The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective
Open accessAbstract
The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the brain and maintains its bathing microenvironment. However, this barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases. Many efforts have been made for improvement of delivering drugs across the BBB in recent years to treat CNS diseases. In this review, the anatomical and functional structure of the BBB is comprehensively discussed. The mechanisms of BBB penetration are summarized, and the methods and effects on increasing BBB permeability are investigated in detail. It also elaborates on the physical, chemical, biological and nanocarrier aspects to improve drug delivery penetration to the brain and introduces some specific drug delivery effects on BBB permeability.
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Cites
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Cited by
The blood-brain barrier: Physiology and strategies for drug delivery
Pandit, R., Chen, L., & Götz, J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.11.009 · Cited by 651
Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
Zhang, W., Mehta, A., Tong, Z., Esser, L., & Voelcker, N. H. (2021) · Advanced Science · doi:10.1002/advs.202003937 · Cited by 430
Ahlawat, J., Guillama Barroso, G., Masoudi Asil, S., Alvarado, M., Armendariz, I., Bernal, J., Carabaza, X., Chavez, S., Cruz, P., Escalante, V., et al. (2020) · ACS Omega · doi:10.1021/acsomega.0c01592 · Cited by 274
Xiong, B., Wang, Y., Chen, Y., Xing, S., Liao, Q., Chen, Y., Li, Q., Li, W., & Sun, H. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00910 · Cited by 232
Self-citationBasheer, N., Smolek, T., Hassan, I., Liu, F., Iqbal, K., Zilka, N., & Novak, P. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02113-z · Cited by 159
Metadata
- Authors
- He, Q., Liu, J., Liang, J., Liu, X., Li, W., Liu, Z., Ding, Z., & Tuo, D.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2018-03-23
- Volume
- 7
- Issue
- 4
- Pages
- 24
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W2792640679
- Cited by
- 298
- References
- 105
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- gold
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- He, Q., Liu, J., Liang, J., Liu, X., Li, W., Liu, Z., Ding, Z., & Tuo, D. (2018). Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective. Cells. https://doi.org/10.3390/cells7040024
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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