lung metastasis, lung cancer, targeted drug delivery, exosome-based drug delivery, systemic administration, tumor accumulation, therapeutic index
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Cells, Cultured, Drug Carriers, Lung Neoplasms, Macrophages, Mice, Inbred C57BL, Polyethylene Glycols, Drug Delivery Systems, Paclitaxel, Mice, Exosomes
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