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Cited by 95Skin Protection and AgingTelomeres, Telomerase, and SenescenceAir Quality and Health Impacts

Effects of Air Pollution on Cellular Senescence and Skin Aging

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Martic, Ines, Jansen-Dürr, Pidder, Cavinato, Maria·2022·Cells
DOI 10.3390/cells11142220PMC PMC9320051
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Abstract

The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin and is known to promote aging and inflammation of this tissue, leading to the onset of skin disorders and to the appearance of wrinkles and pigmentation issues. Besides this, components of air pollution can interact synergistically with ultraviolet light and increase the impact of damage to the skin. However, little is known about the modulation of air pollution on cellular senescence in skin cells and how this can contribute to skin aging. In this review, we are summarizing the current state of knowledge about air pollution components, their involvement in the processes of cellular senescence and skin aging, as well as the current therapeutic and cosmetic interventions proposed to prevent or mitigate the effects of air pollution in the skin.

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  • Chronic stress and pollutants accelerate aging and increase the risk of noncommunicable diseases.

    “Studies have shown that positive environmental exposures—such as the Mediterranean diet and strong community networks—are associated with improved longevity, whereas chronic stress and pollutants accelerate aging and increase the risk of noncommunicable diseases (NCDs) [10,11,12,13].”

    From The Power of Environment: A Comprehensive Review of the Exposome's Role in Healthy Aging, Longevity, and Preventive Medicine-Lessons from Blue Zones and Cilento (2025) · cites this paper as [11]

    The Introduction and Section 4 link air pollution to skin aging, and Section 4.1 says particulate matter can cause cardiovascular and respiratory diseases and cancer. The paper does not establish the claim about chronic stress, and its aging discussion focuses chiefly on skin aging rather than aging generally. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Positive environmental exposures such as the Mediterranean diet and strong community networks are associated with improved longevity.

    “Studies have shown that positive environmental exposures—such as the Mediterranean diet and strong community networks—are associated with improved longevity, whereas chronic stress and pollutants accelerate aging and increase the risk of noncommunicable diseases (NCDs) [10,11,12,13].”

    From The Power of Environment: A Comprehensive Review of the Exposome's Role in Healthy Aging, Longevity, and Preventive Medicine-Lessons from Blue Zones and Cilento (2025) · cites this paper as [11]

    The Introduction discusses pollution and skin aging, while §5, Therapeutics and Cosmetics, discusses dietary components that may protect skin from environmental damage; page numbers are unavailable in our copy. Searches for “Mediterranean,” “community networks,” and diet-related longevity found no passage linking those exposures to improved longevity. (LLM, conf=0.72)

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References 130 · Cited by 95

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Authors
Martic, I., Jansen-Dürr, P., & Cavinato, M.
Affiliations
  • Universität Innsbruck (AT)
  • Institute for Biomedical Aging Research, Universität Innsbruck, 6020 Innsbruck, Austria
Corresponding author
Cavinato, Maria
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2022-07-17
Volume
11
Issue
14
Pages
2220
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells11142220
PMC
PMC9320051
OpenAlex
W4285731951
Cited by
95
References
130
Citations by year
2026: 20 · 2025: 36 · 2024: 19 · 2023: 17 · 2022: 3
FWCI
3.34
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • the Austrian Science Fund (FWF) (P315820, ZAP746010, F.33827/10-2021)
  • Tiroler Wissenschaftsförderung (P315820, ZAP746010, F.33827/10-2021)
  • the University of Innsbruck (P315820, ZAP746010, F.33827/10-2021)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Keywords
air pollution, cellular senescence, skin aging, ultraviolet radiation, synergistic effect, skin inflammation, wrinkles, pigmentation, skin diseases, therapeutic interventions
MeSH terms
Air Pollutants, Air Pollution, Humans, Ultraviolet Rays, Skin Aging, Cellular Senescence

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